Details for: PLCD1

Gene ID: 5333

Symbol: PLCD1

Ensembl ID: ENSG00000187091

Description: phospholipase C delta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.0691
    Cell Significance Index: -11.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.1708
    Cell Significance Index: -10.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.1001
    Cell Significance Index: -11.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6583
    Cell Significance Index: -9.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8535
    Cell Significance Index: -11.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3760
    Cell Significance Index: -5.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2155
    Cell Significance Index: 421.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4035
    Cell Significance Index: 72.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9277
    Cell Significance Index: 837.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8959
    Cell Significance Index: 8.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8701
    Cell Significance Index: 39.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6288
    Cell Significance Index: 68.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5527
    Cell Significance Index: 33.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5399
    Cell Significance Index: 87.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5321
    Cell Significance Index: 7.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4031
    Cell Significance Index: 6.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3966
    Cell Significance Index: 5.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3460
    Cell Significance Index: 23.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3371
    Cell Significance Index: 9.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3014
    Cell Significance Index: 6.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2388
    Cell Significance Index: 6.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2354
    Cell Significance Index: 28.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2260
    Cell Significance Index: 40.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2258
    Cell Significance Index: 26.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2240
    Cell Significance Index: 7.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2201
    Cell Significance Index: 28.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1926
    Cell Significance Index: 26.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1784
    Cell Significance Index: 2.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1658
    Cell Significance Index: 4.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1567
    Cell Significance Index: 15.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1300
    Cell Significance Index: 89.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1085
    Cell Significance Index: 21.5300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1055
    Cell Significance Index: 0.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1040
    Cell Significance Index: 2.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0744
    Cell Significance Index: 3.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0681
    Cell Significance Index: 1.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0651
    Cell Significance Index: 1.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0535
    Cell Significance Index: 23.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0392
    Cell Significance Index: 7.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0287
    Cell Significance Index: 0.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0276
    Cell Significance Index: 0.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0204
    Cell Significance Index: 11.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0143
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0058
    Cell Significance Index: 10.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0055
    Cell Significance Index: 8.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0026
    Cell Significance Index: -0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0079
    Cell Significance Index: -10.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0091
    Cell Significance Index: -3.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0182
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -12.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0218
    Cell Significance Index: -12.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0229
    Cell Significance Index: -2.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0323
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0355
    Cell Significance Index: -6.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0381
    Cell Significance Index: -0.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0409
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0629
    Cell Significance Index: -13.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0661
    Cell Significance Index: -1.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0679
    Cell Significance Index: -8.0100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0737
    Cell Significance Index: -1.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0856
    Cell Significance Index: -6.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0920
    Cell Significance Index: -4.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0968
    Cell Significance Index: -5.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0969
    Cell Significance Index: -4.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1016
    Cell Significance Index: -10.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1031
    Cell Significance Index: -7.2900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1126
    Cell Significance Index: -1.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1140
    Cell Significance Index: -6.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1189
    Cell Significance Index: -7.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1193
    Cell Significance Index: -9.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1269
    Cell Significance Index: -7.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1461
    Cell Significance Index: -9.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1476
    Cell Significance Index: -3.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1481
    Cell Significance Index: -2.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1483
    Cell Significance Index: -3.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1560
    Cell Significance Index: -1.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1564
    Cell Significance Index: -2.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1575
    Cell Significance Index: -10.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1578
    Cell Significance Index: -4.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1655
    Cell Significance Index: -5.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2007
    Cell Significance Index: -5.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2327
    Cell Significance Index: -2.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2363
    Cell Significance Index: -10.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2515
    Cell Significance Index: -8.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2672
    Cell Significance Index: -9.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2784
    Cell Significance Index: -8.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2799
    Cell Significance Index: -10.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2800
    Cell Significance Index: -2.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2812
    Cell Significance Index: -8.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2883
    Cell Significance Index: -4.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** PLCD1 is a phospholipase C enzyme, which catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). 2. **Cellular Localization:** PLCD1 is primarily localized to the plasma membrane, where it plays a critical role in regulating calcium ion dynamics and lipid metabolism. 3. **Protein Interactions:** PLCD1 interacts with various proteins, including guanine nucleotide-binding protein (G protein) subunits, phosphatidylinositol kinase (PIK), and inositol polyphosphate 5-phosphatase (IP5P), modulating its enzymatic activity and signaling output. 4. **Expression Patterns:** PLCD1 is highly expressed in various cell types, including mural cells, kidney cells, immune cells, and neurons, suggesting its importance in maintaining cellular homeostasis and regulating cell proliferation. **Pathways and Functions:** 1. **Calcium Ion Signaling:** PLCD1 plays a critical role in regulating calcium ion dynamics by hydrolyzing PIP2 to produce IP3, which binds to IP3 receptors, releasing calcium ions into the cytosol. 2. **Lipid Metabolism:** PLCD1 is involved in the regulation of lipid metabolism by hydrolyzing PIP2 to produce DAG, which activates protein kinase C (PKC) and modulates various cellular processes. 3. **Cell Proliferation:** PLCD1 has been implicated in regulating cell proliferation by modulating the activity of downstream signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 4. **Immune Cell Function:** PLCD1 is expressed in immune cells, where it plays a role in regulating immune cell function and cytokine production. **Clinical Significance:** 1. **Cancer:** PLCD1 has been implicated in the development and progression of various cancers, including colorectal, breast, and lung cancer, where it regulates cell proliferation and metastasis. 2. **Neurological Disorders:** PLCD1 has been associated with various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, where it regulates calcium ion dynamics and lipid metabolism. 3. **Cardiovascular Disease:** PLCD1 has been implicated in the development of cardiovascular disease, where it regulates calcium ion dynamics and lipid metabolism, contributing to atherosclerosis and cardiac remodeling. 4. **Immunological Disorders:** PLCD1 has been associated with various immunological disorders, including autoimmune diseases and allergies, where it regulates immune cell function and cytokine production. In conclusion, PLCD1 is a critical enzyme involved in various cellular signaling pathways, playing a pivotal role in regulating calcium ion dynamics, lipid metabolism, and cell proliferation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, and immunological disorders. Further research is needed to fully elucidate the role of PLCD1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2832351139

Symbol: PLCD1_HUMAN

Name: Phosphoinositide phospholipase C-delta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7890667

Title: Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis.

PubMed ID: 7890667

DOI: 10.1074/jbc.270.10.5495

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9188725

Title: Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PubMed ID: 9188725

DOI: 10.1021/bi9702288

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21665001

Title: Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1.

PubMed ID: 21665001

DOI: 10.1016/j.ajhg.2011.05.014

Sequence Information:

  • Length: 756
  • Mass: 85665
  • Checksum: 6C6FD7F89BA08C83
  • Sequence:
  • MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT IWQESRKVMR 
    TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV FKDQRNTLDL IAPSPADAQH 
    WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR KADKNKDNKM SFKELQNFLK ELNIQVDDSY 
    ARKIFRECDH SQTDSLEDEE IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ 
    QREEAAGPAL ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ 
    PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ EPIIYHGYTF 
    TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV MARHLHAILG PMLLNRPLDG 
    VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG EGGPEATVVS DEDEAAEMED EAVRSRVQHK 
    PKEDKLRLAQ ELSDMVIYCK SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV 
    RHNVGHLSRI YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGPEMDVYQ GRFQDNGACG 
    YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS IVDPKVTVEI 
    HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI RFLVEDYDAS SKNDFIGQST 
    IPLNSLKQGY RHVHLMSKNG DQHPSATLFV KISLQD

Genular Protein ID: 985926484

Symbol: A8K8F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 756
  • Mass: 85605
  • Checksum: 996067F724059629
  • Sequence:
  • MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT IWQESRKVMR 
    TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV FKDQRNTLDL IAPSPADAQH 
    WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR KADKNKDNKM SFKELQNFLK ELNIQVDDSY 
    ARKIFRECDH SQTDSLEDEE IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ 
    QREEAAGPAL ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ 
    PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ EPIIYHGYTF 
    TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV MARHLHAILG PMLLNRPLDG 
    VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG EGGPEATVVS DEDEAAEMED EAVRSRVQHK 
    PKEDKLRLAQ ELSDMVIYCK SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV 
    RHNVGHLSRI YPAGWRTDSS NYSPVEMWNG GCQIVALNSQ TPGPEMDVYQ GRFQDNGACG 
    YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS IVDPKVTVEI 
    HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI RFLVEDYDAS SKNDFIGQST 
    IPLNSLKQGY RHVHLMSKNG DQHPSATLFV KISLQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.