Details for: PPP2R5C

Gene ID: 5527

Symbol: PPP2R5C

Ensembl ID: ENSG00000078304

Description: protein phosphatase 2 regulatory subunit B'gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 464.1094
    Cell Significance Index: -72.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 298.4111
    Cell Significance Index: -75.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 193.8596
    Cell Significance Index: -79.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 179.5907
    Cell Significance Index: -72.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 174.1179
    Cell Significance Index: -82.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 158.5679
    Cell Significance Index: -81.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 64.2278
    Cell Significance Index: -79.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.1412
    Cell Significance Index: -77.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6813
    Cell Significance Index: -60.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.5699
    Cell Significance Index: -81.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.1715
    Cell Significance Index: -39.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6982
    Cell Significance Index: 2436.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5150
    Cell Significance Index: 504.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3884
    Cell Significance Index: 183.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0740
    Cell Significance Index: 133.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7081
    Cell Significance Index: 612.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6201
    Cell Significance Index: 263.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5351
    Cell Significance Index: 67.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4843
    Cell Significance Index: 83.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4664
    Cell Significance Index: 55.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3638
    Cell Significance Index: 270.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3081
    Cell Significance Index: 904.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9316
    Cell Significance Index: 12.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8716
    Cell Significance Index: 24.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8493
    Cell Significance Index: 153.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7989
    Cell Significance Index: 53.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7460
    Cell Significance Index: 91.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6498
    Cell Significance Index: 76.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6361
    Cell Significance Index: 39.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6010
    Cell Significance Index: 328.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5997
    Cell Significance Index: 16.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4147
    Cell Significance Index: 183.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3658
    Cell Significance Index: 50.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2769
    Cell Significance Index: 52.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2384
    Cell Significance Index: 448.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2117
    Cell Significance Index: 20.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2105
    Cell Significance Index: 9.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1563
    Cell Significance Index: 240.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1460
    Cell Significance Index: 6.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1136
    Cell Significance Index: 72.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1135
    Cell Significance Index: 3.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1113
    Cell Significance Index: 205.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1020
    Cell Significance Index: 138.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0839
    Cell Significance Index: 38.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0729
    Cell Significance Index: 1.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0712
    Cell Significance Index: 7.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0567
    Cell Significance Index: 9.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0396
    Cell Significance Index: -24.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0470
    Cell Significance Index: -34.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0496
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0646
    Cell Significance Index: -47.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0694
    Cell Significance Index: -8.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0831
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1036
    Cell Significance Index: -58.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1175
    Cell Significance Index: -4.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1235
    Cell Significance Index: -15.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2483
    Cell Significance Index: -52.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2484
    Cell Significance Index: -71.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2501
    Cell Significance Index: -36.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2686
    Cell Significance Index: -27.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2725
    Cell Significance Index: -31.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3807
    Cell Significance Index: -9.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4213
    Cell Significance Index: -31.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4586
    Cell Significance Index: -6.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4727
    Cell Significance Index: -12.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5084
    Cell Significance Index: -58.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5137
    Cell Significance Index: -36.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5430
    Cell Significance Index: -56.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5733
    Cell Significance Index: -11.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5820
    Cell Significance Index: -26.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6066
    Cell Significance Index: -31.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6110
    Cell Significance Index: -38.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6211
    Cell Significance Index: -15.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6868
    Cell Significance Index: -78.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8237
    Cell Significance Index: -49.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8475
    Cell Significance Index: -24.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8992
    Cell Significance Index: -71.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0176
    Cell Significance Index: -53.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0800
    Cell Significance Index: -34.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0851
    Cell Significance Index: -29.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1431
    Cell Significance Index: -24.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1734
    Cell Significance Index: -71.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3286
    Cell Significance Index: -22.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3594
    Cell Significance Index: -47.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3615
    Cell Significance Index: -23.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.3744
    Cell Significance Index: -37.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3911
    Cell Significance Index: -72.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4084
    Cell Significance Index: -37.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.4140
    Cell Significance Index: -30.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.4873
    Cell Significance Index: -17.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4944
    Cell Significance Index: -47.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4951
    Cell Significance Index: -48.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5382
    Cell Significance Index: -28.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.6207
    Cell Significance Index: -23.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6706
    Cell Significance Index: -35.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7369
    Cell Significance Index: -63.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7453
    Cell Significance Index: -61.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.7954
    Cell Significance Index: -35.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.8540
    Cell Significance Index: -31.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPP2R5C is a gamma isoform of the PP2A regulatory subunit B, which is highly expressed in T-cells, particularly in CD8-positive, alpha-beta memory T cells and effector CD8-positive, alpha-beta cytokine secreting effector T cells. The protein is characterized by its ability to regulate PP2A activity, which in turn modulates various signaling pathways, including the MAPK, PI3K/AKT, and WNT/β-catenin pathways. **Pathways and Functions:** PPP2R5C is involved in the regulation of several critical cellular processes, including: 1. **Adaptive Immune Response:** PPP2R5C plays a crucial role in the regulation of T-cell responses, particularly in the activation and proliferation of CD8-positive, alpha-beta T cells. 2. **Cell Cycle Checkpoints:** PPP2R5C is involved in the regulation of cell cycle checkpoints, particularly in the G2/M phase, where it modulates the activity of PP2A and the phosphorylation of key proteins. 3. **Gene Expression:** PPP2R5C regulates gene expression by modulating the activity of PP2A, which in turn affects the phosphorylation and degradation of transcription factors and other proteins. 4. **Signaling by Second Messengers:** PPP2R5C is involved in the regulation of signaling by second messengers, including cAMP and IP3, which modulate various cellular processes, including gene expression and cell cycle progression. **Clinical Significance:** Dysregulation of PPP2R5C has been implicated in various diseases, including: 1. **Immunological Disorders:** PPP2R5C is involved in the regulation of T-cell responses, and dysregulation of this protein has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** PPP2R5C has been identified as a tumor suppressor gene, and its dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological Disorders:** PPP2R5C is involved in the regulation of neuronal function, and dysregulation of this protein has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PPP2R5C is a multifaceted protein that plays a critical role in the regulation of immune responses, cell cycle checkpoints, and gene expression. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand the mechanisms by which PPP2R5C regulates cellular processes.

Genular Protein ID: 3524741088

Symbol: 2A5G_HUMAN

Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8617797

Title: Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.

PubMed ID: 8617797

DOI: 10.1074/jbc.271.9.5164

PubMed ID: 8694763

Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.

PubMed ID: 8694763

DOI: 10.1042/bj3170187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 7592815

Title: Identification of a new family of protein phosphatase 2A regulatory subunits.

PubMed ID: 7592815

DOI: 10.1074/jbc.270.44.26123

PubMed ID: 8703017

Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PubMed ID: 8703017

DOI: 10.1074/jbc.271.36.22081

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 16580887

Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

PubMed ID: 16580887

DOI: 10.1016/j.devcel.2006.03.010

PubMed ID: 16456541

Title: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.

PubMed ID: 16456541

DOI: 10.1038/sj.emboj.7600980

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 17967874

Title: Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.

PubMed ID: 17967874

DOI: 10.1128/mcb.00983-07

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 17174897

Title: Structure of the protein phosphatase 2A holoenzyme.

PubMed ID: 17174897

DOI: 10.1016/j.cell.2006.11.033

PubMed ID: 17086192

Title: Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.

PubMed ID: 17086192

DOI: 10.1038/nature05351

PubMed ID: 19716788

Title: Structure and function of the PP2A-shugoshin interaction.

PubMed ID: 19716788

DOI: 10.1016/j.molcel.2009.06.031

PubMed ID: 18618707

Title: The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.

PubMed ID: 18618707

DOI: 10.1002/prot.22150

PubMed ID: 28174209

Title: Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.

PubMed ID: 28174209

DOI: 10.15252/embr.201642788

Sequence Information:

  • Length: 524
  • Mass: 61061
  • Checksum: B9CBF54550D713F8
  • Sequence:
  • MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL 
    SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP 
    EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD 
    FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK 
    EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK 
    EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS 
    DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK 
    LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH 
    QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.