Details for: RBMS2

Gene ID: 5939

Symbol: RBMS2

Ensembl ID: ENSG00000076067

Description: RNA binding motif single stranded interacting protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.2978
    Cell Significance Index: -28.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.7210
    Cell Significance Index: -27.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.7845
    Cell Significance Index: -25.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8881
    Cell Significance Index: -28.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5012
    Cell Significance Index: -27.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5582
    Cell Significance Index: -25.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1869
    Cell Significance Index: -28.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.0832
    Cell Significance Index: 73.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.8292
    Cell Significance Index: 39.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8076
    Cell Significance Index: 210.6500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.8067
    Cell Significance Index: 18.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3814
    Cell Significance Index: 262.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3591
    Cell Significance Index: 29.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3164
    Cell Significance Index: 35.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0729
    Cell Significance Index: 20.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.8143
    Cell Significance Index: 4.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7008
    Cell Significance Index: 632.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4685
    Cell Significance Index: 50.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4611
    Cell Significance Index: 75.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4275
    Cell Significance Index: 32.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3074
    Cell Significance Index: 61.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2986
    Cell Significance Index: 107.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2709
    Cell Significance Index: 5.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2683
    Cell Significance Index: 48.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2522
    Cell Significance Index: 31.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2368
    Cell Significance Index: 3.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2368
    Cell Significance Index: 129.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2317
    Cell Significance Index: 45.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2043
    Cell Significance Index: 14.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1960
    Cell Significance Index: 9.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1887
    Cell Significance Index: 25.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1753
    Cell Significance Index: 17.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1663
    Cell Significance Index: 7.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1447
    Cell Significance Index: 266.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1227
    Cell Significance Index: 54.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1092
    Cell Significance Index: 205.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0972
    Cell Significance Index: 149.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0868
    Cell Significance Index: 2.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0797
    Cell Significance Index: 4.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0764
    Cell Significance Index: 34.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0730
    Cell Significance Index: 46.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0031
    Cell Significance Index: 0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0099
    Cell Significance Index: -1.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0127
    Cell Significance Index: -1.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0196
    Cell Significance Index: -2.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0330
    Cell Significance Index: -24.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0368
    Cell Significance Index: -6.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0479
    Cell Significance Index: -27.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0482
    Cell Significance Index: -30.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0738
    Cell Significance Index: -7.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0802
    Cell Significance Index: -23.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1089
    Cell Significance Index: -14.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1357
    Cell Significance Index: -6.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1405
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1416
    Cell Significance Index: -29.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1474
    Cell Significance Index: -3.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1508
    Cell Significance Index: -3.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1599
    Cell Significance Index: -2.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1738
    Cell Significance Index: -18.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1803
    Cell Significance Index: -3.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1814
    Cell Significance Index: -8.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1830
    Cell Significance Index: -13.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1878
    Cell Significance Index: -12.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2029
    Cell Significance Index: -5.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2211
    Cell Significance Index: -7.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2222
    Cell Significance Index: -26.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2266
    Cell Significance Index: -4.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2341
    Cell Significance Index: -16.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2396
    Cell Significance Index: -14.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2908
    Cell Significance Index: -18.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2929
    Cell Significance Index: -23.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3021
    Cell Significance Index: -19.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3246
    Cell Significance Index: -8.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4162
    Cell Significance Index: -18.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4427
    Cell Significance Index: -6.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4640
    Cell Significance Index: -7.7700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4657
    Cell Significance Index: -5.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4796
    Cell Significance Index: -8.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4945
    Cell Significance Index: -7.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4984
    Cell Significance Index: -26.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5043
    Cell Significance Index: -13.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5102
    Cell Significance Index: -4.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5205
    Cell Significance Index: -19.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5246
    Cell Significance Index: -7.8600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5422
    Cell Significance Index: -7.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5535
    Cell Significance Index: -19.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5636
    Cell Significance Index: -16.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5657
    Cell Significance Index: -3.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5718
    Cell Significance Index: -16.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6032
    Cell Significance Index: -7.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6114
    Cell Significance Index: -21.4200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6202
    Cell Significance Index: -10.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6258
    Cell Significance Index: -16.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6261
    Cell Significance Index: -10.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6265
    Cell Significance Index: -9.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6271
    Cell Significance Index: -15.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RBMS2 is a single-stranded RNA-binding protein that interacts with various RNA species, including mRNA, tRNA, and rRNA. Its high affinity for single-stranded RNAs enables it to regulate RNA stability, translation, and processing. RBMS2 is characterized by its unique RNA-binding motif, which allows it to bind to specific sequences within the RNA secondary structure. This protein is highly conserved across species, suggesting its fundamental importance in maintaining cellular homeostasis. **Pathways and Functions:** RBMS2 is involved in multiple cellular pathways, including: 1. **RNA processing:** RBMS2 regulates the processing of RNA, including splicing, editing, and degradation. Its interaction with RNA-binding proteins and other regulatory factors ensures the accurate processing of RNA molecules. 2. **Translation:** RBMS2 modulates translation by binding to specific mRNAs and regulating their translation efficiency. This process is crucial for controlling protein synthesis and cellular metabolism. 3. **Stability:** RBMS2 maintains RNA stability by binding to specific sequences, preventing RNA degradation and promoting its translation. 4. **Ribonucleoprotein complex formation:** RBMS2 interacts with other RNA-binding proteins to form ribonucleoprotein complexes, which regulate RNA processing and translation. **Clinical Significance:** The significant expression of RBMS2 in brain and kidney tissues highlights its potential involvement in neurological and renal disorders. Alterations in RBMS2 expression have been linked to various diseases, including: 1. **Neurological disorders:** Mutations in RBMS2 have been associated with neurological disorders, such as epilepsy and autism spectrum disorder. 2. **Renal disease:** RBMS2 expression is altered in kidney diseases, including diabetic nephropathy and chronic kidney disease. 3. **Cancer:** RBMS2 has been implicated in cancer development and progression, particularly in brain and kidney cancers. In conclusion, RBMS2 is a critical RNA-binding protein that plays a pivotal role in maintaining cellular homeostasis in brain and kidney tissues. Its involvement in RNA processing, translation, and stability regulation highlights its potential as a therapeutic target for various neurological and renal disorders. Further research is needed to fully elucidate the functions and mechanisms of RBMS2, as well as its clinical significance in human diseases.

Genular Protein ID: 3455815926

Symbol: RBMS2_HUMAN

Name: RNA-binding motif, single-stranded-interacting protein 2

UniProtKB Accession Codes:

Q15434

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8041632

Title: SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins.

PubMed ID: 8041632

DOI: 10.1093/nar/22.13.2687

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 407
  • Mass: 43959
  • Checksum: BAFC794E2318BE0A
  • Sequence:
    • MLLSVTSRPG ISTFGYNRNN KKPYVSLAQQ MAPPSPSNST PNSSSGSNGN DQLSKTNLYI 
RGLQPGTTDQ DLVKLCQPYG KIVSTKAILD KTTNKCKGYG FVDFDSPSAA QKAVTALKAS 
GVQAQMAKQQ EQDPTNLYIS NLPLSMDEQE LEGMLKPFGQ VISTRILRDT SGTSRGVGFA 
RMESTEKCEA IITHFNGKYI KTPPGVPAPS DPLLCKFADG GPKKRQNQGK FVQNGRAWPR 
NADMGVMALT YDPTTALQNG FYPAPYNITP NRMLAQSALS PYLSSPVSSY QRVTQTSPLQ 
VPNPSWMHHH SYLMQPSGSV LTPGMDHPIS LQPASMMGPL TQQLGHLSLS STGTYMPTAA 
AMQGAYISQY TPVPSSSVSV EESSGQQNQV AVDAPSEHGV YSFQFNK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.