Details for: RRM1

Gene ID: 6240

Symbol: RRM1

Ensembl ID: ENSG00000167325

Description: ribonucleotide reductase catalytic subunit M1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.3163
    Cell Significance Index: -24.4300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.0340
    Cell Significance Index: -12.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.8695
    Cell Significance Index: -29.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.1743
    Cell Significance Index: -24.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4624
    Cell Significance Index: -24.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.7202
    Cell Significance Index: -26.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1125
    Cell Significance Index: -27.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2275
    Cell Significance Index: -28.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0072
    Cell Significance Index: -8.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4385
    Cell Significance Index: 396.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3498
    Cell Significance Index: 32.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4727
    Cell Significance Index: 171.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1011
    Cell Significance Index: 129.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.0819
    Cell Significance Index: 27.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9704
    Cell Significance Index: 10.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8728
    Cell Significance Index: 30.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7031
    Cell Significance Index: 310.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6656
    Cell Significance Index: 37.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5950
    Cell Significance Index: 15.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5378
    Cell Significance Index: 14.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5177
    Cell Significance Index: 467.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5085
    Cell Significance Index: 62.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4809
    Cell Significance Index: 34.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4790
    Cell Significance Index: 33.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4772
    Cell Significance Index: 94.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4192
    Cell Significance Index: 13.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4160
    Cell Significance Index: 83.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3932
    Cell Significance Index: 8.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3882
    Cell Significance Index: 20.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3764
    Cell Significance Index: 10.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3731
    Cell Significance Index: 67.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3623
    Cell Significance Index: 197.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3346
    Cell Significance Index: 21.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2931
    Cell Significance Index: 7.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2710
    Cell Significance Index: 187.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2462
    Cell Significance Index: 33.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2388
    Cell Significance Index: 85.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2350
    Cell Significance Index: 12.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1945
    Cell Significance Index: 37.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1932
    Cell Significance Index: 19.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1856
    Cell Significance Index: 4.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1685
    Cell Significance Index: 2.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1431
    Cell Significance Index: 6.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1349
    Cell Significance Index: 17.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0946
    Cell Significance Index: 16.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0920
    Cell Significance Index: 2.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0730
    Cell Significance Index: 2.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0559
    Cell Significance Index: 105.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0375
    Cell Significance Index: 1.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0288
    Cell Significance Index: 18.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0063
    Cell Significance Index: 0.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0013
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0073
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0137
    Cell Significance Index: -1.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0155
    Cell Significance Index: -21.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0175
    Cell Significance Index: -1.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0207
    Cell Significance Index: -15.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0571
    Cell Significance Index: -3.0000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0621
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0784
    Cell Significance Index: -16.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0817
    Cell Significance Index: -23.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0865
    Cell Significance Index: -12.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1085
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1150
    Cell Significance Index: -13.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1276
    Cell Significance Index: -9.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1292
    Cell Significance Index: -9.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1530
    Cell Significance Index: -7.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1711
    Cell Significance Index: -3.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2140
    Cell Significance Index: -9.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2262
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2341
    Cell Significance Index: -26.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2373
    Cell Significance Index: -24.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2506
    Cell Significance Index: -6.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2580
    Cell Significance Index: -17.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2626
    Cell Significance Index: -3.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2895
    Cell Significance Index: -17.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3054
    Cell Significance Index: -24.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3058
    Cell Significance Index: -7.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3086
    Cell Significance Index: -3.2000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3353
    Cell Significance Index: -1.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3820
    Cell Significance Index: -9.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3929
    Cell Significance Index: -17.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4057
    Cell Significance Index: -8.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4650
    Cell Significance Index: -17.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5884
    Cell Significance Index: -17.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5899
    Cell Significance Index: -16.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5903
    Cell Significance Index: -11.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6105
    Cell Significance Index: -14.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6243
    Cell Significance Index: -12.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6426
    Cell Significance Index: -22.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6440
    Cell Significance Index: -20.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6444
    Cell Significance Index: -32.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6637
    Cell Significance Index: -21.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RRM1 is a subunit of the ribonucleotide reductase enzyme, which is a heterotetramer composed of two large subunits (RRM1) and two small subunits (RRM2). The RRM1 subunit contains a conserved catalytic domain that is responsible for the reduction of ribonucleotides to deoxyribonucleotides. This enzyme is essential for the supply of deoxyribonucleotides to DNA polymerases, which are necessary for DNA replication and repair. The RRM1 gene has been identified in various cell types, including neural crest cells, which are precursors to neurons and glial cells in the brain. **Pathways and Functions** RRM1 is involved in several cellular pathways, including: 1. **DNA Synthesis**: RRM1 is essential for the supply of deoxyribonucleotides to DNA polymerases, which are necessary for DNA replication. 2. **DNA Repair**: RRM1 is involved in the repair of DNA damage, particularly in the context of ionizing radiation. 3. **Cell Proliferation**: RRM1 is required for the progression of cells through the cell cycle, particularly during the G1/S transition. 4. **Mitochondrial DNA Replication**: RRM1 is involved in the replication of mitochondrial DNA. 5. **Neuronal Development**: RRM1 is expressed in neural crest cells, which are precursors to neurons and glial cells in the brain. **Clinical Significance** Dysregulation of the RRM1 gene has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RRM1 has been observed in several types of cancer, including leukemia and lymphoma. 2. **Neurological Disorders**: Mutations in the RRM1 gene have been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Radiation-Induced Diseases**: RRM1 is involved in the response to ionizing radiation, and dysregulation of the gene has been implicated in radiation-induced diseases. 4. **Genetic Disorders**: Mutations in the RRM1 gene have been associated with genetic disorders, such as Fanconi anemia and Bloom syndrome. In conclusion, the RRM1 gene plays a critical role in DNA synthesis, repair, and replication, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which RRM1 regulates cellular processes and to develop therapeutic strategies to target this gene in the treatment of disease.

Genular Protein ID: 279777207

Symbol: RIR1_HUMAN

Name: Ribonucleoside-diphosphate reductase large subunit

UniProtKB Accession Codes:

P23921 Q9UNN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 5 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1840662

Title: Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes.

PubMed ID: 1840662

DOI: 10.1093/nar/19.13.3741

PubMed ID: 1627826

Title: Sequence analysis of the large and small subunits of human ribonucleotide reductase.

PubMed ID: 1627826

DOI: 10.3109/10425179209020807

PubMed ID: 9933563

Title: A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region.

PubMed ID: 9933563

DOI: 10.1006/geno.1998.5659

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8188248

Title: Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene.

PubMed ID: 8188248

DOI: 10.1006/geno.1994.1017

PubMed ID: 1867633

Title: Human ribonucleotide reductase. Activation and inhibition by analogs of ATP.

PubMed ID: 1867633

DOI: 10.1016/0006-2952(91)90033-2

PubMed ID: 12615712

Title: Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.

PubMed ID: 12615712

PubMed ID: 16376858

Title: Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.

PubMed ID: 16376858

DOI: 10.1016/j.bbrc.2005.12.019

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25237103

Title: Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes.

PubMed ID: 25237103

DOI: 10.1126/science.1251550

PubMed ID: 21336276

Title: Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.

PubMed ID: 21336276

DOI: 10.1038/nsmb.2007

PubMed ID: 35617047

Title: RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis.

PubMed ID: 35617047

DOI: 10.1172/jci145660

Sequence Information:

  • Length: 792
  • Mass: 90070
  • Checksum: 4470A76C61E8F86A
  • Sequence:
    • MHVIKRDGRQ ERVMFDKITS RIQKLCYGLN MDFVDPAQIT MKVIQGLYSG VTTVELDTLA 
AETAATLTTK HPDYAILAAR IAVSNLHKET KKVFSDVMED LYNYINPHNG KHSPMVAKST 
LDIVLANKDR LNSAIIYDRD FSYNYFGFKT LERSYLLKIN GKVAERPQHM LMRVSVGIHK 
EDIDAAIETY NLLSERWFTH ASPTLFNAGT NRPQLSSCFL LSMKDDSIEG IYDTLKQCAL 
ISKSAGGIGV AVSCIRATGS YIAGTNGNSN GLVPMLRVYN NTARYVDQGG NKRPGAFAIY 
LEPWHLDIFE FLDLKKNTGK EEQRARDLFF ALWIPDLFMK RVETNQDWSL MCPNECPGLD 
EVWGEEFEKL YASYEKQGRV RKVVKAQQLW YAIIESQTET GTPYMLYKDS CNRKSNQQNL 
GTIKCSNLCT EIVEYTSKDE VAVCNLASLA LNMYVTSEHT YDFKKLAEVT KVVVRNLNKI 
IDINYYPVPE ACLSNKRHRP IGIGVQGLAD AFILMRYPFE SAEAQLLNKQ IFETIYYGAL 
EASCDLAKEQ GPYETYEGSP VSKGILQYDM WNVTPTDLWD WKVLKEKIAK YGIRNSLLIA 
PMPTASTAQI LGNNESIEPY TSNIYTRRVL SGEFQIVNPH LLKDLTERGL WHEEMKNQII 
ACNGSIQSIP EIPDDLKQLY KTVWEISQKT VLKMAAERGA FIDQSQSLNI HIAEPNYGKL 
TSMHFYGWKQ GLKTGMYYLR TRPAANPIQF TLNKEKLKDK EKVSKEEEEK ERNTAAMVCS 
LENRDECLMC GS

Genular Protein ID: 2033757829

Symbol: B4E0I8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0I8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 3 RuleBase 1 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 695
  • Mass: 79230
  • Checksum: 120C6624B61228BA
  • Sequence:
    • MEDLYNYINP HNGKHSPMVA KSTLDIVLAN KDRLNSAIIY DRDFSYNYFG FKTLERSYLL 
KINGKVAERP QHMLMRVSVG IHKEDIDAAI ETYNLLSERW FTHASPTLFN AGTNRPQLSS 
CFLLSMKDDS IEGIYDTLKQ CALISKSAGG IGVAVSCIRA TGSYIAGTNG NPNGLVPMLR 
VYNNTARYVD QGGNKRPGAF AIYLEPWHLD IFEFLDLKKN TGKEEQRARD LFFALWIPDL 
FMKRVETNQD WSLMCPNECP GLDEVWGEEF EKLYASYEKQ GRVRKVVKAQ QLWYAIIESQ 
TETGTPYMLY KDSCNRKSNQ QNLGTIKCSN LCTEIVEYTS KDEVAVCNLA SLALNMYVTS 
EHTYDFKKLA EVTKVVVRNL NKIIDINYYP VPEACLSNKR HRPIGIGVQG LADAFILMRY 
PFESAEAQLL NKQIFETIYY GALEASCDLA KEQGPYETYE GSPVSKGILQ YDMWNVTPTD 
LWDWKVLKEK IAKYGIRNSL LIAPMPTAST AQILGNNESI EPYTSNIYTR RVLSGEFQIV 
NPHLLKDLTE RGLWHEEMKN QIIACNGSIQ SIPEIPDDLK QLYKTVWEIS QKTVLKMAAE 
RGAFIDQSQS LNIHIAEPNY GKLTSMHFYG WKQGLKTGMY YLRTRPAANP IQFTLNKEKL 
KDKEKVSKEE EEKERNTAAM VCSLENRDEC LMCGS

Genular Protein ID: 1293256544

Symbol: B4DXD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXD1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 454
  • Mass: 52033
  • Checksum: E7A13E8D971EDEE7
  • Sequence:
    • MKRVETNQDW SLMCPNECPG LDEVWGEEFE KLYASYEKQG RVRKVVKAQQ LWYAIIESQT 
ETGTPYMLYK DSCNRKSNQQ NLGTIKCSNL CTEIVEYTSK DEVAVCNLAS LALNMYVTSE 
HTYDFKKLAE VTKVVVRNLN KIIDINYYPV PEACLSNKRH RPIGIGVQGL ADAFILMRYP 
FESAEAQLLN KQIFETIYYG ALEASCDLAK EQGPYETYEG SPVSKGILQY DMWNVTPTDL 
WDWKVLKEKI AKYGIRNSLL IAPMPTASTA QILGNNESIE PYTSNIYTRR VLSGEFQIVN 
PHLLKDLTER GLWHEEMKNQ IIACNGSIQS IPEIPDDLKQ LYKTVWEISQ KTVLKMAAER 
GAFIDQSQSL NIHIAEPNYG KLTSMHFYGW KQGLKTGMYY LRTRPAANPI QFTLNKERLK 
DKEKVSKEEE EKERNTAAMV CSLENRDECL MCGS

Genular Protein ID: 1190610173

Symbol: E9PL69_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PL69

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 570
  • Mass: 64837
  • Checksum: 96219E93C3749A56
  • Sequence:
    • MKDDSIEGIY DTLKQCALIS KSAGGIGVAV SCIRATGSYI AGTNGNSNGL VPMLRVYNNT 
ARYVDQGGNK RPGAFAIYLE PWHLDIFEFL DLKKNTGKEE QRARDLFFAL WIPDLFMKRV 
ETNQDWSLMC PNECPGLDEV WGEEFEKLYA SYEKQGRVRK VVKAQQLWYA IIESQTETGT 
PYMLYKDSCN RKSNQQNLGT IKCSNLCTEI VEYTSKDEVA VCNLASLALN MYVTSEHTYD 
FKKLAEVTKV VVRNLNKIID INYYPVPEAC LSNKRHRPIG IGVQGLADAF ILMRYPFESA 
EAQLLNKQIF ETIYYGALEA SCDLAKEQGP YETYEGSPVS KGILQYDMWN VTPTDLWDWK 
VLKEKIAKYG IRNSLLIAPM PTASTAQILG NNESIEPYTS NIYTRRVLSG EFQIVNPHLL 
KDLTERGLWH EEMKNQIIAC NGSIQSIPEI PDDLKQLYKT VWEISQKTVL KMAAERGAFI 
DQSQSLNIHI AEPNYGKLTS MHFYGWKQGL KTGMYYLRTR PAANPIQFTL NKEKLKDKEK 
VSKEEEEKER NTAAMVCSLE NRDECLMCGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.