Details for: RPS10

Gene ID: 6204

Symbol: RPS10

Ensembl ID: ENSG00000124614

Description: ribosomal protein S10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 6.76
    Marker Score: 4614
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 6.15
    Marker Score: 4638
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.19
    Marker Score: 25488
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.58
    Marker Score: 7048
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.54
    Marker Score: 2332
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.48
    Marker Score: 1314.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.37
    Marker Score: 7495
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.35
    Marker Score: 148130
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.28
    Marker Score: 3104
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.14
    Marker Score: 12075
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.09
    Marker Score: 2930
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.03
    Marker Score: 39955
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.97
    Marker Score: 3906
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.96
    Marker Score: 16441
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.94
    Marker Score: 9631.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.93
    Marker Score: 4200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.91
    Marker Score: 10807
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.87
    Marker Score: 52059
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.85
    Marker Score: 2340
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.79
    Marker Score: 4209
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.78
    Marker Score: 1625
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.76
    Marker Score: 22817.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 3.75
    Marker Score: 3669
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.69
    Marker Score: 1903
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.67
    Marker Score: 1354
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.64
    Marker Score: 48015
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.64
    Marker Score: 19131
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.62
    Marker Score: 1177
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.53
    Marker Score: 2032
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.5
    Marker Score: 2256
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.43
    Marker Score: 4462
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.42
    Marker Score: 3421.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.41
    Marker Score: 1903
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.4
    Marker Score: 7717
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.39
    Marker Score: 1908
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.36
    Marker Score: 1074
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.35
    Marker Score: 7624
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.34
    Marker Score: 21287
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.32
    Marker Score: 2795
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.31
    Marker Score: 2355
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.29
    Marker Score: 2574
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.28
    Marker Score: 1640
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.27
    Marker Score: 2781
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 3.26
    Marker Score: 991
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.24
    Marker Score: 1129
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.23
    Marker Score: 3027
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.23
    Marker Score: 2542
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.21
    Marker Score: 1108
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.21
    Marker Score: 2261
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.2
    Marker Score: 5310
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.19
    Marker Score: 12308
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.17
    Marker Score: 20649
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 3.14
    Marker Score: 1793
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.1
    Marker Score: 7571
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.1
    Marker Score: 2432
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.06
    Marker Score: 8205
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.06
    Marker Score: 1843
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.06
    Marker Score: 105901
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.04
    Marker Score: 808
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.04
    Marker Score: 6076
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.03
    Marker Score: 1072
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.03
    Marker Score: 1209
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.02
    Marker Score: 5677
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.02
    Marker Score: 1021
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.99
    Marker Score: 10599.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.98
    Marker Score: 925
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.96
    Marker Score: 3391
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.95
    Marker Score: 18833
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.94
    Marker Score: 4731
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.94
    Marker Score: 22978
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.92
    Marker Score: 2965
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.92
    Marker Score: 4947.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.92
    Marker Score: 2801
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.91
    Marker Score: 922
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.91
    Marker Score: 694
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.89
    Marker Score: 1247
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.87
    Marker Score: 2182
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.86
    Marker Score: 4543
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.85
    Marker Score: 4203
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.85
    Marker Score: 2500.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.84
    Marker Score: 2539.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.84
    Marker Score: 1184
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.84
    Marker Score: 3140
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.83
    Marker Score: 933
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.83
    Marker Score: 931
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.83
    Marker Score: 72356
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.82
    Marker Score: 4993
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.81
    Marker Score: 1064
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.81
    Marker Score: 2393
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.81
    Marker Score: 13465.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.8
    Marker Score: 6588
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.8
    Marker Score: 1278
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.79
    Marker Score: 6286
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.78
    Marker Score: 1253
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.78
    Marker Score: 28191
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.78
    Marker Score: 561
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.77
    Marker Score: 11348
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.77
    Marker Score: 1191
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.77
    Marker Score: 1527
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.75
    Marker Score: 1423

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Other Information

**Key Characteristics:** 1. **Ribosomal protein S10**: RPS10 is a 40S ribosomal protein, which is a crucial component of the 40S ribosomal subunit. 2. **Significant expression**: RPS10 is widely expressed in various cell types, including hepatocytes, hematopoietic stem cells, and immune cells. 3. **Ribosomal biogenesis**: RPS10 plays a key role in the regulation of ribosomal biogenesis, ensuring the proper assembly and maturation of ribosomes. 4. **Translation initiation**: RPS10 is involved in the initiation of translation, facilitating the binding of mRNA to the ribosome and the recognition of start codons. **Pathways and Functions:** 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: RPS10 interacts with the cap-binding complex and eIFs, facilitating the activation of mRNA and the initiation of translation. 2. **Axon guidance**: RPS10 has been implicated in axon guidance, a critical process in neuronal development and regeneration. 3. **Cap-dependent translation initiation**: RPS10 plays a central role in cap-dependent translation initiation, ensuring the accurate translation of mRNAs in response to cap-dependent signals. 4. **Cellular responses to stimuli**: RPS10 is involved in cellular responses to stimuli, such as stress, starvation, and infection, by regulating the translation of specific mRNAs. 5. **GTP hydrolysis and joining of the 60S ribosomal subunit**: RPS10 participates in the joining of the 60S ribosomal subunit to the 40S subunit, a critical step in the assembly of functional ribosomes. **Clinical Significance:** 1. **Infectious diseases**: RPS10 has been implicated in the regulation of translation in response to viral infections, such as influenza and SARS-CoV-2. 2. **Cancer**: Dysregulation of RPS10 has been observed in various cancers, suggesting its potential as a therapeutic target. 3. **Metabolic disorders**: RPS10 plays a key role in the regulation of translation in response to metabolic stress, making it a potential target for the treatment of metabolic disorders. 4. **Neurological disorders**: RPS10 has been implicated in axon guidance and neuronal development, suggesting its potential as a therapeutic target for neurological disorders. In conclusion, RPS10 is a critical component of the 40S ribosomal subunit, playing a pivotal role in the regulation of ribosomal biogenesis, translation initiation, and cellular responses to stress. Its dysregulation has been implicated in multiple diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of RPS10 and its role in maintaining cellular homeostasis.

Genular Protein ID: 2737099941

Symbol: RS10_HUMAN

Name: 40S ribosomal protein S10

UniProtKB Accession Codes:

P46783 B2R4E3 Q5TZC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 54 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 70 PDBsum 69 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20159986

Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

PubMed ID: 20159986

DOI: 10.1074/jbc.m110.103911

PubMed ID: 20116044

Title: Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.

PubMed ID: 20116044

DOI: 10.1016/j.ajhg.2009.12.015

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 36445135

Title: Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs.

PubMed ID: 36445135

DOI: 10.1128/mcb.00265-22

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 165
  • Mass: 18898
  • Checksum: 64106DFCD97AABA3
  • Sequence:
    • MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE 
QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGLE GERPARLTRG 
EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.