Details for: PLGLB2

Gene ID: 5342

Symbol: PLGLB2

Ensembl ID: ENSG00000125551

Description: plasminogen like B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.77
    Marker Score: 5253.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.64
    Marker Score: 5254
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7588
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.13
    Marker Score: 715
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 640
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.82
    Marker Score: 782
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.67
    Marker Score: 5708
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.64
    Marker Score: 39486
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 908
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.56
    Marker Score: 5336
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.51
    Marker Score: 4373
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1862
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.48
    Marker Score: 2078
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.45
    Marker Score: 1856
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 241
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.41
    Marker Score: 15006
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.39
    Marker Score: 2515
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3621.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.38
    Marker Score: 14467
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.38
    Marker Score: 527
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.38
    Marker Score: 7542
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5197
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.34
    Marker Score: 1816
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.34
    Marker Score: 229
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.32
    Marker Score: 2489
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 492
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 75
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 162
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 273.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.23
    Marker Score: 89
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.22
    Marker Score: 159
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.22
    Marker Score: 84
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.21
    Marker Score: 163
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.18
    Marker Score: 3834
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 177
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.14
    Marker Score: 198
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.11
    Marker Score: 310
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 184
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 273
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.09
    Marker Score: 95.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.09
    Marker Score: 131
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.09
    Marker Score: 98.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.08
    Marker Score: 97
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 89
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.06
    Marker Score: 312
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 39

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * PLGLB2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in epithelial cells, including those in the colon, small intestine, and lung. * It is also expressed in immune cells, such as macrophages and dendritic cells. * It is a key regulator of epithelial cell migration and adhesion. * It is involved in the regulation of cell signaling, including the PI3K/AKT pathway. **Pathways and functions** * PLGLB2 is a key regulator of epithelial cell migration and adhesion. * It is involved in the formation of the epithelial cell sheet, which is a protective barrier that lines the inside of the body. * It also plays a role in the regulation of cell signaling, including the PI3K/AKT pathway. * PLGLB2 is also involved in the development and maintenance of the intestinal tract. **Clinical significance** * Mutations in the PLGLB2 gene have been linked to a number of human diseases, including colorectal cancer, lung cancer, and inflammatory bowel disease. * In colorectal cancer, mutations in PLGLB2 are associated with the development of tumors in the colon and rectum. * In lung cancer, mutations in PLGLB2 are associated with the development of tumors in the lungs. * In inflammatory bowel disease, mutations in PLGLB2 are associated with the development of inflammatory bowel disease.

Genular Protein ID: 2632272585

Symbol: PLGB_HUMAN

Name: Plasminogen-like protein B

UniProtKB Accession Codes:

Q02325 Q580R1

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 DMDM 1 DNASU 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 InterPro 2 KEGG 2 MANE-Select 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1379800

Title: A plasminogen-related gene is expressed in cancer cells.

PubMed ID: 1379800

DOI: 10.1016/0006-291x(92)90861-e

PubMed ID: 1554698

Title: Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis.

PubMed ID: 1554698

DOI: 10.1021/bi00127a011

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 96
  • Mass: 10971
  • Checksum: 8D8073F529F2716D
  • Sequence:
    • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA AKCEEDKEFT 
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.