Details for: RXRA

Gene ID: 6256

Symbol: RXRA

Ensembl ID: ENSG00000186350

Description: retinoid X receptor alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.2749
    Cell Significance Index: -24.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.4737
    Cell Significance Index: -27.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.7681
    Cell Significance Index: -28.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.5190
    Cell Significance Index: -24.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.7146
    Cell Significance Index: -27.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.4420
    Cell Significance Index: -27.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5381
    Cell Significance Index: -28.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2066
    Cell Significance Index: -28.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4654
    Cell Significance Index: -14.1500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 3.3890
    Cell Significance Index: 8.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8064
    Cell Significance Index: 38.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3198
    Cell Significance Index: 418.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1692
    Cell Significance Index: 266.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0819
    Cell Significance Index: 108.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7809
    Cell Significance Index: 32.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7333
    Cell Significance Index: 281.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4747
    Cell Significance Index: 13.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2566
    Cell Significance Index: 136.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1632
    Cell Significance Index: 514.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0478
    Cell Significance Index: 17.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9940
    Cell Significance Index: 197.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8730
    Cell Significance Index: 313.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8030
    Cell Significance Index: 56.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7099
    Cell Significance Index: 15.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6835
    Cell Significance Index: 47.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4649
    Cell Significance Index: 13.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4018
    Cell Significance Index: 11.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3682
    Cell Significance Index: 0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3474
    Cell Significance Index: 21.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3349
    Cell Significance Index: 45.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3265
    Cell Significance Index: 14.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3048
    Cell Significance Index: 14.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2905
    Cell Significance Index: 58.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2080
    Cell Significance Index: 39.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1995
    Cell Significance Index: 25.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1848
    Cell Significance Index: 18.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1843
    Cell Significance Index: 5.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1636
    Cell Significance Index: 4.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1558
    Cell Significance Index: 11.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1278
    Cell Significance Index: 69.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1198
    Cell Significance Index: 108.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0855
    Cell Significance Index: 14.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0512
    Cell Significance Index: 1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0454
    Cell Significance Index: 85.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0351
    Cell Significance Index: 1.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0256
    Cell Significance Index: 34.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0102
    Cell Significance Index: 15.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0027
    Cell Significance Index: 1.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0016
    Cell Significance Index: -1.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0088
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0139
    Cell Significance Index: -9.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.5200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0218
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0657
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0765
    Cell Significance Index: -16.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0989
    Cell Significance Index: -5.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0995
    Cell Significance Index: -11.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0996
    Cell Significance Index: -28.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1053
    Cell Significance Index: -1.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1064
    Cell Significance Index: -15.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1381
    Cell Significance Index: -3.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1384
    Cell Significance Index: -16.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1402
    Cell Significance Index: -2.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1554
    Cell Significance Index: -2.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1702
    Cell Significance Index: -10.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1718
    Cell Significance Index: -2.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1926
    Cell Significance Index: -14.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2000
    Cell Significance Index: -25.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2069
    Cell Significance Index: -24.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2353
    Cell Significance Index: -14.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2361
    Cell Significance Index: -24.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2517
    Cell Significance Index: -8.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2761
    Cell Significance Index: -21.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2927
    Cell Significance Index: -13.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3008
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3087
    Cell Significance Index: -20.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3252
    Cell Significance Index: -5.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3420
    Cell Significance Index: -20.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3640
    Cell Significance Index: -18.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3803
    Cell Significance Index: -10.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3804
    Cell Significance Index: -5.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3864
    Cell Significance Index: -5.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4123
    Cell Significance Index: -11.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4294
    Cell Significance Index: -8.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4295
    Cell Significance Index: -10.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4865
    Cell Significance Index: -16.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5118
    Cell Significance Index: -26.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5161
    Cell Significance Index: -4.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5239
    Cell Significance Index: -15.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5460
    Cell Significance Index: -9.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5512
    Cell Significance Index: -15.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5596
    Cell Significance Index: -14.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ligand-binding domain**: RXRA possesses a ligand-binding domain that enables it to interact with various ligands, including retinoic acid, bile acids, and cholesterol. 2. **Transcriptional regulation**: RXRA regulates gene expression through the recruitment of coactivators and corepressors, influencing the transcriptional activity of target genes. 3. **Circadian clock regulation**: RXRA interacts with the circadian clock machinery, specifically with the BMAL1 and NPAS2 proteins, to regulate the expression of genes involved in the circadian rhythm. 4. **Bile acid and lipid metabolism**: RXRA plays a crucial role in the regulation of bile acid and lipid metabolism, influencing the synthesis and degradation of these molecules. 5. **Cell differentiation and development**: RXRA is involved in the regulation of cell differentiation and development, particularly in the development of the hindbrain and the differentiation of white adipocytes. **Pathways and Functions** 1. **Activation of anterior hox genes**: RXRA regulates the expression of anterior hox genes in hindbrain development during early embryogenesis. 2. **Activation of gene expression by SREBP**: RXRA activates the expression of genes involved in lipid metabolism in response to SREBP (Sterol Regulatory Element Binding Protein) signaling. 3. **Bile acid and bile salt metabolism**: RXRA regulates the synthesis and degradation of bile acids and bile salts, influencing the homeostasis of these molecules. 4. **Circadian gene expression**: RXRA interacts with the circadian clock machinery to regulate the expression of genes involved in the circadian rhythm. 5. **Cellular responses to stimuli**: RXRA regulates the expression of genes involved in cellular responses to stimuli, such as stress and chemical exposure. **Clinical Significance** 1. **Bile acid disorders**: Mutations in the RXRA gene have been associated with bile acid disorders, such as primary biliary cholangitis and primary sclerosing cholangitis. 2. **Cancer**: RXRA has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 3. **Metabolic disorders**: RXRA plays a crucial role in lipid metabolism, and dysregulation of RXRA has been linked to metabolic disorders, such as obesity and insulin resistance. 4. **Circadian rhythm disorders**: RXRA's involvement in the circadian clock machinery highlights its potential role in the regulation of circadian rhythm disorders, such as delayed sleep phase syndrome. 5. **Steroid hormone regulation**: RXRA regulates the expression of genes involved in steroid hormone metabolism, influencing the homeostasis of these hormones. In conclusion, RXRA is a multifunctional gene that plays a crucial role in various cellular processes, including development, metabolism, and response to stimuli. Its dysregulation has been linked to various diseases, highlighting the importance of RXRA in maintaining cellular homeostasis. Further research is needed to fully understand the mechanisms of RXRA and its role in various diseases.

Genular Protein ID: 609248031

Symbol: RXRA_HUMAN

Name: Retinoic acid receptor RXR-alpha

UniProtKB Accession Codes:

P19793 B3KY83 Q2NL52 Q2V504

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 11 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 21 DrugCentral 1 ELM 1 EMBL 10 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 29 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2159111

Title: Nuclear receptor that identifies a novel retinoic acid response pathway.

PubMed ID: 2159111

DOI: 10.1038/345224a0

PubMed ID: 18619963

Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.

PubMed ID: 18619963

DOI: 10.1016/j.febslet.2008.07.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1310260

Title: 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

PubMed ID: 1310260

DOI: 10.1016/0092-8674(92)90479-v

PubMed ID: 9267036

Title: Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

PubMed ID: 9267036

DOI: 10.1016/s0092-8674(00)80516-4

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 10195690

Title: Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.

PubMed ID: 10195690

DOI: 10.1016/s0303-7207(98)00217-2

PubMed ID: 11162439

Title: Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function.

PubMed ID: 11162439

DOI: 10.1006/bbrc.2000.4043

PubMed ID: 11259580

Title: PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.

PubMed ID: 11259580

DOI: 10.1128/mcb.21.7.2298-2311.2001

PubMed ID: 11915042

Title: Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.

PubMed ID: 11915042

DOI: 10.1053/jhep.2002.32470

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12145331

Title: Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor.

PubMed ID: 12145331

DOI: 10.1210/me.2001-0345

PubMed ID: 15047147

Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.

PubMed ID: 15047147

DOI: 10.1016/j.bbrc.2004.02.179

PubMed ID: 14981089

Title: The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.

PubMed ID: 14981089

DOI: 10.1074/jbc.m309148200

PubMed ID: 15509776

Title: Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.

PubMed ID: 15509776

DOI: 10.1128/mcb.24.22.9705-9725.2004

PubMed ID: 16574651

Title: 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway.

PubMed ID: 16574651

DOI: 10.1074/jbc.m601593200

PubMed ID: 16912044

Title: Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.

PubMed ID: 16912044

DOI: 10.1074/jbc.m604033200

PubMed ID: 17761950

Title: Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.

PubMed ID: 17761950

DOI: 10.1210/me.2007-0107

PubMed ID: 17205979

Title: Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function.

PubMed ID: 17205979

DOI: 10.1074/mcp.m600223-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19786558

Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

PubMed ID: 19786558

DOI: 10.1124/mol.109.057000

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20215566

Title: Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.

PubMed ID: 20215566

DOI: 10.1210/en.2009-1338

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25417649

Title: Retinoid X receptor alpha attenuates host antiviral response by suppressing type I interferon.

PubMed ID: 25417649

DOI: 10.1038/ncomms6494

PubMed ID: 26463675

Title: Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

PubMed ID: 26463675

DOI: 10.1093/brain/awv289

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

PubMed ID: 28698609

Title: Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.

PubMed ID: 28698609

DOI: 10.1038/s41598-017-05081-x

PubMed ID: 30216632

Title: The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling.

PubMed ID: 30216632

DOI: 10.1111/acel.12831

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 7925381

Title: NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.

PubMed ID: 7925381

DOI: 10.1111/j.1432-1033.1994.00639.x

PubMed ID: 7746322

Title: Structural determinants of nuclear receptor assembly on DNA direct repeats.

PubMed ID: 7746322

DOI: 10.1038/375203a0

PubMed ID: 7760929

Title: Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.

PubMed ID: 7760929

DOI: 10.1038/375377a0

PubMed ID: 9698548

Title: High-resolution solution structure of the retinoid X receptor DNA-binding domain.

PubMed ID: 9698548

DOI: 10.1006/jmbi.1998.1908

PubMed ID: 10698945

Title: Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.

PubMed ID: 10698945

DOI: 10.1093/emboj/19.5.1045

PubMed ID: 10835357

Title: Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.

PubMed ID: 10835357

DOI: 10.1093/emboj/19.11.2592

PubMed ID: 10970886

Title: Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.

PubMed ID: 10970886

DOI: 10.1101/gad.802300

PubMed ID: 10669605

Title: Structural basis of RXR-DNA interactions.

PubMed ID: 10669605

DOI: 10.1006/jmbi.1999.3457

PubMed ID: 10882139

Title: Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

PubMed ID: 10882139

DOI: 10.1016/s1097-2765(00)80448-7

PubMed ID: 11698662

Title: Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

PubMed ID: 11698662

DOI: 10.1073/pnas.241410198

PubMed ID: 15610733

Title: The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

PubMed ID: 15610733

DOI: 10.1016/j.molcel.2004.11.036

PubMed ID: 16107141

Title: Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

PubMed ID: 16107141

DOI: 10.1021/jm050532w

PubMed ID: 18800767

Title: Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

PubMed ID: 18800767

DOI: 10.1021/jm800612u

PubMed ID: 19167885

Title: Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.

PubMed ID: 19167885

DOI: 10.1016/j.bmcl.2009.01.004

PubMed ID: 29021580

Title: The quaternary architecture of RARbeta-RXRalpha heterodimer facilitates domain-domain signal transmission.

PubMed ID: 29021580

DOI: 10.1038/s41467-017-00981-y

PubMed ID: 30275017

Title: Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.

PubMed ID: 30275017

DOI: 10.1074/jbc.ra118.004652

Sequence Information:

  • Length: 462
  • Mass: 50811
  • Checksum: 7F952B580AD84C42
  • Sequence:
    • MDTKHFLPLD FSTQVNSSLT SPTGRGSMAA PSLHPSLGPG IGSPGQLHSP ISTLSSPING 
MGPPFSVISS PMGPHSMSVP TTPTLGFSTG SPQLSSPMNP VSSSEDIKPP LGLNGVLKVP 
AHPSGNMASF TKHICAICGD RSSGKHYGVY SCEGCKGFFK RTVRKDLTYT CRDNKDCLID 
KRQRNRCQYC RYQKCLAMGM KREAVQEERQ RGKDRNENEV ESTSSANEDM PVERILEAEL 
AVEPKTETYV EANMGLNPSS PNDPVTNICQ AADKQLFTLV EWAKRIPHFS ELPLDDQVIL 
LRAGWNELLI ASFSHRSIAV KDGILLATGL HVHRNSAHSA GVGAIFDRVL TELVSKMRDM 
QMDKTELGCL RAIVLFNPDS KGLSNPAEVE ALREKVYASL EAYCKHKYPE QPGRFAKLLL 
RLPALRSIGL KCLEHLFFFK LIGDTPIDTF LMEMLEAPHQ MT

Genular Protein ID: 53393343

Symbol: Q6P3U7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P3U7

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 3 RuleBase 2 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 516
  • Mass: 56672
  • Checksum: C18FB97552E55929
  • Sequence:
    • ATFATTRRAA ASARRRRHRS RRLPAARARA GRAGGRRARR PLPAPPAGHE LVADMDTKHF 
LPLDFSTQVN SSLTSPTGRG SMAAPSLHPS LGPGIGSPGQ LHSPISTLSS PINGMGPPFS 
VISSPMGPHS MSVPTTPTLG FSTGSPQLSS PMNPVSSSED IKPPLGLNGV LKVPAHPSGN 
MASFTKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTVRKD LTYTCRDNKD CLIDKRQRNR 
CQYCRYQKCL AMGMKREAVQ EERQRGKDRN ENEVESTSSA NEDMPVERIL EAELAVEPKT 
ETYVEANMGL NPSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSELPLDD QVILLRAGWN 
ELLIASFSHR SIAVKDGILL ATGLHVHRNS AHSAGVGAIF DRVLTELVSK MRDMQMDKTE 
LGCLRAIVLF NPDSKGLSNP AEVEALREKV YASLEAYCKH KYPEQPGRFA KLLLRLPALR 
SIGLKCLEHL FFFKLIGDTP IDTFLMEMLE APHQMT

Genular Protein ID: 616266763

Symbol: A0A5F9ZHH6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A5F9ZHH6

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 435
  • Mass: 47905
  • Checksum: FD265E9526A8B44B
  • Sequence:
    • MAAPSLHPSL GPGIGSPGQL HSPISTLSSP INGMGPPFSV ISSPMGPHSM SVPTTPTLGF 
STGSPQLSSP MNPVSSSEDI KPPLGLNGVL KVPAHPSGNM ASFTKHICAI CGDRSSGKHY 
GVYSCEGCKG FFKRTVRKDL TYTCRDNKDC LIDKRQRNRC QYCRYQKCLA MGMKREAVQE 
ERQRGKDRNE NEVESTSSAN EDMPVERILE AELAVEPKTE TYVEANMGLN PSSPNDPVTN 
ICQAADKQLF TLVEWAKRIP HFSELPLDDQ VILLRAGWNE LLIASFSHRS IAVKDGILLA 
TGLHVHRNSA HSAGVGAIFD RVLTELVSKM RDMQMDKTEL GCLRAIVLFN PDSKGLSNPA 
EVEALREKVY ASLEAYCKHK YPEQPGRFAK LLLRLPALRS IGLKCLEHLF FFKLIGDTPI 
DTFLMEMLEA PHQMT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.