Details for: TPCN1

Gene ID: 53373

Symbol: TPCN1

Ensembl ID: ENSG00000186815

Description: two pore segment channel 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.2154
    Cell Significance Index: -36.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 145.0659
    Cell Significance Index: -36.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.4602
    Cell Significance Index: -30.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6630
    Cell Significance Index: -30.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0254
    Cell Significance Index: -37.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2329
    Cell Significance Index: -31.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2258
    Cell Significance Index: -35.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2297
    Cell Significance Index: -31.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4297
    Cell Significance Index: -37.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0747
    Cell Significance Index: 41.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1474
    Cell Significance Index: 57.5400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.9230
    Cell Significance Index: 26.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8507
    Cell Significance Index: 142.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2378
    Cell Significance Index: 245.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1514
    Cell Significance Index: 52.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0998
    Cell Significance Index: 57.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0838
    Cell Significance Index: 217.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9966
    Cell Significance Index: 28.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9356
    Cell Significance Index: 152.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8489
    Cell Significance Index: 153.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7993
    Cell Significance Index: 15.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6748
    Cell Significance Index: 25.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6445
    Cell Significance Index: 38.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6337
    Cell Significance Index: 9.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6226
    Cell Significance Index: 223.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6199
    Cell Significance Index: 61.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6091
    Cell Significance Index: 26.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4780
    Cell Significance Index: 33.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4768
    Cell Significance Index: 10.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4447
    Cell Significance Index: 9.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4421
    Cell Significance Index: 54.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4398
    Cell Significance Index: 15.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4255
    Cell Significance Index: 19.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4201
    Cell Significance Index: 229.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4103
    Cell Significance Index: 756.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4016
    Cell Significance Index: 756.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3612
    Cell Significance Index: 18.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3172
    Cell Significance Index: 60.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2570
    Cell Significance Index: 35.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2359
    Cell Significance Index: 163.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2313
    Cell Significance Index: 2.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2187
    Cell Significance Index: 197.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2168
    Cell Significance Index: 137.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2054
    Cell Significance Index: 5.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1879
    Cell Significance Index: 3.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1794
    Cell Significance Index: 276.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1237
    Cell Significance Index: 14.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1106
    Cell Significance Index: 3.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1093
    Cell Significance Index: 18.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0769
    Cell Significance Index: 5.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0512
    Cell Significance Index: 23.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0108
    Cell Significance Index: 14.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0079
    Cell Significance Index: -3.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0096
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0224
    Cell Significance Index: -13.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -17.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0259
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0416
    Cell Significance Index: -23.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0429
    Cell Significance Index: -32.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0506
    Cell Significance Index: -2.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0826
    Cell Significance Index: -10.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0918
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0931
    Cell Significance Index: -19.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1093
    Cell Significance Index: -31.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1176
    Cell Significance Index: -13.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1197
    Cell Significance Index: -2.5500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1274
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1417
    Cell Significance Index: -16.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2013
    Cell Significance Index: -26.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2259
    Cell Significance Index: -23.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2277
    Cell Significance Index: -11.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2540
    Cell Significance Index: -3.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2586
    Cell Significance Index: -14.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2652
    Cell Significance Index: -6.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2832
    Cell Significance Index: -5.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2863
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2900
    Cell Significance Index: -33.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3283
    Cell Significance Index: -24.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3466
    Cell Significance Index: -9.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3509
    Cell Significance Index: -21.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3618
    Cell Significance Index: -6.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3744
    Cell Significance Index: -5.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3965
    Cell Significance Index: -20.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4000
    Cell Significance Index: -31.6800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4344
    Cell Significance Index: -2.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4400
    Cell Significance Index: -31.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4464
    Cell Significance Index: -27.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4521
    Cell Significance Index: -29.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4823
    Cell Significance Index: -30.4000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4981
    Cell Significance Index: -7.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5129
    Cell Significance Index: -7.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5814
    Cell Significance Index: -16.5900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.6172
    Cell Significance Index: -9.3900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6176
    Cell Significance Index: -7.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6361
    Cell Significance Index: -15.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6387
    Cell Significance Index: -8.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6396
    Cell Significance Index: -7.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6804
    Cell Significance Index: -21.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Two-pore calcium channel structure**: The TPCN1 protein consists of two pore domains, which are responsible for regulating calcium ion transmembrane transport. 2. **High expression in immune cells**: TPCN1 is highly expressed in cells of the immune system, including hematopoietic cells, mast cells, and epithelial cells. 3. **Regulation of calcium signaling**: The protein plays a critical role in regulating calcium ion transmembrane transport, which is essential for various cellular processes. 4. **Involvement in autophagy**: Recent studies have implicated TPCN1 in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. **Pathways and Functions** The TPCN1 protein is involved in various cellular pathways, including: 1. **Calcium-mediated signaling**: The protein regulates calcium ion transmembrane transport, which is essential for various cellular processes, including cell signaling, differentiation, and survival. 2. **Endocytosis involved in viral entry into host cells**: TPCN1 plays a critical role in regulating calcium ion transmembrane transport, which is essential for the entry of viruses into host cells. 3. **Autophagy**: The protein is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 4. **Lysosomal membrane**: TPCN1 is also involved in regulating the lysosomal membrane, which is essential for cellular homeostasis. **Clinical Significance** The TPCN1 gene has significant implications for various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the TPCN1 gene have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID). 2. **Viral infections**: The protein's role in regulating calcium ion transmembrane transport makes it a critical component in the context of viral entry into host cells. 3. **Cancer**: TPCN1 has been implicated in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. Dysregulation of autophagy has been associated with various types of cancer. In conclusion, the TPCN1 gene is a critical component of the endosomal system, playing a pivotal role in calcium-mediated signaling pathways and autophagy. Its implications for various diseases, including immunodeficiency disorders, viral infections, and cancer, highlight the importance of further research into this fascinating protein.

Genular Protein ID: 2543499877

Symbol: TPC1_HUMAN

Name: Two pore calcium channel protein 1

UniProtKB Accession Codes:

Q9ULQ1 A7E258 Q86XS9 Q8NC20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 19387438

Title: NAADP mobilizes calcium from acidic organelles through two-pore channels.

PubMed ID: 19387438

DOI: 10.1038/nature08030

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19620632

Title: Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.

PubMed ID: 19620632

DOI: 10.1083/jcb.200904073

PubMed ID: 20880839

Title: An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.

PubMed ID: 20880839

DOI: 10.1074/jbc.m110.162073

PubMed ID: 23063126

Title: TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

PubMed ID: 23063126

DOI: 10.1016/j.cell.2012.08.036

PubMed ID: 23394946

Title: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

PubMed ID: 23394946

DOI: 10.1016/j.cell.2013.01.023

PubMed ID: 24776928

Title: The voltage-gated sodium channel TPC1 confers endolysosomal excitability.

PubMed ID: 24776928

DOI: 10.1038/nchembio.1522

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25722412

Title: Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

PubMed ID: 25722412

DOI: 10.1126/science.1258758

PubMed ID: 32679067

Title: Targeting Two-Pore Channels: Current Progress and Future Challenges.

PubMed ID: 32679067

DOI: 10.1016/j.tips.2020.06.002

PubMed ID: 33758061

Title: Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling.

PubMed ID: 33758061

DOI: 10.1126/scisignal.abd5605

PubMed ID: 34362892

Title: Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.

PubMed ID: 34362892

DOI: 10.1038/s41467-021-24735-z

Sequence Information:

  • Length: 816
  • Mass: 94147
  • Checksum: D6D26BFAF33E1463
  • Sequence:
    • MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP SLSSGGESSP 
SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY LFAHNHLFYL MELATALLLL 
LLSLCEAPAV PALRLGIYVH ATLELFALMV VVFELCMKLR WLGLHTFIRH KRTMVKTSVL 
VVQFVEAIVV LVRQMSHVRV TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL 
FFMIIFAILG FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF 
IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI SQRRPAGISY 
RQFEGLMRFY KPRMSARERY LTFKALNQNN TPLLSLKDFY DIYEVAALKW KAKKNREHWF 
DELPRTALLI FKGINILVKS KAFQYFMYLV VAVNGVWILV ETFMLKGGNF FSKHVPWSYL 
VFLTIYGVEL FLKVAGLGPV EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP 
LQLLRLFKLK ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT 
STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY IIMEGVTSQT 
SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN QDSEVDGGIT LEKEISKEEL 
VAVLELYREA RGASSDVTRL LETLSQMERY QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW 
YEEHAREQEQ QRQLSSSAAP AAQQPPGSRQ RSQTVT

Genular Protein ID: 1238764103

Symbol: B7Z3R2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3R2

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 748
  • Mass: 87319
  • Checksum: 96F437FAAD7EAD48
  • Sequence:
    • MNYQEAAIYL QEGENNDKFF THPKDAKALA AYLFAHNHLF YLMELATALL LLLLSLCEAP 
AVPALRLGIY VHATLELFAL MVVVFELCMK LRWLGLHTFI RHKRTMVKTS VLVVQFVEAI 
VVLVRQMSHV RVTRALRCIF LVDCRYCGGV RRNLRQIFQS LPPFMDILLL LLFFMIIFAI 
LGFYLFSPNP SDPYFSTLEN SIVSLFVLLT TANFPDVMMP SYSRNPWSCV FFIVYLSIEL 
YFIMNLLLAV VFDTFNDIEK RKFKSLLLHK RTAIQHAYRL LISQRRPAGI SYRQFEGLMR 
FYKPRMSARE RYLTFKALNQ NNTPLLSLKD FYDIYEVAAL KWKAKKNREH WFDELPRTAL 
LIFKGINILV KSKAFQYFMY LVVAVNGVWI LVETFMLKGG NFFSKHVPWS YLVFLTIYGV 
ELFLKVAGLG PVEYLSSGWN LFDFSVTVFA FLGLLALALN MEPFYFIVVL RPLQLLRLFK 
LKERYRNVLD TMFELLPRMA SLGLTLLIFY YSFAIVGMEF FCGIVFPNCC NTSTVADAYR 
WRNHTVGNRT VVEEGYYYLN NFDNILNSFV TLFELTVVNN WYIIMEGVTS QTSHWSRLYF 
MTFYIVTMVV MTIIVAFILE AFVFRMNYSR KNQDSEVDGG ITLEKEISKE ELVAVLELYR 
EARGASSDVT RLLETLSQME RYQQHSMVFL GRRSRTKSDL SLKMYQEEIQ EWYEEHAREQ 
EQQRQLSSSA APAAQQPPGS RQRSQTVT

Genular Protein ID: 2127539413

Symbol: B3KSG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSG7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 816
  • Mass: 94113
  • Checksum: 3DF1E3FF3E58FF43
  • Sequence:
    • MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP SLSSGGESSP 
SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY LFAHNHLFYL MELATALLLL 
LLSLCEAPAV PALRLGIYVH ATLELFALMV VVFELCMKLR WLGLHTFIRH KRTMVKTSVL 
VVQFVEAIVV LVRQMSHVRV TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL 
FFMIIFAILG FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF 
IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI SQRRPAGISY 
RQFEGLMRLY KPRMSARERY LTFKALNQNN TPLLSLKDFY DIYEVAALKW KAKKNREHWF 
DELPRTALLI FKGINILVKS KAFQYFMYLV VAVNGVWILV ETFMLKGGNF FSKHVPWSYL 
VFLTIYGVEL FLKVAGLGPV EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP 
LQLLRLFKLK ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT 
STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY IIMEGVTSQT 
SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN QDSEVDGGIT LEKEISKEEL 
VAVLELYREA RGASSDVTRL LETLSQMERY QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW 
YEEHAREQEQ QRQLSSSAAP AAQQPPGSRQ RSQTVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.