Details for: RABIF

Gene ID: 5877

Symbol: RABIF

Ensembl ID: ENSG00000183155

Description: RAB interacting factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.0861
    Cell Significance Index: -17.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.8852
    Cell Significance Index: -16.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.3195
    Cell Significance Index: -19.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9008
    Cell Significance Index: -20.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4426
    Cell Significance Index: -19.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1888
    Cell Significance Index: -13.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9930
    Cell Significance Index: -19.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.4319
    Cell Significance Index: 30.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9953
    Cell Significance Index: 59.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7822
    Cell Significance Index: 21.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7781
    Cell Significance Index: 126.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6002
    Cell Significance Index: 114.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5676
    Cell Significance Index: 16.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5390
    Cell Significance Index: 28.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4762
    Cell Significance Index: 32.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4508
    Cell Significance Index: 6.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4065
    Cell Significance Index: 47.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3614
    Cell Significance Index: 44.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3588
    Cell Significance Index: 35.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3578
    Cell Significance Index: 26.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3430
    Cell Significance Index: 61.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3223
    Cell Significance Index: 64.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2859
    Cell Significance Index: 7.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2718
    Cell Significance Index: 148.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2424
    Cell Significance Index: 11.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2375
    Cell Significance Index: 30.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2106
    Cell Significance Index: 41.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2037
    Cell Significance Index: 9.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2033
    Cell Significance Index: 89.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2018
    Cell Significance Index: 3.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1893
    Cell Significance Index: 8.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1645
    Cell Significance Index: 4.7400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1215
    Cell Significance Index: 0.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1115
    Cell Significance Index: 7.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1108
    Cell Significance Index: 39.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0849
    Cell Significance Index: 4.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0820
    Cell Significance Index: 5.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0614
    Cell Significance Index: 7.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0571
    Cell Significance Index: 39.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0492
    Cell Significance Index: 3.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0381
    Cell Significance Index: 5.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0286
    Cell Significance Index: 0.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0060
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0024
    Cell Significance Index: 1.8300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0185
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0247
    Cell Significance Index: -15.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0365
    Cell Significance Index: -22.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0374
    Cell Significance Index: -6.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0381
    Cell Significance Index: -17.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0414
    Cell Significance Index: -11.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0537
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0591
    Cell Significance Index: -6.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0630
    Cell Significance Index: -7.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0665
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1000
    Cell Significance Index: -21.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1013
    Cell Significance Index: -14.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1251
    Cell Significance Index: -7.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1347
    Cell Significance Index: -3.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1376
    Cell Significance Index: -2.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1407
    Cell Significance Index: -3.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1574
    Cell Significance Index: -2.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1881
    Cell Significance Index: -19.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1887
    Cell Significance Index: -14.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2017
    Cell Significance Index: -12.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2018
    Cell Significance Index: -13.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2045
    Cell Significance Index: -4.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2048
    Cell Significance Index: -1.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2086
    Cell Significance Index: -7.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2237
    Cell Significance Index: -17.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2299
    Cell Significance Index: -10.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2314
    Cell Significance Index: -14.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2884
    Cell Significance Index: -10.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2898
    Cell Significance Index: -7.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2918
    Cell Significance Index: -6.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3112
    Cell Significance Index: -1.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3332
    Cell Significance Index: -8.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3569
    Cell Significance Index: -10.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3664
    Cell Significance Index: -6.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3793
    Cell Significance Index: -9.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3793
    Cell Significance Index: -2.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3910
    Cell Significance Index: -6.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3922
    Cell Significance Index: -12.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3966
    Cell Significance Index: -14.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4016
    Cell Significance Index: -14.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4113
    Cell Significance Index: -13.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4207
    Cell Significance Index: -4.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4478
    Cell Significance Index: -7.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4515
    Cell Significance Index: -13.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4809
    Cell Significance Index: -12.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4825
    Cell Significance Index: -12.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4920
    Cell Significance Index: -5.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RABIF is a protein that interacts with RAB GTPases, which are small GTP-binding proteins that regulate membrane trafficking and cellular signaling. RABIF has been identified as a guanyl-nucleotide exchange factor (GEF), which means it can activate RAB GTPases by promoting the exchange of GDP for GTP. This activation is crucial for regulating membrane fusion, protein transport, and signal transduction pathways. RABIF has been expressed in various cell types, including neural progenitor cells, male germ cells, and epithelial cells, suggesting its importance in different cellular contexts. **Pathways and Functions:** RABIF is involved in several cellular pathways, including: 1. **Membrane Fusion:** RABIF regulates membrane fusion by activating RAB GTPases, which control the fusion of vesicles with the plasma membrane. 2. **Protein Transport:** RABIF is involved in protein transport by regulating the movement of vesicles and organelles within the cell. 3. **Small GTPase-Mediated Signal Transduction:** RABIF activates RAB GTPases, which in turn regulate signal transduction pathways involved in cellular responses to stimuli. 4. **Post-Golgi Vesicle-Mediated Transport:** RABIF is involved in the transport of vesicles from the Golgi apparatus to the plasma membrane. **Clinical Significance:** RABIF has been identified in various tissues and cell types, including the nervous system, reproductive system, and epithelial tissues. Its expression in neural progenitor cells suggests a role in neurodevelopment and neurodegenerative diseases. In male germ cells, RABIF may play a role in spermatogenesis. In epithelial cells, RABIF may be involved in the regulation of cell growth and differentiation. Overall, RABIF's involvement in various cellular pathways suggests its potential role in various diseases, including cancer, neurodegenerative disorders, and reproductive disorders. **Conclusion:** In conclusion, RABIF is a protein that plays a crucial role in various cellular processes, including membrane fusion, protein transport, and signal transduction. Its involvement in different cell types and tissues suggests its importance in different cellular contexts. Further research is needed to fully understand the role of RABIF in human health and disease, but its identification as a guanyl-nucleotide exchange factor and its involvement in various cellular pathways make it an attractive target for therapeutic intervention. **References:** * [Insert references to studies that have investigated the role of RABIF in different cellular contexts and diseases] Note: The references should be up-to-date and relevant to the current scientific literature.

Genular Protein ID: 796541809

Symbol: MSS4_HUMAN

Name: Guanine nucleotide exchange factor MSS4

UniProtKB Accession Codes:

P47224 B2R4P4 Q92992

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7619808

Title: Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4.

PubMed ID: 7619808

DOI: 10.1021/bi00028a020

PubMed ID: 9441742

Title: Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer.

PubMed ID: 9441742

DOI: 10.1006/geno.1997.5049

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 31540829

Title: Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.

PubMed ID: 31540829

DOI: 10.1016/j.chom.2019.08.017

PubMed ID: 7651540

Title: Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface.

PubMed ID: 7651540

DOI: 10.1038/376788a0

PubMed ID: 16541104

Title: Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

PubMed ID: 16541104

DOI: 10.1038/sj.emboj.7601044

Sequence Information:

  • Length: 123
  • Mass: 13839
  • Checksum: 78E98395FAE10257
  • Sequence:
    • MEPAEQPSEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK KPALSDGSNP 
DGDLLQEHWL VEDMFIFENV GFTKDVGNIK FLVCADCEIG PIGWHCLDDK NSFYVALERV 
SHE

Genular Protein ID: 2648248479

Symbol: Q53EV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53EV1

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 123
  • Mass: 13869
  • Checksum: 78E98395EEB04757
  • Sequence:
    • MEPAEQPSEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK KPALSDGSNP 
DGDLLQEHWL VEDMFIFENV GFTKDVGNIK FLVCTDCEIG PIGWHCLDDK NSFYVALERV 
SHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.