Details for: PRKCQ

Gene ID: 5588

Symbol: PRKCQ

Ensembl ID: ENSG00000065675

Description: protein kinase C theta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.3122
    Cell Significance Index: -11.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.9881
    Cell Significance Index: -10.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.6640
    Cell Significance Index: -13.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8057
    Cell Significance Index: -12.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8155
    Cell Significance Index: -12.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6074
    Cell Significance Index: -11.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0933
    Cell Significance Index: -6.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.3297
    Cell Significance Index: 38.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.2879
    Cell Significance Index: 58.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0648
    Cell Significance Index: 50.3800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.7936
    Cell Significance Index: 28.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1288
    Cell Significance Index: 51.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9262
    Cell Significance Index: 27.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9085
    Cell Significance Index: 172.9000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7864
    Cell Significance Index: 7.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6922
    Cell Significance Index: 14.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6509
    Cell Significance Index: 64.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4574
    Cell Significance Index: 413.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4472
    Cell Significance Index: 9.5300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.4321
    Cell Significance Index: 4.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4068
    Cell Significance Index: 11.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3874
    Cell Significance Index: 526.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3648
    Cell Significance Index: 9.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3196
    Cell Significance Index: 51.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3039
    Cell Significance Index: 44.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3018
    Cell Significance Index: 32.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2920
    Cell Significance Index: 57.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2690
    Cell Significance Index: 53.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2240
    Cell Significance Index: 13.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1394
    Cell Significance Index: 214.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1377
    Cell Significance Index: 49.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1019
    Cell Significance Index: 3.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1009
    Cell Significance Index: 6.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0754
    Cell Significance Index: 52.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0588
    Cell Significance Index: 1.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0493
    Cell Significance Index: 0.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0374
    Cell Significance Index: 69.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0290
    Cell Significance Index: 1.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0206
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0134
    Cell Significance Index: 25.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0080
    Cell Significance Index: 1.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0038
    Cell Significance Index: 2.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0018
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0112
    Cell Significance Index: -6.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0186
    Cell Significance Index: -11.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0193
    Cell Significance Index: -8.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0214
    Cell Significance Index: -12.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0217
    Cell Significance Index: -0.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0233
    Cell Significance Index: -10.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0247
    Cell Significance Index: -7.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0526
    Cell Significance Index: -7.2300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0568
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0683
    Cell Significance Index: -14.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0759
    Cell Significance Index: -2.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0775
    Cell Significance Index: -9.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0822
    Cell Significance Index: -1.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0870
    Cell Significance Index: -1.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0879
    Cell Significance Index: -11.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0964
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1013
    Cell Significance Index: -11.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1037
    Cell Significance Index: -6.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1066
    Cell Significance Index: -11.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1073
    Cell Significance Index: -13.8600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1113
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1154
    Cell Significance Index: -13.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1253
    Cell Significance Index: -12.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1276
    Cell Significance Index: -9.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1466
    Cell Significance Index: -4.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1474
    Cell Significance Index: -9.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1489
    Cell Significance Index: -9.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1558
    Cell Significance Index: -10.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1573
    Cell Significance Index: -12.4600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1614
    Cell Significance Index: -1.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1645
    Cell Significance Index: -7.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1690
    Cell Significance Index: -7.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1899
    Cell Significance Index: -14.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1956
    Cell Significance Index: -10.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2059
    Cell Significance Index: -10.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2078
    Cell Significance Index: -7.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2138
    Cell Significance Index: -4.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2276
    Cell Significance Index: -3.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2340
    Cell Significance Index: -7.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2361
    Cell Significance Index: -12.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2561
    Cell Significance Index: -11.3300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2672
    Cell Significance Index: -3.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2761
    Cell Significance Index: -4.1600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2867
    Cell Significance Index: -3.0500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2874
    Cell Significance Index: -2.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2926
    Cell Significance Index: -6.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3058
    Cell Significance Index: -11.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3080
    Cell Significance Index: -14.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3136
    Cell Significance Index: -1.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3225
    Cell Significance Index: -6.7300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3321
    Cell Significance Index: -2.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3323
    Cell Significance Index: -8.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRKCQ is a serine/threonine kinase that belongs to the PKC family. It is characterized by its ability to bind to diacylglycerol (DAG) and phospholipids, which activates its catalytic activity. PRKCQ is specifically expressed in immune cells, such as T-cells, B-cells, and dendritic cells, where it plays a crucial role in regulating immune responses. It is also expressed in epithelial cells, where it is involved in the regulation of cell growth and differentiation. **Pathways and Functions:** PRKCQ is involved in various signaling pathways, including: 1. **Adaptive Immune System:** PRKCQ plays a crucial role in the regulation of T-cell activation, cytokine production, and cell survival. It is involved in the signaling pathways of CD4+ and CD8+ T-cells, which are essential for the adaptive immune response. 2. **Apoptosis:** PRKCQ is involved in the regulation of apoptosis in immune cells, where it can either promote or inhibit cell death, depending on the context. 3. **Cell Growth and Differentiation:** PRKCQ is involved in the regulation of cell growth and differentiation in epithelial cells, where it plays a crucial role in the development and maintenance of epithelial tissues. 4. **Inflammation:** PRKCQ is involved in the regulation of inflammatory responses, where it can either promote or inhibit inflammation, depending on the context. **Clinical Significance:** PRKCQ has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** PRKCQ has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it plays a crucial role in the regulation of immune responses. 2. **Cancer:** PRKCQ has been implicated in the development and progression of various cancers, including lymphoma and leukemia, where it plays a crucial role in the regulation of cell growth and survival. 3. **Inflammatory Disorders:** PRKCQ has been implicated in the pathogenesis of inflammatory disorders, such as asthma and inflammatory bowel disease, where it plays a crucial role in the regulation of inflammation. In conclusion, PRKCQ is a multifaceted protein that plays a crucial role in various cellular processes, including immune regulation, cell growth, and differentiation. Its unique expression profile and functional characteristics make it an essential component in the regulation of immune responses, and its dysregulation has been implicated in various immune-related disorders. Further studies are needed to fully understand the role of PRKCQ in immune regulation and its clinical significance in human diseases.

Genular Protein ID: 617138265

Symbol: KPCT_HUMAN

Name: Protein kinase C theta type

UniProtKB Accession Codes:

Q04759 B4DF52 Q14DH6 Q3MJF1 Q64FY5 Q9H508 Q9H549

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 9 RefSeq 9 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7686153

Title: Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets.

PubMed ID: 7686153

DOI: 10.1016/s0021-9258(19)85228-6

PubMed ID: 7983077

Title:

PubMed ID: 7983077

DOI: 10.1016/s0021-9258(18)47426-1

PubMed ID: 8444877

Title: Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

PubMed ID: 8444877

DOI: 10.1016/s0021-9258(18)53494-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8657160

Title: Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes.

PubMed ID: 8657160

DOI: 10.1128/mcb.16.4.1842

PubMed ID: 10636891

Title: Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain.

PubMed ID: 10636891

DOI: 10.1074/jbc.275.3.1902

PubMed ID: 10652356

Title: Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.

PubMed ID: 10652356

DOI: 10.1074/jbc.275.5.3603

PubMed ID: 11342610

Title: Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD.

PubMed ID: 11342610

DOI: 10.4049/jimmunol.166.10.5955

PubMed ID: 11772397

Title: Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction.

PubMed ID: 11772397

DOI: 10.1042/bj3610255

PubMed ID: 14988727

Title: SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.

PubMed ID: 14988727

DOI: 10.1038/sj.emboj.7600125

PubMed ID: 15364919

Title: Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

PubMed ID: 15364919

DOI: 10.1074/jbc.c400186200

PubMed ID: 15254234

Title: Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.

PubMed ID: 15254234

DOI: 10.1128/mcb.24.15.6665-6675.2004

PubMed ID: 16252004

Title: Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

PubMed ID: 16252004

DOI: 10.1038/sj.emboj.7600856

PubMed ID: 16356855

Title: Phosphorylation of the CARMA1 linker controls NF-kappaB activation.

PubMed ID: 16356855

DOI: 10.1016/j.immuni.2005.09.014

PubMed ID: 16709830

Title: Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.

PubMed ID: 16709830

DOI: 10.4049/jimmunol.176.11.6709

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19549985

Title: PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.

PubMed ID: 19549985

DOI: 10.1126/scisignal.2000046

PubMed ID: 21964608

Title: A motif in the V3 domain of the kinase PKC-theta determines its localization in the immunological synapse and functions in T cells via association with CD28.

PubMed ID: 21964608

DOI: 10.1038/ni.2120

PubMed ID: 11861617

Title: Protein kinase C(theta) in T cell activation.

PubMed ID: 11861617

DOI: 10.1146/annurev.immunol.20.100301.064807

PubMed ID: 12473184

Title: Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death.

PubMed ID: 12473184

DOI: 10.1093/oxfordjournals.jbchem.a003295

PubMed ID: 15282562

Title: Protein kinase C and beyond.

PubMed ID: 15282562

DOI: 10.1038/ni1097

PubMed ID: 16978534

Title: Selective function of PKC-theta in T cells.

PubMed ID: 16978534

PubMed ID: 17544292

Title: Protein kinase C theta (PKCtheta): a key player in T cell life and death.

PubMed ID: 17544292

DOI: 10.1016/j.phrs.2007.04.009

PubMed ID: 18328786

Title: T-cell fate and function: PKC-theta and beyond.

PubMed ID: 18328786

DOI: 10.1016/j.it.2008.01.005

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21944869

Title: Protein kinase C-theta in platelet activation.

PubMed ID: 21944869

DOI: 10.1016/j.febslet.2011.09.014

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23509302

Title: Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.

PubMed ID: 23509302

DOI: 10.1073/pnas.1303392110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34593629

Title: Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.

PubMed ID: 34593629

DOI: 10.1073/pnas.2018899118

PubMed ID: 36040231

Title: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

PubMed ID: 36040231

DOI: 10.1042/bcj20220308

PubMed ID: 15364937

Title: Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).

PubMed ID: 15364937

DOI: 10.1074/jbc.m409216200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 706
  • Mass: 81865
  • Checksum: B3C53AB892D5210A
  • Sequence:
    • MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 
DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 
YFLEMSDTKD MNEFETEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 
WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 
ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL DEVDKMCHLP 
EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 
ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 
GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPFD 
CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.