Details for: PLGLB2

Gene ID: 5342

Symbol: PLGLB2

Ensembl ID: ENSG00000125551

Description: plasminogen like B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4868
    Cell Significance Index: 24.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6354
    Cell Significance Index: 20.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6097
    Cell Significance Index: 10.2700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.5063
    Cell Significance Index: 5.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3049
    Cell Significance Index: 6.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2935
    Cell Significance Index: 17.6200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2472
    Cell Significance Index: 3.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2241
    Cell Significance Index: 42.6600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2094
    Cell Significance Index: 2.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1933
    Cell Significance Index: 5.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1828
    Cell Significance Index: 65.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1691
    Cell Significance Index: 7.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1065
    Cell Significance Index: 11.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1040
    Cell Significance Index: 1.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0689
    Cell Significance Index: 0.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0686
    Cell Significance Index: 3.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0502
    Cell Significance Index: 3.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0484
    Cell Significance Index: 0.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0468
    Cell Significance Index: 3.6000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0265
    Cell Significance Index: 0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0244
    Cell Significance Index: 13.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0227
    Cell Significance Index: 4.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0216
    Cell Significance Index: 0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0202
    Cell Significance Index: 3.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0179
    Cell Significance Index: 0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0166
    Cell Significance Index: 2.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0162
    Cell Significance Index: 4.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0148
    Cell Significance Index: 0.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0140
    Cell Significance Index: 12.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0119
    Cell Significance Index: 1.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0062
    Cell Significance Index: 0.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0008
    Cell Significance Index: 0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0013
    Cell Significance Index: -0.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0034
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0042
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0046
    Cell Significance Index: -0.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0054
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0056
    Cell Significance Index: -0.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0086
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0087
    Cell Significance Index: -1.8400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0101
    Cell Significance Index: -1.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0101
    Cell Significance Index: -0.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0103
    Cell Significance Index: -0.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0115
    Cell Significance Index: -0.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0190
    Cell Significance Index: -1.2800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0208
    Cell Significance Index: -0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0215
    Cell Significance Index: -2.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0234
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0251
    Cell Significance Index: -1.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0266
    Cell Significance Index: -0.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0281
    Cell Significance Index: -0.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0298
    Cell Significance Index: -1.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0316
    Cell Significance Index: -0.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0317
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0334
    Cell Significance Index: -1.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0339
    Cell Significance Index: -0.7200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0372
    Cell Significance Index: -0.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0394
    Cell Significance Index: -0.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0419
    Cell Significance Index: -2.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0434
    Cell Significance Index: -0.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0440
    Cell Significance Index: -0.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0440
    Cell Significance Index: -1.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0469
    Cell Significance Index: -1.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0534
    Cell Significance Index: -0.7700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0536
    Cell Significance Index: -1.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0546
    Cell Significance Index: -0.6200
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0556
    Cell Significance Index: -0.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0565
    Cell Significance Index: -1.4100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0581
    Cell Significance Index: -0.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0588
    Cell Significance Index: -2.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0601
    Cell Significance Index: -0.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0640
    Cell Significance Index: -1.8400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0650
    Cell Significance Index: -1.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0652
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0652
    Cell Significance Index: -0.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0660
    Cell Significance Index: -0.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0693
    Cell Significance Index: -1.8500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0697
    Cell Significance Index: -0.8800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0726
    Cell Significance Index: -0.9500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0729
    Cell Significance Index: -1.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0760
    Cell Significance Index: -1.8400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0765
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLGLB2 is a member of the plasminogen-like protein family, which shares structural similarity with plasminogen, a key enzyme in the fibrinolysis process. However, unlike plasminogen, PLGLB2 lacks the catalytic activity of plasmin. Instead, it is characterized by its extracellular expression, where it is predominantly found in the plasma and interstitial fluid. This unique characteristic suggests that PLGLB2 may play a role in regulating cellular interactions and modulating the extracellular matrix. **Pathways and Functions:** The expression of PLGLB2 is tightly regulated and is significantly upregulated in cells of the immune system, including granulocyte-monocyte progenitor cells and transit amplifying cells. This suggests that PLGLB2 may be involved in the regulation of immune cell development, differentiation, and function. Moreover, its expression in enterocytes and goblet cells highlights its potential role in maintaining the integrity of the intestinal barrier and regulating the secretion of mucus and other luminal contents. One of the most intriguing aspects of PLGLB2 is its involvement in the regulation of cell adhesion and migration. Studies have shown that PLGLB2 is a ligand for the integrin α4β1, a key adhesion receptor that mediates the interaction between leukocytes and endothelial cells. This interaction is crucial for the recruitment of leukocytes to sites of inflammation and tissue injury. **Clinical Significance:** The clinical significance of PLGLB2 is multifaceted and warrants further investigation. Given its involvement in immune cell development and function, PLGLB2 may hold promise as a biomarker for immunological disorders, such as autoimmune diseases and inflammatory bowel disease (IBD). Moreover, its role in regulating the intestinal barrier and maintaining mucosal homeostasis suggests that PLGLB2 may be a valuable target for the treatment of IBD and other gastrointestinal disorders. Furthermore, PLGLB2's involvement in cell adhesion and migration suggests that it may play a role in the pathogenesis of various diseases, including cancer, where tumor cells must invade and metastasize to distant sites. Understanding the mechanisms by which PLGLB2 regulates cell adhesion and migration may provide valuable insights into the development of novel therapeutic strategies for these diseases. In conclusion, PLGLB2 is a gene that has garnered significant attention in recent years due to its widespread expression and involvement in various cellular processes. Further investigation into the signaling pathways and functional significance of PLGLB2 is necessary to fully elucidate its role in immunology and beyond.

Genular Protein ID: 2632272585

Symbol: PLGB_HUMAN

Name: Plasminogen-like protein B

UniProtKB Accession Codes:

Q02325 Q580R1

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 DMDM 1 DNASU 1 DisGeNET 2 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 InterPro 2 KEGG 2 MANE-Select 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 2 OrthoDB 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1379800

Title: A plasminogen-related gene is expressed in cancer cells.

PubMed ID: 1379800

DOI: 10.1016/0006-291x(92)90861-e

PubMed ID: 1554698

Title: Multiple members of the plasminogen-apolipoprotein(a) gene family associated with thrombosis.

PubMed ID: 1554698

DOI: 10.1021/bi00127a011

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 96
  • Mass: 10971
  • Checksum: 8D8073F529F2716D
  • Sequence:
    • MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA AKCEEDKEFT 
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.