Details for: PGA5

Gene ID: 5222

Symbol: PGA5

Ensembl ID: ENSG00000256713

Description: pepsinogen A5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 9.5298
    Cell Significance Index: 120.6900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.2973
    Cell Significance Index: 6.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.6988
    Cell Significance Index: 9.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.5081
    Cell Significance Index: 5.2700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.0892
    Cell Significance Index: 0.7900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: 0.0133
    Cell Significance Index: 0.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0087
    Cell Significance Index: -0.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0088
    Cell Significance Index: -0.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: -0.0109
    Cell Significance Index: 0.0200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0114
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0120
    Cell Significance Index: -2.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0151
    Cell Significance Index: -0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0172
    Cell Significance Index: -32.4300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0192
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0302
    Cell Significance Index: -0.3900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0363
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0368
    Cell Significance Index: -0.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0411
    Cell Significance Index: -0.2900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0427
    Cell Significance Index: -0.4200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0439
    Cell Significance Index: -0.4200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0443
    Cell Significance Index: -0.4800
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0498
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0509
    Cell Significance Index: -28.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0515
    Cell Significance Index: -38.1500
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0541
    Cell Significance Index: -0.4300
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0572
    Cell Significance Index: -0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0711
    Cell Significance Index: -25.5200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0715
    Cell Significance Index: -0.4200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.0886
    Cell Significance Index: -0.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1002
    Cell Significance Index: -18.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1211
    Cell Significance Index: -54.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1254
    Cell Significance Index: -1.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1268
    Cell Significance Index: -12.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1273
    Cell Significance Index: -25.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1297
    Cell Significance Index: -26.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1458
    Cell Significance Index: -17.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1510
    Cell Significance Index: -4.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2037
    Cell Significance Index: -12.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2128
    Cell Significance Index: -3.0900
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: -0.2254
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2721
    Cell Significance Index: -37.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2754
    Cell Significance Index: -31.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3124
    Cell Significance Index: -32.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3384
    Cell Significance Index: -17.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3627
    Cell Significance Index: -18.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3660
    Cell Significance Index: -23.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3775
    Cell Significance Index: -54.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3777
    Cell Significance Index: -17.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4070
    Cell Significance Index: -27.3700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4164
    Cell Significance Index: -2.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4768
    Cell Significance Index: -14.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5258
    Cell Significance Index: -18.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6743
    Cell Significance Index: -37.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7310
    Cell Significance Index: -38.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.7489
    Cell Significance Index: -12.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7724
    Cell Significance Index: -27.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8479
    Cell Significance Index: -27.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8529
    Cell Significance Index: -27.9300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.8632
    Cell Significance Index: -11.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8724
    Cell Significance Index: -53.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9023
    Cell Significance Index: -39.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9096
    Cell Significance Index: -24.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9294
    Cell Significance Index: -18.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9382
    Cell Significance Index: -25.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.9690
    Cell Significance Index: -11.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0239
    Cell Significance Index: -29.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0513
    Cell Significance Index: -39.8100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -1.0750
    Cell Significance Index: -12.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0847
    Cell Significance Index: -23.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0900
    Cell Significance Index: -27.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1193
    Cell Significance Index: -27.9200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -1.1205
    Cell Significance Index: -12.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.1254
    Cell Significance Index: -27.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.1344
    Cell Significance Index: -18.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1398
    Cell Significance Index: -29.9700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -1.1733
    Cell Significance Index: -13.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1978
    Cell Significance Index: -43.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2249
    Cell Significance Index: -22.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.2367
    Cell Significance Index: -24.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2377
    Cell Significance Index: -26.7400
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -1.2453
    Cell Significance Index: -11.7800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.2709
    Cell Significance Index: -15.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2721
    Cell Significance Index: -27.0000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.2888
    Cell Significance Index: -18.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.3018
    Cell Significance Index: -25.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3145
    Cell Significance Index: -26.3900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -1.3359
    Cell Significance Index: -16.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3372
    Cell Significance Index: -22.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3498
    Cell Significance Index: -26.6900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -1.3658
    Cell Significance Index: -18.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.3728
    Cell Significance Index: -26.8400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.3786
    Cell Significance Index: -17.7100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.3918
    Cell Significance Index: -15.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pepsinogen A5**: The PGA5 gene encodes for a precursor protein, pepsinogen A5, which is a zymogen that requires activation to become its active form, pepsin A5. 2. **Digestive Function**: Pepsin A5 is a key enzyme involved in protein digestion, breaking down proteins into smaller peptides and amino acids that can be absorbed by the body. 3. **Immune Regulation**: The PGA5 gene is expressed in immune cells, such as T cells and plasma cells, suggesting its role in regulating immune responses. 4. **Tissue Distribution**: The PGA5 gene is expressed in various tissues, including the cerebral cortex, indicating its involvement in neural functions. **Pathways and Functions:** 1. **Aspartic-type endopeptidase activity**: Pepsin A5 is a member of the aspartic-type endopeptidase family, which is involved in protein digestion and hydrolysis. 2. **Digestion**: Pepsin A5 plays a crucial role in protein digestion, breaking down proteins into smaller peptides and amino acids. 3. **Proteolysis**: The PGA5 gene is involved in proteolysis, the process of protein degradation, which is essential for protein digestion and immune regulation. 4. **Extracellular exosome**: The PGA5 gene is associated with the extracellular exosome, a membrane-bound organelle involved in the transport of proteins and lipids. 5. **Multivesicular body lumen**: Pepsin A5 is also involved in the multivesicular body lumen, a compartment involved in protein degradation and recycling. **Clinical Significance:** 1. **Gastrointestinal Disorders**: Alterations in PGA5 gene expression or function may contribute to gastrointestinal disorders, such as peptic ulcers, gastritis, or inflammatory bowel disease. 2. **Immune System Disorders**: Dysregulation of the PGA5 gene may also contribute to immune system disorders, such as autoimmune diseases or immunodeficiency disorders. 3. **Neurological Disorders**: The PGA5 gene's expression in the cerebral cortex suggests its involvement in neural functions, and alterations in its expression may contribute to neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Cancer**: The PGA5 gene's role in protein digestion and regulation of immune responses may also contribute to cancer development and progression. In conclusion, the PGA5 gene plays a critical role in protein digestion and regulation of immune responses, and its dysregulation may contribute to various diseases, including gastrointestinal, immune, and neurological disorders. Further research is necessary to fully understand the functions of PGA5 and its potential therapeutic applications.

Genular Protein ID: 2113045257

Symbol: PEPA5_HUMAN

Name: Pepsin A-5

UniProtKB Accession Codes:

P0DJD9 A8K749 B7ZW62 B7ZW75 P00790 Q7M4R0 Q8N1E3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 13 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2714789

Title: Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.

PubMed ID: 2714789

DOI: 10.1016/0888-7543(89)90325-x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2415509

Title: Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.

PubMed ID: 2415509

DOI: 10.1093/oxfordjournals.jbchem.a135303

PubMed ID: 2515193

Title: A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.

PubMed ID: 2515193

DOI: 10.1093/oxfordjournals.jbchem.a122952

PubMed ID: 3197840

Title: Activation of human pepsinogens.

PubMed ID: 3197840

DOI: 10.1016/0014-5793(88)81033-0

PubMed ID: 4909888

Title: Carboxyl-terminal sequence of human gastricsin and pepsin.

PubMed ID: 4909888

DOI: 10.1016/s0021-9258(18)63137-0

PubMed ID: 6300126

Title: Primary structure of human pepsinogen gene.

PubMed ID: 6300126

DOI: 10.1016/s0021-9258(18)32572-9

PubMed ID: 7663352

Title: Crystal structure of human pepsin and its complex with pepstatin.

PubMed ID: 7663352

DOI: 10.1002/pro.5560040516

Sequence Information:

  • Length: 388
  • Mass: 41993
  • Checksum: 2C456A75DA96CDDA
  • Sequence:
    • MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP 
TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP 
EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD 
GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DKSGSVVIFG GIDSSYYTGS 
LNWVPVTVEG YWQITVDSIT MNGETIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS 
ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNVPTESGEL 
WILGDVFIRQ YFTVFDRANN QVGLAPVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.