Details for: ATXN7
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 16.92rCSI 41.13%PRS 30.16
-
CSI 13.93rCSI 43.54%PRS 32.37
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CSI 12.82rCSI 46.12%PRS 29.95
-
CSI 12.01rCSI 18.55%PRS 44.65
-
CSI 10.75rCSI 40.61%PRS 32.01
-
CSI 9.2rCSI 37.13%PRS 45.57
-
CSI 8.92rCSI 12.62%PRS 55.19
-
CSI 8.84rCSI 12.69%PRS 38.11
-
CSI 8.41rCSI 9.21%PRS 50.89
-
CSI 8.19rCSI 16.27%PRS 45.86
-
CSI 7.57rCSI 10.36%PRS 56.26
-
CSI 7.42rCSI 8.86%PRS 31.02
-
CSI 7.3rCSI 42.95%PRS 32.49
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CSI 6.21rCSI 5.74%PRS 66.99
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CSI 5.73rCSI 42.13%PRS 35.02
-
CSI 4.57rCSI 4.9%PRS 44.99
-
CSI 4.47rCSI 3.47%PRS 47.52
-
CSI 4.32rCSI 12.36%PRS 63.32
-
CSI 4.29rCSI 8.85%PRS 52.39
-
CSI 4.21rCSI 16.36%PRS 55.34
-
CSI 4.07rCSI 3.58%PRS 36.07
-
CSI 4.03rCSI 2.83%PRS 68.22
-
CSI 3.93rCSI 6.92%PRS 45.19
-
CSI 3.79rCSI 2.95%PRS 64.07
-
CSI 3.78rCSI 3.06%PRS 57.39
-
CSI 3.62rCSI 9.52%PRS 69.05
-
CSI 3.59rCSI 5.41%PRS 49.06
-
CSI 3.52rCSI 8.37%PRS 52.41
-
CSI 3.49rCSI 2.43%PRS 59.91
-
CSI 3.39rCSI 2.44%PRS 59.97
-
CSI 3.38rCSI 2.36%PRS 48.8
-
CSI 3.36rCSI 5.14%PRS 56.15
-
CSI 3.32rCSI 2.66%PRS 68.19
-
CSI 3.31rCSI 3.25%PRS 49.4
-
CSI 3.25rCSI 8.47%PRS 46.15
-
CSI 3.08rCSI 4.58%PRS 49.26
-
CSI 3.05rCSI 5.28%PRS 37.73
-
CSI 2.98rCSI 6.8%PRS 40.33
-
CSI 2.9rCSI 3.35%PRS 37.18
-
CSI 2.85rCSI 12.54%PRS 44.36
-
CSI 2.83rCSI 3.31%PRS 62.64
-
CSI 2.78rCSI 66.59%PRS 30.55
-
CSI 2.76rCSI 66.61%PRS 31.43
-
CSI 2.76rCSI 5.5%PRS 64.98
-
CSI 2.75rCSI 3.55%PRS 32.02
-
CSI 2.61rCSI 4.06%PRS 73.6
-
CSI 2.6rCSI 2.15%PRS 47.97
-
CSI 2.58rCSI 3.21%PRS 29.52
-
CSI 2.57rCSI 4.82%PRS 36.76
-
CSI 2.55rCSI 1.77%PRS 55.86
-
CSI 2.54rCSI 1.88%PRS 40.52
-
CSI 2.52rCSI 4.13%PRS 37.55
-
CSI 2.51rCSI 3.13%PRS 49.48
-
CSI 2.46rCSI 6.55%PRS 38.84
-
CSI 2.43rCSI 4.16%PRS 67.35
-
CSI 2.36rCSI 1.86%PRS 34.71
-
CSI 2.34rCSI 6.95%PRS 58.12
-
CSI 2.34rCSI 3.19%PRS 74.25
-
CSI 2.28rCSI 2.92%PRS 42.13
-
CSI 2.24rCSI 5.68%PRS 37.44
-
CSI 2.19rCSI 4.82%PRS 50.84
-
CSI 2.18rCSI 2.98%PRS 51.9
-
CSI 2.17rCSI 8.12%PRS 39.93
-
CSI 2.13rCSI 2.01%PRS 47.64
-
CSI 2.08rCSI 1.23%PRS 62.43
-
CSI 2.06rCSI 3.7%PRS 40.38
-
CSI 2.05rCSI 1.7%PRS 45.46
-
CSI 1.99rCSI 1.95%PRS 62.24
-
CSI 1.99rCSI 4.03%PRS 29.41
-
CSI 1.98rCSI 1.98%PRS 41.07
-
CSI 1.95rCSI 2.43%PRS 58.03
-
CSI 1.95rCSI 4.46%PRS 46.4
-
CSI 1.91rCSI 1.78%PRS 46.61
-
CSI 1.91rCSI 2.31%PRS 54.82
-
CSI 1.91rCSI 3.2%PRS 31.13
-
CSI 1.83rCSI 2.06%PRS 63.4
-
CSI 1.83rCSI 4.1%PRS 31.91
-
CSI 1.83rCSI 1.23%PRS 57.68
-
CSI 1.79rCSI 3.6%PRS 36.82
-
CSI 1.79rCSI 5.09%PRS 46.61
-
CSI 1.77rCSI 6.94%PRS 23.93
-
CSI 1.74rCSI 2.57%PRS 52.13
-
CSI 1.72rCSI 1.8%PRS 49.93
-
CSI 1.68rCSI 2.56%PRS 47.46
-
CSI 1.66rCSI 1.69%PRS 60.15
-
CSI 1.65rCSI 2.66%PRS 33.21
-
CSI 1.65rCSI 3.65%PRS 35.09
-
CSI 1.65rCSI 2.67%PRS 45.3
-
CSI 1.63rCSI 5.09%PRS 34.68
-
CSI 1.62rCSI 5.43%PRS 34.97
-
CSI 1.61rCSI 2.54%PRS 48.07
-
CSI 1.6rCSI 2.57%PRS 37.62
-
CSI 1.58rCSI 2.29%PRS 63.06
-
CSI 1.52rCSI 3.33%PRS 56.46
-
CSI 1.52rCSI 2.68%PRS 30.12
-
CSI 1.5rCSI 4%PRS 39.66
-
CSI 1.49rCSI 1.12%PRS 50.55
-
CSI 1.48rCSI 2.36%PRS 50.88
-
CSI 1.46rCSI 1.3%PRS 45.8
-
CSI 1.4rCSI 1.92%PRS 43.02
-
CSI 0.1rCSI 1.1%PRS 34.7%
-
CSI 0.3rCSI 5.9%PRS 40.6%
-
CSI 0.3rCSI 3.2%PRS 66.5%
-
CSI 0.3rCSI 0.9%PRS 62.2%
-
CSI 0.4rCSI 7.9%PRS 39.4%
-
CSI 0.4rCSI 1.8%PRS 45.7%
-
CSI 0.5rCSI 2.0%PRS 40.0%
-
CSI 0.6rCSI 1.6%PRS 46.3%
-
CSI 0.6rCSI 3.3%PRS 43.7%
-
CSI 0.6rCSI 3.2%PRS 33.4%
-
CSI 0.6rCSI 2.4%PRS 67.4%
-
CSI 0.6rCSI 1.6%PRS 60.0%
-
CSI 0.7rCSI 1.0%PRS 51.9%
-
CSI 0.7rCSI 1.1%PRS 43.6%
-
CSI 0.7rCSI 4.6%PRS 39.5%
-
CSI 0.8rCSI 1.6%PRS 70.9%
-
CSI 0.8rCSI 3.9%PRS 65.0%
-
CSI 0.9rCSI 4.5%PRS 54.8%
-
CSI 0.9rCSI 2.5%PRS 61.1%
-
CSI 0.9rCSI 9.6%PRS 47.5%
-
CSI 1.0rCSI 3.3%PRS 38.1%
-
CSI 1.0rCSI 2.8%PRS 55.5%
-
CSI 1.1rCSI 5.9%PRS 63.6%
-
CSI 1.1rCSI 2.2%PRS 40.8%
-
CSI 1.1rCSI 2.7%PRS 44.9%
-
CSI 1.1rCSI 2.4%PRS 61.4%
-
CSI 1.1rCSI 1.4%PRS 41.0%
-
CSI 1.2rCSI 2.8%PRS 36.2%
-
CSI 1.2rCSI 2.5%PRS 67.3%
-
CSI 1.2rCSI 3.1%PRS 46.4%
-
CSI 1.2rCSI 0.9%PRS 61.5%
-
CSI 1.2rCSI 2.8%PRS 38.4%
-
CSI 1.2rCSI 2.0%PRS 52.3%
-
CSI 1.2rCSI 1.7%PRS 48.3%
-
CSI 1.3rCSI 1.9%PRS 56.3%
-
CSI 1.3rCSI 3.0%PRS 62.1%
-
CSI 1.3rCSI 1.2%PRS 61.8%
-
CSI 1.3rCSI 3.6%PRS 43.6%
-
CSI 1.3rCSI 1.0%PRS 45.9%
-
CSI 1.3rCSI 3.4%PRS 43.0%
-
CSI 1.3rCSI 3.8%PRS 38.3%
-
CSI 1.4rCSI 4.5%PRS 35.8%
-
CSI 1.4rCSI 1.9%PRS 43.0%
-
CSI 1.5rCSI 1.3%PRS 45.8%
-
CSI 1.5rCSI 2.4%PRS 50.9%
-
CSI 1.5rCSI 1.1%PRS 50.6%
-
CSI 1.5rCSI 4.0%PRS 39.7%
-
CSI 1.5rCSI 2.7%PRS 30.1%
-
CSI 1.5rCSI 3.3%PRS 56.5%
-
CSI 1.6rCSI 2.3%PRS 63.1%
-
CSI 1.6rCSI 2.6%PRS 37.6%
-
CSI 1.6rCSI 2.5%PRS 48.1%
-
CSI 1.6rCSI 5.4%PRS 35.0%
-
CSI 1.6rCSI 5.1%PRS 34.7%
-
CSI 1.7rCSI 2.7%PRS 45.3%
-
CSI 1.7rCSI 3.7%PRS 35.1%
-
CSI 1.7rCSI 2.7%PRS 33.2%
-
CSI 1.7rCSI 1.7%PRS 60.2%
-
CSI 1.7rCSI 2.6%PRS 47.5%
-
CSI 1.7rCSI 1.8%PRS 49.9%
-
CSI 1.7rCSI 2.6%PRS 52.1%
-
CSI 1.8rCSI 6.9%PRS 23.9%
-
CSI 1.8rCSI 5.1%PRS 46.6%
-
CSI 1.8rCSI 3.6%PRS 36.8%
-
CSI 1.8rCSI 1.2%PRS 57.7%
-
CSI 1.8rCSI 4.1%PRS 31.9%
-
CSI 1.8rCSI 2.1%PRS 63.4%
-
CSI 1.9rCSI 3.2%PRS 31.1%
-
CSI 1.9rCSI 2.3%PRS 54.8%
-
CSI 1.9rCSI 1.8%PRS 46.6%
-
CSI 2.0rCSI 4.5%PRS 46.4%
-
CSI 2.0rCSI 2.4%PRS 58.0%
-
CSI 2.0rCSI 2.0%PRS 41.1%
-
CSI 2.0rCSI 4.0%PRS 29.4%
-
CSI 2.0rCSI 2.0%PRS 62.2%
-
CSI 2.1rCSI 1.7%PRS 45.5%
-
CSI 2.1rCSI 3.7%PRS 40.4%
-
CSI 2.1rCSI 1.2%PRS 62.4%
-
CSI 2.1rCSI 2.0%PRS 47.6%
-
CSI 2.2rCSI 8.1%PRS 39.9%
-
CSI 2.2rCSI 3.0%PRS 51.9%
-
CSI 2.2rCSI 4.8%PRS 50.8%
-
CSI 2.2rCSI 5.7%PRS 37.4%
-
CSI 2.3rCSI 2.9%PRS 42.1%
-
CSI 2.3rCSI 3.2%PRS 74.3%
-
CSI 2.3rCSI 7.0%PRS 58.1%
-
CSI 2.4rCSI 1.9%PRS 34.7%
-
CSI 2.4rCSI 4.2%PRS 67.4%
-
CSI 2.5rCSI 6.6%PRS 38.8%
-
CSI 2.5rCSI 3.1%PRS 49.5%
-
CSI 2.5rCSI 4.1%PRS 37.6%
-
CSI 2.5rCSI 1.9%PRS 40.5%
-
CSI 2.6rCSI 1.8%PRS 55.9%
-
CSI 2.6rCSI 4.8%PRS 36.8%
-
CSI 2.6rCSI 3.2%PRS 29.5%
-
CSI 2.6rCSI 2.2%PRS 48.0%
-
CSI 2.6rCSI 4.1%PRS 73.6%
-
CSI 2.8rCSI 3.6%PRS 32.0%
-
CSI 2.8rCSI 5.5%PRS 65.0%
-
CSI 2.8rCSI 66.6%PRS 31.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4071940603
Symbol: ATX7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9288099
Title: Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion.
PubMed ID: 9288099
DOI: 10.1038/ng0997-65
PubMed ID: 9425224
Title: Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion.
PubMed ID: 9425224
DOI: 10.1093/hmg/7.2.177
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 12533095
Title: A novel central nervous system-enriched spinocerebellar ataxia type 7 gene product.
PubMed ID: 12533095
PubMed ID: 10441328
Title: Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7.
PubMed ID: 10441328
DOI: 10.1093/hmg/8.9.1657
PubMed ID: 11371513
Title: Ataxin-7 interacts with a Cbl-associated protein that it recruits into neuronal intranuclear inclusions.
PubMed ID: 11371513
PubMed ID: 11734547
Title: Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex.
PubMed ID: 11734547
PubMed ID: 15115762
Title: Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.
PubMed ID: 15115762
DOI: 10.1093/hmg/ddh139
PubMed ID: 15932940
Title: Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
PubMed ID: 15932940
PubMed ID: 16314424
Title: Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.
PubMed ID: 16314424
PubMed ID: 17646170
Title: Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
PubMed ID: 17646170
PubMed ID: 18206972
Title: A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
PubMed ID: 18206972
PubMed ID: 19843541
Title: SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.
PubMed ID: 19843541
DOI: 10.1093/hmg/ddp478
PubMed ID: 22100762
Title: Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network.
PubMed ID: 22100762
DOI: 10.1093/hmg/ddr539
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 892
- Mass: 95451
- Checksum: 9AEA787D77103C5F
- Sequence:
MSERAADDVR GEPRRAAAAA GGAAAAAARQ QQQQQQQQQP PPPQPQRQQH PPPPPRRTRP EDGGPGAAST SAAAMATVGE RRPLPSPEVM LGQSWNLWVE ASKLPGKDGT ELDESFKEFG KNREVMGLCR EDMPIFGFCP AHDDFYLVVC NDCNQVVKPQ AFQSHYERRH SSSSKPPLAV PPTSVFSFFP SLSKSKGGSA SGSNRSSSGG VLSASSSSSK LLKSPKEKLQ LRGNTRPMHP IQQSRVPHGR IMTPSVKVEK IHPKMDGTLL KSAVGPTCPA TVSSLVKPGL NCPSIPKPTL PSPGQILNGK GLPAPPTLEK KPEDNSNNRK FLNKRLSERE FDPDIHCGVI DLDTKKPCTR SLTCKTHSLT QRRAVQGRRK RFDVLLAEHK NKTREKELIR HPDSQQPPQP LRDPHPAPPR TSQEPHQNPH GVIPSESKPF VASKPKPHTP SLPRPPGCPA QQGGSAPIDP PPVHESPHPP LPATEPASRL SSEEGEGDDK EESVEKLDCH YSGHHPQPAS FCTFGSRQIG RGYYVFDSRW NRLRCALNLM VEKHLNAQLW KKIPPVPSTT SPISTRIPHR TNSVPTSQCG VSYLAAATVS TSPVLLSSTC ISPNSKSVPA HGTTLNAQPA ASGAMDPVCS MQSRQVSSSS SSPSTPSGLS SVPSSPMSRK PQKLKSSKSL RPKESSGNST NCQNASSSTS GGSGKKRKNS SPLLVHSSSS SSSSSSSSHS MESFRKNCVA HSGPPYPSTV TSSHSIGLNC VTNKANAVNV RHDQSGRGPP TGSPAESIKR MSVMVNSSDS TLSLGPFIHQ SNELPVNSHG SFSHSHTPLD KLIGKKRKCS PSSSSINNSS SKPTKVAKVP AVNNVHMKHT GTIPGAQGLM NSSLLHQPKA RP
Genular Protein ID: 830248135
Symbol: Q9UPD8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9425224
Title: Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion.
PubMed ID: 9425224
DOI: 10.1093/hmg/7.2.177
Sequence Information:
- Length: 26
- Mass: 2499
- Checksum: EC031EE203172746
- Sequence:
MSERAADDVR GEPRRAAAAA GGAAAA