Details for: PRH1

Gene ID: 5554

Symbol: PRH1

Ensembl ID: ENSG00000231887

Description: proline rich protein HaeIII subfamily 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.3296
    Cell Significance Index: -22.8000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 44.0536
    Cell Significance Index: 245.2100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 40.8479
    Cell Significance Index: 851.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8935
    Cell Significance Index: 162.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2924
    Cell Significance Index: 822.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.9262
    Cell Significance Index: 19.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9251
    Cell Significance Index: 85.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8742
    Cell Significance Index: 70.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6737
    Cell Significance Index: 165.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5232
    Cell Significance Index: 116.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9779
    Cell Significance Index: 106.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7704
    Cell Significance Index: 125.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7691
    Cell Significance Index: 146.3600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5611
    Cell Significance Index: 5.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5032
    Cell Significance Index: 34.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4094
    Cell Significance Index: 26.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4070
    Cell Significance Index: 20.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3075
    Cell Significance Index: 2.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2772
    Cell Significance Index: 17.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2644
    Cell Significance Index: 6.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2602
    Cell Significance Index: 51.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2058
    Cell Significance Index: 9.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2010
    Cell Significance Index: 36.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1965
    Cell Significance Index: 177.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1462
    Cell Significance Index: 17.9800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1259
    Cell Significance Index: 1.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0443
    Cell Significance Index: 5.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0376
    Cell Significance Index: 16.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0175
    Cell Significance Index: 0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0165
    Cell Significance Index: 3.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0112
    Cell Significance Index: 21.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0092
    Cell Significance Index: 14.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0026
    Cell Significance Index: 0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0115
    Cell Significance Index: -8.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0306
    Cell Significance Index: -23.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0365
    Cell Significance Index: -19.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0368
    Cell Significance Index: -16.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0383
    Cell Significance Index: -21.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0489
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0552
    Cell Significance Index: -8.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0758
    Cell Significance Index: -10.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0817
    Cell Significance Index: -10.5500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0839
    Cell Significance Index: -1.4500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0895
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0911
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0975
    Cell Significance Index: -11.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0980
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1028
    Cell Significance Index: -21.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1286
    Cell Significance Index: -15.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1339
    Cell Significance Index: -4.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1489
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1549
    Cell Significance Index: -26.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1642
    Cell Significance Index: -12.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1708
    Cell Significance Index: -17.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1821
    Cell Significance Index: -3.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1848
    Cell Significance Index: -4.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2093
    Cell Significance Index: -2.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2132
    Cell Significance Index: -4.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2248
    Cell Significance Index: -2.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2362
    Cell Significance Index: -24.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2496
    Cell Significance Index: -7.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2701
    Cell Significance Index: -21.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2889
    Cell Significance Index: -17.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2949
    Cell Significance Index: -20.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3239
    Cell Significance Index: -6.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3286
    Cell Significance Index: -17.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3352
    Cell Significance Index: -15.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3494
    Cell Significance Index: -7.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3625
    Cell Significance Index: -7.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3834
    Cell Significance Index: -5.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3868
    Cell Significance Index: -13.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4111
    Cell Significance Index: -11.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4344
    Cell Significance Index: -9.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4409
    Cell Significance Index: -11.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4455
    Cell Significance Index: -23.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4552
    Cell Significance Index: -13.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5104
    Cell Significance Index: -6.3300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.5182
    Cell Significance Index: -4.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5203
    Cell Significance Index: -7.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5232
    Cell Significance Index: -13.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5294
    Cell Significance Index: -18.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5411
    Cell Significance Index: -11.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5574
    Cell Significance Index: -20.4600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5583
    Cell Significance Index: -11.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5617
    Cell Significance Index: -14.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5868
    Cell Significance Index: -9.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6194
    Cell Significance Index: -16.8600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.6318
    Cell Significance Index: -4.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6319
    Cell Significance Index: -5.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6550
    Cell Significance Index: -9.3800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7072
    Cell Significance Index: -13.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7344
    Cell Significance Index: -12.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7537
    Cell Significance Index: -22.2000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7758
    Cell Significance Index: -5.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7969
    Cell Significance Index: -17.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein structure**: PRH1 is characterized by a proline-rich sequence, which is a hallmark of proteins involved in structural and functional roles in cells. 2. **Tissue-specific expression**: PRH1 is expressed in a variety of tissues, including retinal pigment epithelial cells, acinar cells of the salivary gland, kidney proximal convoluted tubule epithelial cells, and specific neuronal populations in the brain. 3. **Protein binding and interactions**: The proline-rich sequences in PRH1 may facilitate protein-protein interactions, which are essential for modulating cellular functions, particularly in the context of synaptic transmission and neuronal activity. **Pathways and Functions:** 1. **Extracellular space and protein binding**: PRH1 may play a role in regulating the extracellular space by interacting with other proteins, influencing cellular processes such as migration, adhesion, and signaling. 2. **Protein binding and interactions**: The proline-rich sequences in PRH1 may facilitate protein-protein interactions, modulating cellular functions, particularly in the context of synaptic transmission and neuronal activity. 3. **Neuronal activity and synaptic transmission**: PRH1 may be involved in regulating neuronal activity, modulating synaptic transmission, and influencing the development and maintenance of neural circuits. **Clinical Significance:** 1. **Neurological disorders**: The expression of PRH1 in specific neuronal populations suggests that dysregulation of PRH1 may contribute to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and other disorders characterized by impaired synaptic transmission. 2. **Salivary gland disorders**: The expression of PRH1 in salivary gland acinar cells suggests that alterations in PRH1 expression may contribute to salivary gland disorders, such as xerostomia (dry mouth) and sialadenitis (inflammation of the salivary glands). 3. **Retinal diseases**: The expression of PRH1 in retinal pigment epithelial cells suggests that alterations in PRH1 expression may contribute to retinal diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa. In conclusion, PRH1 is a gene of proline rich protein HaeIII subfamily 1 that plays a complex role in regulating cellular functions, particularly in the context of neuronal activity and synaptic transmission. Further research is necessary to elucidate the mechanisms by which PRH1 influences cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3630455268

Symbol: PRPC_HUMAN

Name: Salivary acidic proline-rich phosphoprotein 1/2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2993301

Title: Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.

PubMed ID: 2993301

DOI: 10.1016/s0021-9258(17)39156-1

PubMed ID: 3009472

Title: Structures of two HaeIII-type genes in the human salivary proline-rich protein multigene family.

PubMed ID: 3009472

DOI: 10.1016/s0021-9258(19)62674-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7380845

Title: The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a possible precursor of a related salivary protein A.

PubMed ID: 7380845

DOI: 10.1016/s0021-9258(19)70721-2

PubMed ID: 3710693

Title: Complete covalent structure of a proline-rich phosphoprotein, PRP-2, an inhibitor of calcium phosphate crystal growth from human parotid saliva.

PubMed ID: 3710693

DOI: 10.1111/j.1399-3011.1986.tb01030.x

PubMed ID: 3687941

Title: Alleles at the PRH1 locus coding for the human salivary-acidic proline-rich proteins Pa, Db, and PIF.

PubMed ID: 3687941

PubMed ID: 3196309

Title: The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f).

PubMed ID: 3196309

DOI: 10.1042/bj2550015

PubMed ID: 438215

Title: The complete primary structure of a proline-rich phosphoprotein from human saliva.

PubMed ID: 438215

DOI: 10.1016/s0021-9258(17)30083-2

PubMed ID: 7228490

Title: Primary structure of the active tryptic fragments of human and monkey salivary anionic proline-rich proteins.

PubMed ID: 7228490

DOI: 10.1111/j.1399-3011.1981.tb01965.x

PubMed ID: 15693058

Title: Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins.

PubMed ID: 15693058

DOI: 10.1002/pmic.200401156

PubMed ID: 7390979

Title: The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C.

PubMed ID: 7390979

PubMed ID: 1849422

Title: Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.

PubMed ID: 1849422

DOI: 10.1021/bi00228a001

PubMed ID: 10858503

Title: A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry.

PubMed ID: 10858503

DOI: 10.1016/s0014-5793(00)01645-8

PubMed ID: 18463091

Title: Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.

PubMed ID: 18463091

DOI: 10.1074/jbc.m708282200

PubMed ID: 20879038

Title: Finding new posttranslational modifications in salivary proline-rich proteins.

PubMed ID: 20879038

DOI: 10.1002/pmic.201000261

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 10627138

Title: A frequent mutation in the acidic proline-rich protein gene, PRH2, causing a Q147K change closely adjacent to the bacterial binding domain of the cognate salivary PRP (Pr1') in Afro-Americans.

PubMed ID: 10627138

DOI: 10.1002/(sici)1098-1004(1998)12:1<72::aid-humu18>3.0.co;2-w

Sequence Information:

  • Length: 166
  • Mass: 17015
  • Checksum: 2555423D9AE32DE1
  • Sequence:
  • MLLILLSVAL LAFSSAQDLD EDVSQEDVPL VISDGGDSEQ FIDEERQGPP LGGQQSQPSA 
    GDGNQNDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGH PPPPQGRPQG PPQQGGHPRP 
    PRGRPQGPPQ QGGHQQGPPP PPPGKPQGPP PQGGRPQGPP QGQSPQ

Genular Protein ID: 1577049425

Symbol: A0A087WV42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 187
  • Mass: 19134
  • Checksum: CD9CA024EF172963
  • Sequence:
  • MLLILLSVAL LAFSSAQDLN EDVSQEDVPL VISDGGDSEQ FLDEERQGPP LGGQQSQPSA 
    GDGNQDDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGQ QQQGPPPPQG KPQGPPQQGG 
    HPPPPQGRPQ GPPQQGGHPR PPRGRPQGPP QQGGHQQGPP PPPPGKPQGP PPQGGRPQGP 
    PQGQSPQ

Genular Protein ID: 3826158241

Symbol: F1T0A8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 72
  • Mass: 7808
  • Checksum: 3201319ED6C540CA
  • Sequence:
  • MLAPEAVILV MALNMYLQSD VEDHRARDVE VREVHAQLPG QLEEGEQGAG EPLAEDAVRG 
    SPAFGSRPQG HM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.