Details for: SATB1

Gene ID: 6304

Symbol: SATB1

Ensembl ID: ENSG00000182568

Description: SATB homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 202.7706
    Cell Significance Index: -31.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.6751
    Cell Significance Index: -20.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.6461
    Cell Significance Index: -34.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.2172
    Cell Significance Index: -28.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6939
    Cell Significance Index: -28.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.7511
    Cell Significance Index: -31.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2254
    Cell Significance Index: -32.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2412
    Cell Significance Index: -32.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9018
    Cell Significance Index: -24.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6737
    Cell Significance Index: 184.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8295
    Cell Significance Index: 112.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7604
    Cell Significance Index: 42.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7108
    Cell Significance Index: 343.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2984
    Cell Significance Index: 141.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2111
    Cell Significance Index: 72.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1789
    Cell Significance Index: 191.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0930
    Cell Significance Index: 32.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9209
    Cell Significance Index: 59.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8373
    Cell Significance Index: 150.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6750
    Cell Significance Index: 66.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6440
    Cell Significance Index: 33.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6253
    Cell Significance Index: 76.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6057
    Cell Significance Index: 28.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4741
    Cell Significance Index: 36.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4113
    Cell Significance Index: 11.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3708
    Cell Significance Index: 47.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3451
    Cell Significance Index: 215.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3384
    Cell Significance Index: 234.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2883
    Cell Significance Index: 2.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2666
    Cell Significance Index: 16.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2325
    Cell Significance Index: 10.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2152
    Cell Significance Index: 40.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1775
    Cell Significance Index: 30.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1432
    Cell Significance Index: 3.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1236
    Cell Significance Index: 44.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1057
    Cell Significance Index: 12.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1054
    Cell Significance Index: 46.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1005
    Cell Significance Index: 13.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0885
    Cell Significance Index: 3.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0827
    Cell Significance Index: 45.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0715
    Cell Significance Index: 1.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0547
    Cell Significance Index: 3.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0283
    Cell Significance Index: 0.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0182
    Cell Significance Index: 0.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0125
    Cell Significance Index: -11.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0173
    Cell Significance Index: -32.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0190
    Cell Significance Index: -35.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0229
    Cell Significance Index: -35.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0261
    Cell Significance Index: -35.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0265
    Cell Significance Index: -19.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0276
    Cell Significance Index: -1.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0333
    Cell Significance Index: -25.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0417
    Cell Significance Index: -2.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0649
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0650
    Cell Significance Index: -13.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0692
    Cell Significance Index: -3.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0707
    Cell Significance Index: -32.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0858
    Cell Significance Index: -8.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0873
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0915
    Cell Significance Index: -26.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0999
    Cell Significance Index: -1.4300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1003
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1012
    Cell Significance Index: -11.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1076
    Cell Significance Index: -12.6900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1306
    Cell Significance Index: -1.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1373
    Cell Significance Index: -1.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1380
    Cell Significance Index: -2.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1527
    Cell Significance Index: -3.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1540
    Cell Significance Index: -3.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1567
    Cell Significance Index: -4.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1701
    Cell Significance Index: -21.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1858
    Cell Significance Index: -36.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2136
    Cell Significance Index: -24.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2308
    Cell Significance Index: -33.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2342
    Cell Significance Index: -9.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2513
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2867
    Cell Significance Index: -21.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3138
    Cell Significance Index: -32.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3222
    Cell Significance Index: -10.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3357
    Cell Significance Index: -4.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3623
    Cell Significance Index: -11.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3778
    Cell Significance Index: -29.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3788
    Cell Significance Index: -23.2300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4168
    Cell Significance Index: -7.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4203
    Cell Significance Index: -13.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4486
    Cell Significance Index: -11.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4566
    Cell Significance Index: -23.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5091
    Cell Significance Index: -17.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5638
    Cell Significance Index: -9.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5714
    Cell Significance Index: -8.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5873
    Cell Significance Index: -8.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5917
    Cell Significance Index: -20.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6423
    Cell Significance Index: -23.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6779
    Cell Significance Index: -12.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6813
    Cell Significance Index: -3.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7178
    Cell Significance Index: -14.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7256
    Cell Significance Index: -8.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SATB1 is a member of the AT-rich sequence-binding protein family, characterized by its ability to bind specific DNA sequences and regulate gene expression. Its protein structure consists of a unique, high-mobility group (HMG)-box domain, which allows it to interact with chromatin and other proteins. SATB1's expression is restricted to specific cell types, including GABAergic neurons, thymocytes, and T cells, highlighting its role in immune cell development and function. **Pathways and Functions:** SATB1 is involved in several key pathways, including: 1. **Chromatin Organization:** SATB1 regulates chromatin structure and organization by interacting with chromatin-modifying enzymes, such as histone acetyltransferases and deacetylases. This allows it to modulate gene expression and maintain the integrity of the genome. 2. **Transcriptional Regulation:** SATB1 acts as a transcriptional activator or repressor, depending on the context, by binding to specific DNA sequences and recruiting or repelling transcriptional machinery. 3. **Post-translational Modifications:** SATB1 is involved in the regulation of post-translational modifications, such as sumoylation and acetylation, which can alter the function and stability of target proteins. 4. **Apoptosis and Programmed Cell Death:** SATB1 regulates apoptosis by modulating the expression of pro-survival and pro-apoptotic genes. **Clinical Significance:** SATB1's involvement in immune cell development and function has significant implications for various human diseases, including: 1. **Autoimmune Disorders:** SATB1's dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where immune cell dysfunction is a key feature. 2. **Cancer:** SATB1's role in chromatin organization and transcriptional regulation makes it a potential target for cancer therapy, particularly in cancers with altered immune cell infiltrates. 3. **Neurological Disorders:** SATB1's expression in GABAergic neurons and its involvement in chromatin organization and transcriptional regulation make it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SATB1 is a critical transcription factor that regulates gene expression in immune cells and other cell types, influencing chromatin organization, transcriptional regulation, and post-translational modifications. Its dysregulation has significant implications for various human diseases, highlighting the need for further research into the mechanisms of SATB1 and its role in human disease.

Genular Protein ID: 3756134746

Symbol: SATB1_HUMAN

Name: Special AT-rich sequence-binding protein 1

UniProtKB Accession Codes:

Q01826 B3KXF1 C9JTR6 Q59EQ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 10 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1505028

Title: A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition.

PubMed ID: 1505028

DOI: 10.1016/0092-8674(92)90432-c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9111059

Title: An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.

PubMed ID: 9111059

DOI: 10.1074/jbc.272.17.11463

PubMed ID: 9548713

Title: The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.

PubMed ID: 9548713

DOI: 10.1083/jcb.141.2.335

PubMed ID: 10595394

Title: The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.

PubMed ID: 10595394

DOI: 10.1089/104454999314809

PubMed ID: 10800076

Title: The fate of the nuclear matrix-associated-region-binding protein SATB1 during apoptosis.

PubMed ID: 10800076

DOI: 10.1038/sj.cdd.4400668

PubMed ID: 11463840

Title: SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.

PubMed ID: 11463840

DOI: 10.1128/mcb.21.16.5591-5604.2001

PubMed ID: 12036295

Title: The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11.

PubMed ID: 12036295

DOI: 10.1006/geno.2002.6772

PubMed ID: 12374985

Title: SATB1 targets chromatin remodelling to regulate genes over long distances.

PubMed ID: 12374985

DOI: 10.1038/nature01084

PubMed ID: 14605447

Title: SATB1 makes a complex with p300 and represses gp91(phox) promoter activity.

PubMed ID: 14605447

DOI: 10.1111/j.1348-0421.2003.tb03438.x

PubMed ID: 12692553

Title: Tissue-specific nuclear architecture and gene expression regulated by SATB1.

PubMed ID: 12692553

DOI: 10.1038/ng1146

PubMed ID: 15618465

Title: SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.

PubMed ID: 15618465

DOI: 10.1182/blood-2004-08-2988

PubMed ID: 15970696

Title: A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage.

PubMed ID: 15970696

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 15851481

Title: Nuclear matrix binding regulates SATB1-mediated transcriptional repression.

PubMed ID: 15851481

DOI: 10.1074/jbc.m414076200

PubMed ID: 16079286

Title: Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway.

PubMed ID: 16079286

DOI: 10.1242/jcs.02472

PubMed ID: 15713622

Title: Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.

PubMed ID: 15713622

DOI: 10.1128/mcb.25.5.1620-1633.2005

PubMed ID: 16377216

Title: The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation.

PubMed ID: 16377216

DOI: 10.1016/j.cellbi.2005.10.025

PubMed ID: 16630892

Title: Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo.

PubMed ID: 16630892

DOI: 10.1016/j.molcel.2006.03.010

PubMed ID: 17376900

Title: SATB1-binding sequences and Alu-like motifs define a unique chromatin context in the vicinity of human immunodeficiency virus type 1 integration sites.

PubMed ID: 17376900

DOI: 10.1128/jvi.01405-06

PubMed ID: 17173041

Title: Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.

PubMed ID: 17173041

DOI: 10.1038/ncb1516

PubMed ID: 17512569

Title: Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes.

PubMed ID: 17512569

DOI: 10.1016/j.virol.2007.04.024

PubMed ID: 18408014

Title: SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.

PubMed ID: 18408014

DOI: 10.1074/jbc.m800512200

PubMed ID: 18337816

Title: SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis.

PubMed ID: 18337816

DOI: 10.1038/nature06781

PubMed ID: 18187506

Title: PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1.

PubMed ID: 18187506

DOI: 10.1093/nar/gkm1151

PubMed ID: 19332023

Title: SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster.

PubMed ID: 19332023

DOI: 10.1016/j.bbrc.2009.03.122

PubMed ID: 19430959

Title: SATB1 binds an intronic MAR sequence in human PI3kgamma in vitro.

PubMed ID: 19430959

DOI: 10.1007/s11033-009-9538-y

PubMed ID: 19103759

Title: Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.

PubMed ID: 19103759

DOI: 10.1128/mcb.00822-08

PubMed ID: 19247486

Title: Inter-MAR association contributes to transcriptionally active looping events in human beta-globin gene cluster.

PubMed ID: 19247486

DOI: 10.1371/journal.pone.0004629

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16371359

Title: Solution structure and DNA-binding mode of the matrix attachment region-binding domain of the transcription factor SATB1 that regulates the T-cell maturation.

PubMed ID: 16371359

DOI: 10.1074/jbc.m510933200

PubMed ID: 17652321

Title: Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1.

PubMed ID: 17652321

DOI: 10.1093/nar/gkm504

PubMed ID: 33513338

Title: Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction.

PubMed ID: 33513338

DOI: 10.1016/j.ajhg.2021.01.007

Sequence Information:

  • Length: 763
  • Mass: 85957
  • Checksum: D4FE09B09FB7683B
  • Sequence:
    • MDHLNEATQG KEHSEMSNNV SDPKGPPAKI ARLEQNGSPL GRGRLGSTGA KMQGVPLKHS 
GHLMKTNLRK GTMLPVFCVV EHYENAIEYD CKEEHAEFVL VRKDMLFNQL IEMALLSLGY 
SHSSAAQAKG LIQVGKWNPV PLSYVTDAPD ATVADMLQDV YHVVTLKIQL HSCPKLEDLP 
PEQWSHTTVR NALKDLLKDM NQSSLAKECP LSQSMISSIV NSTYYANVSA AKCQEFGRWY 
KHFKKTKDMM VEMDSLSELS QQGANHVNFG QQPVPGNTAE QPPSPAQLSH GSQPSVRTPL 
PNLHPGLVST PISPQLVNQQ LVMAQLLNQQ YAVNRLLAQQ SLNQQYLNHP PPVSRSMNKP 
LEQQVSTNTE VSSEIYQWVR DELKRAGISQ AVFARVAFNR TQGLLSEILR KEEDPKTASQ 
SLLVNLRAMQ NFLQLPEAER DRIYQDERER SLNAASAMGP APLISTPPSR PPQVKTATIA 
TERNGKPENN TMNINASIYD EIQQEMKRAK VSQALFAKVA ATKSQGWLCE LLRWKEDPSP 
ENRTLWENLS MIRRFLSLPQ PERDAIYEQE SNAVHHHGDR PPHIIHVPAE QIQQQQQQQQ 
QQQQQQQAPP PPQPQQQPQT GPRLPPRQPT VASPAESDEE NRQKTRPRTK ISVEALGILQ 
SFIQDVGLYP DEEAIQTLSA QLDLPKYTII KFFQNQRYYL KHHGKLKDNS GLEVDVAEYK 
EEELLKDLEE SVQDKNTNTL FSVKLEEELS VEGNTDINTD LKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.