Details for: PPP2R5C
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 464.1094
Cell Significance Index: -72.1900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 298.4111
Cell Significance Index: -75.6900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 193.8596
Cell Significance Index: -79.8600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 179.5907
Cell Significance Index: -72.9600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 174.1179
Cell Significance Index: -82.2100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 158.5679
Cell Significance Index: -81.5700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.2278
Cell Significance Index: -79.1900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 25.1412
Cell Significance Index: -77.2200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.6813
Cell Significance Index: -60.7600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.5699
Cell Significance Index: -81.1700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.1715
Cell Significance Index: -39.7700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.6982
Cell Significance Index: 2436.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5150
Cell Significance Index: 504.5100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.3884
Cell Significance Index: 183.2900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0740
Cell Significance Index: 133.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7081
Cell Significance Index: 612.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.6201
Cell Significance Index: 263.4900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.5351
Cell Significance Index: 67.9000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4843
Cell Significance Index: 83.2900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.4664
Cell Significance Index: 55.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3638
Cell Significance Index: 270.6600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3081
Cell Significance Index: 904.7500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9316
Cell Significance Index: 12.7100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.8716
Cell Significance Index: 24.8700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8493
Cell Significance Index: 153.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7989
Cell Significance Index: 53.7200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7460
Cell Significance Index: 91.7300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6498
Cell Significance Index: 76.6400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6361
Cell Significance Index: 39.1000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6010
Cell Significance Index: 328.2400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5997
Cell Significance Index: 16.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4147
Cell Significance Index: 183.3600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3658
Cell Significance Index: 50.2300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2769
Cell Significance Index: 52.7000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2384
Cell Significance Index: 448.9600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2117
Cell Significance Index: 20.9400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2105
Cell Significance Index: 9.8100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1563
Cell Significance Index: 240.5700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1460
Cell Significance Index: 6.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1136
Cell Significance Index: 72.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1135
Cell Significance Index: 3.2700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1113
Cell Significance Index: 205.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1020
Cell Significance Index: 138.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0839
Cell Significance Index: 38.0700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0729
Cell Significance Index: 1.5800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0712
Cell Significance Index: 7.7400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0567
Cell Significance Index: 9.6800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0166
Cell Significance Index: -12.5600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0396
Cell Significance Index: -24.7000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0470
Cell Significance Index: -34.7900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0496
Cell Significance Index: -0.8500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0646
Cell Significance Index: -47.4000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0694
Cell Significance Index: -8.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0831
Cell Significance Index: -2.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1036
Cell Significance Index: -58.4300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1175
Cell Significance Index: -4.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1235
Cell Significance Index: -15.8300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2483
Cell Significance Index: -52.2900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2484
Cell Significance Index: -71.4700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2501
Cell Significance Index: -36.3600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2686
Cell Significance Index: -27.4400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2725
Cell Significance Index: -31.7600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3807
Cell Significance Index: -9.1300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4213
Cell Significance Index: -31.4000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4586
Cell Significance Index: -6.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4727
Cell Significance Index: -12.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5084
Cell Significance Index: -58.2400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5137
Cell Significance Index: -36.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5430
Cell Significance Index: -56.5400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5733
Cell Significance Index: -11.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.5820
Cell Significance Index: -26.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6066
Cell Significance Index: -31.5100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6110
Cell Significance Index: -38.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6211
Cell Significance Index: -15.5300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6868
Cell Significance Index: -78.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8237
Cell Significance Index: -49.4500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8475
Cell Significance Index: -24.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8992
Cell Significance Index: -71.2200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0176
Cell Significance Index: -53.4300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0800
Cell Significance Index: -34.5900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.0851
Cell Significance Index: -29.0800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.1431
Cell Significance Index: -24.4400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1734
Cell Significance Index: -71.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.3286
Cell Significance Index: -22.2400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.3594
Cell Significance Index: -47.2400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.3615
Cell Significance Index: -23.4700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.3744
Cell Significance Index: -37.4100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.3911
Cell Significance Index: -72.4600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4084
Cell Significance Index: -37.6800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.4140
Cell Significance Index: -30.0100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.4873
Cell Significance Index: -17.7300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4944
Cell Significance Index: -47.6000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4951
Cell Significance Index: -48.9500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.5382
Cell Significance Index: -28.4300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.6207
Cell Significance Index: -23.3100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.6706
Cell Significance Index: -35.5800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.7369
Cell Significance Index: -63.7600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.7453
Cell Significance Index: -61.1400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.7954
Cell Significance Index: -35.5000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.8540
Cell Significance Index: -31.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3524741088
Symbol: 2A5G_HUMAN
Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8617797
Title: Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.
PubMed ID: 8617797
PubMed ID: 8694763
Title: The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
PubMed ID: 8694763
DOI: 10.1042/bj3170187
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 7584044
Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7584044
PubMed ID: 7592815
Title: Identification of a new family of protein phosphatase 2A regulatory subunits.
PubMed ID: 7592815
PubMed ID: 8703017
Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
PubMed ID: 8703017
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 16580887
Title: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.
PubMed ID: 16580887
PubMed ID: 16456541
Title: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK.
PubMed ID: 16456541
PubMed ID: 16541025
Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
PubMed ID: 16541025
DOI: 10.1038/nature04663
PubMed ID: 17245430
Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
PubMed ID: 17245430
PubMed ID: 17967874
Title: Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.
PubMed ID: 17967874
DOI: 10.1128/mcb.00983-07
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 17174897
Title: Structure of the protein phosphatase 2A holoenzyme.
PubMed ID: 17174897
PubMed ID: 17086192
Title: Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
PubMed ID: 17086192
DOI: 10.1038/nature05351
PubMed ID: 19716788
Title: Structure and function of the PP2A-shugoshin interaction.
PubMed ID: 19716788
PubMed ID: 18618707
Title: The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle.
PubMed ID: 18618707
DOI: 10.1002/prot.22150
PubMed ID: 28174209
Title: Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
PubMed ID: 28174209
Sequence Information:
- Length: 524
- Mass: 61061
- Checksum: B9CBF54550D713F8
- Sequence:
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.