Details for: PIM1

Gene ID: 5292

Symbol: PIM1

Ensembl ID: ENSG00000137193

Description: Pim-1 proto-oncogene, serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.4259
    Cell Significance Index: -22.1800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.5483
    Cell Significance Index: -12.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.3210
    Cell Significance Index: -33.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.7411
    Cell Significance Index: -31.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.4568
    Cell Significance Index: -33.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9889
    Cell Significance Index: -9.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4461
    Cell Significance Index: -29.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9451
    Cell Significance Index: -18.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.7062
    Cell Significance Index: 167.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4893
    Cell Significance Index: -14.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4289
    Cell Significance Index: 178.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1271
    Cell Significance Index: 60.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2690
    Cell Significance Index: 174.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0896
    Cell Significance Index: 19.2600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.0111
    Cell Significance Index: 5.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9577
    Cell Significance Index: 112.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9409
    Cell Significance Index: 24.7400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.8613
    Cell Significance Index: 2.6300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4985
    Cell Significance Index: 3.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4576
    Cell Significance Index: 59.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4424
    Cell Significance Index: 26.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4200
    Cell Significance Index: 9.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3820
    Cell Significance Index: 68.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3818
    Cell Significance Index: 41.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3739
    Cell Significance Index: 71.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3629
    Cell Significance Index: 9.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3616
    Cell Significance Index: 3.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3609
    Cell Significance Index: 44.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3589
    Cell Significance Index: 58.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3513
    Cell Significance Index: 34.7500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3171
    Cell Significance Index: 1.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2824
    Cell Significance Index: 7.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2297
    Cell Significance Index: 10.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1717
    Cell Significance Index: 11.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1632
    Cell Significance Index: 72.1400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.1548
    Cell Significance Index: 2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1400
    Cell Significance Index: 3.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1332
    Cell Significance Index: 38.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1258
    Cell Significance Index: 4.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1118
    Cell Significance Index: 61.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1049
    Cell Significance Index: 20.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0869
    Cell Significance Index: 163.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0703
    Cell Significance Index: 1.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0620
    Cell Significance Index: 1.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0432
    Cell Significance Index: 38.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0278
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0205
    Cell Significance Index: 4.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0057
    Cell Significance Index: 2.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0056
    Cell Significance Index: 3.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0005
    Cell Significance Index: -0.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0145
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0181
    Cell Significance Index: -27.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0196
    Cell Significance Index: -14.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0200
    Cell Significance Index: -13.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0212
    Cell Significance Index: -13.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0233
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0265
    Cell Significance Index: -4.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0327
    Cell Significance Index: -1.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0367
    Cell Significance Index: -26.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0381
    Cell Significance Index: -21.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0397
    Cell Significance Index: -18.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0403
    Cell Significance Index: -0.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0486
    Cell Significance Index: -6.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0492
    Cell Significance Index: -1.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0744
    Cell Significance Index: -7.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0820
    Cell Significance Index: -9.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0885
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0985
    Cell Significance Index: -20.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1031
    Cell Significance Index: -12.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1189
    Cell Significance Index: -17.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1202
    Cell Significance Index: -13.7200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1236
    Cell Significance Index: -1.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1871
    Cell Significance Index: -12.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2254
    Cell Significance Index: -15.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2558
    Cell Significance Index: -26.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2939
    Cell Significance Index: -18.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3056
    Cell Significance Index: -4.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3109
    Cell Significance Index: -5.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3140
    Cell Significance Index: -17.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3154
    Cell Significance Index: -3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3185
    Cell Significance Index: -14.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3275
    Cell Significance Index: -24.4100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3503
    Cell Significance Index: -1.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3623
    Cell Significance Index: -7.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3732
    Cell Significance Index: -4.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3925
    Cell Significance Index: -12.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3933
    Cell Significance Index: -6.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3955
    Cell Significance Index: -24.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4051
    Cell Significance Index: -32.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4142
    Cell Significance Index: -27.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4255
    Cell Significance Index: -21.5100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.4686
    Cell Significance Index: -2.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4794
    Cell Significance Index: -19.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4966
    Cell Significance Index: -31.3000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.6010
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PIM1 is a serine/threonine kinase that belongs to the Pim family of kinases. It is characterized by its ability to phosphorylate and regulate various substrates, including transcription factors, signaling molecules, and cytoskeletal proteins. PIM1 is overexpressed in several types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL), and has been shown to promote cell proliferation, survival, and resistance to apoptosis. **Pathways and Functions:** PIM1 is involved in several signaling pathways, including: 1. **Apoptotic process:** PIM1 can modulate the apoptotic pathway by phosphorylating and regulating pro-apoptotic and anti-apoptotic proteins. 2. **Cell cycle:** PIM1 can regulate the cell cycle by phosphorylating and activating cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CKIs). 3. **Immune system:** PIM1 is expressed in immune cells, including T cells, natural killer cells, and dendritic cells, and plays a role in regulating immune responses, including the activation of T cells and the production of cytokines. 4. **Cardiac muscle cell proliferation:** PIM1 is involved in the regulation of cardiac muscle cell proliferation, which is critical for heart development and repair. **Clinical Significance:** Dysregulation of PIM1 has been implicated in various diseases, including: 1. **Cancer:** PIM1 overexpression has been linked to T-ALL, acute lymphoblastic leukemia (ALL), and other types of cancer. 2. **Autoimmune disorders:** PIM1 has been implicated in the regulation of immune responses and has been linked to autoimmune disorders, including multiple sclerosis and rheumatoid arthritis. 3. **Cardiovascular diseases:** PIM1 has been shown to promote cardiac muscle cell proliferation and has been implicated in the pathogenesis of cardiovascular diseases, including heart failure and atherosclerosis. 4. **Immune-related disorders:** PIM1 has been implicated in the regulation of immune responses and has been linked to immune-related disorders, including graft-versus-host disease and transplant rejection. In conclusion, PIM1 is a serine/threonine kinase with far-reaching implications in immune regulation and disease. Its dysregulation has been linked to various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Further research is needed to fully understand the mechanisms by which PIM1 regulates cellular processes and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Genular Protein ID: 3596247022

Symbol: PIM1_HUMAN

Name: Serine/threonine-protein kinase pim-1

UniProtKB Accession Codes:

P11309 Q38RT9 Q5T7H7 Q96RG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 22 DrugCentral 1 EC 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2205533

Title: Primary structure of the putative human oncogene, pim-1.

PubMed ID: 2205533

DOI: 10.1016/0378-1119(90)90195-w

PubMed ID: 3475233

Title: The cDNA sequence and gene analysis of the human pim oncogene.

PubMed ID: 3475233

DOI: 10.1016/0378-1119(87)90352-0

PubMed ID: 3329709

Title: Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein.

PubMed ID: 3329709

PubMed ID: 3429489

Title: Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases.

PubMed ID: 3429489

DOI: 10.1002/jcb.240350204

PubMed ID: 16186805

Title: The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.

PubMed ID: 16186805

DOI: 10.1038/sj.onc.1209058

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11460166

Title: Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas.

PubMed ID: 11460166

DOI: 10.1038/35085588

PubMed ID: 2837645

Title: Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity.

PubMed ID: 2837645

DOI: 10.1128/mcb.8.4.1498-1503.1988

PubMed ID: 1825810

Title: The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

PubMed ID: 1825810

DOI: 10.1002/j.1460-2075.1991.tb07994.x

PubMed ID: 10664448

Title: Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1.

PubMed ID: 10664448

DOI: 10.1016/s0014-5793(00)01105-4

PubMed ID: 12431783

Title: Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

PubMed ID: 12431783

DOI: 10.1016/s0167-4889(02)00347-6

PubMed ID: 12680209

Title: Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.

PubMed ID: 12680209

PubMed ID: 12473674

Title: Protein phosphatase 2A regulates the stability of Pim protein kinases.

PubMed ID: 12473674

DOI: 10.1074/jbc.m208246200

PubMed ID: 15528381

Title: IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils.

PubMed ID: 15528381

DOI: 10.4049/jimmunol.173.10.6409

PubMed ID: 15798097

Title: Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway.

PubMed ID: 15798097

DOI: 10.1158/1541-7786.mcr-04-0192

PubMed ID: 16356754

Title: The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

PubMed ID: 16356754

DOI: 10.1016/j.biocel.2005.10.010

PubMed ID: 18593906

Title: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.

PubMed ID: 18593906

DOI: 10.1158/0008-5472.can-08-0634

PubMed ID: 18056989

Title: The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.

PubMed ID: 18056989

DOI: 10.1074/jbc.m707773200

PubMed ID: 19749799

Title: PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.

PubMed ID: 19749799

DOI: 10.1038/onc.2009.276

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25121590

Title: EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation.

PubMed ID: 25121590

DOI: 10.1371/journal.ppat.1004304

PubMed ID: 31548394

Title: Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

PubMed ID: 31548394

DOI: 10.1073/pnas.1904774116

PubMed ID: 37797010

Title: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

PubMed ID: 37797010

DOI: 10.1126/science.adg2253

PubMed ID: 15657054

Title: Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

PubMed ID: 15657054

DOI: 10.1074/jbc.m413155200

PubMed ID: 15525646

Title: Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.

PubMed ID: 15525646

DOI: 10.1074/jbc.m409123200

PubMed ID: 15808862

Title: Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.

PubMed ID: 15808862

DOI: 10.1016/j.jmb.2005.02.039

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 313
  • Mass: 35686
  • Checksum: 35BA76D3668E69A3
  • Sequence:
    • MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVSD 
NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF SGVIRLLDWF ERPDSFVLIL 
ERPEPVQDLF DFITERGALQ EELARSFFWQ VLEAVRHCHN CGVLHRDIKD ENILIDLNRG 
ELKLIDFGSG ALLKDTVYTD FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI 
PFEHDEEIIR GQVFFRQRVS SECQHLIRWC LALRPSDRPT FEEIQNHPWM QDVLLPQETA 
EIHLHSLSPG PSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.