Details for: RABGGTA

Gene ID: 5875

Symbol: RABGGTA

Ensembl ID: ENSG00000100949

Description: Rab geranylgeranyltransferase subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.6699
    Cell Significance Index: -13.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.7693
    Cell Significance Index: -12.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 34.1306
    Cell Significance Index: -14.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.6887
    Cell Significance Index: -13.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.2040
    Cell Significance Index: -14.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.9168
    Cell Significance Index: -14.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.3182
    Cell Significance Index: -14.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.9619
    Cell Significance Index: -13.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.3224
    Cell Significance Index: -13.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8412
    Cell Significance Index: -10.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6011
    Cell Significance Index: -14.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5456
    Cell Significance Index: 251.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.0903
    Cell Significance Index: 52.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5809
    Cell Significance Index: -3.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2885
    Cell Significance Index: 17.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1684
    Cell Significance Index: 1054.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8992
    Cell Significance Index: 97.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8807
    Cell Significance Index: 52.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7002
    Cell Significance Index: 81.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5328
    Cell Significance Index: 14.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4862
    Cell Significance Index: 33.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4533
    Cell Significance Index: 12.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4354
    Cell Significance Index: 22.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3899
    Cell Significance Index: 11.4500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3655
    Cell Significance Index: 2.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3551
    Cell Significance Index: 9.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3543
    Cell Significance Index: 16.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2888
    Cell Significance Index: 13.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2322
    Cell Significance Index: 30.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2241
    Cell Significance Index: 42.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2068
    Cell Significance Index: 9.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1999
    Cell Significance Index: 14.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1998
    Cell Significance Index: 10.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1654
    Cell Significance Index: 19.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1506
    Cell Significance Index: 82.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1448
    Cell Significance Index: 2.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1378
    Cell Significance Index: 60.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1283
    Cell Significance Index: 2.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1233
    Cell Significance Index: 24.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1119
    Cell Significance Index: 15.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1082
    Cell Significance Index: 6.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1051
    Cell Significance Index: 7.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1029
    Cell Significance Index: 12.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1011
    Cell Significance Index: 12.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0858
    Cell Significance Index: 1.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0794
    Cell Significance Index: 2.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0604
    Cell Significance Index: 10.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0582
    Cell Significance Index: 9.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0530
    Cell Significance Index: 0.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0512
    Cell Significance Index: 3.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0512
    Cell Significance Index: 35.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0398
    Cell Significance Index: 1.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0337
    Cell Significance Index: 0.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0310
    Cell Significance Index: 0.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0222
    Cell Significance Index: 0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0209
    Cell Significance Index: 7.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0143
    Cell Significance Index: 0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0092
    Cell Significance Index: 0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0030
    Cell Significance Index: 2.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0047
    Cell Significance Index: -0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0139
    Cell Significance Index: -8.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0202
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0229
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0250
    Cell Significance Index: -15.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0382
    Cell Significance Index: -11.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0460
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0466
    Cell Significance Index: -1.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0479
    Cell Significance Index: -1.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0603
    Cell Significance Index: -1.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0633
    Cell Significance Index: -0.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0691
    Cell Significance Index: -2.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0696
    Cell Significance Index: -10.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0717
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0721
    Cell Significance Index: -15.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1166
    Cell Significance Index: -2.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1259
    Cell Significance Index: -1.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1326
    Cell Significance Index: -13.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1493
    Cell Significance Index: -11.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1497
    Cell Significance Index: -11.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1632
    Cell Significance Index: -3.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2006
    Cell Significance Index: -12.3000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2147
    Cell Significance Index: -1.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2217
    Cell Significance Index: -12.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2381
    Cell Significance Index: -8.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2389
    Cell Significance Index: -2.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2491
    Cell Significance Index: -2.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2568
    Cell Significance Index: -6.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2603
    Cell Significance Index: -7.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2611
    Cell Significance Index: -11.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2750
    Cell Significance Index: -9.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RABGGTA gene encodes a subunit of the geranylgeranyltransferase complex, which catalyzes the geranylgeranylation of Rab proteins. This post-translational modification is crucial for the proper localization and function of Rab proteins at the plasma membrane. The RABGGTA gene is associated with the following characteristics: * Significantly expressed in germ cells, epithelial cells, and neurons * Involved in protein geranylgeranylation, a post-translational modification essential for Rab protein function * Participates in various cellular processes, including membrane trafficking, cell signaling, and apoptosis * Regulated by TP53, a tumor suppressor protein that controls transcription of cell death genes **Pathways and Functions:** The RABGGTA gene is involved in several cellular pathways, including: * Protein modification process: Geranylgeranylation of Rab proteins * Post-translational protein modification: Geranylgeranylation of Rab proteins * Protein binding: Interaction with other proteins involved in geranylgeranylation * Protein geranylgeranylation: Catalysis of geranylgeranylation of Rab proteins * Rab-protein geranylgeranyltransferase complex: Subunit of the geranylgeranyltransferase complex * Small GTPase binding: Interaction with small GTPases, including Rab proteins * Transcriptional regulation by TP53: Regulation of transcription of cell death genes **Clinical Significance:** The RABGGTA gene has significant implications in various diseases, including: * Cancer: Dysregulation of TP53 and RABGGTA can contribute to cancer development and progression * Neurodegenerative diseases: Impaired geranylgeranylation of Rab proteins can contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's * Developmental disorders: Abnormal expression of RABGGTA can contribute to developmental disorders, such as neuronal development and differentiation In conclusion, the RABGGTA gene plays a critical role in protein modification and cellular processes, including geranylgeranylation of Rab proteins. Its dysregulation can contribute to various diseases, highlighting the importance of understanding the function and regulation of this gene in maintaining cellular homeostasis.

Genular Protein ID: 1070278994

Symbol: PGTA_HUMAN

Name: Geranylgeranyl transferase type-2 subunit alpha

UniProtKB Accession Codes:

Q92696 A8K5N2 D3DS69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DrugBank 3 EC 2 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8954794

Title: cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter.

PubMed ID: 8954794

DOI: 10.1006/geno.1996.0608

PubMed ID: 9196026

Title: The genes encoding geranylgeranyl transferase alpha-subunit and transglutaminase 1 are very closely linked but not functionally related in terminally differentiating keratinocytes.

PubMed ID: 9196026

DOI: 10.1006/bbrc.1997.6717

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7991565

Title: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

PubMed ID: 7991565

DOI: 10.1073/pnas.91.25.11963

PubMed ID: 18532927

Title: Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.

PubMed ID: 18532927

DOI: 10.1042/bj20080662

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

Sequence Information:

  • Length: 567
  • Mass: 65072
  • Checksum: ABA1AFFC8A496C5F
  • Sequence:
    • MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP 
DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL 
PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS 
WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD 
PQDALRCLHV SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW 
LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK 
STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAT 
YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP 
ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL 
QGNPLCQAVG ILEQLAELLP SVSSVLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.