Details for: SEMG2

Gene ID: 6407

Symbol: SEMG2

Ensembl ID: ENSG00000124157

Description: semenogelin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.04
    Marker Score: 1129
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10815
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7580
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32730.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.01
    Marker Score: 1391
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.99
    Marker Score: 522
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.99
    Marker Score: 2413
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.96
    Marker Score: 546
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.65
    Marker Score: 1036
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.45
    Marker Score: 259
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 262
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.39
    Marker Score: 225
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 544
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2
    Marker Score: 411
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.14
    Marker Score: 387
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.13
    Marker Score: 2016
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.11
    Marker Score: 287
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 678
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.11
    Marker Score: 94
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.08
    Marker Score: 60.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 110
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.01
    Marker Score: 93
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: sperm (CL0000019)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0
    Marker Score: 48
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 7

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Other Information

**Key characteristics:** - SEMG2 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed in a variety of cell types. - SEMG2 is involved in the regulation of sperm motility. **Pathways and functions:** - SEMG2 is involved in the antibacterial humoral response. It is expressed in the epididymis of the testes, where it is produced by Sertoli cells. SEMG2 binds to bacterial lipopolysaccharide (LPS), which is a major component of bacterial cell walls. This binding prevents the LPS from interacting with its receptor on the surface of bacterial cells, which prevents the activation of the immune system. - SEMG2 is also involved in the coagulation cascade. It is expressed in endothelial cells, where it helps to regulate the flow of blood. SEMG2 binds to von Willebrand factor, which is a protein that is involved in the coagulation cascade. This binding prevents the coagulation cascade from proceeding, which helps to maintain blood flow and prevent bleeding. - SEMG2 is also involved in the extra cellular exosome pathway. It is expressed in exosomes, which are small vesicles that are released by cells. SEMG2 binds to phosphatidylserine on the surface of exosomes, which is a protein that is involved in the formation of the blood-brain barrier. This binding allows the exosomes to be taken up by brain cells, where they can exert their effects. **Clinical significance:** - Mutations in SEMG2 have been linked to a number of human diseases, including infertility, bacterial vaginosis, and prostate cancer. - SEMG2 is a potential therapeutic target for these diseases.

Genular Protein ID: 585165474

Symbol: SEMG2_HUMAN

Name: Semenogelin-2

UniProtKB Accession Codes:

Q02383 Q53ZU2 Q6X2M5 Q6X2M6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1584792

Title: Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein.

PubMed ID: 1584792

DOI: 10.1073/pnas.89.10.4559

PubMed ID: 1517240

Title: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.

PubMed ID: 1517240

DOI: 10.1016/s0021-9258(19)37155-8

PubMed ID: 14629036

Title: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.

PubMed ID: 14629036

DOI: 10.1007/s00239-003-2474-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 2757795

Title: Isolation and structure determination of two peptides occurring in human seminal plasma.

PubMed ID: 2757795

PubMed ID: 8665951

Title: Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II.

PubMed ID: 8665951

DOI: 10.1111/j.1432-1033.1996.0048q.x

PubMed ID: 8665956

Title: Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

PubMed ID: 8665956

DOI: 10.1111/j.1432-1033.1996.0088q.x

Sequence Information:

  • Length: 582
  • Mass: 65444
  • Checksum: EBF63FBF3A8EC45B
  • Sequence:
    • MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK 
GSFSIQHTYH VDINDHDWTR KSQQYDLNAL HKATKSKQHL GGSQQLLNYK QEGRDHDKSK 
GHFHMIVIHH KGGQAHHGTQ NPSQDQGNSP SGKGLSSQCS NTEKRLWVHG LSKEQASASG 
AQKGRTQGGS QSSYVLQTEE LVVNKQQRET KNSHQNKGHY QNVVDVREEH SSKLQTSLHP 
AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLSQDQEHG RKAHKISYPS SRTEERQLHH 
GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKISYQS SSTEERHLNC 
GEKGIQKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEYG HKENKISYQS SSTEERRLNS 
GEKDVQKGVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKMSYQS SSTEERRLNY 
GGKSTQKDVS QSSISFQIEK LVEGKSQIQT PNPNQDQWSG QNAKGKSGQS ADSKQDLLSH 
EQKGRYKQES SESHNIVITE HEVAQDDHLT QQYNEDRNPI ST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.