Details for: PF4V1

Gene ID: 5197

Symbol: PF4V1

Ensembl ID: ENSG00000109272

Description: platelet factor 4 variant 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.7581
    Cell Significance Index: -2.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.4765
    Cell Significance Index: -2.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 5.5795
    Cell Significance Index: -2.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.2553
    Cell Significance Index: -2.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5264
    Cell Significance Index: 130.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.7358
    Cell Significance Index: 167.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6165
    Cell Significance Index: 56.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2778
    Cell Significance Index: 72.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.9111
    Cell Significance Index: 28.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.7357
    Cell Significance Index: -2.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.2078
    Cell Significance Index: 35.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0375
    Cell Significance Index: 47.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8913
    Cell Significance Index: 169.6100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7310
    Cell Significance Index: 7.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5935
    Cell Significance Index: 12.6400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4681
    Cell Significance Index: 5.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4499
    Cell Significance Index: 27.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4408
    Cell Significance Index: 43.6100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.4221
    Cell Significance Index: 4.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3984
    Cell Significance Index: 359.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3740
    Cell Significance Index: 40.6800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2853
    Cell Significance Index: 3.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2533
    Cell Significance Index: 41.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2014
    Cell Significance Index: 13.9300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1763
    Cell Significance Index: 2.5600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1487
    Cell Significance Index: 0.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1208
    Cell Significance Index: 1.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0831
    Cell Significance Index: 4.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0802
    Cell Significance Index: 2.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0308
    Cell Significance Index: 0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0256
    Cell Significance Index: 3.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0174
    Cell Significance Index: 0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0168
    Cell Significance Index: 0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0158
    Cell Significance Index: 2.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0064
    Cell Significance Index: 0.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0049
    Cell Significance Index: 2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0026
    Cell Significance Index: -1.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0026
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.6100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0039
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0043
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0093
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0116
    Cell Significance Index: -1.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0122
    Cell Significance Index: -0.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0139
    Cell Significance Index: -1.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0144
    Cell Significance Index: -1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0149
    Cell Significance Index: -0.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0158
    Cell Significance Index: -2.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0191
    Cell Significance Index: -0.9000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0221
    Cell Significance Index: -0.2800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0243
    Cell Significance Index: -0.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0252
    Cell Significance Index: -1.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0252
    Cell Significance Index: -1.3100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0274
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0295
    Cell Significance Index: -2.3400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0301
    Cell Significance Index: -0.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0345
    Cell Significance Index: -2.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0353
    Cell Significance Index: -1.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0426
    Cell Significance Index: -0.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0443
    Cell Significance Index: -1.2700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0452
    Cell Significance Index: -0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0453
    Cell Significance Index: -1.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0458
    Cell Significance Index: -1.6800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0521
    Cell Significance Index: -0.5700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0534
    Cell Significance Index: -0.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0542
    Cell Significance Index: -1.9000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0593
    Cell Significance Index: -0.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0608
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0619
    Cell Significance Index: -1.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0650
    Cell Significance Index: -1.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0709
    Cell Significance Index: -1.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0717
    Cell Significance Index: -2.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0721
    Cell Significance Index: -2.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0725
    Cell Significance Index: -1.0700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0759
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0763
    Cell Significance Index: -1.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0775
    Cell Significance Index: -1.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0785
    Cell Significance Index: -2.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0814
    Cell Significance Index: -2.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0829
    Cell Significance Index: -2.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0841
    Cell Significance Index: -1.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0848
    Cell Significance Index: -1.4200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0860
    Cell Significance Index: -1.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0864
    Cell Significance Index: -1.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0892
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0916
    Cell Significance Index: -1.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0922
    Cell Significance Index: -2.1300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0931
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PF4V1 is a gene that codes for a variant of the PF4 protein, which is a small, secreted protein produced by megakaryocytes and other cells. The PF4 protein plays a critical role in platelet aggregation and blood clot formation. The PF4V1 variant is characterized by a specific amino acid substitution, which may affect its function and interactions with other proteins. The PF4V1 gene is highly expressed in cells involved in the hematopoietic system, including megakaryocytes, granulocytes, and monocytes, as well as in the nervous system, where it is expressed in glutamatergic neurons and oligodendrocyte precursor cells. **Pathways and Functions:** PF4V1 is involved in various signaling pathways that regulate immune response, hemostasis, and inflammation. The PF4 protein interacts with heparin-binding proteins, such as thrombospondin and fibronectin, to regulate platelet aggregation and blood clot formation. It also interacts with chemokines, such as CXCL12, to regulate chemotaxis and migration of immune cells. The PF4V1 gene is involved in the common pathway of fibrin clot formation, which is essential for hemostasis. Additionally, PF4V1 is involved in the inflammatory response, where it regulates the production of pro-inflammatory cytokines and chemokines. **Clinical Significance:** Dysregulation of the PF4V1 gene has been implicated in several diseases, including heparin-induced thrombocytopenia (HIT), a condition characterized by the formation of antibodies against PF4, leading to thrombocytopenia and thrombosis. HIT is a serious condition that requires prompt treatment to prevent cardiovascular complications. Additionally, PF4V1 has been associated with other diseases, including cancer, where it may contribute to tumor progression and metastasis. Furthermore, PF4V1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where it may contribute to neuronal damage and inflammation. In conclusion, the PF4V1 gene plays a complex and multifaceted role in regulating immune response, hemostasis, and inflammation. Its dysregulation has significant clinical implications, highlighting the need for further research into the mechanisms of PF4V1 and its role in various diseases.

Genular Protein ID: 2335566506

Symbol: PF4V_HUMAN

Name: Platelet factor 4 variant

UniProtKB Accession Codes:

P10720 A1L4S0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2725510

Title: Identification and characterization of PF4var1, a human gene variant of platelet factor 4.

PubMed ID: 2725510

DOI: 10.1128/mcb.9.4.1445-1451.1989

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1695112

Title: Structural and functional comparison of the genes for human platelet factor 4 and PF4alt.

PubMed ID: 1695112

PubMed ID: 15459074

Title: Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.

PubMed ID: 15459074

DOI: 10.1161/01.res.0000146674.38319.07

PubMed ID: 23536183

Title: Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1.

PubMed ID: 23536183

DOI: 10.1074/jbc.m113.455329

Sequence Information:

  • Length: 104
  • Mass: 11553
  • Checksum: 786FE2B288532E28
  • Sequence:
    • MSSAARSRLT RATRQEMLFL ALLLLPVVVA FARAEAEEDG DLQCLCVKTT SQVRPRHITS 
LEVIKAGPHC PTAQLIATLK NGRKICLDLQ ALLYKKIIKE HLES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.