Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 106.2713
Cell Significance Index: -16.5300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 65.9587
Cell Significance Index: -16.7300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.8209
Cell Significance Index: -13.7400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.3599
Cell Significance Index: -13.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.4555
Cell Significance Index: -16.5900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2346
Cell Significance Index: -16.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9344
Cell Significance Index: 64.6200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7755
Cell Significance Index: 700.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5525
Cell Significance Index: 110.8300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5511
Cell Significance Index: 64.2200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.5371
Cell Significance Index: 11.7600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5060
Cell Significance Index: 14.4400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4979
Cell Significance Index: 80.9800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4704
Cell Significance Index: 51.1700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4280
Cell Significance Index: 5.8400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3783
Cell Significance Index: 10.9000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3715
Cell Significance Index: 22.3000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2982
Cell Significance Index: 6.4600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2963
Cell Significance Index: 8.2800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2888
Cell Significance Index: 7.8600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2607
Cell Significance Index: 49.6100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2433
Cell Significance Index: 16.3600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2190
Cell Significance Index: 78.5500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2134
Cell Significance Index: 147.5900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2001
Cell Significance Index: 39.7200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1832
Cell Significance Index: 100.0500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1682
Cell Significance Index: 8.7400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1521
Cell Significance Index: 9.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1491
Cell Significance Index: 6.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1472
Cell Significance Index: 65.0700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1298
Cell Significance Index: 23.4000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1190
Cell Significance Index: 3.4100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1133
Cell Significance Index: 3.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0770
Cell Significance Index: 7.6200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0686
Cell Significance Index: 8.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0581
Cell Significance Index: 7.9800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0356
Cell Significance Index: 1.6600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0300
Cell Significance Index: 1.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0282
Cell Significance Index: 53.0700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0166
Cell Significance Index: 0.2500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0010
Cell Significance Index: 1.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0006
Cell Significance Index: -1.0600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0042
Cell Significance Index: -6.3900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0062
Cell Significance Index: -0.3200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0118
Cell Significance Index: -1.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0156
Cell Significance Index: -11.8200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0165
Cell Significance Index: -10.4500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0173
Cell Significance Index: -12.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0216
Cell Significance Index: -16.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0255
Cell Significance Index: -4.3600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0276
Cell Significance Index: -2.1200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0301
Cell Significance Index: -18.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0303
Cell Significance Index: -17.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0306
Cell Significance Index: -13.8800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0459
Cell Significance Index: -0.9000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0469
Cell Significance Index: -2.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0490
Cell Significance Index: -14.0900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0531
Cell Significance Index: -1.1300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0564
Cell Significance Index: -7.2900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0584
Cell Significance Index: -1.8700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0621
Cell Significance Index: -6.3400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0812
Cell Significance Index: -11.8000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0856
Cell Significance Index: -2.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0891
Cell Significance Index: -18.7600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0925
Cell Significance Index: -10.9100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0926
Cell Significance Index: -2.4800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0970
Cell Significance Index: -11.1100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1022
Cell Significance Index: -2.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1087
Cell Significance Index: -7.6900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1151
Cell Significance Index: -2.7600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1253
Cell Significance Index: -7.6800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1293
Cell Significance Index: -9.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1387
Cell Significance Index: -3.6500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1463
Cell Significance Index: -15.2300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1524
Cell Significance Index: -2.5500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1735
Cell Significance Index: -2.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1921
Cell Significance Index: -12.1100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1966
Cell Significance Index: -15.5700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2069
Cell Significance Index: -13.3500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2104
Cell Significance Index: -6.7000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2544
Cell Significance Index: -5.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2642
Cell Significance Index: -13.8700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2845
Cell Significance Index: -9.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2990
Cell Significance Index: -13.2300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3167
Cell Significance Index: -3.4500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3223
Cell Significance Index: -11.2900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3286
Cell Significance Index: -10.7600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3383
Cell Significance Index: -8.4400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3547
Cell Significance Index: -13.4300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3616
Cell Significance Index: -7.1500 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.3683
Cell Significance Index: -3.1300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3836
Cell Significance Index: -14.0800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3888
Cell Significance Index: -8.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4056
Cell Significance Index: -8.4900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4077
Cell Significance Index: -10.4800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4097
Cell Significance Index: -10.9600 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4341
Cell Significance Index: -9.0600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4417
Cell Significance Index: -13.0100 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.4521
Cell Significance Index: -7.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2427747163
Symbol: PLXA1_HUMAN
Name: Plexin-A1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 8570614
Title: A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.
PubMed ID: 8570614
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 34054129
Title: Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.
PubMed ID: 34054129
Sequence Information:
- Length: 1896
- Mass: 211067
- Checksum: 76E5C9C0710C7FC1
- Sequence:
MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG LTHLVVHEQT GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS VQSCPHGLGS TDNVNKLLLL DYAANRLLAC GSASQGICQF LRLDDLFKLG EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ GQAKLFVGTP IDGKSEYFPT LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP AFDIYYVYSF RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK PPKESALCLF TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL QIDDDFCGQD FNQPLGGTVT IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA GTRSGRIRKI LVDLSNPGGR PALAYESVVA QEGSPILRDL VLSPNHQYLY AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI CSRRDACERA DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK FASVDFVFYN CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV NVSEDCPQIL PSTQIYVPVG VVKPITLAAR NLPQPQSGQR GYECLFHIPG SPARVTALRF NSSSLQCQNS SYSYEGNDVS DLPVNLSVVW NGNFVIDNPQ NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR HHCAADTPAS WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA LSPKRFTFVT PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP CSFSWRNSRE IRCLTPPGQS PGSAPIIINI NRAQLTNPEV KYNYTEDPTI LRIDPEWSIN SGGTLLTVTG TNLATVREPR IRAKYGGIER ENGCLVYNDT TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN STSFLYYPDP VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG GGGGLLLLVI VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF AELQTDIHEL TNDLDGAGIP FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS FSMRDRGNVA SLIMTALQGE MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM LTNWFTFLLY KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK AADMDLEWRQ GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL VPKQTSAYNI SNSSTFTKSL SRYESMLRTA SSPDSLRSRT PMITPDLESG TKLWHLVKNH DHLDQREGDR GSKMVSEIYL TRLLATKGTL QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW KSNCLPLRFW VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS ALHEIYSYIT KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.