Details for: PNOC

Gene ID: 5368

Symbol: PNOC

Ensembl ID: ENSG00000168081

Description: prepronociceptin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.9814
    Cell Significance Index: -6.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.6660
    Cell Significance Index: -6.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.2800
    Cell Significance Index: -6.5100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.0834
    Cell Significance Index: 11.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.8612
    Cell Significance Index: 62.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6964
    Cell Significance Index: 42.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6700
    Cell Significance Index: -6.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0661
    Cell Significance Index: 125.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6085
    Cell Significance Index: 218.2500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.5456
    Cell Significance Index: 2.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3903
    Cell Significance Index: 74.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3304
    Cell Significance Index: 20.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2480
    Cell Significance Index: 11.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2249
    Cell Significance Index: 13.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1458
    Cell Significance Index: 15.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1452
    Cell Significance Index: 3.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1288
    Cell Significance Index: 3.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1125
    Cell Significance Index: 1.7400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1102
    Cell Significance Index: 1.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1071
    Cell Significance Index: 74.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0944
    Cell Significance Index: 2.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0890
    Cell Significance Index: 80.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0758
    Cell Significance Index: 1.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0688
    Cell Significance Index: 11.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0645
    Cell Significance Index: 6.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0577
    Cell Significance Index: 3.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0418
    Cell Significance Index: 0.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0230
    Cell Significance Index: 0.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0222
    Cell Significance Index: 2.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0178
    Cell Significance Index: 9.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0140
    Cell Significance Index: 0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0128
    Cell Significance Index: 2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0048
    Cell Significance Index: -0.1000
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.0050
    Cell Significance Index: -0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0098
    Cell Significance Index: -6.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0117
    Cell Significance Index: -2.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0140
    Cell Significance Index: -6.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0147
    Cell Significance Index: -0.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0156
    Cell Significance Index: -4.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0189
    Cell Significance Index: -3.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0215
    Cell Significance Index: -2.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0234
    Cell Significance Index: -3.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0259
    Cell Significance Index: -0.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0280
    Cell Significance Index: -0.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0365
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0368
    Cell Significance Index: -7.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0376
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0394
    Cell Significance Index: -6.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0432
    Cell Significance Index: -0.8500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0432
    Cell Significance Index: -0.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0452
    Cell Significance Index: -6.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0470
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0532
    Cell Significance Index: -6.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0591
    Cell Significance Index: -6.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0655
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0657
    Cell Significance Index: -7.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0671
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0735
    Cell Significance Index: -5.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0821
    Cell Significance Index: -8.3900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0886
    Cell Significance Index: -1.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0944
    Cell Significance Index: -6.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1017
    Cell Significance Index: -4.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1047
    Cell Significance Index: -1.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1125
    Cell Significance Index: -6.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1237
    Cell Significance Index: -2.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1240
    Cell Significance Index: -6.4400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1269
    Cell Significance Index: -2.5300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1270
    Cell Significance Index: -1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1342
    Cell Significance Index: -8.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1387
    Cell Significance Index: -0.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1508
    Cell Significance Index: -6.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1545
    Cell Significance Index: -8.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1624
    Cell Significance Index: -5.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1663
    Cell Significance Index: -5.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1725
    Cell Significance Index: -8.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1730
    Cell Significance Index: -1.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1750
    Cell Significance Index: -5.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1783
    Cell Significance Index: -6.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1805
    Cell Significance Index: -6.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1881
    Cell Significance Index: -5.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1883
    Cell Significance Index: -6.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1971
    Cell Significance Index: -2.3000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2011
    Cell Significance Index: -2.3700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2055
    Cell Significance Index: -2.0700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2089
    Cell Significance Index: -2.8400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2108
    Cell Significance Index: -2.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: PNOC is a 17-amino acid peptide precursor that undergoes post-translational processing to produce the mature nociceptin/orphanin FQ peptide. 2. **Function**: PNOC is involved in various physiological processes, including pain perception, immune responses, and neuroendocrine regulation. 3. **Cellular expression**: PNOC is expressed in multiple cell types, including thymocytes, epithelial cells, and immune cells, indicating its diverse functional roles. 4. **Pathway involvement**: PNOC interacts with G protein-coupled receptors (GPCRs), influencing signaling pathways related to pain perception, immune responses, and neuroendocrine regulation. **Pathways and Functions** PNOC is involved in the following signaling pathways: 1. **G protein-coupled receptor (GPCR) signaling**: PNOC binds to specific GPCRs, triggering the activation of G alpha (i) signaling events and influencing downstream signaling pathways. 2. **Neurotransmitter and neuromodulator signaling**: PNOC interacts with neurotransmitter and neuromodulator receptors, modulating synaptic transmission and neuronal communication. 3. **Immune responses**: PNOC is involved in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 4. **Neuroendocrine regulation**: PNOC influences neuroendocrine processes, including the regulation of hormone secretion and the modulation of stress responses. **Clinical Significance** The dysregulation of PNOC has been implicated in various diseases and disorders, including: 1. **Chronic pain**: Alterations in PNOC expression and function have been linked to chronic pain states, suggesting its potential as a therapeutic target. 2. **Immune disorders**: Dysregulation of PNOC has been observed in immune disorders, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential as a therapeutic target. 3. **Neurodegenerative diseases**: PNOC has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a therapeutic target. 4. **Cancer**: PNOC has been shown to be overexpressed in certain types of cancer, suggesting its potential as a diagnostic and therapeutic target. In conclusion, PNOC is a multifunctional neuropeptide hormone involved in various physiological and pathological processes. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of PNOC and its clinical significance.

Genular Protein ID: 2141905076

Symbol: PNOC_HUMAN

Name: Prepronociceptin

UniProtKB Accession Codes:

Q13519 B7Z749 Q6FH16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8710928

Title: Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.

PubMed ID: 8710928

DOI: 10.1073/pnas.93.16.8666

PubMed ID: 8710930

Title: Primary structure and tissue distribution of the orphanin FQ precursor.

PubMed ID: 8710930

DOI: 10.1073/pnas.93.16.8677

PubMed ID: 12950177

Title: Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.

PubMed ID: 12950177

DOI: 10.1021/bi0300635

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9168905

Title: Solution conformation of nociceptin.

PubMed ID: 9168905

DOI: 10.1006/bbrc.1997.6285

Sequence Information:

  • Length: 176
  • Mass: 20295
  • Checksum: 8FC8DB4BB094CE6A
  • Sequence:
    • MKVLLCDLLL LSLFSSVFSS CQRDCLTCQE KLHPALDSFD LEVCILECEE KVFPSPLWTP 
CTKVMARSSW QLSPAAPEHV AAALYQPRAS EMQHLRRMPR VRSLFQEQEE PEPGMEEAGE 
MEQKQLQKRF GGFTGARKSA RKLANQKRFS EFMRQYLVLS MQSSQRRRTL HQNGNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.