Details for: MAP2K4

Gene ID: 6416

Symbol: MAP2K4

Ensembl ID: ENSG00000065559

Description: mitogen-activated protein kinase kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 332.1863
    Cell Significance Index: -51.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 204.7363
    Cell Significance Index: -51.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.2635
    Cell Significance Index: -52.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.6259
    Cell Significance Index: -42.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.6927
    Cell Significance Index: -42.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.7428
    Cell Significance Index: -52.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.8420
    Cell Significance Index: -50.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5313
    Cell Significance Index: -50.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.4470
    Cell Significance Index: -29.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3982
    Cell Significance Index: -52.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.8682
    Cell Significance Index: 81.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7481
    Cell Significance Index: 551.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.6319
    Cell Significance Index: 176.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5678
    Cell Significance Index: 144.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3152
    Cell Significance Index: 830.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8540
    Cell Significance Index: 367.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7173
    Cell Significance Index: 65.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7064
    Cell Significance Index: 1180.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7058
    Cell Significance Index: 40.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6916
    Cell Significance Index: 23.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6000
    Cell Significance Index: 70.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5144
    Cell Significance Index: 93.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4363
    Cell Significance Index: 40.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2645
    Cell Significance Index: 205.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2162
    Cell Significance Index: 93.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0781
    Cell Significance Index: 26.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0437
    Cell Significance Index: 22.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6432
    Cell Significance Index: 69.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5812
    Cell Significance Index: 57.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5197
    Cell Significance Index: 13.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4536
    Cell Significance Index: 55.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3956
    Cell Significance Index: 6.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3750
    Cell Significance Index: 67.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3695
    Cell Significance Index: 234.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3183
    Cell Significance Index: 9.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3059
    Cell Significance Index: 5.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3016
    Cell Significance Index: 567.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2973
    Cell Significance Index: 6.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2909
    Cell Significance Index: 6.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2564
    Cell Significance Index: 11.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2294
    Cell Significance Index: 3.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2235
    Cell Significance Index: 122.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2014
    Cell Significance Index: 13.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1843
    Cell Significance Index: 283.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1784
    Cell Significance Index: 80.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1439
    Cell Significance Index: 63.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1176
    Cell Significance Index: 216.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0905
    Cell Significance Index: 123.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0781
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0319
    Cell Significance Index: 1.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0068
    Cell Significance Index: 0.0600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0072
    Cell Significance Index: -0.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0250
    Cell Significance Index: -4.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0294
    Cell Significance Index: -4.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0448
    Cell Significance Index: -32.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0475
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0479
    Cell Significance Index: -35.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0638
    Cell Significance Index: -48.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0909
    Cell Significance Index: -51.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0931
    Cell Significance Index: -58.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1451
    Cell Significance Index: -24.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1580
    Cell Significance Index: -45.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1777
    Cell Significance Index: -20.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1783
    Cell Significance Index: -8.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1874
    Cell Significance Index: -24.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1907
    Cell Significance Index: -5.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1933
    Cell Significance Index: -10.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2052
    Cell Significance Index: -15.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2561
    Cell Significance Index: -30.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2605
    Cell Significance Index: -33.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2620
    Cell Significance Index: -55.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2690
    Cell Significance Index: -28.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3170
    Cell Significance Index: -32.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3229
    Cell Significance Index: -8.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3369
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3663
    Cell Significance Index: -41.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3898
    Cell Significance Index: -24.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4334
    Cell Significance Index: -8.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4368
    Cell Significance Index: -30.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4931
    Cell Significance Index: -9.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5073
    Cell Significance Index: -16.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5443
    Cell Significance Index: -43.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5470
    Cell Significance Index: -17.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5655
    Cell Significance Index: -36.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5696
    Cell Significance Index: -8.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5794
    Cell Significance Index: -8.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5813
    Cell Significance Index: -12.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5917
    Cell Significance Index: -8.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5939
    Cell Significance Index: -12.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6148
    Cell Significance Index: -32.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6191
    Cell Significance Index: -13.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6407
    Cell Significance Index: -9.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6691
    Cell Significance Index: -41.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6800
    Cell Significance Index: -8.4800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7527
    Cell Significance Index: -11.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8020
    Cell Significance Index: -7.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9349
    Cell Significance Index: -29.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9580
    Cell Significance Index: -25.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP2K4 exhibits several key characteristics that distinguish it from other MAPK kinases. These include: 1. **Dual specificity**: MAP2K4 possesses dual specificity, allowing it to phosphorylate and activate both MAPKs and other downstream targets. 2. **Regulation of cell growth and differentiation**: MAP2K4 has been implicated in the regulation of cell growth and differentiation, particularly in cardiac muscle cells. 3. **Involvement in immune response**: MAP2K4 plays a critical role in the regulation of immune responses, influencing the activation of various signaling pathways involved in cytokine production and cell-mediated immunity. 4. **Stress response**: MAP2K4 has been shown to regulate cellular responses to stress, including oxidative stress and hydrogen peroxide-induced apoptosis. **Pathways and Functions:** The MAP2K4 gene is involved in a wide range of signaling pathways, including: 1. **MAPK cascade**: MAP2K4 activates MAPKs, which in turn phosphorylate and regulate various downstream targets. 2. **Cytokine signaling**: MAP2K4 regulates cytokine signaling pathways, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **TLR signaling**: MAP2K4 is involved in the regulation of Toll-like receptor (TLR) signaling pathways, which play a critical role in the recognition of pathogens and the activation of innate immunity. 4. **Apoptosis**: MAP2K4 regulates apoptosis, influencing the activation of pro-apoptotic and anti-apoptotic pathways. **Clinical Significance:** The dysregulation of MAP2K4 has been implicated in various diseases, including: 1. **Immune-related disorders**: MAP2K4 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: MAP2K4 has been found to be overexpressed in certain types of cancer, including breast and lung cancer. 3. **Neurological disorders**: MAP2K4 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, MAP2K4 is a multifunctional gene that plays a critical role in regulating various cellular processes, including immune response, cell growth, and stress response. Its dysregulation has been implicated in a range of diseases, highlighting the importance of further research into the mechanisms underlying MAP2K4 function and its implications for human health.

Genular Protein ID: 1176200165

Symbol: MP2K4_HUMAN

Name: Dual specificity mitogen-activated protein kinase kinase 4

UniProtKB Accession Codes:

P45985 B2R7N7 B3KYB2 D3DTS5 Q5U0B8 Q6FHX4 Q6P9H2 Q6PIE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EC 4 EMBL 25 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 9 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7839144

Title: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

PubMed ID: 7839144

DOI: 10.1126/science.7839144

PubMed ID: 7716521

Title: Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

PubMed ID: 7716521

DOI: 10.1126/science.7716521

PubMed ID: 9622070

Title: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.

PubMed ID: 9622070

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9003778

Title: MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

PubMed ID: 9003778

DOI: 10.1002/j.1460-2075.1996.tb01094.x

PubMed ID: 11104681

Title: Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.

PubMed ID: 11104681

DOI: 10.1042/bj3520739

PubMed ID: 11090355

Title: Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

PubMed ID: 11090355

DOI: 10.1126/science.290.5496.1574

PubMed ID: 12189133

Title: Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.

PubMed ID: 12189133

DOI: 10.1074/jbc.m202004200

PubMed ID: 12788955

Title: A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.

PubMed ID: 12788955

DOI: 10.1074/jbc.m304229200

PubMed ID: 15866172

Title: Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.

PubMed ID: 15866172

DOI: 10.1016/j.molcel.2005.04.001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19782076

Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

PubMed ID: 19782076

DOI: 10.1016/j.febslet.2009.09.035

PubMed ID: 17496909

Title: Differential regulation and properties of MAPKs.

PubMed ID: 17496909

DOI: 10.1038/sj.onc.1210392

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20801953

Title: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.

PubMed ID: 20801953

DOI: 10.1093/jb/mvq098

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21333379

Title: The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7.

PubMed ID: 21333379

DOI: 10.1016/j.ejcb.2010.11.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 20732303

Title: Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state.

PubMed ID: 20732303

DOI: 10.1016/j.bbrc.2010.08.071

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 399
  • Mass: 44288
  • Checksum: A472537F2F26770B
  • Sequence:
    • MAAPSPSGGG GSGGGSGSGT PGPVGSPAPG HPAVSSMQGK RKALKLNFAN PPFKSTARFT 
LNPNPTGVQN PHIERLRTHS IESSGKLKIS PEQHWDFTAE DLKDLGEIGR GAYGSVNKMV 
HKPSGQIMAV KRIRSTVDEK EQKQLLMDLD VVMRSSDCPY IVQFYGALFR EGDCWICMEL 
MSTSFDKFYK YVYSVLDDVI PEEILGKITL ATVKALNHLK ENLKIIHRDI KPSNILLDRS 
GNIKLCDFGI SGQLVDSIAK TRDAGCRPYM APERIDPSAS RQGYDVRSDV WSLGITLYEL 
ATGRFPYPKW NSVFDQLTQV VKGDPPQLSN SEEREFSPSF INFVNLCLTK DESKRPKYKE 
LLKHPFILMY EERAVEVACY VCKILDQMPA TPSSPMYVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.