Details for: PSKH1

Gene ID: 5681

Symbol: PSKH1

Ensembl ID: ENSG00000159792

Description: protein serine kinase H1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 79.0767
    Cell Significance Index: -12.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.8481
    Cell Significance Index: -12.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.6826
    Cell Significance Index: -10.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3643
    Cell Significance Index: -10.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4789
    Cell Significance Index: -12.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5766
    Cell Significance Index: -12.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3324
    Cell Significance Index: -13.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8923
    Cell Significance Index: -6.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1646
    Cell Significance Index: 31.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0911
    Cell Significance Index: 107.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9015
    Cell Significance Index: 813.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8805
    Cell Significance Index: 52.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7612
    Cell Significance Index: 82.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5853
    Cell Significance Index: 95.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5800
    Cell Significance Index: 115.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4035
    Cell Significance Index: 27.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3975
    Cell Significance Index: 79.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3752
    Cell Significance Index: 43.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3389
    Cell Significance Index: 9.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3193
    Cell Significance Index: 24.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2983
    Cell Significance Index: 13.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2556
    Cell Significance Index: 6.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2318
    Cell Significance Index: 14.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2128
    Cell Significance Index: 4.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2038
    Cell Significance Index: 3.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1922
    Cell Significance Index: 68.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1859
    Cell Significance Index: 33.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1704
    Cell Significance Index: 8.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1594
    Cell Significance Index: 110.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1587
    Cell Significance Index: 19.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1393
    Cell Significance Index: 1.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1158
    Cell Significance Index: 5.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1148
    Cell Significance Index: 15.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1124
    Cell Significance Index: 61.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0918
    Cell Significance Index: 40.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0853
    Cell Significance Index: 4.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0787
    Cell Significance Index: 14.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0534
    Cell Significance Index: 2.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0467
    Cell Significance Index: 1.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0261
    Cell Significance Index: 0.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0251
    Cell Significance Index: 3.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0232
    Cell Significance Index: 1.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0205
    Cell Significance Index: 0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0132
    Cell Significance Index: 24.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0082
    Cell Significance Index: 1.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0040
    Cell Significance Index: 2.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0032
    Cell Significance Index: 0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0027
    Cell Significance Index: 4.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0016
    Cell Significance Index: 0.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0040
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0169
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0276
    Cell Significance Index: -0.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0277
    Cell Significance Index: -3.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0352
    Cell Significance Index: -10.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0369
    Cell Significance Index: -2.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0379
    Cell Significance Index: -2.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0437
    Cell Significance Index: -4.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0437
    Cell Significance Index: -5.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0443
    Cell Significance Index: -1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0479
    Cell Significance Index: -1.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0498
    Cell Significance Index: -3.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0614
    Cell Significance Index: -1.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0626
    Cell Significance Index: -3.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0655
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0675
    Cell Significance Index: -14.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0834
    Cell Significance Index: -3.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0970
    Cell Significance Index: -2.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0980
    Cell Significance Index: -6.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1013
    Cell Significance Index: -1.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1120
    Cell Significance Index: -11.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1124
    Cell Significance Index: -1.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1134
    Cell Significance Index: -8.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1196
    Cell Significance Index: -2.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1254
    Cell Significance Index: -6.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1285
    Cell Significance Index: -7.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1303
    Cell Significance Index: -2.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1365
    Cell Significance Index: -2.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1514
    Cell Significance Index: -2.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1930
    Cell Significance Index: -2.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1956
    Cell Significance Index: -10.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2026
    Cell Significance Index: -4.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2071
    Cell Significance Index: -1.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2167
    Cell Significance Index: -4.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2197
    Cell Significance Index: -5.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2377
    Cell Significance Index: -4.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2403
    Cell Significance Index: -3.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2443
    Cell Significance Index: -6.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2499
    Cell Significance Index: -7.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2528
    Cell Significance Index: -8.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2560
    Cell Significance Index: -8.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2598
    Cell Significance Index: -9.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSKH1 is a member of the protein kinase family, which is characterized by their ability to phosphorylate and regulate the activity of downstream targets. The enzyme is specifically involved in serine/threonine phosphorylation, which is a critical post-translational modification that can alter the function and localization of proteins. PSKH1 is expressed in a wide range of cell types, including neural progenitor cells, cerebral cortex GABAergic interneurons, and cardiac muscle myoblasts. Its expression is also observed in other tissues, such as the brain, heart, and intestinal epithelium. **Pathways and Functions:** PSKH1 is involved in various signaling pathways that regulate cell growth, differentiation, and migration. Some of the key pathways associated with PSKH1 include: 1. **Heart development:** PSKH1 plays a crucial role in the development of the heart, where it regulates the expression of genes involved in cardiac morphogenesis and function. 2. **Neurodevelopment:** PSKH1 is expressed in neural progenitor cells and cerebral cortex GABAergic interneurons, where it regulates the expression of genes involved in neuronal differentiation and migration. 3. **Cell signaling:** PSKH1 is involved in various cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which regulate cell growth, survival, and migration. 4. **Cytoskeleton organization:** PSKH1 regulates the organization of the cytoskeleton, which is essential for cell migration, division, and morphology. **Clinical Significance:** PSKH1 has been implicated in various human diseases, including: 1. **Congenital heart defects:** Mutations in the PSKH1 gene have been associated with congenital heart defects, such as atrial septal defects and ventricular septal defects. 2. **Neurodevelopmental disorders:** PSKH1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer:** PSKH1 has been found to be overexpressed in certain types of cancer, including breast and colon cancer. 4. **Cardiovascular disease:** PSKH1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In conclusion, PSKH1 is a multifaceted enzyme that plays a critical role in various cellular processes, including cell signaling, differentiation, and development. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the mechanisms and clinical implications of PSKH1 dysfunction.

Genular Protein ID: 3458827067

Symbol: KPSH1_HUMAN

Name: Serine/threonine-protein kinase H1

UniProtKB Accession Codes:

P11801 Q9NY19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11087665

Title: Characterization of PSKH1, a novel human protein serine kinase with centrosomal, Golgi, and nuclear localization.

PubMed ID: 11087665

DOI: 10.1006/geno.2000.6365

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2948189

Title: Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

PubMed ID: 2948189

DOI: 10.1073/pnas.84.2.388

PubMed ID: 12466556

Title: PSKH1, a novel splice factor compartment-associated serine kinase.

PubMed ID: 12466556

DOI: 10.1093/nar/gkf648

PubMed ID: 14644153

Title: Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus.

PubMed ID: 14644153

DOI: 10.1016/j.yexcr.2003.07.009

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 424
  • Mass: 48035
  • Checksum: B357757DDC12388D
  • Sequence:
    • MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH 
PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT 
RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL 
FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF 
GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD 
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA 
SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ 
QYNG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.