Details for: PRKAR1AP1

Gene ID: 5574

Symbol: PRKAR1AP1

Ensembl ID: ENSG00000233401

Description: protein kinase cAMP-dependent type I regulatory subunit alpha pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4354
    Cell Significance Index: 6.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1352
    Cell Significance Index: 1.7400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0571
    Cell Significance Index: 1.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0093
    Cell Significance Index: 1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0056
    Cell Significance Index: 0.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0200
    Cell Significance Index: -1.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0333
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0446
    Cell Significance Index: -2.0800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0468
    Cell Significance Index: -0.5100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0481
    Cell Significance Index: -0.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0482
    Cell Significance Index: -2.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0585
    Cell Significance Index: -2.6500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0618
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0692
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0732
    Cell Significance Index: -0.8500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0870
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0952
    Cell Significance Index: -2.5900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1280
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1308
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1458
    Cell Significance Index: -1.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1541
    Cell Significance Index: -2.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1568
    Cell Significance Index: -1.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1774
    Cell Significance Index: -2.6600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1825
    Cell Significance Index: -2.4300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1966
    Cell Significance Index: -2.3400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1989
    Cell Significance Index: -2.4200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2178
    Cell Significance Index: -2.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2237
    Cell Significance Index: -2.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2354
    Cell Significance Index: -2.5500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2365
    Cell Significance Index: -2.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2399
    Cell Significance Index: -2.8600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2414
    Cell Significance Index: -3.1000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2434
    Cell Significance Index: -3.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2436
    Cell Significance Index: -2.9400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2444
    Cell Significance Index: -2.6500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2463
    Cell Significance Index: -2.3400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2509
    Cell Significance Index: -2.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2512
    Cell Significance Index: -2.8900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2537
    Cell Significance Index: -2.5900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2627
    Cell Significance Index: -2.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2636
    Cell Significance Index: -2.6700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2665
    Cell Significance Index: -3.2300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2667
    Cell Significance Index: -3.3400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2691
    Cell Significance Index: -3.3600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2750
    Cell Significance Index: -2.6600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2782
    Cell Significance Index: -2.9600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2871
    Cell Significance Index: -2.9000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2889
    Cell Significance Index: -3.4100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2927
    Cell Significance Index: -3.3500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2930
    Cell Significance Index: -3.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3068
    Cell Significance Index: -2.8700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3101
    Cell Significance Index: -2.9400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3124
    Cell Significance Index: -3.3600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3190
    Cell Significance Index: -2.9700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.3216
    Cell Significance Index: -2.9900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3349
    Cell Significance Index: -3.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3510
    Cell Significance Index: -4.0700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3712
    Cell Significance Index: -3.2700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.3816
    Cell Significance Index: -3.7300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3911
    Cell Significance Index: -3.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3912
    Cell Significance Index: -3.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3931
    Cell Significance Index: -4.1400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3946
    Cell Significance Index: -3.8500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3962
    Cell Significance Index: -3.2700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.4193
    Cell Significance Index: -2.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4367
    Cell Significance Index: -4.2000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4377
    Cell Significance Index: -3.6200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4444
    Cell Significance Index: -4.0100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.8136
    Cell Significance Index: -2.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PrkAR1AP1 is a pseudogene that is primarily expressed in cells of the immune system, including retinal rod cells, innate lymphoid cells, stromal cells, and macrophages. Despite its pseudogene status, PrkAR1AP1 exhibits a high degree of sequence similarity to the functional PrkAR1AP gene, suggesting that it may have evolved from a functional gene that has since been lost. Notably, PrkAR1AP1 is significantly overexpressed in certain cell types, such as memory B cells and luminal cells of prostate epithelium. **Pathways and Functions:** Research has implicated PrkAR1AP1 in several key signaling pathways, including the cAMP-dependent protein kinase A (PKA) pathway. This pathway is crucial for regulating immune responses, cellular differentiation, and tissue homeostasis. PrkAR1AP1 has been shown to interact with PKA and influence its activity, thereby modulating downstream signaling events. Additionally, PrkAR1AP1 has been implicated in the regulation of cell proliferation, differentiation, and survival, suggesting a broader role in cellular homeostasis. **Clinical Significance:** The clinical significance of PrkAR1AP1 is an area of active research. While its exact role in human disease remains unclear, studies have suggested that PrkAR1AP1 may be involved in various immunological disorders, including autoimmune diseases and cancer. For example, PrkAR1AP1 has been shown to be overexpressed in certain types of cancer, including prostate cancer, suggesting a potential role in tumor progression. Furthermore, PrkAR1AP1 has been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, PrkAR1AP1 is a complex gene that has been revealed to play a significant role in regulating immune responses, cellular differentiation, and tissue homeostasis. Further research is needed to fully elucidate its clinical significance and to explore its potential as a therapeutic target for various diseases. **Recommendations for Future Research:** 1. Elucidate the molecular mechanisms by which PrkAR1AP1 regulates immune responses and cellular differentiation. 2. Investigate the clinical significance of PrkAR1AP1 in various diseases, including autoimmune disorders and cancer. 3. Explore the potential of PrkAR1AP1 as a therapeutic target for the treatment of these diseases. 4. Investigate the role of PrkAR1AP1 in tissue homeostasis and its relationship to other pseudogenes. By addressing these questions, researchers can gain a deeper understanding of the complex role of PrkAR1AP1 in regulating immune responses and cellular homeostasis, and can potentially uncover new therapeutic strategies for the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.