Details for: INPP5K

Gene ID: 51763

Symbol: INPP5K

Ensembl ID: ENSG00000132376

Description: inositol polyphosphate-5-phosphatase K

Associated with

  • Metabolism
    (R-HSA-1430728)
  • Metabolism of lipids
    (R-HSA-556833)
  • Phospholipid metabolism
    (R-HSA-1483257)
  • Pi metabolism
    (R-HSA-1483255)
  • Synthesis of pips at the plasma membrane
    (R-HSA-1660499)
  • Actin cytoskeleton organization
    (GO:0030036)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to hormone stimulus
    (GO:0032870)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dephosphorylation
    (GO:0016311)
  • Endoplasmic reticulum
    (GO:0005783)
  • Glucose homeostasis
    (GO:0042593)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
    (GO:0052659)
  • Inositol-1,4,5-trisphosphate 5-phosphatase activity
    (GO:0052658)
  • Inositol-polyphosphate 5-phosphatase activity
    (GO:0004445)
  • Inositol bisphosphate phosphatase activity
    (GO:0016312)
  • Inositol trisphosphate phosphatase activity
    (GO:0046030)
  • In utero embryonic development
    (GO:0001701)
  • Lipid phosphatase activity
    (GO:0042577)
  • Membrane
    (GO:0016020)
  • Negative regulation by host of viral transcription
    (GO:0043922)
  • Negative regulation of calcium ion transport
    (GO:0051926)
  • Negative regulation of d-glucose transmembrane transport
    (GO:0010829)
  • Negative regulation of dephosphorylation
    (GO:0035305)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of glycogen (starch) synthase activity
    (GO:2000466)
  • Negative regulation of glycogen biosynthetic process
    (GO:0045719)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of peptidyl-serine phosphorylation
    (GO:0033137)
  • Negative regulation of peptidyl-threonine phosphorylation
    (GO:0010801)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of protein kinase activity
    (GO:0006469)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of protein targeting to membrane
    (GO:0090315)
  • Negative regulation of single stranded viral rna replication via double stranded dna intermediate
    (GO:0045869)
  • Negative regulation of stress fiber assembly
    (GO:0051497)
  • Neuron projection
    (GO:0043005)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
    (GO:0034485)
  • Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
    (GO:0004439)
  • Phosphatidylinositol biosynthetic process
    (GO:0006661)
  • Phosphatidylinositol dephosphorylation
    (GO:0046856)
  • Phosphatidylinositol phosphate 5-phosphatase activity
    (GO:0034595)
  • Phosphatidylinositol trisphosphate phosphatase activity
    (GO:0034594)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of renal water transport
    (GO:2001153)
  • Positive regulation of urine volume
    (GO:0035810)
  • Protein binding
    (GO:0005515)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Regulation of glycogen biosynthetic process
    (GO:0005979)
  • Ruffle
    (GO:0001726)
  • Ruffle assembly
    (GO:0097178)
  • Ruffle membrane
    (GO:0032587)
  • Trans-golgi network
    (GO:0005802)
  • Vasopressin receptor activity
    (GO:0005000)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.6985
    Cell Significance Index: -13.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.2995
    Cell Significance Index: -14.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.5778
    Cell Significance Index: -14.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 32.2521
    Cell Significance Index: -16.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7279
    Cell Significance Index: -14.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5952
    Cell Significance Index: -12.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0446
    Cell Significance Index: -15.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8015
    Cell Significance Index: -8.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7279
    Cell Significance Index: -11.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3354
    Cell Significance Index: 18.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1896
    Cell Significance Index: 193.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0683
    Cell Significance Index: 964.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8247
    Cell Significance Index: 13.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7471
    Cell Significance Index: 81.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7295
    Cell Significance Index: 43.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5498
    Cell Significance Index: 64.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5489
    Cell Significance Index: 16.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5262
    Cell Significance Index: 27.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4070
    Cell Significance Index: 28.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4025
    Cell Significance Index: 8.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3942
    Cell Significance Index: 20.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3446
    Cell Significance Index: 9.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2917
    Cell Significance Index: 34.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2746
    Cell Significance Index: 17.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2610
    Cell Significance Index: 52.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2581
    Cell Significance Index: 49.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2359
    Cell Significance Index: 11.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2279
    Cell Significance Index: 10.3300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1898
    Cell Significance Index: 2.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1754
    Cell Significance Index: 77.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1625
    Cell Significance Index: 29.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1495
    Cell Significance Index: 19.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1467
    Cell Significance Index: 52.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1383
    Cell Significance Index: 6.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1306
    Cell Significance Index: 16.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1297
    Cell Significance Index: 3.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1052
    Cell Significance Index: 7.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1027
    Cell Significance Index: 3.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1004
    Cell Significance Index: 19.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0912
    Cell Significance Index: 6.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0864
    Cell Significance Index: 8.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0858
    Cell Significance Index: 46.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0835
    Cell Significance Index: 5.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0795
    Cell Significance Index: 10.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0771
    Cell Significance Index: 2.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0629
    Cell Significance Index: 8.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0498
    Cell Significance Index: 93.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0427
    Cell Significance Index: 3.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0352
    Cell Significance Index: 0.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0334
    Cell Significance Index: 0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0295
    Cell Significance Index: 54.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0259
    Cell Significance Index: 39.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0182
    Cell Significance Index: 11.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0085
    Cell Significance Index: 1.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0012
    Cell Significance Index: 1.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0111
    Cell Significance Index: -1.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0190
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0213
    Cell Significance Index: -2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0289
    Cell Significance Index: -18.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0419
    Cell Significance Index: -0.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0437
    Cell Significance Index: -12.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0541
    Cell Significance Index: -1.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0573
    Cell Significance Index: -3.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0598
    Cell Significance Index: -1.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0629
    Cell Significance Index: -3.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0726
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0789
    Cell Significance Index: -9.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0852
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0863
    Cell Significance Index: -18.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0939
    Cell Significance Index: -5.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0966
    Cell Significance Index: -0.8900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0986
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1031
    Cell Significance Index: -6.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1099
    Cell Significance Index: -2.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1221
    Cell Significance Index: -3.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1313
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1333
    Cell Significance Index: -13.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1533
    Cell Significance Index: -4.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1611
    Cell Significance Index: -4.3100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1654
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1723
    Cell Significance Index: -4.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1837
    Cell Significance Index: -14.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1871
    Cell Significance Index: -4.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1935
    Cell Significance Index: -8.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2064
    Cell Significance Index: -1.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2109
    Cell Significance Index: -5.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2299
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2422
    Cell Significance Index: -5.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2440
    Cell Significance Index: -9.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2517
    Cell Significance Index: -15.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2587
    Cell Significance Index: -5.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2903
    Cell Significance Index: -3.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3171
    Cell Significance Index: -8.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3333
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Structure:** INPP5K is a membrane-bound enzyme belonging to the inositol polyphosphate-5-phosphatase family, characterized by its unique structure and enzymatic activity. 2. **Subcellular Localization:** INPP5K is primarily localized to the plasma membrane, where it regulates various signaling pathways. 3. **Regulatory Mechanisms:** INPP5K is negatively regulated by several proteins and pathways, including insulin receptor signaling, phosphatidylinositol 3-kinase/protein kinase B signal transduction, and MAP kinase activity. **Pathways and Functions:** 1. **Glucose Homeostasis:** INPP5K regulates glucose metabolism by inhibiting insulin receptor signaling, thereby modulating glycogen synthesis and storage. 2. **Cellular Response to Hormones:** INPP5K mediates the negative regulation of hormone-stimulated signaling pathways, including those involved in cellular proliferation, differentiation, and survival. 3. **Actin Cytoskeleton Organization:** INPP5K regulates actin dynamics by negatively controlling the activity of the Wiskott-Aldrich syndrome protein, which is essential for maintaining cytoskeletal stability. 4. **Inositol Phosphate Signaling:** INPP5K dephosphorylates inositol-1,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby regulating calcium signaling and cellular responses to hormones. 5. **Regulation of Lipid Metabolism:** INPP5K modulates lipid metabolism by negatively regulating phosphatidylinositol biosynthesis and phospholipid metabolism. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Dysregulation of INPP5K has been implicated in the development of type 2 diabetes, insulin resistance, and metabolic syndrome. 2. **Immune System Dysregulation:** INPP5K plays a crucial role in regulating immune cell function, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** INPP5K has been identified as a tumor suppressor gene, and its dysregulation has been associated with cancer progression and metastasis. 4. **Neurological Disorders:** INPP5K has been implicated in the regulation of neuronal function and has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, INPP5K is a multifunctional gene that plays a critical role in regulating various cellular processes, including glucose homeostasis, hormone signaling, and lipid metabolism. Its dysregulation has been implicated in several diseases, including diabetes, immune system dysregulation, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms of INPP5K and its role in human disease.

Genular Protein ID: 1537285289

Symbol: INP5K_HUMAN

Name: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

UniProtKB Accession Codes:

Q9BT40 B2R6I2 B2R750 D3DTH8 Q15733 Q9NPJ5 Q9P2R5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 20 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 57 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 10 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10753883

Title: Identification and characterization of a novel inositol polyphosphate 5-phosphatase.

PubMed ID: 10753883

DOI: 10.1074/jbc.275.15.10870

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12536145

Title: Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.

PubMed ID: 12536145

DOI: 10.1074/jbc.m209991200

PubMed ID: 16824732

Title: The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.

PubMed ID: 16824732

DOI: 10.1016/j.cellsig.2006.05.010

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26940976

Title: Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.

PubMed ID: 26940976

DOI: 10.1111/gtc.12353

PubMed ID: 28190456

Title: Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital muscular dystrophy with cataracts and mild cognitive impairment.

PubMed ID: 28190456

DOI: 10.1016/j.ajhg.2017.01.024

PubMed ID: 28190459

Title: Mutations in INPP5K cause a form of Congenital Muscular Dystrophy overlapping Marinesco-Sjoegren Syndrome and dystroglycanopathy.

PubMed ID: 28190459

DOI: 10.1016/j.ajhg.2017.01.019

Sequence Information:

  • Length: 448
  • Mass: 51090
  • Checksum: 46FAA48C6E2EEAD4
  • Sequence:
    • MSSRKLSGPK GRRLSIHVVT WNVASAAPPL DLSDLLQLNN RNLNLDIYVI GLQELNSGII 
SLLSDAAFND SWSSFLMDVL SPLSFIKVSH VRMQGILLLV FAKYQHLPYI QILSTKSTPT 
GLFGYWGNKG GVNICLKLYG YYVSIINCHL PPHISNNYQR LEHFDRILEM QNCEGRDIPN 
ILDHDLIIWF GDMNFRIEDF GLHFVRESIK NRCYGGLWEK DQLSIAKKHD PLLREFQEGR 
LLFPPTYKFD RNSNDYDTSE KKRKPAWTDR ILWRLKRQPC AGPDTPIPPA SHFSLSLRGY 
SSHMTYGISD HKPVSGTFDL ELKPLVSAPL IVLMPEDLWT VENDMMVSYS STSDFPSSPW 
DWIGLYKVGL RDVNDYVSYA WVGDSKVSCS DNLNQVYIDI SNIPTTEDEF LLCYYSNSLR 
SVVGISRPFQ IPPGSLREDP LGEAQPQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.