Details for: PLXNA1

Gene ID: 5361

Symbol: PLXNA1

Ensembl ID: ENSG00000114554

Description: plexin A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.2713
    Cell Significance Index: -16.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.9587
    Cell Significance Index: -16.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.8209
    Cell Significance Index: -13.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.3599
    Cell Significance Index: -13.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4555
    Cell Significance Index: -16.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2346
    Cell Significance Index: -16.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9344
    Cell Significance Index: 64.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7755
    Cell Significance Index: 700.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5525
    Cell Significance Index: 110.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5511
    Cell Significance Index: 64.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5371
    Cell Significance Index: 11.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5060
    Cell Significance Index: 14.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4979
    Cell Significance Index: 80.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4704
    Cell Significance Index: 51.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4280
    Cell Significance Index: 5.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3783
    Cell Significance Index: 10.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3715
    Cell Significance Index: 22.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2982
    Cell Significance Index: 6.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2963
    Cell Significance Index: 8.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2888
    Cell Significance Index: 7.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2607
    Cell Significance Index: 49.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2433
    Cell Significance Index: 16.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2190
    Cell Significance Index: 78.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2134
    Cell Significance Index: 147.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2001
    Cell Significance Index: 39.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1832
    Cell Significance Index: 100.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1682
    Cell Significance Index: 8.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1521
    Cell Significance Index: 9.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1491
    Cell Significance Index: 6.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1472
    Cell Significance Index: 65.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1298
    Cell Significance Index: 23.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1190
    Cell Significance Index: 3.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1133
    Cell Significance Index: 3.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0770
    Cell Significance Index: 7.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0686
    Cell Significance Index: 8.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0581
    Cell Significance Index: 7.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0356
    Cell Significance Index: 1.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0300
    Cell Significance Index: 1.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0282
    Cell Significance Index: 53.0700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0166
    Cell Significance Index: 0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0010
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0062
    Cell Significance Index: -0.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0118
    Cell Significance Index: -1.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0173
    Cell Significance Index: -12.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -16.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0276
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0303
    Cell Significance Index: -17.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0306
    Cell Significance Index: -13.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0459
    Cell Significance Index: -0.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0469
    Cell Significance Index: -2.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0490
    Cell Significance Index: -14.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0531
    Cell Significance Index: -1.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0564
    Cell Significance Index: -7.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0584
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0621
    Cell Significance Index: -6.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0812
    Cell Significance Index: -11.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0856
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0891
    Cell Significance Index: -18.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0925
    Cell Significance Index: -10.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0926
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0970
    Cell Significance Index: -11.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1022
    Cell Significance Index: -2.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1087
    Cell Significance Index: -7.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1151
    Cell Significance Index: -2.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1253
    Cell Significance Index: -7.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1293
    Cell Significance Index: -9.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1387
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1463
    Cell Significance Index: -15.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1524
    Cell Significance Index: -2.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1735
    Cell Significance Index: -2.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1921
    Cell Significance Index: -12.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1966
    Cell Significance Index: -15.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2069
    Cell Significance Index: -13.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2104
    Cell Significance Index: -6.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2544
    Cell Significance Index: -5.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2642
    Cell Significance Index: -13.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2845
    Cell Significance Index: -9.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2990
    Cell Significance Index: -13.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3167
    Cell Significance Index: -3.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3223
    Cell Significance Index: -11.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3286
    Cell Significance Index: -10.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3383
    Cell Significance Index: -8.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3547
    Cell Significance Index: -13.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3616
    Cell Significance Index: -7.1500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3683
    Cell Significance Index: -3.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3836
    Cell Significance Index: -14.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3888
    Cell Significance Index: -8.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4056
    Cell Significance Index: -8.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4077
    Cell Significance Index: -10.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4097
    Cell Significance Index: -10.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4341
    Cell Significance Index: -9.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4417
    Cell Significance Index: -13.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4521
    Cell Significance Index: -7.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Plexin A1 is a type I transmembrane receptor, characterized by a large extracellular domain, a transmembrane domain, and a short cytoplasmic domain. It is a high-affinity receptor for semaphorin 3A (Sema3A), a member of the semaphorin family of secreted proteins. The interaction between Plexin A1 and Sema3A triggers a signaling cascade that regulates various cellular processes, including axon guidance, cell migration, and cell shape. **Pathways and Functions** PLXNA1 is involved in several signaling pathways, including: 1. **Axon guidance**: Plexin A1 plays a crucial role in regulating axon growth, branching, and targeting during nervous system development. 2. **Sema3A signaling**: The interaction between Plexin A1 and Sema3A inhibits integrin adhesion, promoting repulsion and guiding axons away from obstacles. 3. **Regulation of cell migration**: Plexin A1 regulates cell migration by modulating the activity of Rho GTPases, which control cytoskeleton dynamics and cell shape. 4. **Neuron projection extension**: Plexin A1 promotes the extension of neuronal projections by regulating the activity of Miro GTPases, which control mitochondrial dynamics. 5. **Negative regulation of cell adhesion**: Plexin A1 inhibits cell adhesion by regulating the activity of integrins and other adhesion molecules. **Significance in Developmental Biology** PLXNA1 is essential for the proper development of the nervous system, including the formation of axons, dendrites, and synapses. Mutations in the PLXNA1 gene have been implicated in various neurological disorders, such as autism spectrum disorder, schizophrenia, and intellectual disability. **Clinical Significance** Plexin A1 has been implicated in several clinical disorders, including: 1. **Neuropathic pain**: Plexin A1 has been shown to play a role in the regulation of pain transmission. 2. **Migraine**: Plexin A1 has been implicated in the pathogenesis of migraine, a disorder characterized by recurrent episodes of severe headache. 3. **Neurodegenerative diseases**: Plexin A1 has been shown to play a role in the regulation of axonal transport and the maintenance of neural function in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, Plexin A1 is a critical regulator of various cellular processes, including axon guidance, cell migration, and signal transduction. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the mechanisms of PLXNA1 and its clinical applications.

Genular Protein ID: 2427747163

Symbol: PLXA1_HUMAN

Name: Plexin-A1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 8570614

Title: A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PubMed ID: 8570614

DOI: 10.1073/pnas.93.2.674

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 34054129

Title: Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.

PubMed ID: 34054129

DOI: 10.1038/s41436-021-01196-9

Sequence Information:

  • Length: 1896
  • Mass: 211067
  • Checksum: 76E5C9C0710C7FC1
  • Sequence:
  • MPLPPRSLQV LLLLLLLLLL LPGMWAEAGL PRAGGGSQPP FRTFSASDWG LTHLVVHEQT 
    GEVYVGAVNR IYKLSGNLTL LRAHVTGPVE DNEKCYPPPS VQSCPHGLGS TDNVNKLLLL 
    DYAANRLLAC GSASQGICQF LRLDDLFKLG EPHHRKEHYL SSVQEAGSMA GVLIAGPPGQ 
    GQAKLFVGTP IDGKSEYFPT LSSRRLMANE EDADMFGFVY QDEFVSSQLK IPSDTLSKFP 
    AFDIYYVYSF RSEQFVYYLT LQLDTQLTSP DAAGEHFFTS KIVRLCVDDP KFYSYVEFPI 
    GCEQAGVEYR LVQDAYLSRP GRALAHQLGL AEDEDVLFTV FAQGQKNRVK PPKESALCLF 
    TLRAIKEKIK ERIQSCYRGE GKLSLPWLLN KELGCINSPL QIDDDFCGQD FNQPLGGTVT 
    IEGTPLFVDK DDGLTAVAAY DYRGRTVVFA GTRSGRIRKI LVDLSNPGGR PALAYESVVA 
    QEGSPILRDL VLSPNHQYLY AMTEKQVTRV PVESCVQYTS CELCLGSRDP HCGWCVLHSI 
    CSRRDACERA DEPQRFAADL LQCVQLTVQP RNVSVTMSQV PLVLQAWNVP DLSAGVNCSF 
    EDFTESESVL EDGRIHCRSP SAREVAPITR GQGDQRVVKL YLKSKETGKK FASVDFVFYN 
    CSVHQSCLSC VNGSFPCHWC KYRHVCTHNV ADCAFLEGRV NVSEDCPQIL PSTQIYVPVG 
    VVKPITLAAR NLPQPQSGQR GYECLFHIPG SPARVTALRF NSSSLQCQNS SYSYEGNDVS 
    DLPVNLSVVW NGNFVIDNPQ NIQAHLYKCP ALRESCGLCL KADPRFECGW CVAERRCSLR 
    HHCAADTPAS WMHARHGSSR CTDPKILKLS PETGPRQGGT RLTITGENLG LRFEDVRLGV 
    RVGKVLCSPV ESEYISAEQI VCEIGDASSV RAHDALVEVC VRDCSPHYRA LSPKRFTFVT 
    PTFYRVSPSR GPLSGGTWIG IEGSHLNAGS DVAVSVGGRP CSFSWRNSRE IRCLTPPGQS 
    PGSAPIIINI NRAQLTNPEV KYNYTEDPTI LRIDPEWSIN SGGTLLTVTG TNLATVREPR 
    IRAKYGGIER ENGCLVYNDT TMVCRAPSVA NPVRSPPELG ERPDELGFVM DNVRSLLVLN 
    STSFLYYPDP VLEPLSPTGL LELKPSSPLI LKGRNLLPPA PGNSRLNYTV LIGSTPCTLT 
    VSETQLLCEA PNLTGQHKVT VRAGGFEFSP GTLQVYSDSL LTLPAIVGIG GGGGLLLLVI 
    VAVLIAYKRK SRDADRTLKR LQLQMDNLES RVALECKEAF AELQTDIHEL TNDLDGAGIP 
    FLDYRTYAMR VLFPGIEDHP VLKEMEVQAN VEKSLTLFGQ LLTKKHFLLT FIRTLEAQRS 
    FSMRDRGNVA SLIMTALQGE MEYATGVLKQ LLSDLIEKNL ESKNHPKLLL RRTESVAEKM 
    LTNWFTFLLY KFLKECAGEP LFMLYCAIKQ QMEKGPIDAI TGEARYSLSE DKLIRQQIDY 
    KTLTLNCVNP ENENAPEVPV KGLDCDTVTQ AKEKLLDAAY KGVPYSQRPK AADMDLEWRQ 
    GRMARIILQD EDVTTKIDND WKRLNTLAHY QVTDGSSVAL VPKQTSAYNI SNSSTFTKSL 
    SRYESMLRTA SSPDSLRSRT PMITPDLESG TKLWHLVKNH DHLDQREGDR GSKMVSEIYL 
    TRLLATKGTL QKFVDDLFET IFSTAHRGSA LPLAIKYMFD FLDEQADKHQ IHDADVRHTW 
    KSNCLPLRFW VNVIKNPQFV FDIHKNSITD ACLSVVAQTF MDSCSTSEHK LGKDSPSNKL 
    LYAKDIPNYK SWVERYYADI AKMPAISDQD MSAYLAEQSR LHLSQFNSMS ALHEIYSYIT 
    KYKDEILAAL EKDEQARRQR LRSKLEQVVD TMALSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.