Details for: RBL2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 313.5422
Cell Significance Index: -48.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 195.4713
Cell Significance Index: -49.5800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 114.6565
Cell Significance Index: -46.5800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 107.8533
Cell Significance Index: -50.9200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 98.7975
Cell Significance Index: -50.8200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.0289
Cell Significance Index: -46.8100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.8125
Cell Significance Index: -50.3200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.4245
Cell Significance Index: -41.3200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.8273
Cell Significance Index: -42.4700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9319
Cell Significance Index: -51.0300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.7238
Cell Significance Index: -23.4700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7658
Cell Significance Index: 354.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2684
Cell Significance Index: 137.9600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2038
Cell Significance Index: 238.8900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.1800
Cell Significance Index: 23.0300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0506
Cell Significance Index: 63.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0429
Cell Significance Index: 169.6300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9846
Cell Significance Index: 353.1700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8693
Cell Significance Index: 784.8800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8109
Cell Significance Index: 99.7100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7865
Cell Significance Index: 141.7900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7797
Cell Significance Index: 539.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7380
Cell Significance Index: 41.4100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7121
Cell Significance Index: 54.6500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.6867
Cell Significance Index: 42.2100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6765
Cell Significance Index: 66.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6339
Cell Significance Index: 43.8400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5111
Cell Significance Index: 15.0100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4332
Cell Significance Index: 19.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4225
Cell Significance Index: 16.0000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4144
Cell Significance Index: 5.1400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3968
Cell Significance Index: 18.5000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3226
Cell Significance Index: 38.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3144
Cell Significance Index: 43.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2589
Cell Significance Index: 7.2400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2353
Cell Significance Index: 128.5100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1952
Cell Significance Index: 367.4500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1901
Cell Significance Index: 84.0500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1819
Cell Significance Index: 12.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1798
Cell Significance Index: 5.1800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1625
Cell Significance Index: 30.9300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1448
Cell Significance Index: 222.9100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1441
Cell Significance Index: 6.5300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1413
Cell Significance Index: 260.5500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1086
Cell Significance Index: 68.9700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0837
Cell Significance Index: 4.3500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0702
Cell Significance Index: 1.9100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0631
Cell Significance Index: 10.7700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0571
Cell Significance Index: 77.6100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0549
Cell Significance Index: 0.9400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0419
Cell Significance Index: 2.7100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0373
Cell Significance Index: 4.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0264
Cell Significance Index: 11.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0054
Cell Significance Index: 0.1900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0004
Cell Significance Index: 0.0100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0134
Cell Significance Index: -9.8300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0281
Cell Significance Index: -21.2700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0361
Cell Significance Index: -26.7300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0421
Cell Significance Index: -26.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0578
Cell Significance Index: -32.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0641
Cell Significance Index: -3.3400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0912
Cell Significance Index: -1.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0935
Cell Significance Index: -9.5500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1488
Cell Significance Index: -31.3500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1579
Cell Significance Index: -45.4400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1659
Cell Significance Index: -24.1100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1872
Cell Significance Index: -4.0600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2163
Cell Significance Index: -5.5600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2208
Cell Significance Index: -28.5300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2226
Cell Significance Index: -4.7400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2402
Cell Significance Index: -16.9900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2492
Cell Significance Index: -11.7100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2610
Cell Significance Index: -5.5800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2818
Cell Significance Index: -32.8400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3065
Cell Significance Index: -22.8400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3413
Cell Significance Index: -39.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3564
Cell Significance Index: -37.1100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4104
Cell Significance Index: -46.8500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4317
Cell Significance Index: -27.2100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4466
Cell Significance Index: -7.4800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4643
Cell Significance Index: -24.3800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5148
Cell Significance Index: -7.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5308
Cell Significance Index: -17.0000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5419
Cell Significance Index: -13.5500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5568
Cell Significance Index: -44.1000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5645
Cell Significance Index: -12.3600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.6566
Cell Significance Index: -15.1700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6661
Cell Significance Index: -40.8400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.6832
Cell Significance Index: -18.2400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.6953
Cell Significance Index: -18.6300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7130
Cell Significance Index: -12.0100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7285
Cell Significance Index: -9.9400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7352
Cell Significance Index: -6.7700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7532
Cell Significance Index: -21.5000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7537
Cell Significance Index: -11.1300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8891
Cell Significance Index: -29.1100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9095
Cell Significance Index: -23.9200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.9111
Cell Significance Index: -13.7300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9175
Cell Significance Index: -29.2200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0526
Cell Significance Index: -22.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3505749220
Symbol: RBL2_HUMAN
Name: Retinoblastoma-like protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8253383
Title: The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.
PubMed ID: 8253383
PubMed ID: 8253384
Title: Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.
PubMed ID: 8253384
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8361765
Title: Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.
PubMed ID: 8361765
PubMed ID: 8643454
Title: Genomic structure of the human retinoblastoma-related Rb2/p130 gene.
PubMed ID: 8643454
PubMed ID: 11042701
Title: Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells.
PubMed ID: 11042701
PubMed ID: 12450794
Title: Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.
PubMed ID: 12450794
PubMed ID: 12435635
Title: The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).
PubMed ID: 12435635
DOI: 10.1101/gad.1011202
PubMed ID: 16600870
Title: The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
PubMed ID: 16600870
PubMed ID: 17671431
Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.
PubMed ID: 17671431
DOI: 10.4161/cc.6.15.4512
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20485545
Title: JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.
PubMed ID: 20485545
PubMed ID: 22002537
Title: Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.
PubMed ID: 22002537
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 32105419
Title: Biallelic loss-of-function variants in RBL2 in siblings with a neurodevelopmental disorder.
PubMed ID: 32105419
DOI: 10.1002/acn3.50992
PubMed ID: 33980986
Title: RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
PubMed ID: 33980986
PubMed ID: 26237509
Title: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
PubMed ID: 26237509
DOI: 10.1038/nsmb.3063
Sequence Information:
- Length: 1139
- Mass: 128367
- Checksum: D129032FB1F383D4
- Sequence:
MPSGGDQSPP PPPPPPAAAA SDEEEEDDGE AEDAAPPAES PTPQIQQRFD ELCSRLNMDE AARAEAWDSY RSMSESYTLE GNDLHWLACA LYVACRKSVP TVSKGTVEGN YVSLTRILKC SEQSLIEFFN KMKKWEDMAN LPPHFRERTE RLERNFTVSA VIFKKYEPIF QDIFKYPQEE QPRQQRGRKQ RRQPCTVSEI FHFCWVLFIY AKGNFPMISD DLVNSYHLLL CALDLVYGNA LQCSNRKELV NPNFKGLSED FHAKDSKPSS DPPCIIEKLC SLHDGLVLEA KGIKEHFWKP YIRKLYEKKL LKGKEENLTG FLEPGNFGES FKAINKAYEE YVLSVGNLDE RIFLGEDAEE EIGTLSRCLN AGSGTETAER VQMKNILQQH FDKSKALRIS TPLTGVRYIK ENSPCVTPVS TATHSLSRLH TMLTGLRNAP SEKLEQILRT CSRDPTQAIA NRLKEMFEIY SQHFQPDEDF SNCAKEIASK HFRFAEMLYY KVLESVIEQE QKRLGDMDLS GILEQDAFHR SLLACCLEVV TFSYKPPGNF PFITEIFDVP LYHFYKVIEV FIRAEDGLCR EVVKHLNQIE EQILDHLAWK PESPLWEKIR DNENRVPTCE EVMPPQNLER ADEICIAGSP LTPRRVTEVR ADTGGLGRSI TSPTTLYDRY SSPPASTTRR RLFVENDSPS DGGTPGRMPP QPLVNAVPVQ NVSGETVSVT PVPGQTLVTM ATATVTANNG QTVTIPVQGI ANENGGITFF PVQVNVGGQA QAVTGSIQPL SAQALAGSLS SQQVTGTTLQ VPGQVAIQQI SPGGQQQKQG QSVTSSSNRP RKTSSLSLFF RKVYHLAAVR LRDLCAKLDI SDELRKKIWT CFEFSIIQCP ELMMDRHLDQ LLMCAIYVMA KVTKEDKSFQ NIMRCYRTQP QARSQVYRSV LIKGKRKRRN SGSSDSRSHQ NSPTELNKDR TSRDSSPVMR SSSTLPVPQP SSAPPTPTRL TGANSDMEEE ERGDLIQFYN NIYIKQIKTF AMKYSQANMD APPLSPYPFV RTGSPRRIQL SQNHPVYISP HKNETMLSPR EKIFYYFSNS PSKRLREINS MIRTGETPTK KRGILLEDGS ESPAKRICPE NHSALLRRLQ DVANDRGSH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.