Details for: PTPA

Gene ID: 5524

Symbol: PTPA

Ensembl ID: ENSG00000119383

Description: protein phosphatase 2 phosphatase activator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 76.4903
    Cell Significance Index: -31.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.0588
    Cell Significance Index: -31.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.4758
    Cell Significance Index: -26.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.6720
    Cell Significance Index: -30.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.9761
    Cell Significance Index: -26.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5978
    Cell Significance Index: -28.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3869
    Cell Significance Index: -25.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1547
    Cell Significance Index: -13.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9536
    Cell Significance Index: 227.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7437
    Cell Significance Index: 283.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6508
    Cell Significance Index: 26.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1124
    Cell Significance Index: 121.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0346
    Cell Significance Index: 53.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0054
    Cell Significance Index: 201.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6013
    Cell Significance Index: 108.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5731
    Cell Significance Index: 26.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5630
    Cell Significance Index: 38.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5434
    Cell Significance Index: 107.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5386
    Cell Significance Index: 66.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5188
    Cell Significance Index: 283.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4930
    Cell Significance Index: 176.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4100
    Cell Significance Index: 21.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4060
    Cell Significance Index: 11.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3750
    Cell Significance Index: 10.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3527
    Cell Significance Index: 67.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3461
    Cell Significance Index: 239.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3342
    Cell Significance Index: 4.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3335
    Cell Significance Index: 25.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3222
    Cell Significance Index: 14.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3199
    Cell Significance Index: 6.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3180
    Cell Significance Index: 140.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3154
    Cell Significance Index: 43.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3116
    Cell Significance Index: 16.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2562
    Cell Significance Index: 33.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2025
    Cell Significance Index: 5.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1726
    Cell Significance Index: 20.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1691
    Cell Significance Index: 12.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1595
    Cell Significance Index: 4.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0953
    Cell Significance Index: 1.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0930
    Cell Significance Index: 4.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0677
    Cell Significance Index: 2.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0623
    Cell Significance Index: 7.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0600
    Cell Significance Index: 5.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0587
    Cell Significance Index: 3.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0572
    Cell Significance Index: 1.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0368
    Cell Significance Index: 1.2800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0330
    Cell Significance Index: 0.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0297
    Cell Significance Index: 26.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0216
    Cell Significance Index: 1.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0076
    Cell Significance Index: 5.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0020
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0071
    Cell Significance Index: -0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0171
    Cell Significance Index: -26.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0333
    Cell Significance Index: -3.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0340
    Cell Significance Index: -21.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0352
    Cell Significance Index: -0.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0370
    Cell Significance Index: -2.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0376
    Cell Significance Index: -0.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0482
    Cell Significance Index: -27.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0532
    Cell Significance Index: -33.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0547
    Cell Significance Index: -24.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0597
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0646
    Cell Significance Index: -7.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0907
    Cell Significance Index: -2.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0924
    Cell Significance Index: -26.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0983
    Cell Significance Index: -6.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1061
    Cell Significance Index: -15.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1541
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1590
    Cell Significance Index: -33.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1696
    Cell Significance Index: -3.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1709
    Cell Significance Index: -3.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2390
    Cell Significance Index: -10.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2522
    Cell Significance Index: -3.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2650
    Cell Significance Index: -20.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2784
    Cell Significance Index: -28.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2805
    Cell Significance Index: -15.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2902
    Cell Significance Index: -11.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3415
    Cell Significance Index: -12.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3468
    Cell Significance Index: -5.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3566
    Cell Significance Index: -21.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3868
    Cell Significance Index: -11.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3872
    Cell Significance Index: -12.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4128
    Cell Significance Index: -4.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4231
    Cell Significance Index: -3.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4259
    Cell Significance Index: -10.8800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4395
    Cell Significance Index: -4.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4508
    Cell Significance Index: -4.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5072
    Cell Significance Index: -7.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5427
    Cell Significance Index: -10.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5521
    Cell Significance Index: -13.2400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5725
    Cell Significance Index: -12.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5824
    Cell Significance Index: -18.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5974
    Cell Significance Index: -15.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6115
    Cell Significance Index: -20.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6120
    Cell Significance Index: -8.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** PTPA acts as a phosphatase activator, enhancing the activity of PP2A, a serine/threonine phosphatase involved in various cellular processes. 2. **Expression:** PTPA is expressed in a wide range of cell types, including extravillous trophoblast, cardiac muscle cell, kidney capillary endothelial cell, and myeloid dendritic cell. 3. **Pathway regulation:** PTPA regulates various signaling pathways, including negative regulation of phosphoprotein phosphatase activity, negative regulation of protein dephosphorylation, and positive regulation of apoptotic process. 4. **Protein interactions:** PTPA interacts with PP2A, protein phosphatase regulator, and protein phosphatase type 2a complex, suggesting its role in regulating PP2A activity. **Pathways and Functions:** 1. **Negative regulation of phosphoprotein phosphatase activity:** PTPA inhibits the activity of phosphoprotein phosphatases, thereby regulating protein dephosphorylation. 2. **Negative regulation of protein dephosphorylation:** PTPA reduces protein dephosphorylation, which is essential for maintaining cellular homeostasis. 3. **Positive regulation of apoptotic process:** PTPA enhances the apoptotic process by regulating pro-apoptotic proteins. 4. **Regulation of phosphoprotein phosphatase activity:** PTPA regulates the activity of phosphoprotein phosphatases, which is crucial for maintaining cellular function. **Clinical Significance:** The dysregulation of PTPA has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example: 1. **Cancer:** Altered PTPA expression has been observed in various types of cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Cardiovascular disease:** PTPA has been implicated in the regulation of cardiac muscle cell function, and its dysregulation may contribute to cardiovascular disease. 3. **Neurological disorders:** PTPA has been shown to regulate neuronal function, and its dysregulation may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PTPA plays a crucial role in regulating PP2A activity, protein dephosphorylation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of PTPA in maintaining cellular homeostasis and overall health. Further research is needed to fully understand the mechanisms of PTPA and its role in various diseases.

Genular Protein ID: 557433060

Symbol: PTPA_HUMAN

Name: Serine/threonine-protein phosphatase 2A activator

UniProtKB Accession Codes:

Q15257 A2A347 A9IZU4 B4DXM4 Q15258 Q53GZ3 Q5TZQ2 Q9BUK1 Q9NNZ7 Q9NNZ8 Q9NNZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 48 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 6 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8195217

Title: Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A.

PubMed ID: 8195217

DOI: 10.1016/s0021-9258(17)40733-2

PubMed ID: 8530035

Title: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A.

PubMed ID: 8530035

DOI: 10.1006/geno.1995.1140

PubMed ID: 10880964

Title: Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene.

PubMed ID: 10880964

DOI: 10.1046/j.1432-1327.2000.01486.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17333320

Title: Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis.

PubMed ID: 17333320

DOI: 10.1007/s10495-006-0050-8

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16782712

Title: The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

PubMed ID: 16782712

DOI: 10.1074/jbc.c600100200

PubMed ID: 16885030

Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.

PubMed ID: 16885030

DOI: 10.1016/j.molcel.2006.07.008

PubMed ID: 16916641

Title: Structure and mechanism of the phosphotyrosyl phosphatase activator.

PubMed ID: 16916641

DOI: 10.1016/j.molcel.2006.07.027

PubMed ID: 25003389

Title: Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.

PubMed ID: 25003389

DOI: 10.1515/hsz-2014-0106

PubMed ID: 36073231

Title: PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.

PubMed ID: 36073231

DOI: 10.1093/brain/awac326

Sequence Information:

  • Length: 358
  • Mass: 40668
  • Checksum: 2A962521AF5B4CF7
  • Sequence:
    • MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK 
GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA GHCAPSEAIE KLVALLNTLD 
RWIDETPPVD QPSRFGNKAY RTWYAKLDEE AENLVATVVP THLAAAVPEV AVYLKESVGN 
STRIDYGTGH EAAFAAFLCC LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG 
SQGVWGLDDF QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT 
GPFAEHSNQL WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL PIHPVTSG

Genular Protein ID: 2214688446

Symbol: F6WIT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6WIT2

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 288
  • Mass: 32936
  • Checksum: 3405CE3F7E82238A
  • Sequence:
    • MGKWKRSQAY ADYIGFILTL NEGVKGKKLT FEYRVSEAIE KLVALLNTLD RWIDETPPVD 
QPSRFGNKAY RTWYAKLDEE AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH 
EAAFAAFLCC LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF 
QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT GPFAEHSNQL 
WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL PIHPVTSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.