Details for: PRKCI

Gene ID: 5584

Symbol: PRKCI

Ensembl ID: ENSG00000163558

Description: protein kinase C iota

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.4131
    Cell Significance Index: -47.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 181.9089
    Cell Significance Index: -46.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0938
    Cell Significance Index: -37.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.6442
    Cell Significance Index: -37.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.8132
    Cell Significance Index: -47.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7366
    Cell Significance Index: -44.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1818
    Cell Significance Index: -48.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3988
    Cell Significance Index: -20.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4220
    Cell Significance Index: 167.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1960
    Cell Significance Index: 440.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9939
    Cell Significance Index: 1800.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5485
    Cell Significance Index: 42.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3580
    Cell Significance Index: 147.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0595
    Cell Significance Index: 40.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0311
    Cell Significance Index: 45.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0124
    Cell Significance Index: 28.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0055
    Cell Significance Index: 360.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9604
    Cell Significance Index: 64.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8692
    Cell Significance Index: 18.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8291
    Cell Significance Index: 164.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8069
    Cell Significance Index: 36.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7880
    Cell Significance Index: 22.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7810
    Cell Significance Index: 96.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7568
    Cell Significance Index: 39.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7077
    Cell Significance Index: 43.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7048
    Cell Significance Index: 127.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6826
    Cell Significance Index: 472.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6179
    Cell Significance Index: 337.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5385
    Cell Significance Index: 15.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5057
    Cell Significance Index: 23.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4278
    Cell Significance Index: 32.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4002
    Cell Significance Index: 8.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3167
    Cell Significance Index: 140.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3115
    Cell Significance Index: 586.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2973
    Cell Significance Index: 16.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2927
    Cell Significance Index: 6.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2814
    Cell Significance Index: 36.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2714
    Cell Significance Index: 37.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2248
    Cell Significance Index: 2.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1581
    Cell Significance Index: 15.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1492
    Cell Significance Index: 7.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1290
    Cell Significance Index: 237.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1218
    Cell Significance Index: 2.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1157
    Cell Significance Index: 178.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1152
    Cell Significance Index: 73.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0667
    Cell Significance Index: 1.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0615
    Cell Significance Index: 1.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0352
    Cell Significance Index: 15.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0270
    Cell Significance Index: 36.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0027
    Cell Significance Index: -0.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0041
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0233
    Cell Significance Index: -3.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0393
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0554
    Cell Significance Index: -41.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0678
    Cell Significance Index: -12.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0853
    Cell Significance Index: -53.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0854
    Cell Significance Index: -48.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1103
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1245
    Cell Significance Index: -21.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1287
    Cell Significance Index: -2.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1343
    Cell Significance Index: -38.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1487
    Cell Significance Index: -15.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1750
    Cell Significance Index: -3.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1770
    Cell Significance Index: -12.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1950
    Cell Significance Index: -14.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2090
    Cell Significance Index: -24.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2332
    Cell Significance Index: -7.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2517
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2521
    Cell Significance Index: -53.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2683
    Cell Significance Index: -31.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2955
    Cell Significance Index: -33.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3051
    Cell Significance Index: -4.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3072
    Cell Significance Index: -19.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3330
    Cell Significance Index: -34.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3749
    Cell Significance Index: -19.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3928
    Cell Significance Index: -13.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4785
    Cell Significance Index: -30.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4787
    Cell Significance Index: -37.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4981
    Cell Significance Index: -26.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5044
    Cell Significance Index: -30.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5395
    Cell Significance Index: -14.1900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5985
    Cell Significance Index: -8.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6507
    Cell Significance Index: -13.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7211
    Cell Significance Index: -23.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7214
    Cell Significance Index: -20.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7350
    Cell Significance Index: -15.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7357
    Cell Significance Index: -23.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7529
    Cell Significance Index: -12.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7843
    Cell Significance Index: -15.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8335
    Cell Significance Index: -22.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8455
    Cell Significance Index: -21.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8471
    Cell Significance Index: -16.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9526
    Cell Significance Index: -33.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9704
    Cell Significance Index: -28.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0022
    Cell Significance Index: -29.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0284
    Cell Significance Index: -37.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PRKCI is a member of the PKC family, which is characterized by its ability to phosphorylate and activate downstream targets. PRKCI is specifically known for its: * **Isoform-specificity**: PRKCI is one of the four isoforms of the PKC family, and its isoform-specificity is thought to be critical for its function. The iota isoform is unique in its ability to regulate cell polarity and migration. * **Cell-type specificity**: PRKCI is significantly expressed in various cell types, including epithelial cells, neurons, and glial cells, highlighting its functional significance in different cell types. * **Regulation of cell polarity**: PRKCI is involved in the regulation of cell polarity, which is critical for cell migration, differentiation, and survival. **Pathways and Functions** PRKCI is involved in various signaling pathways, including: * **Cell polarity regulation**: PRKCI regulates cell polarity by phosphorylating and activating downstream targets, such as the Par polarity complex. * **Cell migration**: PRKCI regulates cell migration by phosphorylating and activating downstream targets, such as the actin cytoskeleton. * **Apoptosis regulation**: PRKCI regulates apoptosis by phosphorylating and activating downstream targets, such as the NF-κB pathway. * **Neurotransmitter regulation**: PRKCI regulates neurotransmitter release by phosphorylating and activating downstream targets, such as the postsynaptic membrane neurotransmitter receptors. **Clinical Significance** PRKCI has been implicated in various diseases, including: * **Neurological disorders**: PRKCI has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * **Cancer**: PRKCI has been implicated in cancer, including glioblastoma, breast cancer, and prostate cancer. * **Neurodevelopmental disorders**: PRKCI has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. Overall, PRKCI is a critical regulator of cell signaling, polarity, and migration, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functional significance of PRKCI and its role in human disease.

Genular Protein ID: 1449855425

Symbol: KPCI_HUMAN

Name: Protein kinase C iota type

UniProtKB Accession Codes:

P41743 D3DNQ4 Q8WW06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 3 ELM 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 53 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8226978

Title: Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

PubMed ID: 8226978

DOI: 10.1016/s0021-9258(20)80525-0

PubMed ID: 7607695

Title: Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.

PubMed ID: 7607695

DOI: 10.1016/0888-7543(95)80190-w

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8524286

Title: Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.

PubMed ID: 8524286

DOI: 10.1128/mcb.16.1.105

PubMed ID: 9346882

Title: Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis.

PubMed ID: 9346882

DOI: 10.1074/jbc.272.44.27521

PubMed ID: 9566925

Title: Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

PubMed ID: 9566925

DOI: 10.1128/mcb.18.5.3069

PubMed ID: 10467349

Title: Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway.

PubMed ID: 10467349

DOI: 10.1038/sj.cdd.4400548

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 10906326

Title: Unique structural and functional properties of the ATP-binding domain of atypical protein kinase C-iota.

PubMed ID: 10906326

DOI: 10.1074/jbc.m002742200

PubMed ID: 11042363

Title: Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.

PubMed ID: 11042363

DOI: 10.1016/s0169-328x(00)00187-x

PubMed ID: 11260256

Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.

PubMed ID: 11260256

DOI: 10.1046/j.1365-2443.2001.00404.x

PubMed ID: 11257119

Title: Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.

PubMed ID: 11257119

DOI: 10.1083/jcb.152.6.1183

PubMed ID: 11724794

Title: Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway.

PubMed ID: 11724794

DOI: 10.1074/jbc.m109744200

PubMed ID: 11713277

Title: Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.

PubMed ID: 11713277

DOI: 10.1128/mcb.21.24.8414-8427.2001

PubMed ID: 11891849

Title: Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.

PubMed ID: 11891849

DOI: 10.1002/jcb.10101.abs

PubMed ID: 12893243

Title: Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.

PubMed ID: 12893243

DOI: 10.1016/s0006-291x(03)01187-2

PubMed ID: 12725730

Title: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.

PubMed ID: 12725730

DOI: 10.1016/s0960-9822(03)00244-6

PubMed ID: 12871960

Title: Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates.

PubMed ID: 12871960

DOI: 10.1074/jbc.m305381200

PubMed ID: 14570876

Title: Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.

PubMed ID: 14570876

DOI: 10.1074/jbc.m309343200

PubMed ID: 14684752

Title: Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.

PubMed ID: 14684752

DOI: 10.1074/jbc.c300431200

PubMed ID: 15994303

Title: Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.

PubMed ID: 15994303

DOI: 10.1074/jbc.m505402200

PubMed ID: 15695176

Title: Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.

PubMed ID: 15695176

DOI: 10.1016/j.tice.2004.10.004

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 16452474

Title: Src-dependent protein kinase C iota/lambda (aPKCiota/lambda) tyrosine phosphorylation is required for aPKCiota/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-Golgi intermediates.

PubMed ID: 16452474

DOI: 10.1074/jbc.m513031200

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 18270268

Title: Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells.

PubMed ID: 18270268

DOI: 10.1242/jcs.016246

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19327373

Title: Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.

PubMed ID: 19327373

DOI: 10.1016/j.mvr.2009.01.014

PubMed ID: 19617897

Title: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

PubMed ID: 19617897

DOI: 10.1038/onc.2009.217

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21419810

Title: PKC-? promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.

PubMed ID: 21419810

DOI: 10.1016/j.bbamcr.2011.03.007

PubMed ID: 21189248

Title: Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

PubMed ID: 21189248

DOI: 10.1074/jbc.m110.196113

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15143057

Title: Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.

PubMed ID: 15143057

DOI: 10.1074/jbc.m403092200

PubMed ID: 15590654

Title: Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.

PubMed ID: 15590654

DOI: 10.1074/jbc.m409823200

PubMed ID: 16125198

Title: Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.

PubMed ID: 16125198

DOI: 10.1016/j.jmb.2005.07.060

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 596
  • Mass: 68262
  • Checksum: 1E3F8C1D4BFC734F
  • Sequence:
    • MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF 
DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE 
DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK 
KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR 
ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ 
TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA 
EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI 
APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR 
IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK 
PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.