Details for: MAP2K4
Gene ID: 6416
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MAP2K4
Ensembl ID: ENSG00000065559
Description: mitogen-activated protein kinase kinase 4
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 43.58rCSI 52.06%PRS 31.31
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CSI 43.2rCSI 53.74%PRS 29.83
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CSI 36.99rCSI 59.49%PRS 33.54
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CSI 36.65rCSI 61.51%PRS 31.46
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CSI 35.74rCSI 46.08%PRS 32.35
-
CSI 30.8rCSI 54.39%PRS 30.44
-
CSI 28.22rCSI 68.58%PRS 30.48
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CSI 23.87rCSI 51.77%PRS 37.42
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CSI 22.71rCSI 70.98%PRS 32.68
-
CSI 21.77rCSI 68.09%PRS 35.01
-
CSI 20.02rCSI 53.31%PRS 39.29
-
CSI 19.44rCSI 46.49%PRS 36.52
-
CSI 19.13rCSI 68.84%PRS 30.28
-
CSI 18.86rCSI 71.26%PRS 32.32
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CSI 18.02rCSI 44.6%PRS 45.38
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CSI 17.86rCSI 39.45%PRS 35.5
-
CSI 17.69rCSI 58.12%PRS 36.13
-
CSI 15.59rCSI 35.55%PRS 45.6
-
CSI 13.75rCSI 17.01%PRS 43.22
-
CSI 11.87rCSI 69.92%PRS 32.81
-
CSI 11.6rCSI 21.73%PRS 37.1
-
CSI 10.74rCSI 9.21%PRS 55.93
-
CSI 9.51rCSI 21.71%PRS 40.74
-
CSI 9.41rCSI 69.19%PRS 35.36
-
CSI 8.75rCSI 35.31%PRS 46.01
-
CSI 8.6rCSI 9.93%PRS 41.54
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CSI 8.59rCSI 10.29%PRS 66.26
-
CSI 8.42rCSI 17.29%PRS 41.05
-
CSI 8.31rCSI 16.86%PRS 29.71
-
CSI 8.1rCSI 10.4%PRS 42.64
-
CSI 7.98rCSI 12.73%PRS 41.05
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CSI 7.94rCSI 8.29%PRS 47.93
-
CSI 7.93rCSI 11.96%PRS 49.53
-
CSI 7.82rCSI 20.3%PRS 52.42
-
CSI 7.73rCSI 26.47%PRS 38.53
-
CSI 7.58rCSI 11.58%PRS 47.89
-
CSI 7.35rCSI 21.01%PRS 63.77
-
CSI 6.83rCSI 9.49%PRS 46.71
-
CSI 6.5rCSI 11.4%PRS 39.72
-
CSI 6.44rCSI 6.67%PRS 53.2
-
CSI 6.44rCSI 24.12%PRS 40.36
-
CSI 6.43rCSI 16.61%PRS 43.51
-
CSI 6.32rCSI 4.78%PRS 60.1
-
CSI 5.82rCSI 9.52%PRS 37.94
-
CSI 5.75rCSI 10.13%PRS 45.62
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CSI 5.58rCSI 11.58%PRS 45.32
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CSI 5.38rCSI 17.22%PRS 44.5
-
CSI 5.31rCSI 4.19%PRS 35.11
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CSI 5.25rCSI 11.79%PRS 67
-
CSI 5.16rCSI 6.62%PRS 45.27
-
CSI 5.05rCSI 9.08%PRS 40.73
-
CSI 5.03rCSI 10.1%PRS 37.17
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CSI 4.97rCSI 42.85%PRS 35.03
-
CSI 4.91rCSI 11.23%PRS 46.85
-
CSI 4.85rCSI 4.47%PRS 48.15
-
CSI 4.73rCSI 10.91%PRS 38.64
-
CSI 4.69rCSI 3.47%PRS 40.95
-
CSI 4.65rCSI 8.04%PRS 38.15
-
CSI 4.54rCSI 18%PRS 49.17
-
CSI 4.44rCSI 22.06%PRS 46.69
-
CSI 4.42rCSI 3.32%PRS 51.08
-
CSI 4.35rCSI 17.72%PRS 44.32
-
CSI 4.34rCSI 12.88%PRS 58.64
-
CSI 4.28rCSI 6.07%PRS 44.3
-
CSI 4.24rCSI 5.67%PRS 48.67
-
CSI 4.18rCSI 3.89%PRS 47.05
-
CSI 4.17rCSI 6.63%PRS 40.37
-
CSI 4.11rCSI 22.12%PRS 62.3
-
CSI 4.07rCSI 4.92%PRS 55.31
-
CSI 3.99rCSI 15.62%PRS 24.61
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CSI 3.97rCSI 9.69%PRS 42.97
-
CSI 3.96rCSI 5.41%PRS 43.39
-
CSI 3.95rCSI 62.35%PRS 51.99
-
CSI 3.84rCSI 22.16%PRS 48.94
-
CSI 3.71rCSI 3.51%PRS 48.11
-
CSI 3.68rCSI 3.35%PRS 62.32
-
CSI 3.56rCSI 9.29%PRS 46.69
-
CSI 3.55rCSI 7.81%PRS 32.25
-
CSI 3.54rCSI 3.7%PRS 50.39
-
CSI 3.4rCSI 7.49%PRS 51.38
-
CSI 3.4rCSI 5.37%PRS 48.53
-
CSI 3.34rCSI 10.3%PRS 59.02
-
CSI 3.29rCSI 15.76%PRS 46.28
-
CSI 3.27rCSI 5.23%PRS 51.4
-
CSI 3.23rCSI 2.61%PRS 57.87
-
CSI 3.21rCSI 45.58%PRS 39.61
-
CSI 3.19rCSI 4.57%PRS 38.55
-
CSI 3.17rCSI 4.66%PRS 42.74
-
CSI 3.16rCSI 8.99%PRS 47.07
-
CSI 3.1rCSI 5.11%PRS 52.83
-
CSI 3.08rCSI 23.16%PRS 66.92
-
CSI 3.08rCSI 5.59%PRS 40.82
-
CSI 3.01rCSI 8.31%PRS 44.02
-
CSI 3.01rCSI 72.13%PRS 30.94
-
CSI 3.01rCSI 61.22%PRS 39.79
-
CSI 2.98rCSI 71.89%PRS 31.82
-
CSI 2.96rCSI 6.64%PRS 32.21
-
CSI 2.95rCSI 3.95%PRS 55.8
-
CSI 2.88rCSI 58.64%PRS 41.02
-
CSI 2.84rCSI 2.73%PRS 38.09
-
CSI 0.5rCSI 5.0%PRS 48.0%
-
CSI 0.5rCSI 0.7%PRS 63.7%
-
CSI 0.5rCSI 1.2%PRS 44.8%
-
CSI 0.6rCSI 6.3%PRS 40.1%
-
CSI 0.6rCSI 2.7%PRS 40.5%
-
CSI 0.6rCSI 4.8%PRS 42.4%
-
CSI 0.6rCSI 3.4%PRS 55.3%
-
CSI 0.7rCSI 4.7%PRS 42.6%
-
CSI 0.7rCSI 4.1%PRS 39.9%
-
CSI 0.7rCSI 1.4%PRS 52.8%
-
CSI 0.7rCSI 1.4%PRS 49.5%
-
CSI 0.7rCSI 3.2%PRS 44.8%
-
CSI 0.8rCSI 2.9%PRS 40.4%
-
CSI 0.8rCSI 2.2%PRS 62.6%
-
CSI 0.8rCSI 4.7%PRS 44.3%
-
CSI 0.9rCSI 1.2%PRS 55.5%
-
CSI 0.9rCSI 2.1%PRS 52.9%
-
CSI 0.9rCSI 1.7%PRS 57.7%
-
CSI 0.9rCSI 7.1%PRS 44.8%
-
CSI 0.9rCSI 2.3%PRS 57.3%
-
CSI 0.9rCSI 4.7%PRS 59.2%
-
CSI 1.0rCSI 3.9%PRS 58.5%
-
CSI 1.0rCSI 8.7%PRS 42.0%
-
CSI 1.0rCSI 1.4%PRS 52.4%
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CSI 1.1rCSI 5.5%PRS 44.0%
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CSI 1.1rCSI 5.2%PRS 44.6%
-
CSI 1.1rCSI 4.9%PRS 33.4%
-
CSI 1.1rCSI 9.6%PRS 47.5%
-
CSI 1.1rCSI 2.9%PRS 69.5%
-
CSI 1.2rCSI 1.0%PRS 36.5%
-
CSI 1.2rCSI 3.8%PRS 49.4%
-
CSI 1.2rCSI 3.3%PRS 61.6%
-
CSI 1.3rCSI 2.0%PRS 54.6%
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CSI 1.3rCSI 8.9%PRS 45.9%
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CSI 1.4rCSI 1.6%PRS 37.6%
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CSI 1.4rCSI 4.0%PRS 38.7%
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CSI 1.4rCSI 3.6%PRS 49.6%
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CSI 1.4rCSI 4.5%PRS 46.5%
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CSI 1.4rCSI 1.1%PRS 46.3%
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CSI 1.5rCSI 6.7%PRS 69.3%
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CSI 1.6rCSI 7.4%PRS 65.4%
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CSI 1.6rCSI 4.3%PRS 55.1%
-
CSI 1.7rCSI 1.5%PRS 52.2%
-
CSI 1.7rCSI 3.5%PRS 46.3%
-
CSI 1.8rCSI 4.9%PRS 46.8%
-
CSI 1.8rCSI 2.9%PRS 38.0%
-
CSI 1.8rCSI 6.1%PRS 35.3%
-
CSI 1.8rCSI 3.0%PRS 25.0%
-
CSI 1.8rCSI 4.1%PRS 61.9%
-
CSI 1.8rCSI 7.1%PRS 64.9%
-
CSI 1.9rCSI 2.9%PRS 45.1%
-
CSI 2.0rCSI 1.3%PRS 58.2%
-
CSI 2.0rCSI 2.6%PRS 52.2%
-
CSI 2.0rCSI 3.7%PRS 63.8%
-
CSI 2.1rCSI 4.5%PRS 57.0%
-
CSI 2.1rCSI 2.5%PRS 45.3%
-
CSI 2.1rCSI 3.6%PRS 55.7%
-
CSI 2.1rCSI 3.1%PRS 52.5%
-
CSI 2.1rCSI 2.3%PRS 45.5%
-
CSI 2.1rCSI 3.4%PRS 58.3%
-
CSI 2.1rCSI 5.6%PRS 55.2%
-
CSI 2.2rCSI 5.8%PRS 56.0%
-
CSI 2.2rCSI 5.8%PRS 40.1%
-
CSI 2.2rCSI 5.6%PRS 37.8%
-
CSI 2.2rCSI 14.3%PRS 52.7%
-
CSI 2.2rCSI 9.9%PRS 46.2%
-
CSI 2.2rCSI 2.8%PRS 58.6%
-
CSI 2.4rCSI 2.6%PRS 51.3%
-
CSI 2.4rCSI 19.5%PRS 41.8%
-
CSI 2.4rCSI 16.5%PRS 44.8%
-
CSI 2.5rCSI 3.8%PRS 44.0%
-
CSI 2.5rCSI 5.9%PRS 49.4%
-
CSI 2.5rCSI 1.9%PRS 48.0%
-
CSI 2.5rCSI 3.7%PRS 50.6%
-
CSI 2.6rCSI 6.2%PRS 57.6%
-
CSI 2.6rCSI 3.3%PRS 50.0%
-
CSI 2.7rCSI 4.8%PRS 45.9%
-
CSI 2.7rCSI 6.8%PRS 55.8%
-
CSI 2.7rCSI 3.3%PRS 41.2%
-
CSI 2.7rCSI 2.7%PRS 41.5%
-
CSI 2.7rCSI 7.0%PRS 46.8%
-
CSI 2.7rCSI 2.5%PRS 55.0%
-
CSI 2.7rCSI 15.3%PRS 33.7%
-
CSI 2.7rCSI 13.1%PRS 48.1%
-
CSI 2.8rCSI 4.3%PRS 56.8%
-
CSI 2.8rCSI 2.7%PRS 49.8%
-
CSI 2.8rCSI 17.4%PRS 67.7%
-
CSI 2.8rCSI 2.7%PRS 38.1%
-
CSI 2.9rCSI 58.6%PRS 41.0%
-
CSI 3.0rCSI 4.0%PRS 55.8%
-
CSI 3.0rCSI 6.6%PRS 32.2%
-
CSI 3.0rCSI 71.9%PRS 31.8%
-
CSI 3.0rCSI 61.2%PRS 39.8%
-
CSI 3.0rCSI 72.1%PRS 30.9%
-
CSI 3.0rCSI 8.3%PRS 44.0%
-
CSI 3.1rCSI 5.6%PRS 40.8%
-
CSI 3.1rCSI 23.2%PRS 66.9%
-
CSI 3.1rCSI 5.1%PRS 52.8%
-
CSI 3.2rCSI 9.0%PRS 47.1%
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CSI 3.2rCSI 4.7%PRS 42.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1176200165
Symbol: MP2K4_HUMAN
Name: Dual specificity mitogen-activated protein kinase kinase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7839144
Title: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.
PubMed ID: 7839144
PubMed ID: 7716521
Title: Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
PubMed ID: 7716521
PubMed ID: 9622070
Title: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.
PubMed ID: 9622070
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9003778
Title: MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
PubMed ID: 9003778
PubMed ID: 11104681
Title: Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.
PubMed ID: 11104681
DOI: 10.1042/bj3520739
PubMed ID: 11090355
Title: Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
PubMed ID: 11090355
PubMed ID: 12189133
Title: Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.
PubMed ID: 12189133
PubMed ID: 12788955
Title: A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.
PubMed ID: 12788955
PubMed ID: 15866172
Title: Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.
PubMed ID: 15866172
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19782076
Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
PubMed ID: 19782076
PubMed ID: 17496909
Title: Differential regulation and properties of MAPKs.
PubMed ID: 17496909
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20801953
Title: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.
PubMed ID: 20801953
DOI: 10.1093/jb/mvq098
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21333379
Title: The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7.
PubMed ID: 21333379
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 20732303
Title: Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state.
PubMed ID: 20732303
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 399
- Mass: 44288
- Checksum: A472537F2F26770B
- Sequence:
MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD