Details for: SORT1

Gene ID: 6272

Symbol: SORT1

Ensembl ID: ENSG00000134243

Description: sortilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 390.7545
    Cell Significance Index: -60.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 239.0364
    Cell Significance Index: -60.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 127.2339
    Cell Significance Index: -60.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.4533
    Cell Significance Index: -47.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.0987
    Cell Significance Index: -55.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.2881
    Cell Significance Index: -60.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0528
    Cell Significance Index: -80.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.8041
    Cell Significance Index: -58.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.4104
    Cell Significance Index: -60.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9255
    Cell Significance Index: -26.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7930
    Cell Significance Index: 193.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7522
    Cell Significance Index: 70.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.6418
    Cell Significance Index: 75.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.5937
    Cell Significance Index: 174.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1184
    Cell Significance Index: 162.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0920
    Cell Significance Index: 419.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9322
    Cell Significance Index: 3638.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7247
    Cell Significance Index: 200.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4988
    Cell Significance Index: 537.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3591
    Cell Significance Index: 33.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3464
    Cell Significance Index: 146.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.8545
    Cell Significance Index: 88.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8525
    Cell Significance Index: 21.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8187
    Cell Significance Index: 566.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7723
    Cell Significance Index: 153.2700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7220
    Cell Significance Index: 11.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6454
    Cell Significance Index: 30.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5723
    Cell Significance Index: 103.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4698
    Cell Significance Index: 29.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4662
    Cell Significance Index: 10.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3945
    Cell Significance Index: 215.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3607
    Cell Significance Index: 44.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3388
    Cell Significance Index: 153.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3263
    Cell Significance Index: 9.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3124
    Cell Significance Index: 30.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3033
    Cell Significance Index: 17.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2758
    Cell Significance Index: 175.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2135
    Cell Significance Index: 34.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1387
    Cell Significance Index: 255.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1129
    Cell Significance Index: 173.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0805
    Cell Significance Index: 15.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0660
    Cell Significance Index: 2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0158
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0478
    Cell Significance Index: -36.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0716
    Cell Significance Index: -31.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0738
    Cell Significance Index: -41.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1265
    Cell Significance Index: -4.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1414
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1565
    Cell Significance Index: -32.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1734
    Cell Significance Index: -49.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2355
    Cell Significance Index: -24.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2447
    Cell Significance Index: -15.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3060
    Cell Significance Index: -34.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3125
    Cell Significance Index: -35.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3453
    Cell Significance Index: -44.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3807
    Cell Significance Index: -28.3700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4107
    Cell Significance Index: -8.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4121
    Cell Significance Index: -56.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4268
    Cell Significance Index: -22.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4849
    Cell Significance Index: -57.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5099
    Cell Significance Index: -65.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5277
    Cell Significance Index: -7.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5579
    Cell Significance Index: -36.0000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5972
    Cell Significance Index: -8.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6142
    Cell Significance Index: -48.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7085
    Cell Significance Index: -19.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7088
    Cell Significance Index: -33.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7189
    Cell Significance Index: -6.6200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7583
    Cell Significance Index: -7.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8132
    Cell Significance Index: -26.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8306
    Cell Significance Index: -19.1900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.8331
    Cell Significance Index: -10.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8802
    Cell Significance Index: -45.8500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.9355
    Cell Significance Index: -10.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9649
    Cell Significance Index: -30.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9664
    Cell Significance Index: -50.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9690
    Cell Significance Index: -59.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1228
    Cell Significance Index: -79.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1442
    Cell Significance Index: -27.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1857
    Cell Significance Index: -25.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1872
    Cell Significance Index: -38.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2399
    Cell Significance Index: -14.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.2746
    Cell Significance Index: -25.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3016
    Cell Significance Index: -22.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.3028
    Cell Significance Index: -34.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3082
    Cell Significance Index: -45.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3361
    Cell Significance Index: -46.4300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.3781
    Cell Significance Index: -19.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3812
    Cell Significance Index: -29.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.4132
    Cell Significance Index: -24.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4244
    Cell Significance Index: -52.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4284
    Cell Significance Index: -26.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4683
    Cell Significance Index: -36.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SORT1 is a 100-kDa transmembrane protein that belongs to the Vps (vacuolar protein sorting) family. It is characterized by its ability to interact with various signaling molecules, including insulin, nerve growth factor (NGF), and neurotensin. SORT1 has been shown to bind to the insulin receptor, influencing glucose uptake and metabolism. Additionally, SORT1 has been implicated in the regulation of NGF signaling, which is critical for neuronal survival and development. Its ability to interact with other proteins, such as clathrin and retromer, highlights its involvement in endocytosis and vesicle trafficking processes. **Pathways and Functions:** SORT1 is involved in various cellular pathways, including: 1. **Endocytosis and Vesicle Trafficking:** SORT1 interacts with clathrin and retromer, facilitating the formation and transport of clathrin-coated vesicles and regulating the sorting of proteins to lysosomes. 2. **Gene Regulation:** SORT1 has been shown to influence the expression of genes involved in cell differentiation, survival, and metabolism. 3. **Neurotrophin Signaling:** SORT1 interacts with NGF, modulating its signaling pathways and influencing neuronal survival and development. 4. **Insulin Signaling:** SORT1 binds to the insulin receptor, regulating glucose uptake and metabolism. **Clinical Significance:** SORT1 has been implicated in various diseases, including: 1. **Diabetes:** SORT1 has been shown to regulate glucose uptake and metabolism, making it a potential target for the treatment of diabetes. 2. **Neurodegenerative Diseases:** SORT1's involvement in NGF signaling and neuronal survival highlights its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Obesity:** SORT1's regulation of lipoprotein lipase activity and fat cell differentiation suggests its involvement in obesity and metabolic disorders. 4. **Cancer:** SORT1's role in regulating gene expression and cell differentiation may also contribute to its involvement in cancer development and progression. In conclusion, SORT1 is a multifaceted protein that plays a crucial role in various cellular processes, including endocytosis, vesicle trafficking, and regulation of gene expression. Its involvement in disease pathways highlights its potential as a therapeutic target for the treatment of various conditions, including diabetes, neurodegenerative diseases, obesity, and cancer. Further research is needed to fully elucidate the mechanisms underlying SORT1's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 1232067740

Symbol: SORT_HUMAN

Name: 100 kDa NT receptor

UniProtKB Accession Codes:

Q99523 B4DWI3 C0JYZ0 Q8IZ49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013611

Title: Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.

PubMed ID: 9013611

DOI: 10.1074/jbc.272.6.3599

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9756851

Title: The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor.

PubMed ID: 9756851

DOI: 10.1074/jbc.273.41.26273

PubMed ID: 9927419

Title: Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.

PubMed ID: 9927419

DOI: 10.1093/emboj/18.3.595

PubMed ID: 9657377

Title: The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.

PubMed ID: 9657377

DOI: 10.1016/s0014-5793(98)00559-6

PubMed ID: 10085125

Title: Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.

PubMed ID: 10085125

DOI: 10.1074/jbc.274.13.8832

PubMed ID: 11331584

Title: The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.

PubMed ID: 11331584

DOI: 10.1093/emboj/20.9.2180

PubMed ID: 11390366

Title: Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.

PubMed ID: 11390366

DOI: 10.1074/jbc.c100218200

PubMed ID: 12419319

Title: Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line.

PubMed ID: 12419319

DOI: 10.1016/s0006-291x(02)02564-0

PubMed ID: 12209882

Title: Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization.

PubMed ID: 12209882

DOI: 10.1002/jcp.10151

PubMed ID: 11859376

Title: Structural basis for recognition of acidic-cluster dileucine sequence by GGA1.

PubMed ID: 11859376

DOI: 10.1038/415937a

PubMed ID: 14657016

Title: The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.

PubMed ID: 14657016

DOI: 10.1093/emboj/cdg629

PubMed ID: 12598608

Title: Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia.

PubMed ID: 12598608

DOI: 10.1523/jneurosci.23-04-01198.2003

PubMed ID: 15313463

Title: Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells.

PubMed ID: 15313463

DOI: 10.1016/j.biocel.2004.04.013

PubMed ID: 15364913

Title: Functional organization of the sortilin Vps10p domain.

PubMed ID: 15364913

DOI: 10.1074/jbc.m408873200

PubMed ID: 14985763

Title: Sortilin is essential for proNGF-induced neuronal cell death.

PubMed ID: 14985763

DOI: 10.1038/nature02319

PubMed ID: 15930396

Title: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

PubMed ID: 15930396

DOI: 10.1523/jneurosci.5123-04.2005

PubMed ID: 15987945

Title: Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

PubMed ID: 15987945

DOI: 10.1523/jneurosci.1017-05.2005

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 16787399

Title: The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor.

PubMed ID: 16787399

DOI: 10.1111/j.1600-0854.2006.00429.x

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18817523

Title: Palmitoylation controls recycling in lysosomal sorting and trafficking.

PubMed ID: 18817523

DOI: 10.1111/j.1600-0854.2008.00814.x

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20048080

Title: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.

PubMed ID: 20048080

DOI: 10.1158/0008-5472.can-09-1252

PubMed ID: 20686565

Title: Biological, clinical and population relevance of 95 loci for blood lipids.

PubMed ID: 20686565

DOI: 10.1038/nature09270

PubMed ID: 20686566

Title: From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

PubMed ID: 20686566

DOI: 10.1038/nature09266

PubMed ID: 21092856

Title: Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

PubMed ID: 21092856

DOI: 10.1016/j.neuron.2010.09.034

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21102451

Title: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

PubMed ID: 21102451

DOI: 10.1038/nn.2689

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 19122660

Title: Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.

PubMed ID: 19122660

DOI: 10.1038/nsmb.1543

PubMed ID: 20015111

Title: GGA autoinhibition revisited.

PubMed ID: 20015111

DOI: 10.1111/j.1600-0854.2009.01017.x

Sequence Information:

  • Length: 831
  • Mass: 92068
  • Checksum: 91F96A3035A4B43A
  • Sequence:
    • MERPWGAADG LSRWPHGLGL LLLLQLLPPS TLSQDRLDAP PPPAAPLPRW SGPIGVSWGL 
RAAAAGGAFP RGGRWRRSAP GEDEECGRVR DFVAKLANNT HQHVFDDLRG SVSLSWVGDS 
TGVILVLTTF HVPLVIMTFG QSKLYRSEDY GKNFKDITDL INNTFIRTEF GMAIGPENSG 
KVVLTAEVSG GSRGGRIFRS SDFAKNFVQT DLPFHPLTQM MYSPQNSDYL LALSTENGLW 
VSKNFGGKWE EIHKAVCLAK WGSDNTIFFT TYANGSCKAD LGALELWRTS DLGKSFKTIG 
VKIYSFGLGG RFLFASVMAD KDTTRRIHVS TDQGDTWSMA QLPSVGQEQF YSILAANDDM 
VFMHVDEPGD TGFGTIFTSD DRGIVYSKSL DRHLYTTTGG ETDFTNVTSL RGVYITSVLS 
EDNSIQTMIT FDQGGRWTHL RKPENSECDA TAKNKNECSL HIHASYSISQ KLNVPMAPLS 
EPNAVGIVIA HGSVGDAISV MVPDVYISDD GGYSWTKMLE GPHYYTILDS GGIIVAIEHS 
SRPINVIKFS TDEGQCWQTY TFTRDPIYFT GLASEPGARS MNISIWGFTE SFLTSQWVSY 
TIDFKDILER NCEEKDYTIW LAHSTDPEDY EDGCILGYKE QFLRLRKSSV CQNGRDYVVT 
KQPSICLCSL EDFLCDFGYY RPENDSKCVE QPELKGHDLE FCLYGREEHL TTNGYRKIPG 
DKCQGGVNPV REVKDLKKKC TSNFLSPEKQ NSKSNSVPII LAIVGLMLVT VVAGVLIVKK 
YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.