Details for: RPS10

Gene ID: 6204

Symbol: RPS10

Ensembl ID: ENSG00000124614

Description: ribosomal protein S10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 447.2899
    Cell Significance Index: -184.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 379.7954
    Cell Significance Index: -179.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 336.8681
    Cell Significance Index: -173.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 267.8898
    Cell Significance Index: -179.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9136
    Cell Significance Index: -66.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 13.3162
    Cell Significance Index: 356.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 9.9335
    Cell Significance Index: 291.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 9.2065
    Cell Significance Index: 235.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 8.4825
    Cell Significance Index: 866.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.6734
    Cell Significance Index: 83.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.3310
    Cell Significance Index: 153.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.2176
    Cell Significance Index: 510.4600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.6995
    Cell Significance Index: 39.3600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.6847
    Cell Significance Index: 56.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.5406
    Cell Significance Index: 307.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.3412
    Cell Significance Index: 50.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 6.2154
    Cell Significance Index: 802.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.1785
    Cell Significance Index: 70.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.1776
    Cell Significance Index: 759.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.1301
    Cell Significance Index: 2710.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.8745
    Cell Significance Index: 103.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.4622
    Cell Significance Index: 189.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.2362
    Cell Significance Index: 150.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.0960
    Cell Significance Index: 699.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.0599
    Cell Significance Index: 377.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.8681
    Cell Significance Index: 877.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.7109
    Cell Significance Index: 603.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0212
    Cell Significance Index: 37.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.4375
    Cell Significance Index: 340.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3813
    Cell Significance Index: 1846.6000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.3701
    Cell Significance Index: 20.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3455
    Cell Significance Index: 215.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1298
    Cell Significance Index: 85.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.6723
    Cell Significance Index: 61.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.1849
    Cell Significance Index: 373.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7881
    Cell Significance Index: 1614.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2738
    Cell Significance Index: 59.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9253
    Cell Significance Index: 106.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.9130
    Cell Significance Index: 691.0400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7227
    Cell Significance Index: 6.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6228
    Cell Significance Index: 118.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4803
    Cell Significance Index: 12.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2012
    Cell Significance Index: 23.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0448
    Cell Significance Index: 32.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0358
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0367
    Cell Significance Index: -22.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0557
    Cell Significance Index: -1.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0735
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0757
    Cell Significance Index: -56.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0803
    Cell Significance Index: -151.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1138
    Cell Significance Index: -64.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1168
    Cell Significance Index: -4.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1176
    Cell Significance Index: -216.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1403
    Cell Significance Index: -215.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1780
    Cell Significance Index: -241.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2003
    Cell Significance Index: -9.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2517
    Cell Significance Index: -159.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3666
    Cell Significance Index: -131.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3788
    Cell Significance Index: -79.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3837
    Cell Significance Index: -174.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4799
    Cell Significance Index: -138.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4945
    Cell Significance Index: -25.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5509
    Cell Significance Index: -14.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6765
    Cell Significance Index: -135.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7159
    Cell Significance Index: -22.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9061
    Cell Significance Index: -15.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.9388
    Cell Significance Index: -186.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1664
    Cell Significance Index: -133.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.2253
    Cell Significance Index: -178.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2379
    Cell Significance Index: -65.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2605
    Cell Significance Index: -70.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2644
    Cell Significance Index: -79.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.3470
    Cell Significance Index: -93.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4006
    Cell Significance Index: -23.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4083
    Cell Significance Index: -111.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.6823
    Cell Significance Index: -59.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.8075
    Cell Significance Index: -188.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.0467
    Cell Significance Index: -122.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.0942
    Cell Significance Index: -31.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.2965
    Cell Significance Index: -140.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4583
    Cell Significance Index: -188.6500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -2.4930
    Cell Significance Index: -15.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.5327
    Cell Significance Index: -63.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.8955
    Cell Significance Index: -62.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -2.9065
    Cell Significance Index: -42.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.9576
    Cell Significance Index: -198.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.3701
    Cell Significance Index: -45.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.4810
    Cell Significance Index: -102.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -3.8738
    Cell Significance Index: -103.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -4.0194
    Cell Significance Index: -74.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.0676
    Cell Significance Index: -149.3200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -4.0867
    Cell Significance Index: -85.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -4.4146
    Cell Significance Index: -45.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.7567
    Cell Significance Index: -122.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -4.8610
    Cell Significance Index: -121.4100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.0662
    Cell Significance Index: -78.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -6.0864
    Cell Significance Index: -199.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -6.4270
    Cell Significance Index: -225.1500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -6.4921
    Cell Significance Index: -61.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.5209
    Cell Significance Index: -111.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal protein S10**: RPS10 is a 40S ribosomal protein, which is a crucial component of the 40S ribosomal subunit. 2. **Significant expression**: RPS10 is widely expressed in various cell types, including hepatocytes, hematopoietic stem cells, and immune cells. 3. **Ribosomal biogenesis**: RPS10 plays a key role in the regulation of ribosomal biogenesis, ensuring the proper assembly and maturation of ribosomes. 4. **Translation initiation**: RPS10 is involved in the initiation of translation, facilitating the binding of mRNA to the ribosome and the recognition of start codons. **Pathways and Functions:** 1. **Activation of mRNA upon binding of the cap-binding complex and eIFs**: RPS10 interacts with the cap-binding complex and eIFs, facilitating the activation of mRNA and the initiation of translation. 2. **Axon guidance**: RPS10 has been implicated in axon guidance, a critical process in neuronal development and regeneration. 3. **Cap-dependent translation initiation**: RPS10 plays a central role in cap-dependent translation initiation, ensuring the accurate translation of mRNAs in response to cap-dependent signals. 4. **Cellular responses to stimuli**: RPS10 is involved in cellular responses to stimuli, such as stress, starvation, and infection, by regulating the translation of specific mRNAs. 5. **GTP hydrolysis and joining of the 60S ribosomal subunit**: RPS10 participates in the joining of the 60S ribosomal subunit to the 40S subunit, a critical step in the assembly of functional ribosomes. **Clinical Significance:** 1. **Infectious diseases**: RPS10 has been implicated in the regulation of translation in response to viral infections, such as influenza and SARS-CoV-2. 2. **Cancer**: Dysregulation of RPS10 has been observed in various cancers, suggesting its potential as a therapeutic target. 3. **Metabolic disorders**: RPS10 plays a key role in the regulation of translation in response to metabolic stress, making it a potential target for the treatment of metabolic disorders. 4. **Neurological disorders**: RPS10 has been implicated in axon guidance and neuronal development, suggesting its potential as a therapeutic target for neurological disorders. In conclusion, RPS10 is a critical component of the 40S ribosomal subunit, playing a pivotal role in the regulation of ribosomal biogenesis, translation initiation, and cellular responses to stress. Its dysregulation has been implicated in multiple diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms of RPS10 and its role in maintaining cellular homeostasis.

Genular Protein ID: 2737099941

Symbol: RS10_HUMAN

Name: 40S ribosomal protein S10

UniProtKB Accession Codes:

P46783 B2R4E3 Q5TZC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 67 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 84 PDBsum 84 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20159986

Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

PubMed ID: 20159986

DOI: 10.1074/jbc.m110.103911

PubMed ID: 20116044

Title: Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.

PubMed ID: 20116044

DOI: 10.1016/j.ajhg.2009.12.015

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 36445135

Title: Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs.

PubMed ID: 36445135

DOI: 10.1128/mcb.00265-22

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

  • Length: 165
  • Mass: 18898
  • Checksum: 64106DFCD97AABA3
  • Sequence:
    • MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE 
QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGLE GERPARLTRG 
EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.