Details for: RBBP8

Gene ID: 5932

Symbol: RBBP8

Ensembl ID: ENSG00000101773

Description: RB binding protein 8, endonuclease

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.9441
    Cell Significance Index: -19.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 84.3310
    Cell Significance Index: -21.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 56.7062
    Cell Significance Index: -23.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1929
    Cell Significance Index: -21.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.9881
    Cell Significance Index: -24.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.6972
    Cell Significance Index: -21.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6706
    Cell Significance Index: -23.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8620
    Cell Significance Index: -23.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9883
    Cell Significance Index: -23.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.6603
    Cell Significance Index: 49.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4063
    Cell Significance Index: -7.4600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3197
    Cell Significance Index: 17.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9613
    Cell Significance Index: 53.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9183
    Cell Significance Index: 53.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6324
    Cell Significance Index: 161.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5410
    Cell Significance Index: 250.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4742
    Cell Significance Index: 34.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2082
    Cell Significance Index: 72.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0168
    Cell Significance Index: 52.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0040
    Cell Significance Index: 109.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9569
    Cell Significance Index: 117.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9347
    Cell Significance Index: 25.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9086
    Cell Significance Index: 180.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8388
    Cell Significance Index: 14.1300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7674
    Cell Significance Index: 1.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7638
    Cell Significance Index: 153.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7607
    Cell Significance Index: 336.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7526
    Cell Significance Index: 135.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7259
    Cell Significance Index: 51.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6738
    Cell Significance Index: 6.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6721
    Cell Significance Index: 426.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6157
    Cell Significance Index: 336.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6089
    Cell Significance Index: 17.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5905
    Cell Significance Index: 69.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5608
    Cell Significance Index: 12.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5387
    Cell Significance Index: 30.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4913
    Cell Significance Index: 12.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4648
    Cell Significance Index: 32.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4539
    Cell Significance Index: 854.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3883
    Cell Significance Index: 6.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3700
    Cell Significance Index: 19.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2955
    Cell Significance Index: 13.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2831
    Cell Significance Index: 12.8300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2676
    Cell Significance Index: 2.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2496
    Cell Significance Index: 172.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2144
    Cell Significance Index: 5.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1864
    Cell Significance Index: 2.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1338
    Cell Significance Index: 6.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1225
    Cell Significance Index: 43.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1036
    Cell Significance Index: 13.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0848
    Cell Significance Index: 2.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0630
    Cell Significance Index: 10.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0528
    Cell Significance Index: 1.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0482
    Cell Significance Index: 6.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0475
    Cell Significance Index: 3.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0399
    Cell Significance Index: 73.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0320
    Cell Significance Index: 23.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0250
    Cell Significance Index: 1.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0248
    Cell Significance Index: 3.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0199
    Cell Significance Index: 30.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0021
    Cell Significance Index: 0.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0019
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0015
    Cell Significance Index: -1.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0098
    Cell Significance Index: -1.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0159
    Cell Significance Index: -8.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0167
    Cell Significance Index: -0.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0172
    Cell Significance Index: -1.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0283
    Cell Significance Index: -2.8900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0304
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0356
    Cell Significance Index: -0.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0398
    Cell Significance Index: -7.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0532
    Cell Significance Index: -15.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0534
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0619
    Cell Significance Index: -7.0900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0694
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0744
    Cell Significance Index: -8.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0965
    Cell Significance Index: -6.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1104
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1134
    Cell Significance Index: -12.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1284
    Cell Significance Index: -13.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1354
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1637
    Cell Significance Index: -7.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1687
    Cell Significance Index: -2.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1833
    Cell Significance Index: -2.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1986
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2011
    Cell Significance Index: -15.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2070
    Cell Significance Index: -7.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2079
    Cell Significance Index: -12.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2137
    Cell Significance Index: -7.4300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2194
    Cell Significance Index: -1.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2493
    Cell Significance Index: -16.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2680
    Cell Significance Index: -5.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2772
    Cell Significance Index: -2.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3015
    Cell Significance Index: -7.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3151
    Cell Significance Index: -19.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3346
    Cell Significance Index: -5.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Endonuclease activity**: RBBP8 is a DNA endonuclease that cleaves DNA at specific sequences, generating 3'-phosphoglycolate termini. 2. **Homologous recombination repair (HRR)**: RBBP8 is involved in HRR, a process that repairs DNA DSBs by using a template with a similar sequence. 3. **Non-homologous end joining (MMEJ)**: RBBP8 also participates in MMEJ, a pathway that repairs DNA DSBs by joining the broken ends directly. 4. **Single-strand annealing (SSA)**: RBBP8 is involved in SSA, a process that resolves DSBs by annealing complementary single-stranded DNA ends. 5. **Regulation of cell cycle**: RBBP8 is also involved in regulating the cell cycle, particularly at the G1/S and G2/M transitions. **Pathways and Functions:** 1. **Blastocyst hatching**: RBBP8 is involved in the hatching process of blastocysts, which is critical for implantation and embryonic development. 2. **Brca1-c complex**: RBBP8 interacts with the Brca1-c complex, which plays a key role in HRR and maintaining genome stability. 3. **Cell cycle checkpoints**: RBBP8 is involved in regulating cell cycle checkpoints, particularly at the G2/M transition, to prevent aberrant cell proliferation. 4. **DNA double-strand break processing**: RBBP8 is essential for processing DNA DSBs, which is critical for maintaining genome integrity. 5. **Gene expression regulation**: RBBP8 regulates gene expression by interacting with transcription factors, such as TP53 and E2F6. **Clinical Significance:** 1. **Cancer predisposition**: Mutations in RBBP8 have been associated with an increased risk of cancer, particularly breast and ovarian cancer. 2. **Brca1-related disorders**: RBBP8 is involved in the Brca1-c complex, which is critical for maintaining genome stability. Mutations in RBBP8 can lead to Brca1-related disorders. 3. **Reproductive disorders**: RBBP8 is essential for embryonic development and reproduction. Mutations in RBBP8 can lead to reproductive disorders, such as infertility and miscarriage. 4. **Neurological disorders**: RBBP8 is involved in regulating gene expression and maintaining genome stability. Mutations in RBBP8 have been associated with neurological disorders, such as epilepsy and schizophrenia. In conclusion, RBBP8 is a multifaceted protein that plays a critical role in DNA repair, cell cycle regulation, and gene expression. Its involvement in various pathways, including HRR, MMEJ, and SSA, highlights its importance in maintaining genome stability. The clinical significance of RBBP8 mutations underscores the need for further research into its function and its role in human disease.

Genular Protein ID: 3816387270

Symbol: CTIP_HUMAN

Name: DNA endonuclease RBBP8

UniProtKB Accession Codes:

Q99708 A6NKN2 A8K8W6 E7ETY1 O75371 Q8NHQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 17 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9721205

Title: Molecular cloning and characterization of a novel retinoblastoma-binding protein.

PubMed ID: 9721205

DOI: 10.1006/geno.1998.5368

PubMed ID: 9535825

Title: Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif.

PubMed ID: 9535825

DOI: 10.1074/jbc.273.15.8549

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10764811

Title: Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor.

PubMed ID: 10764811

DOI: 10.1074/jbc.m909494199

PubMed ID: 10910365

Title: Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.

PubMed ID: 10910365

DOI: 10.1038/35018134

PubMed ID: 11751867

Title: The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.

PubMed ID: 11751867

DOI: 10.1074/jbc.m110603200

PubMed ID: 14654780

Title: SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.

PubMed ID: 14654780

DOI: 10.1038/sj.onc.1206994

PubMed ID: 15084581

Title: Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.

PubMed ID: 15084581

DOI: 10.1074/jbc.m313974200

PubMed ID: 15485915

Title: DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains.

PubMed ID: 15485915

DOI: 10.1128/mcb.24.21.9478-9486.2004

PubMed ID: 16818604

Title: BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.

PubMed ID: 16818604

DOI: 10.1101/gad.1431006

PubMed ID: 16581787

Title: CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.

PubMed ID: 16581787

DOI: 10.1128/mcb.26.8.3124-3134.2006

PubMed ID: 18171986

Title: CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer.

PubMed ID: 18171986

DOI: 10.1158/1541-7786.mcr-07-0126

PubMed ID: 17965729

Title: Human CtIP promotes DNA end resection.

PubMed ID: 17965729

DOI: 10.1038/nature06337

PubMed ID: 19270026

Title: Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.

PubMed ID: 19270026

DOI: 10.1093/hmg/ddp107

PubMed ID: 19202191

Title: Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.

PubMed ID: 19202191

DOI: 10.1074/jbc.m808906200

PubMed ID: 19759395

Title: N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.

PubMed ID: 19759395

DOI: 10.1074/jbc.m109.023424

PubMed ID: 20064462

Title: CtIP links DNA double-strand break sensing to resection.

PubMed ID: 20064462

DOI: 10.1016/j.molcel.2009.12.002

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20829486

Title: Human SIRT6 promotes DNA end resection through CtIP deacetylation.

PubMed ID: 20829486

DOI: 10.1126/science.1192049

PubMed ID: 30975768

Title:

PubMed ID: 30975768

DOI: 10.1126/science.aax4558

PubMed ID: 21799032

Title: Modification of BRCA1-associated breast and ovarian cancer risk by BRCA1-interacting genes.

PubMed ID: 21799032

DOI: 10.1158/0008-5472.can-11-0773

PubMed ID: 21998596

Title: CtIP mutations cause Seckel and Jawad syndromes.

PubMed ID: 21998596

DOI: 10.1371/journal.pgen.1002310

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23273981

Title: Activation of DSB processing requires phosphorylation of CtIP by ATR.

PubMed ID: 23273981

DOI: 10.1016/j.molcel.2012.11.020

PubMed ID: 23623683

Title: Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.

PubMed ID: 23623683

DOI: 10.1016/j.molcel.2013.03.023

PubMed ID: 25349192

Title: APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.

PubMed ID: 25349192

DOI: 10.15252/embj.201489017

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27814491

Title: Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts.

PubMed ID: 27814491

DOI: 10.1016/j.molcel.2016.10.010

PubMed ID: 27889449

Title: Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection.

PubMed ID: 27889449

DOI: 10.1016/j.molcel.2016.10.017

PubMed ID: 27561354

Title: Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.

PubMed ID: 27561354

DOI: 10.1038/ncomms12628

PubMed ID: 26721387

Title: Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.

PubMed ID: 26721387

DOI: 10.1093/nar/gkv1526

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 24389050

Title: Genomic analysis of primordial dwarfism reveals novel disease genes.

PubMed ID: 24389050

DOI: 10.1101/gr.160572.113

PubMed ID: 26502057

Title: Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

PubMed ID: 26502057

DOI: 10.1038/ncb3260

PubMed ID: 26807646

Title: EXD2 promotes homologous recombination by facilitating DNA end resection.

PubMed ID: 26807646

DOI: 10.1038/ncb3303

PubMed ID: 28834754

Title: SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination.

PubMed ID: 28834754

DOI: 10.1016/j.celrep.2017.08.008

PubMed ID: 29042561

Title: AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.

PubMed ID: 29042561

DOI: 10.1038/s41467-017-01151-w

PubMed ID: 30601117

Title: CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair.

PubMed ID: 30601117

DOI: 10.7554/elife.42129

PubMed ID: 30787182

Title: NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.

PubMed ID: 30787182

DOI: 10.15252/embj.2018101005

PubMed ID: 33836577

Title: A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.

PubMed ID: 33836577

DOI: 10.1073/pnas.2016287118

PubMed ID: 35219381

Title: Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation.

PubMed ID: 35219381

DOI: 10.1016/j.molcel.2022.01.020

PubMed ID: 16101277

Title: Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

PubMed ID: 16101277

DOI: 10.1021/bi0509651

PubMed ID: 23353824

Title: Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

PubMed ID: 23353824

DOI: 10.1016/j.jmb.2013.01.017

PubMed ID: 25558984

Title: CtIP tetramer assembly is required for DNA-end resection and repair.

PubMed ID: 25558984

DOI: 10.1038/nsmb.2937

PubMed ID: 34129781

Title: Structural basis for the coiled-coil architecture of human CtIP.

PubMed ID: 34129781

DOI: 10.1098/rsob.210060

Sequence Information:

  • Length: 897
  • Mass: 101942
  • Checksum: E028DE56DE55C0F2
  • Sequence:
    • MNISGSSCGS PNSADTSSDF KDLWTKLKEC HDREVQGLQV KVTKLKQERI LDAQRLEEFF 
TKNQQLREQQ KVLHETIKVL EDRLRAGLCD RCAVTEEHMR KKQQEFENIR QQNLKLITEL 
MNERNTLQEE NKKLSEQLQQ KIENDQQHQA AELECEEDVI PDSPITAFSF SGVNRLRRKE 
NPHVRYIEQT HTKLEHSVCA NEMRKVSKSS THPQHNPNEN EILVADTYDQ SQSPMAKAHG 
TSSYTPDKSS FNLATVVAET LGLGVQEESE TQGPMSPLGD ELYHCLEGNH KKQPFEESTR 
NTEDSLRFSD STSKTPPQEE LPTRVSSPVF GATSSIKSGL DLNTSLSPSL LQPGKKKHLK 
TLPFSNTCIS RLEKTRSKSE DSALFTHHSL GSEVNKIIIQ SSNKQILINK NISESLGEQN 
RTEYGKDSNT DKHLEPLKSL GGRTSKRKKT EEESEHEVSC PQASFDKENA FPFPMDNQFS 
MNGDCVMDKP LDLSDRFSAI QRQEKSQGSE TSKNKFRQVT LYEALKTIPK GFSSSRKASD 
GNCTLPKDSP GEPCSQECII LQPLNKCSPD NKPSLQIKEE NAVFKIPLRP RESLETENVL 
DDIKSAGSHE PIKIQTRSDH GGCELASVLQ LNPCRTGKIK SLQNNQDVSF ENIQWSIDPG 
ADLSQYKMDV TVIDTKDGSQ SKLGGETVDM DCTLVSETVL LKMKKQEQKG EKSSNEERKM 
NDSLEDMFDR TTHEEYESCL ADSFSQAADE EEELSTATKK LHTHGDKQDK VKQKAFVEPY 
FKGDERETSL QNFPHIEVVR KKEERRKLLG HTCKECEIYY ADMPAEEREK KLASCSRHRF 
RYIPPNTPEN FWEVGFPSTQ TCMERGYIKE DLDPCPRPKR RQPYNAIFSP KGKEQKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.