Details for: PTGFRN

Gene ID: 5738

Symbol: PTGFRN

Ensembl ID: ENSG00000134247

Description: prostaglandin F2 receptor inhibitor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.5923
    Cell Significance Index: -24.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.6436
    Cell Significance Index: -23.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1682
    Cell Significance Index: -24.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2454
    Cell Significance Index: -11.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.0661
    Cell Significance Index: 69.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0325
    Cell Significance Index: 330.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9934
    Cell Significance Index: 197.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7139
    Cell Significance Index: 45.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1977
    Cell Significance Index: 130.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7052
    Cell Significance Index: 82.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6712
    Cell Significance Index: 51.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5768
    Cell Significance Index: 12.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5302
    Cell Significance Index: 15.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5208
    Cell Significance Index: 104.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4929
    Cell Significance Index: 13.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4681
    Cell Significance Index: 92.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4525
    Cell Significance Index: 23.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4393
    Cell Significance Index: 19.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4373
    Cell Significance Index: 12.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4216
    Cell Significance Index: 29.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3897
    Cell Significance Index: 172.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3559
    Cell Significance Index: 321.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3180
    Cell Significance Index: 6.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3032
    Cell Significance Index: 165.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3001
    Cell Significance Index: 36.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2396
    Cell Significance Index: 11.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2110
    Cell Significance Index: 38.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1798
    Cell Significance Index: 34.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1770
    Cell Significance Index: 2.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1701
    Cell Significance Index: 12.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1567
    Cell Significance Index: 26.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1174
    Cell Significance Index: 2.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1088
    Cell Significance Index: 2.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1044
    Cell Significance Index: 14.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0896
    Cell Significance Index: 61.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0750
    Cell Significance Index: 1.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0589
    Cell Significance Index: 2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0504
    Cell Significance Index: 2.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0346
    Cell Significance Index: 3.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0237
    Cell Significance Index: 10.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0233
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0206
    Cell Significance Index: 38.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0029
    Cell Significance Index: 1.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0021
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0039
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0139
    Cell Significance Index: -18.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0238
    Cell Significance Index: -17.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0338
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0559
    Cell Significance Index: -11.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0613
    Cell Significance Index: -17.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0645
    Cell Significance Index: -1.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0776
    Cell Significance Index: -11.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0908
    Cell Significance Index: -1.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0934
    Cell Significance Index: -12.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0956
    Cell Significance Index: -1.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1040
    Cell Significance Index: -6.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1225
    Cell Significance Index: -2.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1256
    Cell Significance Index: -12.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2001
    Cell Significance Index: -22.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2021
    Cell Significance Index: -21.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2083
    Cell Significance Index: -24.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2251
    Cell Significance Index: -16.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2284
    Cell Significance Index: -7.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2302
    Cell Significance Index: -3.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2410
    Cell Significance Index: -10.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2631
    Cell Significance Index: -17.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2833
    Cell Significance Index: -22.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2919
    Cell Significance Index: -17.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2944
    Cell Significance Index: -10.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3145
    Cell Significance Index: -11.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3405
    Cell Significance Index: -4.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3446
    Cell Significance Index: -17.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3692
    Cell Significance Index: -23.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3774
    Cell Significance Index: -8.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3936
    Cell Significance Index: -24.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4562
    Cell Significance Index: -23.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4986
    Cell Significance Index: -7.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5250
    Cell Significance Index: -10.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5567
    Cell Significance Index: -28.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5598
    Cell Significance Index: -20.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5703
    Cell Significance Index: -6.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5759
    Cell Significance Index: -13.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5900
    Cell Significance Index: -20.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5922
    Cell Significance Index: -19.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5937
    Cell Significance Index: -15.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5942
    Cell Significance Index: -8.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6062
    Cell Significance Index: -12.8700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6073
    Cell Significance Index: -6.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6252
    Cell Significance Index: -8.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6769
    Cell Significance Index: -7.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6845
    Cell Significance Index: -11.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6920
    Cell Significance Index: -22.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7015
    Cell Significance Index: -20.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PTGFRN gene exhibits several distinctive characteristics that set it apart from other genes. Firstly, its primary function is to inhibit the prostaglandin F2 receptor, a receptor that plays a crucial role in mediating inflammatory responses and immune reactions. This inhibitory action suggests that the PTGFRN gene may have anti-inflammatory properties, which could be beneficial in treating various inflammatory disorders. Additionally, the PTGFRN gene is expressed in a wide range of cell types, including those involved in immune responses, muscle regeneration, and neuronal function, underscoring its potential involvement in multiple physiological processes. **Pathways and Functions:** The PTGFRN gene is intricately linked to several cellular signaling pathways, including those involved in inflammation, immune responses, and cellular regeneration. The inhibition of the prostaglandin F2 receptor by the PTGFRN gene likely modulates these pathways, leading to anti-inflammatory effects and potentially therapeutic applications. Specifically, the PTGFRN gene is involved in: 1. **Myoblast fusion**: The PTGFRN gene plays a crucial role in skeletal muscle regeneration, where it inhibits the prostaglandin F2 receptor to facilitate myoblast fusion and muscle growth. 2. **Lipid droplet organization**: The PTGFRN gene is involved in regulating lipid droplet organization in cells, which is essential for maintaining cellular homeostasis. 3. **Protein binding**: The PTGFRN gene interacts with various proteins, including the prostaglandin F2 receptor, to modulate cellular signaling pathways. **Clinical Significance:** The PTGFRN gene has significant implications for human diseases, particularly those related to inflammation, immune responses, and muscle regeneration. The anti-inflammatory properties of the PTGFRN gene make it a potential therapeutic target for treating conditions such as: 1. **Inflammatory disorders**: The PTGFRN gene's ability to inhibit the prostaglandin F2 receptor suggests that it could be used to treat inflammatory disorders, such as arthritis, asthma, and allergies. 2. **Muscle wasting diseases**: The PTGFRN gene's involvement in skeletal muscle regeneration makes it a potential therapeutic target for treating muscle wasting diseases, such as muscular dystrophy. 3. **Neurological disorders**: The PTGFRN gene's expression in neuronal cells suggests that it may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the PTGFRN gene is a fascinating and complex gene that plays a crucial role in regulating various cellular processes. Its anti-inflammatory properties and involvement in multiple physiological pathways make it a potential therapeutic target for treating human diseases. Further research is necessary to fully elucidate the PTGFRN gene's functions and clinical significance, but its discovery has opened up new avenues for understanding the intricate relationships between cellular signaling pathways and human diseases.

Genular Protein ID: 3318641421

Symbol: FPRP_HUMAN

Name: Prostaglandin F2 receptor negative regulator

UniProtKB Accession Codes:

Q9P2B2 Q5VVU9 Q8N2K6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278880

Title: The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.

PubMed ID: 11278880

DOI: 10.1074/jbc.m011297200

PubMed ID: 17960739

Title: Glycosylation status of the membrane protein CD9P-1.

PubMed ID: 17960739

DOI: 10.1002/pmic.200700355

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 879
  • Mass: 98556
  • Checksum: 9712C398A74DF570
  • Sequence:
    • MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF 
SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS 
TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH 
LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA 
DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN 
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV 
RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF 
ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK 
QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN 
IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN 
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW 
SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL 
DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV 
HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS 
TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.