Details for: PTPA
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 9.49rCSI 17.06%PRS 31.68
-
CSI 7.79rCSI 31.14%PRS 59.63
-
CSI 6.91rCSI 30.41%PRS 32.31
-
CSI 6.73rCSI 11.02%PRS 29.44
-
CSI 6.19rCSI 4.65%PRS 40.15
-
CSI 5.21rCSI 4.23%PRS 38.25
-
CSI 5.2rCSI 16.86%PRS 40.95
-
CSI 5.16rCSI 4.28%PRS 35.86
-
CSI 5.15rCSI 13.02%PRS 44.92
-
CSI 3.9rCSI 8.62%PRS 27.56
-
CSI 3.76rCSI 4.51%PRS 35.71
-
CSI 3.37rCSI 2.56%PRS 47.43
-
CSI 3.26rCSI 4.51%PRS 43.44
-
CSI 3.2rCSI 13.62%PRS 36.4
-
CSI 2.94rCSI 3.58%PRS 44.42
-
CSI 2.68rCSI 3.99%PRS 40.63
-
CSI 2.65rCSI 2.55%PRS 38.05
-
CSI 2.64rCSI 2.32%PRS 42.09
-
CSI 2.48rCSI 1.92%PRS 37.23
-
CSI 2.43rCSI 3.09%PRS 42.12
-
CSI 2.4rCSI 15.01%PRS 30.92
-
CSI 2.36rCSI 3.82%PRS 36.33
-
CSI 2.32rCSI 1.79%PRS 35.75
-
CSI 2.24rCSI 5.11%PRS 36.74
-
CSI 2.23rCSI 2.33%PRS 37.92
-
CSI 2.22rCSI 2.32%PRS 35.02
-
CSI 2.2rCSI 1.83%PRS 38.14
-
CSI 2.16rCSI 3.11%PRS 51.13
-
CSI 2.12rCSI 5.39%PRS 34.67
-
CSI 2.12rCSI 7.94%PRS 31.74
-
CSI 2.1rCSI 3.07%PRS 38.01
-
CSI 2.1rCSI 1.95%PRS 37.11
-
CSI 2.06rCSI 3.28%PRS 46.86
-
CSI 2.05rCSI 3.01%PRS 34.35
-
CSI 2.01rCSI 2.89%PRS 45.16
-
CSI 1.99rCSI 1.67%PRS 42.4
-
CSI 1.99rCSI 1.83%PRS 38.38
-
CSI 1.98rCSI 4.45%PRS 24.56
-
CSI 1.96rCSI 2.78%PRS 34.87
-
CSI 1.94rCSI 2.85%PRS 47.64
-
CSI 1.89rCSI 3.26%PRS 29.33
-
CSI 1.87rCSI 2.48%PRS 41.33
-
CSI 1.87rCSI 3.52%PRS 46.44
-
CSI 1.86rCSI 1.86%PRS 32.23
-
CSI 1.86rCSI 10.49%PRS 25.6
-
CSI 1.86rCSI 3.85%PRS 35.94
-
CSI 1.79rCSI 1.87%PRS 37.41
-
CSI 1.77rCSI 1.58%PRS 36.85
-
CSI 1.76rCSI 1.98%PRS 52.97
-
CSI 1.72rCSI 3.03%PRS 23.17
-
CSI 1.69rCSI 3.02%PRS 53.37
-
CSI 1.69rCSI 3.82%PRS 43.46
-
CSI 1.68rCSI 2.08%PRS 33.58
-
CSI 1.67rCSI 2.55%PRS 41.63
-
CSI 1.67rCSI 1.47%PRS 28.02
-
CSI 1.66rCSI 1.57%PRS 38.49
-
CSI 1.65rCSI 1.59%PRS 29.12
-
CSI 1.63rCSI 2.49%PRS 34.57
-
CSI 1.63rCSI 6.63%PRS 36.3
-
CSI 1.62rCSI 2.84%PRS 30.55
-
CSI 1.61rCSI 3.86%PRS 28.34
-
CSI 1.58rCSI 2.31%PRS 39.89
-
CSI 1.55rCSI 1.82%PRS 41.1
-
CSI 1.54rCSI 2.43%PRS 38.13
-
CSI 1.53rCSI 2.09%PRS 32.08
-
CSI 1.5rCSI 2.05%PRS 40.12
-
CSI 1.5rCSI 2.15%PRS 30
-
CSI 1.48rCSI 1.72%PRS 28.72
-
CSI 1.47rCSI 2.21%PRS 38.75
-
CSI 1.45rCSI 2.08%PRS 40.08
-
CSI 1.4rCSI 2.5%PRS 35.72
-
CSI 1.35rCSI 2.09%PRS 35.5
-
CSI 1.35rCSI 2.27%PRS 24.04
-
CSI 1.35rCSI 1.68%PRS 22.73
-
CSI 1.32rCSI 3.27%PRS 35.5
-
CSI 1.31rCSI 1.4%PRS 35.13
-
CSI 1.3rCSI 2.49%PRS 60.84
-
CSI 1.29rCSI 1.67%PRS 24.87
-
CSI 1.26rCSI 2.59%PRS 60.05
-
CSI 1.26rCSI 2.55%PRS 22.6
-
CSI 1.2rCSI 2.77%PRS 30.8
-
CSI 1.17rCSI 2.98%PRS 29.35
-
CSI 1.1rCSI 3.71%PRS 48.36
-
CSI 1.05rCSI 2.05%PRS 38.9
-
CSI 0.99rCSI 1.7%PRS 46.51
-
CSI 0.99rCSI 4.41%PRS 36.01
-
CSI 0.99rCSI 1.24%PRS 50.38
-
CSI 0.99rCSI 2.11%PRS 52.34
-
CSI 0.97rCSI 1.57%PRS 25.94
-
CSI 0.96rCSI 1.14%PRS 23.99
-
CSI 0.69rCSI 1.68%PRS 23.35
-
CSI 0.67rCSI 1.95%PRS 40.08
-
CSI 0.63rCSI 1.43%PRS 36.51
-
CSI 0.61rCSI 3.56%PRS 48.53
-
CSI 0.56rCSI 1.74%PRS 25.07
-
CSI 0.55rCSI 1.71%PRS 27.08
-
CSI 0.47rCSI 3.81%PRS 33.29
-
CSI 0.44rCSI 1.66%PRS 24.94
-
CSI 0.42rCSI 1.49%PRS 23.05
-
CSI 0.34rCSI 1.69%PRS 47.38
-
CSI 0.1rCSI 1.3%PRS 54.6%
-
CSI 0.2rCSI 2.3%PRS 65.9%
-
CSI 0.3rCSI 1.6%PRS 25.2%
-
CSI 0.3rCSI 1.3%PRS 54.5%
-
CSI 0.3rCSI 0.5%PRS 29.4%
-
CSI 0.3rCSI 1.7%PRS 47.4%
-
CSI 0.4rCSI 1.5%PRS 23.1%
-
CSI 0.4rCSI 1.7%PRS 24.9%
-
CSI 0.5rCSI 3.8%PRS 33.3%
-
CSI 0.6rCSI 1.7%PRS 27.1%
-
CSI 0.6rCSI 1.7%PRS 25.1%
-
CSI 0.6rCSI 3.6%PRS 48.5%
-
CSI 0.6rCSI 1.4%PRS 36.5%
-
CSI 0.7rCSI 2.0%PRS 40.1%
-
CSI 0.7rCSI 1.7%PRS 23.4%
-
CSI 1.0rCSI 1.1%PRS 24.0%
-
CSI 1.0rCSI 1.6%PRS 25.9%
-
CSI 1.0rCSI 2.1%PRS 52.3%
-
CSI 1.0rCSI 1.2%PRS 50.4%
-
CSI 1.0rCSI 4.4%PRS 36.0%
-
CSI 1.0rCSI 1.7%PRS 46.5%
-
CSI 1.1rCSI 2.1%PRS 38.9%
-
CSI 1.1rCSI 3.7%PRS 48.4%
-
CSI 1.2rCSI 3.0%PRS 29.4%
-
CSI 1.2rCSI 2.8%PRS 30.8%
-
CSI 1.3rCSI 2.6%PRS 22.6%
-
CSI 1.3rCSI 2.6%PRS 60.1%
-
CSI 1.3rCSI 1.7%PRS 24.9%
-
CSI 1.3rCSI 2.5%PRS 60.8%
-
CSI 1.3rCSI 1.4%PRS 35.1%
-
CSI 1.3rCSI 3.3%PRS 35.5%
-
CSI 1.4rCSI 1.7%PRS 22.7%
-
CSI 1.4rCSI 2.3%PRS 24.0%
-
CSI 1.4rCSI 2.1%PRS 35.5%
-
CSI 1.4rCSI 2.5%PRS 35.7%
-
CSI 1.5rCSI 2.1%PRS 40.1%
-
CSI 1.5rCSI 2.2%PRS 38.8%
-
CSI 1.5rCSI 1.7%PRS 28.7%
-
CSI 1.5rCSI 2.2%PRS 30.0%
-
CSI 1.5rCSI 2.1%PRS 40.1%
-
CSI 1.5rCSI 2.1%PRS 32.1%
-
CSI 1.5rCSI 2.4%PRS 38.1%
-
CSI 1.6rCSI 1.8%PRS 41.1%
-
CSI 1.6rCSI 2.3%PRS 39.9%
-
CSI 1.6rCSI 3.9%PRS 28.3%
-
CSI 1.6rCSI 2.8%PRS 30.6%
-
CSI 1.6rCSI 6.6%PRS 36.3%
-
CSI 1.6rCSI 2.5%PRS 34.6%
-
CSI 1.7rCSI 1.6%PRS 29.1%
-
CSI 1.7rCSI 1.6%PRS 38.5%
-
CSI 1.7rCSI 1.5%PRS 28.0%
-
CSI 1.7rCSI 2.6%PRS 41.6%
-
CSI 1.7rCSI 2.1%PRS 33.6%
-
CSI 1.7rCSI 3.8%PRS 43.5%
-
CSI 1.7rCSI 3.0%PRS 53.4%
-
CSI 1.7rCSI 3.0%PRS 23.2%
-
CSI 1.8rCSI 2.0%PRS 53.0%
-
CSI 1.8rCSI 1.6%PRS 36.9%
-
CSI 1.8rCSI 1.9%PRS 37.4%
-
CSI 1.9rCSI 3.9%PRS 35.9%
-
CSI 1.9rCSI 10.5%PRS 25.6%
-
CSI 1.9rCSI 1.9%PRS 32.2%
-
CSI 1.9rCSI 3.5%PRS 46.4%
-
CSI 1.9rCSI 2.5%PRS 41.3%
-
CSI 1.9rCSI 3.3%PRS 29.3%
-
CSI 1.9rCSI 2.9%PRS 47.6%
-
CSI 2.0rCSI 2.8%PRS 34.9%
-
CSI 2.0rCSI 4.5%PRS 24.6%
-
CSI 2.0rCSI 1.8%PRS 38.4%
-
CSI 2.0rCSI 1.7%PRS 42.4%
-
CSI 2.0rCSI 2.9%PRS 45.2%
-
CSI 2.1rCSI 3.0%PRS 34.4%
-
CSI 2.1rCSI 3.3%PRS 46.9%
-
CSI 2.1rCSI 2.0%PRS 37.1%
-
CSI 2.1rCSI 3.1%PRS 38.0%
-
CSI 2.1rCSI 7.9%PRS 31.7%
-
CSI 2.1rCSI 5.4%PRS 34.7%
-
CSI 2.2rCSI 3.1%PRS 51.1%
-
CSI 2.2rCSI 1.8%PRS 38.1%
-
CSI 2.2rCSI 2.3%PRS 35.0%
-
CSI 2.2rCSI 2.3%PRS 37.9%
-
CSI 2.2rCSI 5.1%PRS 36.7%
-
CSI 2.3rCSI 1.8%PRS 35.8%
-
CSI 2.4rCSI 3.8%PRS 36.3%
-
CSI 2.4rCSI 15.0%PRS 30.9%
-
CSI 2.4rCSI 3.1%PRS 42.1%
-
CSI 2.5rCSI 1.9%PRS 37.2%
-
CSI 2.6rCSI 2.3%PRS 42.1%
-
CSI 2.7rCSI 2.6%PRS 38.1%
-
CSI 2.7rCSI 4.0%PRS 40.6%
-
CSI 2.9rCSI 3.6%PRS 44.4%
-
CSI 3.2rCSI 13.6%PRS 36.4%
-
CSI 3.3rCSI 4.5%PRS 43.4%
-
CSI 3.4rCSI 2.6%PRS 47.4%
-
CSI 3.8rCSI 4.5%PRS 35.7%
-
CSI 3.9rCSI 8.6%PRS 27.6%
-
CSI 5.2rCSI 13.0%PRS 44.9%
-
CSI 5.2rCSI 4.3%PRS 35.9%
-
CSI 5.2rCSI 16.9%PRS 41.0%
-
CSI 5.2rCSI 4.2%PRS 38.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 557433060
Symbol: PTPA_HUMAN
Name: Serine/threonine-protein phosphatase 2A activator
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8195217
Title: Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A.
PubMed ID: 8195217
PubMed ID: 8530035
Title: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A.
PubMed ID: 8530035
PubMed ID: 10880964
Title: Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene.
PubMed ID: 10880964
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17333320
Title: Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis.
PubMed ID: 17333320
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 16782712
Title: The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
PubMed ID: 16782712
PubMed ID: 16885030
Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
PubMed ID: 16885030
PubMed ID: 16916641
Title: Structure and mechanism of the phosphotyrosyl phosphatase activator.
PubMed ID: 16916641
PubMed ID: 25003389
Title: Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
PubMed ID: 25003389
PubMed ID: 36073231
Title: PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
PubMed ID: 36073231
Sequence Information:
- Length: 358
- Mass: 40668
- Checksum: 2A962521AF5B4CF7
- Sequence:
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA GHCAPSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT GPFAEHSNQL WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL PIHPVTSG
Genular Protein ID: 2214688446
Symbol: F6WIT2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 288
- Mass: 32936
- Checksum: 3405CE3F7E82238A
- Sequence:
MGKWKRSQAY ADYIGFILTL NEGVKGKKLT FEYRVSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT GPFAEHSNQL WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL PIHPVTSG