Details for: SBF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 104.2784
Cell Significance Index: -16.2200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 63.7903
Cell Significance Index: -16.1800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 36.1347
Cell Significance Index: -17.0600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 36.0855
Cell Significance Index: -14.6600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 32.3493
Cell Significance Index: -16.6400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.4073
Cell Significance Index: -14.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.4555
Cell Significance Index: -16.5900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.1369
Cell Significance Index: -16.4400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2511
Cell Significance Index: -16.7800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.1847
Cell Significance Index: -6.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3755
Cell Significance Index: 136.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1848
Cell Significance Index: 192.7000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1775
Cell Significance Index: 16.0700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1332
Cell Significance Index: 1023.2300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7837
Cell Significance Index: 85.2400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7230
Cell Significance Index: 20.8300 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.6432
Cell Significance Index: 1.4500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6421
Cell Significance Index: 38.5500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5160
Cell Significance Index: 11.1800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4997
Cell Significance Index: 32.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4568
Cell Significance Index: 20.7100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4510
Cell Significance Index: 311.9500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3773
Cell Significance Index: 44.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3738
Cell Significance Index: 74.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3696
Cell Significance Index: 10.3300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3084
Cell Significance Index: 16.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2969
Cell Significance Index: 7.9600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2941
Cell Significance Index: 13.7100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2766
Cell Significance Index: 19.1300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2653
Cell Significance Index: 47.8300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2015
Cell Significance Index: 39.9900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1961
Cell Significance Index: 5.6200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1829
Cell Significance Index: 65.6200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1711
Cell Significance Index: 93.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1650
Cell Significance Index: 20.2900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1246
Cell Significance Index: 4.3800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1240
Cell Significance Index: 3.1000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1175
Cell Significance Index: 16.1300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1051
Cell Significance Index: 4.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0989
Cell Significance Index: 43.7300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0937
Cell Significance Index: 17.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0507
Cell Significance Index: 8.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0396
Cell Significance Index: 2.6600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0371
Cell Significance Index: 0.7700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0338
Cell Significance Index: 0.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0076
Cell Significance Index: 14.2700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.7000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0053
Cell Significance Index: -8.1400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0064
Cell Significance Index: -0.8200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0067
Cell Significance Index: -0.1800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0094
Cell Significance Index: -12.8100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0138
Cell Significance Index: -8.7500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0150
Cell Significance Index: -10.9900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0167
Cell Significance Index: -12.6400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0171
Cell Significance Index: -7.7800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0222
Cell Significance Index: -16.4800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0259
Cell Significance Index: -0.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0291
Cell Significance Index: -3.7700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0298
Cell Significance Index: -16.7800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0315
Cell Significance Index: -19.7000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0357
Cell Significance Index: -2.7400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0428
Cell Significance Index: -2.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0448
Cell Significance Index: -1.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0467
Cell Significance Index: -4.7700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0504
Cell Significance Index: -14.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0511
Cell Significance Index: -5.9600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0523
Cell Significance Index: -3.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0535
Cell Significance Index: -7.7800 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0557
Cell Significance Index: -0.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0673
Cell Significance Index: -4.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0689
Cell Significance Index: -7.9000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0772
Cell Significance Index: -5.4600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0790
Cell Significance Index: -2.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0947
Cell Significance Index: -19.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1076
Cell Significance Index: -1.8000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1278
Cell Significance Index: -2.1900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1373
Cell Significance Index: -3.6100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1416
Cell Significance Index: -3.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1477
Cell Significance Index: -15.3800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1651
Cell Significance Index: -8.6700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1657
Cell Significance Index: -4.2600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1659
Cell Significance Index: -10.1700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1677
Cell Significance Index: -9.4100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1896
Cell Significance Index: -15.0100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1954
Cell Significance Index: -10.1800 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.2007
Cell Significance Index: -3.2200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2035
Cell Significance Index: -4.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2617
Cell Significance Index: -11.5800 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.2684
Cell Significance Index: -1.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2857
Cell Significance Index: -9.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3110
Cell Significance Index: -8.3200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3119
Cell Significance Index: -11.8100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3156
Cell Significance Index: -4.4300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3187
Cell Significance Index: -4.4700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.3323
Cell Significance Index: -4.7300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3350
Cell Significance Index: -11.6400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3401
Cell Significance Index: -4.8700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3510
Cell Significance Index: -11.1800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3637
Cell Significance Index: -12.7400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3748
Cell Significance Index: -13.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2053935131
Symbol: MTMR5_HUMAN
Name: Myotubularin-related protein 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9537414
Title: Association of SET domain and myotubularin-related proteins modulates growth control.
PubMed ID: 9537414
DOI: 10.1038/ng0498-331
PubMed ID: 9736772
Title: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
PubMed ID: 9736772
PubMed ID: 10848615
Title: Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.
PubMed ID: 10848615
PubMed ID: 12668758
Title: Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.
PubMed ID: 12668758
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20937701
Title: Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
PubMed ID: 20937701
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 35580604
Title: Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons.
PubMed ID: 35580604
PubMed ID: 34718573
Title: Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination.
PubMed ID: 34718573
DOI: 10.1093/hmg/ddab311
PubMed ID: 23749797
Title: SET binding factor 1 (SBF1) mutation causes Charcot-Marie-Tooth disease type 4B3.
PubMed ID: 23749797
Sequence Information:
- Length: 1868
- Mass: 208443
- Checksum: E2C80DF9FB94AF1C
- Sequence:
MARLADYFVL VAFGPHPRGS GEGQGQILQR FPEKDWEDNP FPQGIELFCQ PSGWQLCPER NPPTFFVAVL TDINSERHYC ACLTFWEPAE PSQQETTRVE DATEREEEGD EGGQTHLSPT APAPSAQLFA PKTLVLVSRL DHTEVFRNSL GLIYAIHVEG LNVCLENVIG NLLTCTVPLA GGSQRTISLG AGDRQVIQTP LADSLPVSRC SVALLFRQLG ITNVLSLFCA ALTEHKVLFL SRSYQRLADA CRGLLALLFP LRYSFTYVPI LPAQLLEVLS TPTPFIIGVN AAFQAETQEL LDVIVADLDG GTVTIPECVH IPPLPEPLQS QTHSVLSMVL DPELELADLA FPPPTTSTSS LKMQDKELRA VFLRLFAQLL QGYRWCLHVV RIHPEPVIRF HKAAFLGQRG LVEDDFLMKV LEGMAFAGFV SERGVPYRPT DLFDELVAHE VARMRADENH PQRVLRHVQE LAEQLYKNEN PYPAVAMHKV QRPGESSHLR RVPRPFPRLD EGTVQWIVDQ AAAKMQGAPP AVKAERRTTV PSGPPMTAIL ERCSGLHVNS ARRLEVVRNC ISYVFEGKML EAKKLLPAVL RALKGRAARR CLAQELHLHV QQNRAVLDHQ QFDFVVRMMN CCLQDCTSLD EHGIAAALLP LVTAFCRKLS PGVTQFAYSC VQEHVVWSTP QFWEAMFYGD VQTHIRALYL EPTEDLAPAQ EVGEAPSQED ERSALDVASE QRRLWPTLSR EKQQELVQKE ESTVFSQAIH YANRMSYLLL PLDSSKSRLL RERAGLGDLE SASNSLVTNS MAGSVAESYD TESGFEDAET CDVAGAVVRF INRFVDKVCT ESGVTSDHLK GLHVMVPDIV QMHIETLEAV QRESRRLPPI QKPKLLRPRL LPGEECVLDG LRVYLLPDGR EEGAGGSAGG PALLPAEGAV FLTTYRVIFT GMPTDPLVGE QVVVRSFPVA ALTKEKRISV QTPVDQLLQD GLQLRSCTFQ LLKMAFDEEV GSDSAELFRK QLHKLRYPPD IRATFAFTLG SAHTPGRPPR VTKDKGPSLR TLSRNLVKNA KKTIGRQHVT RKKYNPPSWE HRGQPPPEDQ EDEISVSEEL EPSTLTPSSA LKPSDRMTMS SLVERACCRD YQRLGLGTLS SSLSRAKSEP FRISPVNRMY AICRSYPGLL IVPQSVQDNA LQRVSRCYRQ NRFPVVCWRS GRSKAVLLRS GGLHGKGVVG LFKAQNAPSP GQSQADSSSL EQEKYLQAVV SSMPRYADAS GRNTLSGFSS AHMGSHGKWG SVRTSGRSSG LGTDVGSRLA GRDALAPPQA NGGPPDPGFL RPQRAALYIL GDKAQLKGVR SDPLQQWELV PIEVFEARQV KASFKKLLKA CVPGCPAAEP SPASFLRSLE DSEWLIQIHK LLQVSVLVVE LLDSGSSVLV GLEDGWDITT QVVSLVQLLS DPFYRTLEGF RLLVEKEWLS FGHRFSHRGA HTLAGQSSGF TPVFLQFLDC VHQVHLQFPM EFEFSQFYLK FLGYHHVSRR FRTFLLDSDY ERIELGLLYE EKGERRGQVP CRSVWEYVDR LSKRTPVFHN YMYAPEDAEV LRPYSNVSNL KVWDFYTEET LAEGPPYDWE LAQGPPEPPE EERSDGGAPQ SRRRVVWPCY DSCPRAQPDA ISRLLEELQR LETELGQPAE RWKDTWDRVK AAQRLEGRPD GRGTPSSLLV STAPHHRRSL GVYLQEGPVG STLSLSLDSD QSSGSTTSGS RQAARRSTST LYSQFQTAES ENRSYEGTLY KKGAFMKPWK ARWFVLDKTK HQLRYYDHRV DTECKGVIDL AEVEAVAPGT PTMGAPKTVD EKAFFDVKTT RRVYNFCAQD VPSAQQWVDR IQSCLSDA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.