Details for: SRL

Gene ID: 6345

Symbol: SRL

Ensembl ID: ENSG00000185739

Description: sarcalumenin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.9255
    Cell Significance Index: 120.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.0143
    Cell Significance Index: 308.0500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.9324
    Cell Significance Index: 63.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.3177
    Cell Significance Index: 85.2800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.6344
    Cell Significance Index: 30.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3251
    Cell Significance Index: -2.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2585
    Cell Significance Index: 18.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7845
    Cell Significance Index: 6.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3731
    Cell Significance Index: 5.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3716
    Cell Significance Index: 23.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2088
    Cell Significance Index: 2.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1724
    Cell Significance Index: 2.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1340
    Cell Significance Index: 3.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0843
    Cell Significance Index: 15.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0837
    Cell Significance Index: 12.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0671
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0489
    Cell Significance Index: 33.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0443
    Cell Significance Index: 7.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0442
    Cell Significance Index: 5.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0291
    Cell Significance Index: 1.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0226
    Cell Significance Index: 1.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0189
    Cell Significance Index: 25.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0166
    Cell Significance Index: 7.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0166
    Cell Significance Index: 3.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0069
    Cell Significance Index: 10.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0067
    Cell Significance Index: 12.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0083
    Cell Significance Index: -1.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0092
    Cell Significance Index: -5.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0129
    Cell Significance Index: -0.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0129
    Cell Significance Index: -1.6600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0168
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0178
    Cell Significance Index: -3.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0181
    Cell Significance Index: -0.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0229
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0267
    Cell Significance Index: -5.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0275
    Cell Significance Index: -1.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0313
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0343
    Cell Significance Index: -4.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0372
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0403
    Cell Significance Index: -5.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0406
    Cell Significance Index: -0.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0411
    Cell Significance Index: -4.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0471
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0481
    Cell Significance Index: -5.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0491
    Cell Significance Index: -5.0200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0509
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0527
    Cell Significance Index: -2.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0538
    Cell Significance Index: -1.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0569
    Cell Significance Index: -1.1100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0606
    Cell Significance Index: -0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0707
    Cell Significance Index: -5.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0726
    Cell Significance Index: -4.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0739
    Cell Significance Index: -4.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0866
    Cell Significance Index: -5.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0884
    Cell Significance Index: -1.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0892
    Cell Significance Index: -1.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0896
    Cell Significance Index: -1.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0899
    Cell Significance Index: -4.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0938
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0951
    Cell Significance Index: -4.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0967
    Cell Significance Index: -4.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0981
    Cell Significance Index: -1.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0984
    Cell Significance Index: -4.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1029
    Cell Significance Index: -3.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1031
    Cell Significance Index: -4.4800
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1051
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1110
    Cell Significance Index: -5.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1115
    Cell Significance Index: -3.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1132
    Cell Significance Index: -3.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1145
    Cell Significance Index: -5.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1152
    Cell Significance Index: -3.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1171
    Cell Significance Index: -1.9600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1224
    Cell Significance Index: -1.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1275
    Cell Significance Index: -3.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1278
    Cell Significance Index: -4.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1302
    Cell Significance Index: -4.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1305
    Cell Significance Index: -2.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1331
    Cell Significance Index: -1.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1346
    Cell Significance Index: -4.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1402
    Cell Significance Index: -4.4900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1420
    Cell Significance Index: -1.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1474
    Cell Significance Index: -2.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1475
    Cell Significance Index: -3.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1516
    Cell Significance Index: -3.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1524
    Cell Significance Index: -4.8200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1541
    Cell Significance Index: -1.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1591
    Cell Significance Index: -2.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1592
    Cell Significance Index: -3.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1650
    Cell Significance Index: -4.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Sarcalumenin is a protein-coding gene that belongs to the GTP-binding protein family. It is primarily expressed in muscle cells, particularly in the sarcoplasmic reticulum, which is a crucial organelle responsible for calcium storage and release. The Sarcalumenin protein is characterized by its unique structure, which consists of a GTP-binding domain and a transmembrane domain. This protein is highly conserved across species, suggesting its essential role in muscle function. **Pathways and Functions:** Sarcalumenin is involved in several critical pathways that regulate muscle function and development. These include: 1. **GTP-binding pathway:** Sarcalumenin interacts with GTP-binding proteins to regulate muscle contraction and relaxation. This interaction is essential for the proper functioning of the sarcoplasmic reticulum and the subsequent release of calcium ions. 2. **Sarcoplasmic reticulum lumen pathway:** Sarcalumenin is localized to the sarcoplasmic reticulum lumen, where it regulates the release of calcium ions. This process is critical for muscle contraction and relaxation. 3. **Sarcoplasmic reticulum membrane pathway:** Sarcalumenin is also localized to the sarcoplasmic reticulum membrane, where it regulates the influx of calcium ions. This process is essential for the proper functioning of the sarcoplasmic reticulum and muscle contraction. In addition to its role in muscle contraction and relaxation, Sarcalumenin is also involved in cell signaling pathways that regulate muscle development and differentiation. **Clinical Significance:** Dysregulation of Sarcalumenin has been implicated in various muscle disorders, including: 1. **Muscular dystrophy:** Mutations in the Sarcalumenin gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac arrhythmias:** Abnormal expression of Sarcalumenin has been linked to cardiac arrhythmias, which are abnormal heart rhythms that can be life-threatening. 3. **Muscle wasting:** Sarcalumenin dysregulation has also been implicated in muscle wasting disorders, such as cachexia, which is characterized by progressive weight loss and muscle degradation. In conclusion, Sarcalumenin is a critical gene that plays a pivotal role in muscle function and development. Its dysregulation has been implicated in various muscle disorders, highlighting the importance of this gene in maintaining muscle homeostasis. Further research is necessary to fully understand the mechanisms by which Sarcalumenin regulates muscle function and to develop effective therapeutic strategies for muscle disorders.

Genular Protein ID: 3028119639

Symbol: SRCA_HUMAN

Name: Sarcalumenin

UniProtKB Accession Codes:

Q86TD4 B4DYT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 473
  • Mass: 54431
  • Checksum: 976721235C129CB7
  • Sequence:
    • MRALVLLGCL LASLLFSGQA EETEDANEEA PLRDRSHIEK TLMLNEDKPS DDYSAVLQRL 
RKIYHSSIKP LEQSYKYNEL RQHEITDGEI TSKPMVLFLG PWSVGKSTMI NYLLGLENTR 
YQLYTGAEPT TSEFTVLMHG PKLKTIEGIV MAADSARSFS PLEKFGQNFL EKLIGIEVPH 
KLLERVTFVD TPGIIENRKQ QERGYPFNDV CQWFIDRADL IFVVFDPTKL DVGLELEMLF 
RQLKGRESQI RIILNKADNL ATQMLMRVYG ALFWSLAPLI NVTEPPRVYV SSFWPQEYKP 
DTHQELFLQE EISLLEDLNQ VIENRLENKI AFIRQHAIRV RIHALLVDRY LQTYKDKMTF 
FSDGELVFKD IVEDPDKFYI FKTILAKTNV SKFDLPNREA YKDFFGINPI SSFKLLSQQC 
SYMGGCFLEK IERAITQELP GLLGSLGLGK NPGALNCDKT GCSETPKNRY RKH

Genular Protein ID: 1079196498

Symbol: B3KPP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPP4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 397
  • Mass: 45978
  • Checksum: AC0C2B0CC1FB8830
  • Sequence:
    • MRALVLLGCL LASLLFSGQA EETEDANEEA PLRDRSHIEK TLMLNEDKPS DDYSAVLQRL 
RKIYHSSIKP LEQSYKYNEL RQHEITDGEI TSKPMVLFLG PWSVGKSTMI NYLLGLENTR 
YQLYTGAEPT TSEFTVLMHG PKLKTIEGIV MAADSARSFS PLEKFGQNFL EKLIGIEVPH 
KLLERVTFVD TPGIIENRKQ QERGYPFNDV CQWFIDRADL IFVVFDPTKL DVGLELEMLF 
RQLKGRESQI RIILNKADNL ATQMLMRVYG ALFWSLAPLI NVTEPPRVYV SSFWPQEYKP 
DTHQELFLQE EISLLEDLNQ VIENRLENKI AFIRQHAIRV RIHALLVDRY LQTYKDKMTF 
FSDGELVFKD IVEDPDKFYI FKTILAKTNV SKFDLPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.