Details for: RAD17

Gene ID: 5884

Symbol: RAD17

Ensembl ID: ENSG00000152942

Description: RAD17 checkpoint clamp loader component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.4450
    Cell Significance Index: -21.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.0818
    Cell Significance Index: -22.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.3232
    Cell Significance Index: -24.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.8451
    Cell Significance Index: -27.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.9744
    Cell Significance Index: -22.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.9227
    Cell Significance Index: -22.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1613
    Cell Significance Index: -23.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7392
    Cell Significance Index: -26.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2087
    Cell Significance Index: -24.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5902
    Cell Significance Index: -17.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5868
    Cell Significance Index: -7.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6173
    Cell Significance Index: 263.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2515
    Cell Significance Index: 78.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1501
    Cell Significance Index: 28.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0582
    Cell Significance Index: 115.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9949
    Cell Significance Index: 59.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7951
    Cell Significance Index: 157.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7864
    Cell Significance Index: 157.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7172
    Cell Significance Index: 8.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6911
    Cell Significance Index: 68.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5861
    Cell Significance Index: 69.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5395
    Cell Significance Index: 37.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4457
    Cell Significance Index: 25.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4401
    Cell Significance Index: 19.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4331
    Cell Significance Index: 299.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4136
    Cell Significance Index: 148.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3802
    Cell Significance Index: 68.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3371
    Cell Significance Index: 25.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3139
    Cell Significance Index: 9.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3095
    Cell Significance Index: 8.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2861
    Cell Significance Index: 39.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2663
    Cell Significance Index: 32.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2529
    Cell Significance Index: 11.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2425
    Cell Significance Index: 12.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2357
    Cell Significance Index: 12.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2160
    Cell Significance Index: 117.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2098
    Cell Significance Index: 189.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1874
    Cell Significance Index: 4.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1868
    Cell Significance Index: 4.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1744
    Cell Significance Index: 77.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1361
    Cell Significance Index: 7.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1233
    Cell Significance Index: 2.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0971
    Cell Significance Index: 18.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0836
    Cell Significance Index: 10.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0769
    Cell Significance Index: 8.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0637
    Cell Significance Index: 10.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0474
    Cell Significance Index: 0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0454
    Cell Significance Index: 2.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0320
    Cell Significance Index: 60.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0317
    Cell Significance Index: 0.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0122
    Cell Significance Index: 0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0119
    Cell Significance Index: 7.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0103
    Cell Significance Index: 15.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0069
    Cell Significance Index: 12.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0026
    Cell Significance Index: 1.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0064
    Cell Significance Index: -2.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0074
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0125
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0211
    Cell Significance Index: -13.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0217
    Cell Significance Index: -16.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0364
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0477
    Cell Significance Index: -6.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0613
    Cell Significance Index: -2.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0640
    Cell Significance Index: -2.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0659
    Cell Significance Index: -2.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0660
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0719
    Cell Significance Index: -15.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0881
    Cell Significance Index: -25.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0945
    Cell Significance Index: -2.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1050
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1082
    Cell Significance Index: -12.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1136
    Cell Significance Index: -14.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1754
    Cell Significance Index: -3.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1787
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1842
    Cell Significance Index: -21.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1882
    Cell Significance Index: -14.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2002
    Cell Significance Index: -5.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2044
    Cell Significance Index: -21.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2114
    Cell Significance Index: -5.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2191
    Cell Significance Index: -17.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2687
    Cell Significance Index: -6.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3023
    Cell Significance Index: -6.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3368
    Cell Significance Index: -7.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3577
    Cell Significance Index: -4.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3619
    Cell Significance Index: -11.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3639
    Cell Significance Index: -11.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4033
    Cell Significance Index: -3.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4176
    Cell Significance Index: -12.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4277
    Cell Significance Index: -26.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4286
    Cell Significance Index: -10.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4289
    Cell Significance Index: -4.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4567
    Cell Significance Index: -16.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4582
    Cell Significance Index: -9.0600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4623
    Cell Significance Index: -6.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Checkpoint Clamp Loader Function**: RAD17 is a component of the checkpoint clamp loader complex, which is responsible for loading the MRN (Mre11-Rad50-Nbs1) complex onto DNA double-strand breaks, facilitating the recruitment of other repair proteins. 2. **ATR Activation**: RAD17 is essential for the activation of the ATR kinase in response to replication stress, ensuring the accurate repair of DNA damage. 3. **Cell Cycle Regulation**: RAD17 regulates the cell cycle, particularly at the G2/M checkpoint, where it interacts with TP53 to regulate its activity. 4. **TP53 Regulation**: RAD17 interacts with TP53 to regulate its activity, modulating the cell's response to DNA damage. 5. **Expression in Various Cell Types**: RAD17 is highly expressed in cardiac muscle cells, oogonial cells, and male germ cells, highlighting its importance in maintaining genome stability. **Pathways and Functions** 1. **Activation of ATR in Response to Replication Stress**: RAD17 is involved in the activation of the ATR kinase in response to replication stress, ensuring the accurate repair of DNA double-strand breaks. 2. **Cell Cycle Checkpoint Signaling**: RAD17 regulates the cell cycle, particularly at the G2/M checkpoint, where it interacts with TP53 to regulate its activity. 3. **DNA Damage Response**: RAD17 is essential for the DNA damage response, facilitating the recruitment of other repair proteins to damaged DNA. 4. **Homologous Recombination Repair**: RAD17 is involved in the homologous recombination repair pathway, ensuring the accurate repair of DNA double-strand breaks. 5. **Regulation of Phosphorylation**: RAD17 regulates the phosphorylation of other proteins, modulating the cell's response to DNA damage. **Clinical Significance** 1. **Cancer Association**: RAD17 has been associated with various cancers, including breast, prostate, and lung cancer, where it plays a crucial role in maintaining genome stability. 2. **Genetic Disorders**: RAD17 mutations have been linked to genetic disorders, such as Fanconi anemia, where it plays a critical role in the DNA damage response. 3. **Radiosensitivity**: RAD17 is involved in the response to radiation-induced DNA damage, highlighting its importance in cancer therapy and radiation protection. 4. **Aging and Age-Related Diseases**: RAD17 is highly expressed in various cell types, suggesting its involvement in the aging process and age-related diseases, such as atherosclerosis and neurodegenerative disorders. In conclusion, RAD17 is a critical gene involved in the DNA damage response, cell cycle regulation, and homologous recombination repair. Its dysregulation has been linked to various cancers, genetic disorders, and aging-related diseases, highlighting its importance in maintaining genome stability and overall health.

Genular Protein ID: 2153561272

Symbol: RAD17_HUMAN

Name: Cell cycle checkpoint protein RAD17

UniProtKB Accession Codes:

O75943 A8K8X2 D3DWA5 O75714 Q7Z3S4 Q9UNK7 Q9UNR7 Q9UNR8 Q9UPF5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 1 DIP 2 DNASU 1 DisGeNET 1 EMBL 32 EMDB 1 Ensembl 17 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 7 RefSeq 12 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878245

Title: cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.

PubMed ID: 9878245

DOI: 10.1006/geno.1998.5587

PubMed ID: 9660800

Title: Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.

PubMed ID: 9660800

DOI: 10.1074/jbc.273.29.18340

PubMed ID: 10232579

Title: HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.

PubMed ID: 10232579

PubMed ID: 9933569

Title: Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.

PubMed ID: 9933569

DOI: 10.1006/geno.1998.5642

PubMed ID: 10480350

Title: Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.

PubMed ID: 10480350

DOI: 10.1007/s004399900067

PubMed ID: 10208430

Title: hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.

PubMed ID: 10208430

DOI: 10.1038/sj.onc.1202469

PubMed ID: 11715513

Title: Human hR24L gene is involved in DNA excision repair and recombination repair.

PubMed ID: 11715513

PubMed ID: 11602352

Title: Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation.

PubMed ID: 11602352

DOI: 10.1016/s0378-1119(01)00692-8

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10593953

Title: HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation.

PubMed ID: 10593953

DOI: 10.1074/jbc.274.51.36544

PubMed ID: 10884395

Title: The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9.

PubMed ID: 10884395

DOI: 10.1074/jbc.m005782200

PubMed ID: 11418864

Title: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

PubMed ID: 11418864

DOI: 10.1038/35082110

PubMed ID: 11572977

Title: Purification and characterization of human DNA damage checkpoint Rad complexes.

PubMed ID: 11572977

DOI: 10.1073/pnas.201373498

PubMed ID: 11687627

Title: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

PubMed ID: 11687627

DOI: 10.1073/pnas.231364598

PubMed ID: 11799063

Title: Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

PubMed ID: 11799063

DOI: 10.1101/gad.950302

PubMed ID: 12400013

Title: Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block.

PubMed ID: 12400013

DOI: 10.1038/sj.onc.1205872

PubMed ID: 12672690

Title: Genomic instability and endoreduplication triggered by RAD17 deletion.

PubMed ID: 12672690

DOI: 10.1101/gad.1065103

PubMed ID: 14611806

Title: Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene.

PubMed ID: 14611806

DOI: 10.1016/s0888-7543(03)00200-3

PubMed ID: 14500819

Title: The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon.

PubMed ID: 14500819

DOI: 10.1093/nar/gkg765

PubMed ID: 14624239

Title: Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA.

PubMed ID: 14624239

DOI: 10.1371/journal.pbio.0000033

PubMed ID: 12578958

Title: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

PubMed ID: 12578958

DOI: 10.1073/pnas.0437927100

PubMed ID: 14871926

Title: Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.

PubMed ID: 14871926

DOI: 10.1101/gad.1176004

PubMed ID: 15538388

Title: Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling.

PubMed ID: 15538388

DOI: 10.1038/sj.emboj.7600463

PubMed ID: 15235112

Title: Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.

PubMed ID: 15235112

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21659603

Title: A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

PubMed ID: 21659603

DOI: 10.1126/science.1203430

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24534091

Title: Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

PubMed ID: 24534091

DOI: 10.1002/embj.201386064

PubMed ID: 36841485

Title: The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.

PubMed ID: 36841485

DOI: 10.1016/j.jbc.2023.103061

Sequence Information:

  • Length: 681
  • Mass: 77055
  • Checksum: 796C2BD48F7995A3
  • Sequence:
    • MSKTFLRPKV SSTKVTDWVD PSFDDFLECS GVSTITATSL GVNNSSHRRK NGPSTLESSR 
FPARKRGNLS SLEQIYGLEN SKEYLSENEP WVDKYKPETQ HELAVHKKKI EEVETWLKAQ 
VLERQPKQGG SILLITGPPG CGKTTTLKIL SKEHGIQVQE WINPVLPDFQ KDDFKGMFNT 
ESSFHMFPYQ SQIAVFKEFL LRATKYNKLQ MLGDDLRTDK KIILVEDLPN QFYRDSHTLH 
EVLRKYVRIG RCPLIFIISD SLSGDNNQRL LFPKEIQEEC SISNISFNPV APTIMMKFLN 
RIVTIEANKN GGKITVPDKT SLELLCQGCS GDIRSAINSL QFSSSKGENN LRPRKKGMSL 
KSDAVLSKSK RRKKPDRVFE NQEVQAIGGK DVSLFLFRAL GKILYCKRAS LTELDSPRLP 
SHLSEYERDT LLVEPEEVVE MSHMPGDLFN LYLHQNYIDF FMEIDDIVRA SEFLSFADIL 
SGDWNTRSLL REYSTSIATR GVMHSNKARG YAHCQGGGSS FRPLHKPQWF LINKKYRENC 
LAAKALFPDF CLPALCLQTQ LLPYLALLTI PMRNQAQISF IQDIGRLPLK RHFGRLKMEA 
LTDREHGMID PDSGDEAQLN GGHSAEESLG EPTQATVPET WSLPLSQNSA SELPASQPQP 
FSAQGDMEEN IIIEDYESDG T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.