Details for: PGGT1B

Gene ID: 5229

Symbol: PGGT1B

Ensembl ID: ENSG00000164219

Description: protein geranylgeranyltransferase type I subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.3977
    Cell Significance Index: -28.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.2515
    Cell Significance Index: -26.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.0178
    Cell Significance Index: -29.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.3128
    Cell Significance Index: -23.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.1508
    Cell Significance Index: -27.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.8585
    Cell Significance Index: -29.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.3342
    Cell Significance Index: -28.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2730
    Cell Significance Index: -27.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3821
    Cell Significance Index: -29.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1795
    Cell Significance Index: -18.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7972
    Cell Significance Index: 193.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5777
    Cell Significance Index: 99.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5397
    Cell Significance Index: 179.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3623
    Cell Significance Index: 16.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1494
    Cell Significance Index: 186.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9188
    Cell Significance Index: 184.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7665
    Cell Significance Index: 530.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7358
    Cell Significance Index: 15.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6776
    Cell Significance Index: 9.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6300
    Cell Significance Index: 9.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5758
    Cell Significance Index: 114.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5366
    Cell Significance Index: 96.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4321
    Cell Significance Index: 155.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4071
    Cell Significance Index: 21.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3933
    Cell Significance Index: 48.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3728
    Cell Significance Index: 20.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3422
    Cell Significance Index: 46.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3357
    Cell Significance Index: 21.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3292
    Cell Significance Index: 62.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3200
    Cell Significance Index: 24.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2551
    Cell Significance Index: 112.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2162
    Cell Significance Index: 10.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2087
    Cell Significance Index: 113.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1922
    Cell Significance Index: 22.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1346
    Cell Significance Index: 3.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1090
    Cell Significance Index: 7.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0842
    Cell Significance Index: 10.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0794
    Cell Significance Index: 4.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0547
    Cell Significance Index: 5.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0487
    Cell Significance Index: 1.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0430
    Cell Significance Index: 1.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0386
    Cell Significance Index: 2.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0107
    Cell Significance Index: 6.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0050
    Cell Significance Index: 9.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0048
    Cell Significance Index: 7.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0098
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0225
    Cell Significance Index: -17.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0256
    Cell Significance Index: -19.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0334
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0375
    Cell Significance Index: -1.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0391
    Cell Significance Index: -5.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0406
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0437
    Cell Significance Index: -7.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0480
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0495
    Cell Significance Index: -27.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0563
    Cell Significance Index: -5.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0576
    Cell Significance Index: -3.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0741
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0795
    Cell Significance Index: -1.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0805
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0813
    Cell Significance Index: -3.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0829
    Cell Significance Index: -23.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1083
    Cell Significance Index: -12.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1237
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1537
    Cell Significance Index: -32.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1676
    Cell Significance Index: -5.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1907
    Cell Significance Index: -5.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2035
    Cell Significance Index: -5.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2117
    Cell Significance Index: -4.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2126
    Cell Significance Index: -11.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2136
    Cell Significance Index: -4.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2193
    Cell Significance Index: -3.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2423
    Cell Significance Index: -6.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2577
    Cell Significance Index: -26.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2845
    Cell Significance Index: -22.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3132
    Cell Significance Index: -7.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3160
    Cell Significance Index: -4.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3269
    Cell Significance Index: -16.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3333
    Cell Significance Index: -6.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3407
    Cell Significance Index: -20.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3520
    Cell Significance Index: -18.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3708
    Cell Significance Index: -3.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4235
    Cell Significance Index: -11.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4528
    Cell Significance Index: -10.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4629
    Cell Significance Index: -9.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4985
    Cell Significance Index: -7.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5006
    Cell Significance Index: -14.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5365
    Cell Significance Index: -15.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5526
    Cell Significance Index: -12.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5630
    Cell Significance Index: -17.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5641
    Cell Significance Index: -14.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5797
    Cell Significance Index: -18.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6001
    Cell Significance Index: -19.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Geranylgeranylation**: PGGT1B is a key enzyme responsible for the geranylgeranylation of proteins, a post-translational modification that involves the addition of a geranylgeranyl group to the C-terminal cysteine residue of proteins. 2. **Subunit of Geranylgeranyltransferase Type I**: PGGT1B is a subunit of the geranylgeranyltransferase type I (GGT1) complex, which consists of two subunits: PGGT1A and PGGT1B. 3. **Tissue-Specific Expression**: PGGT1B is highly expressed in neurons, particularly in the cerebral cortex, retina, and photoreceptor cells, highlighting its crucial role in neuronal development and function. 4. **Zinc Binding**: PGGT1B contains a zinc-binding motif, which is essential for the enzyme's catalytic activity. **Pathways and Functions:** 1. **Protein Geranylgeranylation**: PGGT1B catalyzes the geranylgeranylation of proteins, which is essential for their proper functioning in various cellular processes, including cell signaling, adhesion, and membrane trafficking. 2. **Neuronal Signaling**: Geranylgeranylation of proteins involved in neuronal signaling, such as Ras and Rho, is crucial for the regulation of synaptic plasticity, neuronal growth, and differentiation. 3. **Cell Adhesion**: Geranylgeranylation of proteins involved in cell adhesion, such as N-Ras and Rho, is essential for the regulation of cell-cell interactions and tissue organization. 4. **Membrane Trafficking**: Geranylgeranylation of proteins involved in membrane trafficking, such as Rab and Arf, is crucial for the regulation of vesicle transport and membrane dynamics. **Clinical Significance:** 1. **Neurological Disorders**: Dysregulation of PGGT1B has been linked to several neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: Geranylgeranylation of proteins involved in cell signaling and adhesion is also implicated in the development and progression of various cancers. 3. **Neurodevelopmental Disorders**: Abnormalities in PGGT1B expression and function have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Therapeutic Targeting**: Understanding the functions and dysregulation of PGGT1B offers potential therapeutic avenues for the treatment of neurological and cancerous diseases. In conclusion, PGGT1B is a critical protein subunit involved in the geranylgeranyltransferase activity, which plays a vital role in various cellular processes, including neuronal signaling, cell adhesion, and membrane trafficking. Further research is necessary to elucidate the mechanisms underlying the dysregulation of PGGT1B and its implications in neurological and cancerous diseases.

Genular Protein ID: 3707776324

Symbol: PGTB1_HUMAN

Name: Geranylgeranyl transferase type-1 subunit beta

UniProtKB Accession Codes:

P53609 Q5MJP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SFLD 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8106351

Title: cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.

PubMed ID: 8106351

DOI: 10.1016/s0021-9258(17)41845-x

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 377
  • Mass: 42368
  • Checksum: AA04C9B34B8A3FDC
  • Sequence:
    • MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI AFFALSGLDM 
LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY LGIPFNPSKA PGTAHPYDSG 
HIAMTYTGLS CLVILGDDLS RVNKEACLAG LRALQLEDGS FCAVPEGSEN DMRFVYCASC 
ICYMLNNWSG MDMKKAITYI RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF 
SEKELNRIKR WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS 
TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT SERLLDLHQS 
WKTKDSKQCS ENVHIST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.