RPS10 | ENSG00000124614 | NCBI 6204

Details for: RPS10

Gene ID: 6204

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPS10

Ensembl ID: ENSG00000124614

Description: ribosomal protein S10

Cell Significance Landscape

Display Count:

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

neural crest cell CL0011012

CSI 103.51

rCSI 81.81%

PRS 2.09
keratinocyte CL0000312

CSI 92.43

rCSI 77.48%

PRS 3.63
intestinal epithelial cell CL0002563

CSI 86.01

rCSI 89.9%

PRS 3.22
epithelial cell of lower respiratory tract CL0002632

CSI 83.29

rCSI 64.57%

PRS 2.87
epithelial cell of lung CL0000082

CSI 80.95

rCSI 67.11%

PRS 2.82
early lymphoid progenitor CL0000936

CSI 75.21

rCSI 66.06%

PRS 3.37
activated type II NK T cell CL0000931

CSI 68.4

rCSI 76.99%

PRS 5.1
granulocyte monocyte progenitor cell CL0000557

CSI 66.94

rCSI 57.96%

PRS 3.37
transit amplifying cell of colon CL0009011

CSI 62.06

rCSI 72.89%

PRS 3.69
ciliated epithelial cell CL0000067

CSI 60.54

rCSI 53.24%

PRS 2.19
myeloid leukocyte CL0000766

CSI 56.75

rCSI 52.36%

PRS 3.05
hematopoietic stem cell CL0000037

CSI 55.83

rCSI 37.11%

PRS 3.59
mature T cell CL0002419

CSI 52.59

rCSI 40.91%

PRS 4.37
mesodermal cell CL0000222

CSI 52.55

rCSI 63.08%

PRS 3.01
common myeloid progenitor CL0000049

CSI 51.87

rCSI 41.94%

PRS 2.95
enteric smooth muscle cell CL0002504

CSI 51.62

rCSI 73.66%

PRS 3.45
peripheral nervous system neuron CL2000032

CSI 51.11

rCSI 69.64%

PRS 2.73
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 46.81

rCSI 54.06%

PRS 2.79
radial glial cell CL0000681

CSI 41.07

rCSI 57.06%

PRS 3.21
neuroblast (sensu Vertebrata) CL0000031

CSI 40.75

rCSI 52.29%

PRS 3.02
CD4-positive, alpha-beta thymocyte CL0000810

CSI 40.14

rCSI 32.15%

PRS 5.65
common dendritic progenitor CL0001029

CSI 39.06

rCSI 49.02%

PRS 3.82
mucous neck cell CL0000651

CSI 36.48

rCSI 52.58%

PRS 4.91
pancreatic D cell CL0000173

CSI 35

rCSI 34.43%

PRS 3.34
megakaryocyte-erythroid progenitor cell CL0000050

CSI 33.86

rCSI 30.58%

PRS 2.65
pancreatic acinar cell CL0002064

CSI 32.96

rCSI 43.81%

PRS 3.31
pro-B cell CL0000826

CSI 31.48

rCSI 26.07%

PRS 3.01
stromal cell of ovary CL0002132

CSI 31.14

rCSI 85.56%

PRS 5.11
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 31.1

rCSI 30.55%

PRS 4.85
colon goblet cell CL0009039

CSI 31.07

rCSI 73.86%

PRS 4.62
fallopian tube secretory epithelial cell CL4030006

CSI 31.04

rCSI 29.88%

PRS 3.14
common lymphoid progenitor CL0000051

CSI 30.82

rCSI 41.18%

PRS 5.77
promyelocyte CL0000836

CSI 30.3

rCSI 43.71%

PRS 4.18
group 3 innate lymphoid cell CL0001071

CSI 30.2

rCSI 22.69%

PRS 3.1
glioblast CL0000030

CSI 30.11

rCSI 48.04%

PRS 2.65
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 29.73

rCSI 37.36%

PRS 16.45
fibroblast of lung CL0002553

CSI 28.88

rCSI 26.87%

PRS 3
CD1c-positive myeloid dendritic cell CL0002399

CSI 28.73

rCSI 34.7%

PRS 3.48
conventional dendritic cell CL0000990

CSI 28.6

rCSI 23.87%

PRS 10
interstitial cell of Cajal CL0002088

CSI 28.25

rCSI 35.95%

PRS 3.53
elicited macrophage CL0000861

CSI 28.21

rCSI 25.9%

PRS 3.43
class switched memory B cell CL0000972

CSI 27.46

rCSI 20.5%

PRS 5.1
mature NK T cell CL0000814

CSI 27.39

rCSI 35.03%

PRS 14.04
CD4-positive helper T cell CL0000492

CSI 27.27

rCSI 20.63%

PRS 4.22
alveolar type 1 fibroblast cell CL4028004

CSI 27.24

rCSI 29.84%

PRS 3.52
extravillous trophoblast CL0008036

CSI 26.91

rCSI 33.29%

PRS 2.65
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 26.59

rCSI 18.67%

PRS 9.16
acinar cell CL0000622

CSI 26.33

rCSI 38.62%

PRS 4
placental villous trophoblast CL2000060

CSI 26.25

rCSI 40.56%

PRS 2.83
goblet cell CL0000160

CSI 26.07

rCSI 24.64%

PRS 3.15
bronchus fibroblast of lung CL2000093

CSI 25.83

rCSI 20.98%

PRS 3.16
respiratory hillock cell CL4030023

CSI 25.59

rCSI 45.63%

PRS 5.24
transitional stage B cell CL0000818

CSI 25.35

rCSI 82.99%

PRS 9.54
myofibroblast cell CL0000186

CSI 25.35

rCSI 35.11%

PRS 4.35
enteroendocrine cell CL0000164

CSI 25.01

rCSI 34.18%

PRS 3.34
enterocyte CL0000584

CSI 24.88

rCSI 40.11%

PRS 4.91
skin fibroblast CL0002620

CSI 24.86

rCSI 21.43%

PRS 5.04
progenitor cell CL0011026

CSI 24.42

rCSI 51.94%

PRS 6.01
basal cell of prostate epithelium CL0002341

CSI 24.41

rCSI 70.63%

PRS 6.67
microcirculation associated smooth muscle cell CL0008035

CSI 24.19

rCSI 70.03%

PRS 3.43
follicular B cell CL0000843

CSI 24.07

rCSI 87.49%

PRS 15.79
plasmablast CL0000980

CSI 23.63

rCSI 18.59%

PRS 3.58
intestinal crypt stem cell of small intestine CL0009017

CSI 23.38

rCSI 63.02%

PRS 3.97
conjunctival epithelial cell CL1000432

CSI 22.27

rCSI 34.01%

PRS 3.05
CD8-positive, alpha-beta thymocyte CL0000811

CSI 21.65

rCSI 33.75%

PRS 7.86
renal alpha-intercalated cell CL0005011

CSI 21.57

rCSI 28.84%

PRS 4.11
B cell CL0000236

CSI 21.55

rCSI 28.83%

PRS 18.25
alveolar adventitial fibroblast CL4028006

CSI 21.54

rCSI 34.02%

PRS 3.03
pancreatic ductal cell CL0002079

CSI 21.5

rCSI 41.81%

PRS 3.08
CD4-positive, alpha-beta T cell CL0000624

CSI 21.23

rCSI 27.17%

PRS 60.15
epithelial cell CL0000066

CSI 21.21

rCSI 32.6%

PRS 4.39
perivascular cell CL4033054

CSI 21.18

rCSI 28.96%

PRS 3.44
tendon cell CL0000388

CSI 20.79

rCSI 54.02%

PRS 9.53
luminal epithelial cell of mammary gland CL0002326

CSI 20.39

rCSI 37.05%

PRS 4.64
melanocyte CL0000148

CSI 20.26

rCSI 15.01%

PRS 2.86
CD14-positive, CD16-positive monocyte CL0002397

CSI 20.17

rCSI 26.43%

PRS 4.21
M cell of gut CL0000682

CSI 20.11

rCSI 21.37%

PRS 5.44
Hofbauer cell CL3000001

CSI 19.8

rCSI 37.38%

PRS 3.75
intraepithelial lymphocyte CL0002496

CSI 19.6

rCSI 53.34%

PRS 14.96
endothelial cell of artery CL1000413

CSI 19.54

rCSI 28.63%

PRS 18.63
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 19.15

rCSI 22.87%

PRS 5.28
non-classical monocyte CL0000875

CSI 19.06

rCSI 30.56%

PRS 10.07
fraction A pre-pro B cell CL0002045

CSI 19.05

rCSI 21.8%

PRS 6.28
intestine goblet cell CL0019031

CSI 18.95

rCSI 16.82%

PRS 3.02
kidney epithelial cell CL0002518

CSI 18.56

rCSI 35.43%

PRS 7.47
muscle cell CL0000187

CSI 18.21

rCSI 37.39%

PRS 7.39
blood vessel endothelial cell CL0000071

CSI 18.09

rCSI 37.53%

PRS 3.01
helper T cell CL0000912

CSI 17.93

rCSI 25.35%

PRS 4.65
retinal blood vessel endothelial cell CL0002585

CSI 17.84

rCSI 28.5%

PRS 3.3
precursor B cell CL0000817

CSI 17.83

rCSI 15.62%

PRS 4.07
mammary gland epithelial cell CL0002327

CSI 17.71

rCSI 62.13%

PRS 5.49
memory B cell CL0000787

CSI 17.33

rCSI 17.11%

PRS 13.38
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 17.32

rCSI 10.23%

PRS 4.21
plasma cell CL0000786

CSI 17.21

rCSI 22.56%

PRS 16.46
plasmacytoid dendritic cell CL0000784

CSI 17.09

rCSI 17.31%

PRS 20
dendritic cell CL0000451

CSI 17

rCSI 20.95%

PRS 10.07
classical monocyte CL0000860

CSI 16.94

rCSI 25.11%

PRS 35.38
gamma-delta T cell CL0000798

CSI 16.68

rCSI 19.59%

PRS 30.02
lung ciliated cell CL1000271

CSI 16.63

rCSI 19.22%

PRS 2.19
promonocyte CL0000559

CSI 16.55

rCSI 28.35%

PRS 4.02

pulmonary capillary endothelial cell CL4028001

CSI -46.5

rCSI -88.7%

PRS 4.9%
rod bipolar cell CL0000751

CSI -39.2

rCSI -70.4%

PRS 2.6%
kidney collecting duct principal cell CL1001431

CSI -19.7

rCSI -99.2%

PRS 19.7%
pulmonary ionocyte CL0017000

CSI -15.8

rCSI -19.2%

PRS 3.8%
cerebral cortex neuron CL0010012

CSI -15.6

rCSI -63.5%

PRS 3.9%
neural cell CL0002319

CSI -13.8

rCSI -51.9%

PRS 6.9%
duct epithelial cell CL0000068

CSI -10.9

rCSI -16.0%

PRS 3.2%
platelet CL0000233

CSI -10.1

rCSI -42.0%

PRS 9.4%
kidney collecting duct intercalated cell CL1001432

CSI -6.3

rCSI -44.9%

PRS 13.2%
brush cell CL0002204

CSI -4.9

rCSI -9.6%

PRS 8.9%
alpha-beta T cell CL0000789

CSI -4.7

rCSI -5.5%

PRS 5.0%
diffuse bipolar 6 cell CL4033032

CSI -4.2

rCSI -21.9%

PRS 7.7%
endocrine cell CL0000163

CSI -4.0

rCSI -20.3%

PRS 14.7%
Schwann cell CL0002573

CSI -3.3

rCSI -9.4%

PRS 4.2%
endothelial cell of arteriole CL1000412

CSI -3.0

rCSI -16.5%

PRS 15.9%
alternatively activated macrophage CL0000890

CSI -2.9

rCSI -3.7%

PRS 4.6%
serous secreting cell CL0000313

CSI -2.3

rCSI -11.5%

PRS 16.0%
cord blood hematopoietic stem cell CL2000095

CSI -2.0

rCSI -37.9%

PRS 26.2%
adipocyte CL0000136

CSI -1.8

rCSI -2.3%

PRS 4.0%
OFF midget ganglion cell CL4033047

CSI -1.7

rCSI -33.7%

PRS 3.7%
enteroglial cell CL4040002

CSI -1.6

rCSI -8.6%

PRS 7.9%
ON-bipolar cell CL0000749

CSI -1.6

rCSI -2.3%

PRS 4.0%
primordial germ cell CL0000670

CSI -1.5

rCSI -7.4%

PRS 23.8%
H2 horizontal cell CL0004218

CSI -1.4

rCSI -7.2%

PRS 5.4%
H1 horizontal cell CL0004217

CSI -1.4

rCSI -5.7%

PRS 7.7%
glycinergic amacrine cell CL4030028

CSI -1.4

rCSI -3.7%

PRS 4.4%
microglial cell CL0000129

CSI -1.2

rCSI -4.9%

PRS 15.0%
erythroid lineage cell CL0000764

CSI -0.9

rCSI -5.9%

PRS 8.5%
cone retinal bipolar cell CL0000752

CSI -0.9

rCSI -11.7%

PRS 19.9%
cell of skeletal muscle CL0000188

CSI -0.8

rCSI -8.3%

PRS 22.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI -0.5

rCSI -4.5%

PRS 8.4%
respiratory epithelial cell CL0002368

CSI -0.1

rCSI -0.5%

PRS 10.2%
kidney distal convoluted tubule epithelial cell CL1000849

CSI -0.1

rCSI -0.9%

PRS 5.4%
cardiac endothelial cell CL0010008

CSI 0.3

rCSI 1.1%

PRS 3.5%
enterocyte of epithelium of large intestine CL0002071

CSI 0.3

rCSI 1.6%

PRS 6.4%
basal cell of epithelium of trachea CL1000348

CSI 0.3

rCSI 2.3%

PRS 10.0%
cerebellar granule cell CL0001031

CSI 0.4

rCSI 0.6%

PRS 3.2%
group 3 innate lymphoid cell, human CL0001078

CSI 0.4

rCSI 8.2%

PRS 54.9%
forebrain neuroblast CL1000042

CSI 0.5

rCSI 5.3%

PRS 41.1%
amacrine cell CL0000561

CSI 0.5

rCSI 1.4%

PRS 2.7%
kidney resident macrophage CL1000698

CSI 0.6

rCSI 11.6%

PRS 63.5%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.6

rCSI 7.2%

PRS 13.3%
osteoblast CL0000062

CSI 0.6

rCSI 15.8%

PRS 29.5%
mesangial cell CL0000650

CSI 0.7

rCSI 2.7%

PRS 5.6%
large pre-B-II cell CL0000957

CSI 0.7

rCSI 2.0%

PRS 5.4%
squamous epithelial cell CL0000076

CSI 0.7

rCSI 1.7%

PRS 4.1%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 0.8

rCSI 2.0%

PRS 11.2%
neuroendocrine cell CL0000165

CSI 0.8

rCSI 3.1%

PRS 6.6%
neural progenitor cell CL0011020

CSI 0.8

rCSI 3.6%

PRS 3.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.9

rCSI 1.6%

PRS 1.9%
Bergmann glial cell CL0000644

CSI 1.0

rCSI 1.4%

PRS 3.4%
retinal ganglion cell CL0000740

CSI 1.1

rCSI 2.3%

PRS 2.2%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.1

rCSI 1.1%

PRS 4.4%
tracheal goblet cell CL1000329

CSI 1.1

rCSI 2.5%

PRS 6.2%
retinal pigment epithelial cell CL0002586

CSI 1.3

rCSI 2.6%

PRS 3.4%
B-1 B cell CL0000819

CSI 1.4

rCSI 35.5%

PRS 18.4%
professional antigen presenting cell CL0000145

CSI 1.4

rCSI 4.8%

PRS 14.3%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 1.4

rCSI 43.8%

PRS 39.9%
B-2 B cell CL0000822

CSI 1.5

rCSI 30.7%

PRS 19.7%
myoepithelial cell CL0000185

CSI 1.5

rCSI 3.8%

PRS 3.8%
lung pericyte CL0009089

CSI 1.6

rCSI 4.1%

PRS 3.6%
germinal center B cell CL0000844

CSI 1.6

rCSI 4.8%

PRS 8.3%
eosinophil CL0000771

CSI 1.6

rCSI 10.7%

PRS 8.0%
lung microvascular endothelial cell CL2000016

CSI 1.8

rCSI 34.8%

PRS 11.2%
regular atrial cardiac myocyte CL0002129

CSI 1.9

rCSI 6.0%

PRS 3.8%
parietal cell CL0000162

CSI 2.0

rCSI 17.0%

PRS 21.7%
podocyte CL0000653

CSI 2.0

rCSI 8.8%

PRS 3.1%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 2.1

rCSI 11.7%

PRS 17.8%
mesenchymal lymphangioblast CL0005021

CSI 2.1

rCSI 55.2%

PRS 17.2%
blood vessel smooth muscle cell CL0019018

CSI 2.2

rCSI 17.5%

PRS 3.2%
endothelial cell of venule CL1000414

CSI 2.2

rCSI 19.2%

PRS 20.0%
P/D1 enteroendocrine cell CL0002268

CSI 2.2

rCSI 12.2%

PRS 7.9%
stratified epithelial cell CL0000079

CSI 2.3

rCSI 14.4%

PRS 15.9%
bronchiolar smooth muscle cell CL4033017

CSI 2.4

rCSI 36.3%

PRS 10.2%
decidual natural killer cell, human CL0002343

CSI 2.4

rCSI 24.6%

PRS 29.1%
corneal epithelial cell CL0000575

CSI 2.4

rCSI 6.9%

PRS 6.0%
pluripotent stem cell CL0002248

CSI 2.5

rCSI 73.4%

PRS 7.5%
tissue-resident macrophage CL0000864

CSI 2.5

rCSI 11.5%

PRS 8.7%
unswitched memory B cell CL0000970

CSI 2.5

rCSI 2.1%

PRS 5.1%
mesenchymal stem cell CL0000134

CSI 2.6

rCSI 28.5%

PRS 5.6%
tuft cell of colon CL0009041

CSI 2.7

rCSI 6.2%

PRS 7.6%
renal intercalated cell CL0005010

CSI 2.7

rCSI 23.9%

PRS 29.7%
epithelial cell of nephron CL1000449

CSI 2.7

rCSI 25.8%

PRS 14.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.8

rCSI 13.9%

PRS 4.0%
adventitial cell CL0002503

CSI 2.8

rCSI 6.7%

PRS 4.9%
neuroplacodal cell CL0000032

CSI 2.8

rCSI 26.2%

PRS 12.1%
odontoblast CL0000060

CSI 2.9

rCSI 64.5%

PRS 18.1%
retinal cone cell CL0000573

CSI 2.9

rCSI 4.7%

PRS 2.4%
Cajal-Retzius cell CL0000695

CSI 2.9

rCSI 23.1%

PRS 7.4%
Merkel cell CL0000242

CSI 3.0

rCSI 68.5%

PRS 22.9%
vasa recta ascending limb cell CL1001131

CSI 3.0

rCSI 13.6%

PRS 14.7%
enterocyte of epithelium of small intestine CL1000334

CSI 3.2

rCSI 49.3%

PRS 8.2%
intestinal tuft cell CL0019032

CSI 3.2

rCSI 4.9%

PRS 3.5%
mature B cell CL0000785

CSI 3.3

rCSI 2.8%

PRS 3.7%
centrilobular region hepatocyte CL0019029

CSI 3.3

rCSI 8.6%

PRS 5.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.3

rCSI 8.6%

PRS 2.9%
group 2 innate lymphoid cell CL0001069

CSI 3.4

rCSI 18.2%

PRS 10.7%
epithelial cell of urethra CL1000296

CSI 3.4

rCSI 86.2%

PRS 10.8%
periportal region hepatocyte CL0019026

CSI 3.5

rCSI 13.5%

PRS 5.2%
prostate gland microvascular endothelial cell CL2000059

CSI 3.6

rCSI 85.0%

PRS 11.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPS10](/details-gene/6204) encodes ribosomal protein S10, a fundamental component of the 40S small ribosomal subunit. As an integral part of the cell's protein synthesis machinery, its primary function is to provide structural integrity to the ribosome and participate in the process of translation. Consistent with this ubiquitous and essential role, [RPS10](/details-gene/6204) shows high expression in cell types characterized by rapid proliferation, high metabolic activity, and extensive protein production. These include progenitor populations such as [neural crest cell](/details-cell/CL0011012) and hematopoietic progenitors, as well as cells forming active barrier tissues like [keratinocyte](/details-cell/CL0000312)s and various intestinal and respiratory epithelial cells. Clinically, mutations in the [RPS10](/details-gene/6204) gene are implicated in Diamond-Blackfan anemia, a ribosomopathy characterized by a failure of erythroid progenitor development ([Link](https://doi.org/10.1016/j.ajhg.2009.12.015)). ## Cellular Roles and Expression Landscape The expression profile of [RPS10](/details-gene/6204) underscores its critical role in cellular growth, differentiation, and maintenance. **Overall**, its significance is highest in populations of highly proliferative or biosynthetically active cells. This is evidenced by its top ranking in developmentally crucial [neural crest cell](/details-cell/CL0011012)s (CSI: 103.51) and in cells maintaining protective barriers, such as [keratinocyte](/details-cell/CL0000312) (CSI: 92.43), [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 86.01), and [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 83.29). Furthermore, its high significance in various progenitor lineages, including [early lymphoid progenitor](/details-cell/CL0000936), [granulocyte monocyte progenitor cell](/details-cell/CL0000557), and [hematopoietic stem cell](/details-cell/CL0000037), highlights the necessity of robust translational capacity for lineage commitment and expansion. Conversely, [RPS10](/details-gene/6204) expression is significantly lower in terminally differentiated or metabolically quiescent cells. Its status as an anti-marker in cell types like [pulmonary capillary endothelial cell](/details-cell/CL4028001) (CSI: -46.53), specialized retinal neurons such as [rod bipolar cell](/details-cell/CL0000751) (CSI: -39.16), and [cerebral cortex neuron](/details-cell/CL0010012) (CSI: -15.57) suggests that once cells reach a mature, stable state, the requirement for high-level ribosome biogenesis diminishes relative to actively dividing or secreting cells. The low significance in anucleated [platelet](/details-cell/CL0000233)s (CSI: -10.12) is also consistent with their lack of translational machinery. This expression pattern defines [RPS10](/details-gene/6204) as a workhorse gene whose activity is tightly coupled to a cell's proliferative and biosynthetic demands. ## Pathways and Molecular Function Functionally, [RPS10](/details-gene/6204) is annotated as a core '[structural constituent of ribosome](/details-ontology/GO:0003735)' and is central to '[cytoplasmic translation](/details-ontology/GO:0002181)'. Its involvement is critical across all major phases of protein synthesis, as detailed in Reactome pathways such as '[Eukaryotic translation initiation](/details-ontology/R-HSA-72613)', '[Peptide chain elongation](/details-ontology/R-HSA-156902)', and '[Eukaryotic translation termination](/details-ontology/R-HSA-72764)'. The gene's function extends to ribosome biogenesis itself, as seen in its role in '[Major pathway of rrna processing in the nucleolus and cytosol](/details-ontology/R-HSA-6791226)', a process that can be regulated by post-translational modifications ([Link](https://doi.org/10.1074/jbc.m110.103911)). Beyond this fundamental role, [RPS10](/details-gene/6204) is implicated in broader biological contexts that rely on precise control of protein synthesis. These include '[Developmental biology](/details-ontology/R-HSA-1266738)' and '[Nervous system development](/details-ontology/R-HSA-9675108)', aligning with its high expression in progenitor cells. The translational machinery, including [RPS10](/details-gene/6204), is also a key interface for host-pathogen interactions. Its involvement in pathways like '[Viral mrna translation](/details-ontology/R-HSA-192823)', specifically related to '[Influenza infection](/details-ontology/R-HSA-168255)' and '[Sars-cov-2 infection](/details-ontology/R-HSA-9694516)', indicates that it is part of the host apparatus co-opted by viruses for their replication. It also participates in ribosome-associated quality control mechanisms, which clear stalled ribosomes ([Link](https://doi.org/10.1016/j.molcel.2016.12.026), [Link](https://doi.org/10.1016/j.molcel.2019.12.024)). ## Research Directions The central role of [RPS10](/details-gene/6204) in translation makes it a critical gene for cellular homeostasis, and its dysregulation is directly linked to human disease. The established connection between [RPS10](/details-gene/6204) mutations and Diamond-Blackfan anemia (DBA), a congenital bone marrow failure syndrome, provides a clear avenue for further investigation into the pathogenesis of ribosomopathies. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis:** Haploinsufficiency of [RPS10](/details-gene/6204) leads to lineage-specific defects in hematopoiesis not solely due to reduced translational capacity, but through the induction of ribosomal stress and p53-mediated apoptosis, to which erythroid progenitors are uniquely sensitive. 2. **Hypothesis:** The efficiency of viral replication, particularly for RNA viruses like SARS-CoV-2 and Influenza, is dependent on the post-translational modification status (e.g., ubiquitination or methylation) of [RPS10](/details-gene/6204), which may alter the ribosome's affinity for viral IRES elements or cap-dependent translation machinery. A key experiment to test the first hypothesis would be to use CRISPR-Cas9 to generate heterozygous knockouts of [RPS10](/details-gene/6204) in human CD34+ hematopoietic stem and progenitor cells. These engineered cells could then be differentiated in vitro towards erythroid, myeloid, and lymphoid lineages. The experimental readouts would include quantification of proliferation rates, apoptosis (via Annexin V/PI staining), and cell cycle arrest at different stages of differentiation for each lineage. Concurrently, activation of the p53 pathway could be measured via Western blot analysis for total and phosphorylated p53, as well as its downstream targets like p21. This would directly assess whether [RPS10](/details-gene/6204) haploinsufficiency disproportionately affects erythroid development and clarify the role of the p53 stress-response pathway. **Therapeutic Potential:** As an essential and ubiquitously expressed housekeeping gene, [RPS10](/details-gene/6204) is not a suitable target for systemic inhibition, as this would be universally toxic. However, understanding its role in the pathophysiology of DBA could inform therapeutic strategies aimed at mitigating the effects of its haploinsufficiency, such as approaches to stabilize the ribosome or inhibit downstream stress pathways (e.g., p53 inhibition) specifically in hematopoietic progenitors. In the context of cancer, where ribosome biogenesis is often upregulated, targeting this process is a valid strategy. While directly targeting [RPS10](/details-gene/6204) is impractical, modulating the activity of enzymes that modify it, such as PRMT5 which methylates RPS10 ([Link](https://doi.org/10.1074/jbc.m110.103911)), could offer a more specific therapeutic window.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S10

Genular Protein ID: 2737099941

Symbol: RS10_HUMAN

Name: 40S ribosomal protein S10

UniProtKB Accession Codes:

P46783 B2R4E3 Q5TZC0

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 20159986

Title: Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

PubMed ID: 20159986

DOI: 10.1074/jbc.m110.103911

PubMed ID: 20116044

Title: Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia.

PubMed ID: 20116044

DOI: 10.1016/j.ajhg.2009.12.015

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 28065601

Title: Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination.

PubMed ID: 28065601

DOI: 10.1016/j.molcel.2016.11.039

PubMed ID: 28132843

Title: ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation.

PubMed ID: 28132843

DOI: 10.1016/j.molcel.2016.12.026

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 32011234

Title: Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized.

PubMed ID: 32011234

DOI: 10.7554/elife.54023

PubMed ID: 31981475

Title: The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation.

PubMed ID: 31981475

DOI: 10.1016/j.molcel.2019.12.024

PubMed ID: 36445135

Title: Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs.

PubMed ID: 36445135

DOI: 10.1128/mcb.00265-22

PubMed ID: 36302773

Title: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

PubMed ID: 36302773

DOI: 10.1038/s41467-022-34097-9

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

Sequence Information:

Length: 165
Mass: 18898
Checksum: 64106DFCD97AABA3
Sequence:

MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE 
QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGLE GERPARLTRG 
EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ

Details for: RPS10

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. PubMed ID: 7772601

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis. PubMed ID: 20159986

Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. PubMed ID: 20116044

A new system for naming ribosomal proteins. PubMed ID: 24524803

Initiation of quality control during poly(A) translation requires site-specific ribosome ubiquitination. PubMed ID: 28065601

ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. PubMed ID: 28132843

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. PubMed ID: 28685749

Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized. PubMed ID: 32011234

The G3BP1-family-USP10 deubiquitinase complex rescues ubiquitinated 40S subunits of ribosomes stalled in translation from lysosomal degradation. PubMed ID: 31981475

Deubiquitinase OTUD1 resolves stalled translation on polyA and rare codon rich mRNAs. PubMed ID: 36445135

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. PubMed ID: 36302773

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399