Details for: PSMD5

Gene ID: 5711

Symbol: PSMD5

Ensembl ID: ENSG00000095261

Description: proteasome 26S subunit, non-ATPase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.8144
    Cell Significance Index: -25.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.6745
    Cell Significance Index: -26.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.1750
    Cell Significance Index: -28.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.9006
    Cell Significance Index: -22.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2717
    Cell Significance Index: -27.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7355
    Cell Significance Index: -26.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0729
    Cell Significance Index: -27.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3455
    Cell Significance Index: -19.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0678
    Cell Significance Index: -13.2800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.0501
    Cell Significance Index: 66.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6815
    Cell Significance Index: 116.2900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2722
    Cell Significance Index: 20.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9724
    Cell Significance Index: 195.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9456
    Cell Significance Index: 110.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9190
    Cell Significance Index: 99.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8418
    Cell Significance Index: 50.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8272
    Cell Significance Index: 134.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7454
    Cell Significance Index: 20.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6547
    Cell Significance Index: 129.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5699
    Cell Significance Index: 31.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5693
    Cell Significance Index: 15.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5082
    Cell Significance Index: 182.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4826
    Cell Significance Index: 3.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3688
    Cell Significance Index: 22.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3622
    Cell Significance Index: 7.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3150
    Cell Significance Index: 24.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2998
    Cell Significance Index: 36.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2920
    Cell Significance Index: 40.1000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2873
    Cell Significance Index: 2.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2712
    Cell Significance Index: 48.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2711
    Cell Significance Index: 187.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2525
    Cell Significance Index: 5.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2464
    Cell Significance Index: 11.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2341
    Cell Significance Index: 6.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2338
    Cell Significance Index: 127.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2291
    Cell Significance Index: 206.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2267
    Cell Significance Index: 100.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1748
    Cell Significance Index: 17.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1739
    Cell Significance Index: 12.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1494
    Cell Significance Index: 10.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1436
    Cell Significance Index: 6.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1317
    Cell Significance Index: 25.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1120
    Cell Significance Index: 19.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0809
    Cell Significance Index: 152.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0610
    Cell Significance Index: 38.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0553
    Cell Significance Index: 7.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0520
    Cell Significance Index: 2.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0519
    Cell Significance Index: 6.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0463
    Cell Significance Index: 21.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0449
    Cell Significance Index: 0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0441
    Cell Significance Index: 67.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0375
    Cell Significance Index: 69.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0315
    Cell Significance Index: 0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0097
    Cell Significance Index: 13.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0041
    Cell Significance Index: 0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0036
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0234
    Cell Significance Index: -17.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0240
    Cell Significance Index: -13.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0242
    Cell Significance Index: -0.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0375
    Cell Significance Index: -1.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0603
    Cell Significance Index: -7.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0639
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0709
    Cell Significance Index: -14.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0768
    Cell Significance Index: -22.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0798
    Cell Significance Index: -5.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0816
    Cell Significance Index: -2.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0827
    Cell Significance Index: -3.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1043
    Cell Significance Index: -10.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1213
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1228
    Cell Significance Index: -14.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1385
    Cell Significance Index: -4.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1467
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1626
    Cell Significance Index: -2.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1667
    Cell Significance Index: -17.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1812
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1891
    Cell Significance Index: -21.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2213
    Cell Significance Index: -6.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2326
    Cell Significance Index: -4.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2359
    Cell Significance Index: -12.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2870
    Cell Significance Index: -22.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2906
    Cell Significance Index: -15.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3359
    Cell Significance Index: -7.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3369
    Cell Significance Index: -8.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3409
    Cell Significance Index: -2.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3571
    Cell Significance Index: -9.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3583
    Cell Significance Index: -5.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3873
    Cell Significance Index: -8.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4193
    Cell Significance Index: -8.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4351
    Cell Significance Index: -12.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4506
    Cell Significance Index: -14.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4566
    Cell Significance Index: -28.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4849
    Cell Significance Index: -5.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4856
    Cell Significance Index: -15.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4879
    Cell Significance Index: -10.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proteasome Subunit:** PSMD5 is a non-ATPase regulatory subunit of the 26S proteasome complex, which is composed of two subunits: the 19S regulatory subunit and the 20S catalytic subunit. 2. **Ubiquitin-Proteasome System (UPS):** PSMD5 plays a critical role in the UPS, which is responsible for degrading a wide range of proteins, including those involved in immune response, cell cycle regulation, and protein quality control. 3. **Immune Regulation:** PSMD5 has been implicated in modulating immune responses, particularly in the context of cancer and autoimmune diseases. 4. **Cellular Homeostasis:** PSMD5 is involved in maintaining cellular homeostasis by regulating protein degradation, which is essential for maintaining protein quality and preventing protein misfolding. **Pathways and Functions:** 1. **Antigen Processing and Presentation (APCP):** PSMD5 is involved in APCP, which is the process by which antigens are processed and presented to T-cells by MHC class I and II molecules. 2. **Adaptive Immune Response:** PSMD5 modulates the adaptive immune response by regulating the degradation of proteins involved in T-cell activation and proliferation. 3. **Apoptosis:** PSMD5 is involved in regulating apoptosis, which is the process of programmed cell death, by modulating the degradation of pro-apoptotic and anti-apoptotic proteins. 4. **Cell Cycle Regulation:** PSMD5 regulates cell cycle progression by modulating the degradation of proteins involved in cell cycle control. **Clinical Significance:** 1. **Cancer:** PSMD5 has been implicated in cancer, particularly in the context of lymphoma and leukemia, where it is involved in regulating immune responses and cell cycle progression. 2. **Autoimmune Diseases:** PSMD5 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it is involved in regulating immune responses and protein degradation. 3. **Infectious Diseases:** PSMD5 is involved in regulating immune responses to infectious diseases, particularly in the context of viral infections. 4. **Neurological Disorders:** PSMD5 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is involved in regulating protein degradation and immune responses. In conclusion, PSMD5 is a critical component of the ubiquitin-proteasome system, which plays a vital role in regulating protein degradation, immune response, and cellular homeostasis. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the mechanisms by which PSMD5 regulates immune responses and cellular homeostasis, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3176569332

Symbol: PSMD5_HUMAN

Name: 26S proteasome non-ATPase regulatory subunit 5

UniProtKB Accession Codes:

Q16401 B4DZM8 Q15045 Q4VXG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 59 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7559544

Title: Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats.

PubMed ID: 7559544

DOI: 10.1074/jbc.270.40.23726

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19490896

Title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.

PubMed ID: 19490896

DOI: 10.1016/j.cell.2009.05.008

PubMed ID: 19217412

Title: Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome.

PubMed ID: 19217412

DOI: 10.1016/j.molcel.2009.01.010

PubMed ID: 19412159

Title: Chaperone-mediated pathway of proteasome regulatory particle assembly.

PubMed ID: 19412159

DOI: 10.1038/nature08063

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 504
  • Mass: 56196
  • Checksum: 30F31602DDF4EF89
  • Sequence:
    • MAAQALALLR EVARLEAPLE ELRALHSVLQ AVPLNELRQQ AAELRLGPLF SLLNENHREK 
TTLCVSILER LLQAMEPVHV ARNLRVDLQR GLIHPDDSVK ILTLSQIGRI VENSDAVTEI 
LNNAELLKQI VYCIGGENLS VAKAAIKSLS RISLTQAGLE ALFESNLLDD LKSVMKTNDI 
VRYRVYELII EISSVSPESL NYCTTSGLVT QLLRELTGED VLVRATCIEM VTSLAYTHHG 
RQYLAQEGVI DQISNIIVGA DSDPFSSFYL PGFVKFFGNL AVMDSPQQIC ERYPIFVEKV 
FEMIESQDPT MIGVAVDTVG ILGSNVEGKQ VLQKTGTRFE RLLMRIGHQS KNAPVELKIR 
CLDAISSLLY LPPEQQTDDL LRMTESWFSS LSRDPLELFR GISSQPFPEL HCAALKVFTA 
IANQPWAQKL MFNSPGFVEY VVDRSVEHDK ASKDAKYELV KALANSKTIA EIFGNPNYLR 
LRTYLSEGPY YVKPVSTTAV EGAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.