Details for: SHC3

Gene ID: 53358

Symbol: SHC3

Ensembl ID: ENSG00000148082

Description: SHC adaptor protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.3918
    Cell Significance Index: -34.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.1332
    Cell Significance Index: -26.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8655
    Cell Significance Index: -8.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8752
    Cell Significance Index: 82.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7117
    Cell Significance Index: 543.9700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.4461
    Cell Significance Index: 32.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3044
    Cell Significance Index: 87.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1819
    Cell Significance Index: 423.9100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.1682
    Cell Significance Index: 8.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1598
    Cell Significance Index: 51.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1453
    Cell Significance Index: 792.1300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.0618
    Cell Significance Index: 13.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0599
    Cell Significance Index: 40.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6244
    Cell Significance Index: 16.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6080
    Cell Significance Index: 37.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2987
    Cell Significance Index: 7.2400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.2932
    Cell Significance Index: 3.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2106
    Cell Significance Index: 5.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1159
    Cell Significance Index: 22.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0877
    Cell Significance Index: 2.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0816
    Cell Significance Index: 16.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0718
    Cell Significance Index: 4.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0306
    Cell Significance Index: 27.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0094
    Cell Significance Index: 1.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0144
    Cell Significance Index: -0.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0258
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0328
    Cell Significance Index: -24.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0408
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0411
    Cell Significance Index: -30.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0438
    Cell Significance Index: -32.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0441
    Cell Significance Index: -24.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0442
    Cell Significance Index: -28.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0483
    Cell Significance Index: -21.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0530
    Cell Significance Index: -24.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0570
    Cell Significance Index: -35.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0591
    Cell Significance Index: -33.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0677
    Cell Significance Index: -1.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0701
    Cell Significance Index: -3.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0816
    Cell Significance Index: -23.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0849
    Cell Significance Index: -13.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0939
    Cell Significance Index: -16.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1075
    Cell Significance Index: -5.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1131
    Cell Significance Index: -2.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1199
    Cell Significance Index: -3.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1428
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1561
    Cell Significance Index: -19.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1595
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1619
    Cell Significance Index: -34.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1661
    Cell Significance Index: -1.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1824
    Cell Significance Index: -5.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1833
    Cell Significance Index: -19.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1837
    Cell Significance Index: -25.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1881
    Cell Significance Index: -27.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1986
    Cell Significance Index: -4.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2166
    Cell Significance Index: -7.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2321
    Cell Significance Index: -29.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2342
    Cell Significance Index: -30.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2377
    Cell Significance Index: -4.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2439
    Cell Significance Index: -28.4200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2522
    Cell Significance Index: -2.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2574
    Cell Significance Index: -7.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2642
    Cell Significance Index: -27.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2784
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2953
    Cell Significance Index: -33.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3046
    Cell Significance Index: -23.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3074
    Cell Significance Index: -6.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3110
    Cell Significance Index: -21.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3184
    Cell Significance Index: -32.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3419
    Cell Significance Index: -24.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3481
    Cell Significance Index: -20.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3600
    Cell Significance Index: -8.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3914
    Cell Significance Index: -13.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4028
    Cell Significance Index: -10.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4167
    Cell Significance Index: -31.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5012
    Cell Significance Index: -10.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5051
    Cell Significance Index: -26.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5081
    Cell Significance Index: -10.5400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5152
    Cell Significance Index: -6.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5222
    Cell Significance Index: -32.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5869
    Cell Significance Index: -27.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5954
    Cell Significance Index: -11.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5966
    Cell Significance Index: -5.6600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6023
    Cell Significance Index: -11.8600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6268
    Cell Significance Index: -7.9100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.6781
    Cell Significance Index: -4.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6900
    Cell Significance Index: -11.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7021
    Cell Significance Index: -15.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7467
    Cell Significance Index: -27.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8063
    Cell Significance Index: -12.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8402
    Cell Significance Index: -17.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8500
    Cell Significance Index: -21.8500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8563
    Cell Significance Index: -10.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.8708
    Cell Significance Index: -11.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8984
    Cell Significance Index: -17.9200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.9618
    Cell Significance Index: -6.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Adaptor function**: SHC3 acts as an adaptor protein, bridging signals from various receptors and integrating them into downstream signaling cascades. 2. **Receptor tyrosine kinase binding**: SHC3 interacts with multiple receptor tyrosine kinases (RTKs), such as EGFR, RTK3, and RTK4, facilitating signal transduction. 3. **Phosphotyrosine residue binding**: SHC3 binds to phosphotyrosine residues on activated RTKs, stabilizing the signal and recruiting other signaling molecules. 4. **Cell surface and intracellular localization**: SHC3 is primarily localized to the plasma membrane and cytosol, allowing it to participate in both cell surface receptor signaling and intracellular signal transduction. **Pathways and Functions** 1. **Neurotrophin signaling**: SHC3 is involved in the signaling pathways of neurotrophins, such as NTRK1 (trka), NTRK2 (trkb), and NTRK3 (trkc), which play critical roles in neuronal development and survival. 2. **EGFR signaling**: SHC3 interacts with EGFR, a key receptor tyrosine kinase involved in cell growth, differentiation, and survival. 3. **Raf/MEK/ERK signaling**: SHC3 is part of the Raf/MEK/ERK signaling cascade, which regulates cell proliferation, differentiation, and survival. 4. **P13K/Akt signaling**: SHC3 also interacts with the P13K/Akt signaling pathway, which is involved in cell survival, metabolism, and angiogenesis. **Clinical Significance** 1. **Cancer**: Dysregulation of SHC3 signaling has been implicated in various cancers, including breast, lung, and brain tumors, where it can contribute to tumor growth, progression, and metastasis. 2. **Neurological disorders**: SHC3 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), where it may play a role in neurodegeneration and neuronal death. 3. **Developmental disorders**: Mutations in SHC3 have been associated with developmental disorders, such as X-linked intellectual disability and autism spectrum disorder, highlighting the gene's importance in neural development and function. In conclusion, SHC3 is a critical gene involved in numerous signaling pathways and developmental processes. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and developmental disorders. Further research on SHC3 is necessary to fully understand its role in human health and disease.

Genular Protein ID: 2999827326

Symbol: SHC3_HUMAN

Name: SHC-transforming protein 3

UniProtKB Accession Codes:

Q92529 Q5T7I7 Q8TAP2 Q9UCX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8808684

Title: N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.

PubMed ID: 8808684

PubMed ID: 8760305

Title: A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.

PubMed ID: 8760305

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12006576

Title: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.

PubMed ID: 12006576

DOI: 10.1074/jbc.m111659200

Sequence Information:

  • Length: 594
  • Mass: 64056
  • Checksum: 047A9D08002E41BF
  • Sequence:
    • MLPRTKYNRF RNDSVTSVDD LLHSLSVSGG GGKVSAARAT PAAAPYLVSG EALRKAPDDG 
PGSLGHLLHK VSHLKLSSSG LRGLSSAARE RAGARLSGSC SAPSLAAPDG SAPSAPRAPA 
MSAARKGRPG DEPLPRPPRG APHASDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQI 
TREAISRVCE AVPGAKGAFK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD 
SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA 
FELRFKQYLQ CPTKIPALHD RMQSLDEPWT EEEGDGSDHP YYNSIPSKMP PPGGFLDTRL 
KPRPHAPDTA QFAGKEQTYY QGRHLGDTFG EDWQQTPLRQ GSSDIYSTPE GKLHVAPTGE 
APTYVNTQQI PPQAWPAAVS SAESSPRKDL FDMKPFEDAL KNQPLGPVLS KAASVECISP 
VSPRAPDAKM LEELQAETWY QGEMSRKEAE GLLEKDGDFL VRKSTTNPGS FVLTGMHNGQ 
AKHLLLVDPE GTIRTKDRVF DSISHLINHH LESSLPIVSA GSELCLQQPV ERKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.