Details for: PRKCI
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 26.51rCSI 25.52%PRS 51.29
-
CSI 19.88rCSI 48.33%PRS 33.04
-
CSI 19.64rCSI 28.3%PRS 63.71
-
CSI 15.03rCSI 54.1%PRS 32.94
-
CSI 13.57rCSI 42.41%PRS 35.58
-
CSI 12.56rCSI 10.15%PRS 60.83
-
CSI 10.93rCSI 16.7%PRS 51.62
-
CSI 10.42rCSI 7.88%PRS 64.48
-
CSI 9.86rCSI 26.36%PRS 42.91
-
CSI 9.45rCSI 35.7%PRS 35.05
-
CSI 9.44rCSI 14.51%PRS 50.69
-
CSI 8.83rCSI 9.15%PRS 56.9
-
CSI 8.46rCSI 13.61%PRS 41.12
-
CSI 8.01rCSI 25.65%PRS 47.74
-
CSI 7.13rCSI 12.56%PRS 48.54
-
CSI 7.07rCSI 41.63%PRS 35.64
-
CSI 7.01rCSI 20.31%PRS 41.61
-
CSI 6.4rCSI 6.55%PRS 68.37
-
CSI 6.33rCSI 5.25%PRS 52.46
-
CSI 5.97rCSI 7.27%PRS 58.81
-
CSI 5.9rCSI 9.01%PRS 60.43
-
CSI 5.63rCSI 6.75%PRS 48.88
-
CSI 5.13rCSI 3.98%PRS 51.71
-
CSI 4.46rCSI 5.51%PRS 46.81
-
CSI 4.45rCSI 5.71%PRS 48.77
-
CSI 4.45rCSI 7.85%PRS 33.23
-
CSI 4.4rCSI 9.86%PRS 34.95
-
CSI 4.29rCSI 24.27%PRS 36.75
-
CSI 4.27rCSI 26.67%PRS 43.12
-
CSI 4.17rCSI 5.79%PRS 50.28
-
CSI 4.1rCSI 19.65%PRS 49.87
-
CSI 3.97rCSI 10.25%PRS 46.56
-
CSI 3.95rCSI 2.33%PRS 67.52
-
CSI 3.67rCSI 4.57%PRS 32.5
-
CSI 3.62rCSI 3.78%PRS 51.44
-
CSI 3.57rCSI 2.65%PRS 43.88
-
CSI 3.51rCSI 4.19%PRS 34.06
-
CSI 3.4rCSI 6.9%PRS 32.26
-
CSI 3.37rCSI 24.78%PRS 38.32
-
CSI 3.23rCSI 5.16%PRS 44.42
-
CSI 3.19rCSI 4.27%PRS 59.58
-
CSI 3.16rCSI 6.73%PRS 64.81
-
CSI 3.14rCSI 6.81%PRS 40.38
-
CSI 3.09rCSI 7.83%PRS 59.39
-
CSI 3.09rCSI 4.38%PRS 47.49
-
CSI 3.07rCSI 4.98%PRS 48.79
-
CSI 2.95rCSI 5.17%PRS 43.06
-
CSI 2.92rCSI 3.99%PRS 53.34
-
CSI 2.91rCSI 9.37%PRS 49.86
-
CSI 2.87rCSI 4.23%PRS 45.62
-
CSI 2.81rCSI 8.35%PRS 61.41
-
CSI 2.79rCSI 2.45%PRS 39.62
-
CSI 2.73rCSI 2.54%PRS 50.65
-
CSI 2.66rCSI 2.65%PRS 44.84
-
CSI 2.65rCSI 4.81%PRS 67.2
-
CSI 2.65rCSI 5.32%PRS 40.4
-
CSI 2.64rCSI 2.49%PRS 51.41
-
CSI 2.61rCSI 62.57%PRS 33.65
-
CSI 2.57rCSI 61.99%PRS 34.59
-
CSI 2.57rCSI 5.86%PRS 43.74
-
CSI 2.55rCSI 4.42%PRS 41.35
-
CSI 2.53rCSI 2%PRS 38.22
-
CSI 2.5rCSI 2.62%PRS 54.18
-
CSI 2.5rCSI 2.41%PRS 41.5
-
CSI 2.49rCSI 3.55%PRS 53.46
-
CSI 2.49rCSI 5.74%PRS 41.45
-
CSI 2.48rCSI 2.66%PRS 49.29
-
CSI 2.45rCSI 3.35%PRS 56.16
-
CSI 2.45rCSI 2.82%PRS 44.92
-
CSI 2.44rCSI 3.78%PRS 59.73
-
CSI 2.41rCSI 9.81%PRS 47.49
-
CSI 2.35rCSI 6.79%PRS 67
-
CSI 2.35rCSI 1.58%PRS 62.73
-
CSI 2.34rCSI 3.47%PRS 56.39
-
CSI 2.31rCSI 4.13%PRS 49.59
-
CSI 2.26rCSI 6.67%PRS 54.9
-
CSI 2.26rCSI 5.73%PRS 40.85
-
CSI 2.17rCSI 6.29%PRS 53.1
-
CSI 2.16rCSI 5.17%PRS 60.5
-
CSI 2.16rCSI 4.48%PRS 48.42
-
CSI 2.13rCSI 2.74%PRS 35.23
-
CSI 2.11rCSI 1.75%PRS 49.71
-
CSI 2.09rCSI 1.69%PRS 51.95
-
CSI 2.08rCSI 4.75%PRS 50.34
-
CSI 2.07rCSI 9.19%PRS 49.93
-
CSI 2.05rCSI 2.73%PRS 56.37
-
CSI 2.05rCSI 3.84%PRS 40.06
-
CSI 2.03rCSI 2.78%PRS 46.13
-
CSI 2.03rCSI 4.46%PRS 65.14
-
CSI 2.01rCSI 5.24%PRS 50.03
-
CSI 2.01rCSI 3.58%PRS 66.05
-
CSI 2.01rCSI 2.55%PRS 56.76
-
CSI 1.99rCSI 3.27%PRS 40.9
-
CSI 1.98rCSI 1.76%PRS 49.47
-
CSI 1.93rCSI 5.15%PRS 41.89
-
CSI 1.93rCSI 7.77%PRS 49.26
-
CSI 1.88rCSI 1.63%PRS 55.4
-
CSI 1.88rCSI 2.21%PRS 54.16
-
CSI 1.88rCSI 2.99%PRS 43.54
-
CSI 1.84rCSI 4.55%PRS 48.83
-
CSI 0.2rCSI 2.2%PRS 74.9%
-
CSI 0.2rCSI 4.7%PRS 43.8%
-
CSI 0.2rCSI 3.6%PRS 70.8%
-
CSI 0.3rCSI 5.2%PRS 42.5%
-
CSI 0.3rCSI 4.7%PRS 55.6%
-
CSI 0.3rCSI 4.3%PRS 42.6%
-
CSI 0.3rCSI 3.3%PRS 69.6%
-
CSI 0.5rCSI 1.5%PRS 65.9%
-
CSI 0.6rCSI 2.2%PRS 43.1%
-
CSI 0.6rCSI 0.9%PRS 48.8%
-
CSI 0.6rCSI 3.1%PRS 63.8%
-
CSI 0.7rCSI 3.5%PRS 49.5%
-
CSI 0.7rCSI 3.3%PRS 36.0%
-
CSI 0.7rCSI 1.6%PRS 48.5%
-
CSI 0.8rCSI 2.2%PRS 64.7%
-
CSI 0.8rCSI 3.5%PRS 68.4%
-
CSI 0.8rCSI 1.6%PRS 53.2%
-
CSI 0.8rCSI 4.4%PRS 65.6%
-
CSI 0.9rCSI 2.6%PRS 67.5%
-
CSI 0.9rCSI 3.1%PRS 39.0%
-
CSI 1.0rCSI 3.0%PRS 37.9%
-
CSI 1.0rCSI 1.0%PRS 64.4%
-
CSI 1.0rCSI 7.6%PRS 69.8%
-
CSI 1.0rCSI 0.9%PRS 47.7%
-
CSI 1.0rCSI 2.5%PRS 60.2%
-
CSI 1.0rCSI 2.3%PRS 38.4%
-
CSI 1.1rCSI 3.6%PRS 37.8%
-
CSI 1.1rCSI 1.6%PRS 41.5%
-
CSI 1.1rCSI 2.3%PRS 43.5%
-
CSI 1.2rCSI 3.2%PRS 47.0%
-
CSI 1.2rCSI 4.1%PRS 65.6%
-
CSI 1.2rCSI 1.7%PRS 54.4%
-
CSI 1.2rCSI 1.5%PRS 62.2%
-
CSI 1.2rCSI 27.9%PRS 72.9%
-
CSI 1.2rCSI 3.2%PRS 72.3%
-
CSI 1.2rCSI 7.0%PRS 51.5%
-
CSI 1.2rCSI 3.5%PRS 66.5%
-
CSI 1.2rCSI 2.0%PRS 61.9%
-
CSI 1.3rCSI 1.9%PRS 68.3%
-
CSI 1.3rCSI 1.0%PRS 51.5%
-
CSI 1.3rCSI 3.1%PRS 56.1%
-
CSI 1.3rCSI 3.1%PRS 62.0%
-
CSI 1.3rCSI 3.0%PRS 66.8%
-
CSI 1.4rCSI 3.0%PRS 60.3%
-
CSI 1.4rCSI 3.3%PRS 39.4%
-
CSI 1.4rCSI 3.7%PRS 49.5%
-
CSI 1.4rCSI 6.3%PRS 43.4%
-
CSI 1.4rCSI 2.1%PRS 62.4%
-
CSI 1.5rCSI 2.3%PRS 52.1%
-
CSI 1.5rCSI 3.8%PRS 55.4%
-
CSI 1.5rCSI 3.6%PRS 45.8%
-
CSI 1.5rCSI 2.7%PRS 44.1%
-
CSI 1.5rCSI 1.9%PRS 55.8%
-
CSI 1.5rCSI 3.6%PRS 52.4%
-
CSI 1.6rCSI 2.6%PRS 34.2%
-
CSI 1.6rCSI 2.1%PRS 52.1%
-
CSI 1.6rCSI 2.0%PRS 53.3%
-
CSI 1.6rCSI 1.7%PRS 47.9%
-
CSI 1.6rCSI 3.0%PRS 72.4%
-
CSI 1.6rCSI 1.3%PRS 56.0%
-
CSI 1.6rCSI 2.6%PRS 55.0%
-
CSI 1.6rCSI 3.7%PRS 48.8%
-
CSI 1.7rCSI 2.7%PRS 36.3%
-
CSI 1.7rCSI 4.5%PRS 59.4%
-
CSI 1.7rCSI 14.4%PRS 38.1%
-
CSI 1.7rCSI 2.5%PRS 49.2%
-
CSI 1.8rCSI 2.0%PRS 41.0%
-
CSI 1.8rCSI 1.6%PRS 65.7%
-
CSI 1.8rCSI 1.3%PRS 53.3%
-
CSI 1.8rCSI 6.9%PRS 43.4%
-
CSI 1.8rCSI 4.6%PRS 48.8%
-
CSI 1.9rCSI 3.0%PRS 43.5%
-
CSI 1.9rCSI 2.2%PRS 54.2%
-
CSI 1.9rCSI 1.6%PRS 55.4%
-
CSI 1.9rCSI 7.8%PRS 49.3%
-
CSI 1.9rCSI 5.2%PRS 41.9%
-
CSI 2.0rCSI 1.8%PRS 49.5%
-
CSI 2.0rCSI 3.3%PRS 40.9%
-
CSI 2.0rCSI 2.6%PRS 56.8%
-
CSI 2.0rCSI 3.6%PRS 66.1%
-
CSI 2.0rCSI 5.2%PRS 50.0%
-
CSI 2.0rCSI 4.5%PRS 65.1%
-
CSI 2.0rCSI 2.8%PRS 46.1%
-
CSI 2.1rCSI 3.8%PRS 40.1%
-
CSI 2.1rCSI 2.7%PRS 56.4%
-
CSI 2.1rCSI 9.2%PRS 49.9%
-
CSI 2.1rCSI 4.8%PRS 50.3%
-
CSI 2.1rCSI 1.7%PRS 52.0%
-
CSI 2.1rCSI 1.8%PRS 49.7%
-
CSI 2.1rCSI 2.7%PRS 35.2%
-
CSI 2.2rCSI 4.5%PRS 48.4%
-
CSI 2.2rCSI 5.2%PRS 60.5%
-
CSI 2.2rCSI 6.3%PRS 53.1%
-
CSI 2.3rCSI 5.7%PRS 40.9%
-
CSI 2.3rCSI 6.7%PRS 54.9%
-
CSI 2.3rCSI 4.1%PRS 49.6%
-
CSI 2.3rCSI 3.5%PRS 56.4%
-
CSI 2.4rCSI 1.6%PRS 62.7%
-
CSI 2.4rCSI 6.8%PRS 67.0%
-
CSI 2.4rCSI 9.8%PRS 47.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1449855425
Symbol: KPCI_HUMAN
Name: Protein kinase C iota type
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8226978
Title: Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.
PubMed ID: 8226978
PubMed ID: 7607695
Title: Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.
PubMed ID: 7607695
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8524286
Title: Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.
PubMed ID: 8524286
DOI: 10.1128/mcb.16.1.105
PubMed ID: 9346882
Title: Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis.
PubMed ID: 9346882
PubMed ID: 9566925
Title: Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.
PubMed ID: 9566925
PubMed ID: 10467349
Title: Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway.
PubMed ID: 10467349
PubMed ID: 10356400
Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.
PubMed ID: 10356400
PubMed ID: 10906326
Title: Unique structural and functional properties of the ATP-binding domain of atypical protein kinase C-iota.
PubMed ID: 10906326
PubMed ID: 11042363
Title: Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.
PubMed ID: 11042363
PubMed ID: 11260256
Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
PubMed ID: 11260256
PubMed ID: 11257119
Title: Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.
PubMed ID: 11257119
PubMed ID: 11724794
Title: Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway.
PubMed ID: 11724794
PubMed ID: 11713277
Title: Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.
PubMed ID: 11713277
PubMed ID: 11891849
Title: Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.
PubMed ID: 11891849
PubMed ID: 12893243
Title: Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.
PubMed ID: 12893243
PubMed ID: 12725730
Title: Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity.
PubMed ID: 12725730
PubMed ID: 12871960
Title: Atypical protein kinase C plays a critical role in protein transport from pre-Golgi intermediates.
PubMed ID: 12871960
PubMed ID: 14570876
Title: Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.
PubMed ID: 14570876
PubMed ID: 14684752
Title: Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.
PubMed ID: 14684752
PubMed ID: 15994303
Title: Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.
PubMed ID: 15994303
PubMed ID: 15695176
Title: Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.
PubMed ID: 15695176
PubMed ID: 16792529
Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
PubMed ID: 16792529
DOI: 10.1042/bj20060511
PubMed ID: 16452474
Title: Src-dependent protein kinase C iota/lambda (aPKCiota/lambda) tyrosine phosphorylation is required for aPKCiota/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-Golgi intermediates.
PubMed ID: 16452474
PubMed ID: 17313651
Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.
PubMed ID: 17313651
PubMed ID: 18270268
Title: Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells.
PubMed ID: 18270268
DOI: 10.1242/jcs.016246
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19327373
Title: Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells.
PubMed ID: 19327373
PubMed ID: 19617897
Title: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.
PubMed ID: 19617897
DOI: 10.1038/onc.2009.217
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21419810
Title: PKC-? promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway.
PubMed ID: 21419810
PubMed ID: 21189248
Title: Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.
PubMed ID: 21189248
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 15143057
Title: Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.
PubMed ID: 15143057
PubMed ID: 15590654
Title: Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.
PubMed ID: 15590654
PubMed ID: 16125198
Title: Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
PubMed ID: 16125198
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 596
- Mass: 68262
- Checksum: 1E3F8C1D4BFC734F
- Sequence:
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL CNEVRDMCSF DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE LLIHVFPCVP ERPGMPCPGE DKSIYRRGAR RWRKLYCANG HTFQAKRFNR RAHCAICTDR IWGLGRQGYK CINCKLLVHK KCHKLVTIEC GRHSLPQEPV MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR ESGKASSSLG LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL PEEHARFYSA EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC KEGLRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIVGSSD NPDQNTEDYL FQVILEKQIR IPRSLSVKAA SVLKSFLNKD PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK PNISGEFGLD NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV