Details for: RGL2

Gene ID: 5863

Symbol: RGL2

Ensembl ID: ENSG00000237441

Description: ral guanine nucleotide dissociation stimulator like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.7244
    Cell Significance Index: -23.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.0981
    Cell Significance Index: -20.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.3111
    Cell Significance Index: -27.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 56.7791
    Cell Significance Index: -23.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.4607
    Cell Significance Index: -20.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.0478
    Cell Significance Index: -21.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2464
    Cell Significance Index: -23.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7612
    Cell Significance Index: -23.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 6.6331
    Cell Significance Index: 345.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0592
    Cell Significance Index: -23.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4510
    Cell Significance Index: -11.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1083
    Cell Significance Index: -15.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6623
    Cell Significance Index: 22.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6245
    Cell Significance Index: 84.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5938
    Cell Significance Index: 25.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3917
    Cell Significance Index: 1256.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9349
    Cell Significance Index: 43.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9003
    Cell Significance Index: 25.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8817
    Cell Significance Index: 24.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8387
    Cell Significance Index: 136.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8219
    Cell Significance Index: 89.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7064
    Cell Significance Index: 52.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5625
    Cell Significance Index: 33.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4789
    Cell Significance Index: 5.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4468
    Cell Significance Index: 2.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4426
    Cell Significance Index: 79.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4354
    Cell Significance Index: 56.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4095
    Cell Significance Index: 223.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3748
    Cell Significance Index: 74.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3727
    Cell Significance Index: 17.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3540
    Cell Significance Index: 45.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3534
    Cell Significance Index: 43.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3440
    Cell Significance Index: 22.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3303
    Cell Significance Index: 45.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2665
    Cell Significance Index: 4.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2607
    Cell Significance Index: 13.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2540
    Cell Significance Index: 175.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2195
    Cell Significance Index: 97.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2144
    Cell Significance Index: 43.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2025
    Cell Significance Index: 14.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2006
    Cell Significance Index: 13.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1885
    Cell Significance Index: 11.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1785
    Cell Significance Index: 111.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1760
    Cell Significance Index: 20.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1553
    Cell Significance Index: 7.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1482
    Cell Significance Index: 4.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1474
    Cell Significance Index: 14.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1243
    Cell Significance Index: 44.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1004
    Cell Significance Index: 2.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0857
    Cell Significance Index: 3.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0478
    Cell Significance Index: 1.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0340
    Cell Significance Index: 1.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0333
    Cell Significance Index: 6.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0323
    Cell Significance Index: 5.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0103
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0100
    Cell Significance Index: -18.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -18.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0155
    Cell Significance Index: -9.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0190
    Cell Significance Index: -25.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0260
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0362
    Cell Significance Index: -16.4500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0423
    Cell Significance Index: -0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0475
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0645
    Cell Significance Index: -7.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0658
    Cell Significance Index: -3.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0723
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0775
    Cell Significance Index: -16.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0883
    Cell Significance Index: -25.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1057
    Cell Significance Index: -2.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1141
    Cell Significance Index: -16.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1202
    Cell Significance Index: -2.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1458
    Cell Significance Index: -17.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1495
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1766
    Cell Significance Index: -20.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1864
    Cell Significance Index: -1.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2076
    Cell Significance Index: -2.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2214
    Cell Significance Index: -7.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2266
    Cell Significance Index: -23.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2306
    Cell Significance Index: -10.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2487
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2797
    Cell Significance Index: -22.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2806
    Cell Significance Index: -11.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2893
    Cell Significance Index: -7.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2941
    Cell Significance Index: -5.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2967
    Cell Significance Index: -11.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3122
    Cell Significance Index: -5.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3158
    Cell Significance Index: -17.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3285
    Cell Significance Index: -3.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3376
    Cell Significance Index: -2.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3457
    Cell Significance Index: -9.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4244
    Cell Significance Index: -26.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4321
    Cell Significance Index: -6.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4685
    Cell Significance Index: -17.2000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4789
    Cell Significance Index: -8.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGL2 is a small, cytoplasmic protein that belongs to the Ral guanine nucleotide dissociation stimulator family. It is characterized by its ability to stimulate the dissociation of guanine nucleotides from GTP-bound Ral proteins, thereby regulating their activity and influencing downstream signaling pathways. RGL2 is highly expressed in various cell types, including lung endothelial cells, pulmonary interstitial fibroblasts, and myeloid leukocytes. **Pathways and Functions:** RGL2 is involved in multiple signaling pathways, including: 1. **Mapk1/Mapk3 signaling:** RGL2 modulates the activity of the MAPK1/3 (p38) pathway, which is crucial for cell differentiation, survival, and apoptosis. 2. **Raf/map kinase cascade:** RGL2 regulates the Raf MAPK pathway, which is involved in cell growth, differentiation, and survival. 3. **Ras protein signal transduction:** RGL2 influences the activity of Ras proteins, which are key regulators of cell growth, differentiation, and survival. 4. **Regulation of Ral protein signal transduction:** RGL2 facilitates the dissociation of guanine nucleotides from GTP-bound Ral proteins, thereby modulating their activity and influencing downstream signaling pathways. RGL2's functions include: 1. **Negative regulation of cardiac muscle cell apoptotic process:** RGL2 inhibits apoptosis in cardiac muscle cells, which may contribute to the development of heart failure. 2. **Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction:** RGL2 promotes the activation of the PI3K/Akt pathway, which is involved in cell survival and metabolism. **Clinical Significance:** RGL2's dysregulation has been implicated in various diseases, including: 1. **Cardiac diseases:** RGL2's role in regulating cardiac muscle cell apoptosis may contribute to the development of heart failure. 2. **Cancer:** Alterations in RGL2 expression and function have been observed in various types of cancer, including lung, breast, and colon cancer. 3. **Neurological disorders:** RGL2's involvement in the Raf MAPK pathway may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Inflammatory diseases:** RGL2's role in regulating immune cell function may contribute to the development of inflammatory diseases, such as rheumatoid arthritis and asthma. In conclusion, RGL2 is a multifunctional protein that plays a critical role in regulating various cellular processes, including signal transduction, cell survival, and apoptosis regulation. Further studies are needed to fully elucidate RGL2's functions and clinical significance, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2255940277

Symbol: RGL2_HUMAN

Name: Ral guanine nucleotide dissociation stimulator-like 2

UniProtKB Accession Codes:

O15211 B4DG72 Q5STK0 Q9Y3F3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9545376

Title: TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.

PubMed ID: 9545376

DOI: 10.1006/jmbi.1998.1637

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8976381

Title: Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS.

PubMed ID: 8976381

DOI: 10.1159/000134431

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21160498

Title: Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis.

PubMed ID: 21160498

DOI: 10.1038/jid.2010.387

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 777
  • Mass: 83549
  • Checksum: 91AFBAB4D6CEE4A1
  • Sequence:
    • MLPRPLRLLL DTSPPGGVVL SSFRSRDPEE GGGPGGLVVG GGQEEEEEEE EEAPVSVWDE 
EEDGAVFTVT SRQYRPLDPL VPMPPPRSSR RLRAGTLEAL VRHLLDTRTS GTDVSFMSAF 
LATHRAFTST PALLGLMADR LEALESHPTD ELERTTEVAI SVLSTWLASH PEDFGSEAKG 
QLDRLESFLL QTGYAAGKGV GGGSADLIRN LRSRVDPQAP DLPKPLALPG DPPADPTDVL 
VFLADHLAEQ LTLLDAELFL NLIPSQCLGG LWGHRDRPGH SHLCPSVRAT VTQFNKVAGA 
VVSSVLGATS TGEGPGEVTI RPLRPPQRAR LLEKWIRVAE ECRLLRNFSS VYAVVSALQS 
SPIHRLRAAW GEATRDSLRV FSSLCQIFSE EDNYSQSREL LVQEVKLQSP LEPHSKKAPR 
SGSRGGGVVP YLGTFLKDLV MLDAASKDEL ENGYINFDKR RKEFAVLSEL RRLQNECRGY 
NLQPDHDIQR WLQGLRPLTE AQSHRVSCEV EPPGSSDPPA PRVLRPTLVI SQWTEVLGSV 
GVPTPLVSCD RPSTGGDEAP TTPAPLLTRL AQHMKWPSVS SLDSALESSP SLHSPADPSH 
LSPPASSPRP SRGHRRSASC GSPLSGGAEE ASGGTGYGGE GSGPGASDCR IIRVQMELGE 
DGSVYKSILV TSQDKAPSVI SRVLKKNNRD SAVASEYELV QLLPGERELT IPASANVFYA 
MDGASHDFLL RQRRRSSTAT PGVTSGPSAS GTPPSEGGGG SFPRIKATGR KIARALF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.