Details for: SGK1

Gene ID: 6446

Symbol: SGK1

Ensembl ID: ENSG00000118515

Description: serum/glucocorticoid regulated kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 275.9780
    Cell Significance Index: -70.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 151.7758
    Cell Significance Index: -61.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.3513
    Cell Significance Index: -70.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.8965
    Cell Significance Index: -68.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.7295
    Cell Significance Index: -61.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.5714
    Cell Significance Index: -69.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.3261
    Cell Significance Index: -67.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.4641
    Cell Significance Index: -69.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.7747
    Cell Significance Index: -70.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.9444
    Cell Significance Index: -28.3300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.4638
    Cell Significance Index: 20.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4450
    Cell Significance Index: 238.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1454
    Cell Significance Index: 1128.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.8931
    Cell Significance Index: 5447.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8090
    Cell Significance Index: 106.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8009
    Cell Significance Index: 123.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4273
    Cell Significance Index: 311.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.2440
    Cell Significance Index: 1425.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9938
    Cell Significance Index: 36.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7925
    Cell Significance Index: 1239.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7506
    Cell Significance Index: 79.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5809
    Cell Significance Index: 74.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4378
    Cell Significance Index: 39.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4299
    Cell Significance Index: 286.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4276
    Cell Significance Index: 40.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2984
    Cell Significance Index: 28.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2574
    Cell Significance Index: 555.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1787
    Cell Significance Index: 70.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0945
    Cell Significance Index: 119.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0384
    Cell Significance Index: 937.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7830
    Cell Significance Index: 101.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7722
    Cell Significance Index: 21.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5391
    Cell Significance Index: 36.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4872
    Cell Significance Index: 57.4500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.4669
    Cell Significance Index: 1.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4501
    Cell Significance Index: 9.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4298
    Cell Significance Index: 20.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4271
    Cell Significance Index: 26.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3956
    Cell Significance Index: 6.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3624
    Cell Significance Index: 6.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3600
    Cell Significance Index: 9.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3197
    Cell Significance Index: 11.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2939
    Cell Significance Index: 541.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2914
    Cell Significance Index: 159.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2745
    Cell Significance Index: 37.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2697
    Cell Significance Index: 33.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2227
    Cell Significance Index: 38.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2069
    Cell Significance Index: 5.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1950
    Cell Significance Index: 35.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1798
    Cell Significance Index: 276.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1764
    Cell Significance Index: 2.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1595
    Cell Significance Index: 31.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1377
    Cell Significance Index: 26.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1215
    Cell Significance Index: 6.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0503
    Cell Significance Index: 3.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0368
    Cell Significance Index: 0.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0251
    Cell Significance Index: 2.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0454
    Cell Significance Index: -61.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0555
    Cell Significance Index: -25.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0608
    Cell Significance Index: -46.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0667
    Cell Significance Index: -48.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0705
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0727
    Cell Significance Index: -53.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0772
    Cell Significance Index: -43.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0834
    Cell Significance Index: -52.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2132
    Cell Significance Index: -61.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2986
    Cell Significance Index: -62.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3049
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3755
    Cell Significance Index: -43.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3825
    Cell Significance Index: -19.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4242
    Cell Significance Index: -44.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4609
    Cell Significance Index: -32.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4829
    Cell Significance Index: -55.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4833
    Cell Significance Index: -7.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5469
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6386
    Cell Significance Index: -72.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7399
    Cell Significance Index: -58.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7535
    Cell Significance Index: -13.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7753
    Cell Significance Index: -57.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7825
    Cell Significance Index: -49.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.8308
    Cell Significance Index: -12.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8425
    Cell Significance Index: -20.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8480
    Cell Significance Index: -51.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8837
    Cell Significance Index: -25.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8941
    Cell Significance Index: -68.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9151
    Cell Significance Index: -19.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.9896
    Cell Significance Index: -10.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9923
    Cell Significance Index: -21.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0530
    Cell Significance Index: -22.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0647
    Cell Significance Index: -55.9000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1264
    Cell Significance Index: -16.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1471
    Cell Significance Index: -57.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1845
    Cell Significance Index: -14.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2330
    Cell Significance Index: -26.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2357
    Cell Significance Index: -69.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2462
    Cell Significance Index: -39.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2798
    Cell Significance Index: -40.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.3220
    Cell Significance Index: -18.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SGK1 is a member of the AGC kinase family, which also includes AKT and GSK3. SGK1 is activated by serum and glucocorticoids, and its activity is also modulated by other signaling pathways, including the PI3K/Akt pathway. SGK1 has a unique ability to phosphorylate and activate various substrates, including transcription factors, ion channels, and transporters. SGK1 is also involved in the regulation of cell growth, migration, and survival, and its dysregulation has been implicated in various diseases, including hypertension, kidney disease, and cancer. **Pathways and Functions** SGK1 is involved in various signaling pathways that regulate cellular processes, including: 1. **Apoptotic process**: SGK1 regulates the activity of pro-apoptotic and anti-apoptotic proteins, and its dysregulation has been implicated in various apoptotic disorders. 2. **ATP binding**: SGK1 regulates the activity of ATP-binding proteins, which are involved in energy metabolism and cellular homeostasis. 3. **Calcium channel regulator activity**: SGK1 regulates the activity of calcium channels, which are involved in cellular signaling and calcium homeostasis. 4. **Cellular response to aldosterone**: SGK1 regulates the activity of aldosterone receptors, which are involved in the regulation of electrolyte balance and blood pressure. 5. **Chloride channel regulator activity**: SGK1 regulates the activity of chloride channels, which are involved in cellular signaling and electrolyte balance. 6. **DNA damage response**: SGK1 regulates the activity of proteins involved in DNA damage response, including TP53 and ATM. 7. **Intracellular signaling by second messengers**: SGK1 regulates the activity of second messengers, including cAMP and cGMP, which are involved in cellular signaling and homeostasis. **Clinical Significance** SGK1 has been implicated in various diseases, including: 1. **Hypertension**: SGK1 regulates the activity of sodium channels and transporters, which are involved in blood pressure regulation. 2. **Kidney disease**: SGK1 regulates the activity of sodium channels and transporters, which are involved in renal sodium ion absorption and electrolyte balance. 3. **Cancer**: SGK1 regulates the activity of transcription factors and signaling pathways, which are involved in cell growth, migration, and survival. 4. **Neurological disorders**: SGK1 regulates the activity of ion channels and transporters, which are involved in neuronal signaling and homeostasis. In conclusion, SGK1 is a serine/threonine-protein kinase that plays a crucial role in various cellular processes, including cell growth, migration, and survival. Its dysregulation has been implicated in various diseases, including hypertension, kidney disease, and cancer. Further research is necessary to fully understand the mechanisms of SGK1 and its role in various diseases.

Genular Protein ID: 3278246402

Symbol: SGK1_HUMAN

Name: Serine/threonine-protein kinase Sgk1

UniProtKB Accession Codes:

O00141 B7UUP7 B7UUP8 B7UUP9 B7Z5B2 E1P583 Q5TCN2 Q5TCN3 Q5TCN4 Q5VY65 Q9UN56

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 3 ELM 1 EMBL 17 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 5 RefSeq 6 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9114008

Title: Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

PubMed ID: 9114008

DOI: 10.1073/pnas.94.9.4440

PubMed ID: 9722955

Title: Genomic organization and chromosomal localization of the human SGK protein kinase gene.

PubMed ID: 9722955

DOI: 10.1006/geno.1998.5258

PubMed ID: 18753299

Title: An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function.

PubMed ID: 18753299

DOI: 10.1152/ajprenal.90239.2008

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10548550

Title: Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

PubMed ID: 10548550

DOI: 10.1042/bj3440189

PubMed ID: 10191262

Title: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.

PubMed ID: 10191262

DOI: 10.1042/bj3390319

PubMed ID: 10884438

Title: Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.

PubMed ID: 10884438

DOI: 10.1073/pnas.97.14.8157

PubMed ID: 11254654

Title: BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.

PubMed ID: 11254654

DOI: 10.1074/jbc.c000838200

PubMed ID: 11096081

Title: Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin.

PubMed ID: 11096081

DOI: 10.1074/jbc.m007052200

PubMed ID: 11410590

Title: Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.

PubMed ID: 11410590

DOI: 10.1074/jbc.m102808200

PubMed ID: 11154281

Title: Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).

PubMed ID: 11154281

DOI: 10.1128/mcb.21.3.952-965.2001

PubMed ID: 11696533

Title: Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

PubMed ID: 11696533

DOI: 10.1074/jbc.c100623200

PubMed ID: 12590200

Title: Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms.

PubMed ID: 12590200

DOI: 10.1159/000068699

PubMed ID: 12397388

Title: K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.

PubMed ID: 12397388

DOI: 10.1007/s00424-002-0873-2

PubMed ID: 14623317

Title: Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1.

PubMed ID: 14623317

DOI: 10.1016/j.bbrc.2003.10.037

PubMed ID: 12650886

Title: Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A.

PubMed ID: 12650886

DOI: 10.1016/s0008-6363(02)00837-4

PubMed ID: 12761204

Title: Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1.

PubMed ID: 12761204

DOI: 10.1093/jb/mvg010

PubMed ID: 12911626

Title: Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.

PubMed ID: 12911626

DOI: 10.1046/j.1471-4159.2003.01937.x

PubMed ID: 12631736

Title: Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain.

PubMed ID: 12631736

DOI: 10.1091/mbc.e02-03-0170

PubMed ID: 12634932

Title: Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.

PubMed ID: 12634932

DOI: 10.1007/s00424-002-0982-y

PubMed ID: 15044175

Title: Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1.

PubMed ID: 15044175

DOI: 10.1152/ajpgi.00121.2003

PubMed ID: 14706641

Title: Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B.

PubMed ID: 14706641

DOI: 10.1016/j.bbrc.2003.12.011

PubMed ID: 15319523

Title: Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes.

PubMed ID: 15319523

DOI: 10.1159/000080329

PubMed ID: 15234985

Title: A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit.

PubMed ID: 15234985

DOI: 10.1074/jbc.m403260200

PubMed ID: 15040001

Title: Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1.

PubMed ID: 15040001

DOI: 10.1002/jcp.10430

PubMed ID: 15496163

Title: Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.

PubMed ID: 15496163

DOI: 10.1111/j.1523-1755.2004.00966.x

PubMed ID: 15888551

Title: Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1.

PubMed ID: 15888551

DOI: 10.1152/ajpcell.00597.2004

PubMed ID: 15845389

Title: The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2.

PubMed ID: 15845389

DOI: 10.1016/j.bbrc.2005.03.159

PubMed ID: 15737648

Title: Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.

PubMed ID: 15737648

DOI: 10.1016/j.bbrc.2005.02.035

PubMed ID: 16036218

Title: Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3.

PubMed ID: 16036218

DOI: 10.1016/j.bbrc.2005.06.164

PubMed ID: 15733869

Title: Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.

PubMed ID: 15733869

DOI: 10.1016/j.febslet.2005.01.040

PubMed ID: 15576372

Title: Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.

PubMed ID: 15576372

DOI: 10.1074/jbc.m411053200

PubMed ID: 16443776

Title: SGK1 kinase upregulates GLUT1 activity and plasma membrane expression.

PubMed ID: 16443776

DOI: 10.2337/diabetes.55.02.06.db05-0720

PubMed ID: 16982696

Title: Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau.

PubMed ID: 16982696

DOI: 10.1128/mcb.01017-06

PubMed ID: 17202226

Title: Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells.

PubMed ID: 17202226

DOI: 10.1152/ajpcell.00399.2006

PubMed ID: 17382906

Title: Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.

PubMed ID: 17382906

DOI: 10.1016/j.bbrc.2007.03.029

PubMed ID: 18005662

Title: Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3.

PubMed ID: 18005662

DOI: 10.1016/j.febslet.2007.11.006

PubMed ID: 18304449

Title: Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue.

PubMed ID: 18304449

DOI: 10.5483/bmbrep.2008.41.1.041

PubMed ID: 18925875

Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

PubMed ID: 18925875

DOI: 10.1042/bj20081668

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18334630

Title: A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons.

PubMed ID: 18334630

DOI: 10.1073/pnas.0800958105

PubMed ID: 19068477

Title: Regulation of a third conserved phosphorylation site in SGK1.

PubMed ID: 19068477

DOI: 10.1074/jbc.m807502200

PubMed ID: 19447520

Title: Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

PubMed ID: 19447520

DOI: 10.1016/j.jhep.2009.02.027

PubMed ID: 19756449

Title: Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

PubMed ID: 19756449

DOI: 10.1007/s00109-009-0525-5

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20511718

Title: The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19.

PubMed ID: 20511718

DOI: 10.1159/000315092

PubMed ID: 20338997

Title: mTOR complex-2 activates ENaC by phosphorylating SGK1.

PubMed ID: 20338997

DOI: 10.1681/asn.2009111168

PubMed ID: 20730100

Title: Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

PubMed ID: 20730100

DOI: 10.1371/journal.pone.0012163

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21865597

Title: Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.

PubMed ID: 21865597

DOI: 10.1091/mbc.e11-04-0328

PubMed ID: 36373794

Title: WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.

PubMed ID: 36373794

DOI: 10.1242/jcs.260313

PubMed ID: 12649597

Title: Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity.

PubMed ID: 12649597

DOI: 10.1159/000070244

PubMed ID: 16460280

Title: Sgk kinases and their role in epithelial transport.

PubMed ID: 16460280

DOI: 10.1146/annurev.physiol.68.040104.131654

PubMed ID: 20919962

Title: Second AKT: the rise of SGK in cancer signalling.

PubMed ID: 20919962

DOI: 10.3109/08977194.2010.518616

PubMed ID: 20530112

Title: Significance of SGK1 in the regulation of neuronal function.

PubMed ID: 20530112

DOI: 10.1113/jphysiol.2010.190926

PubMed ID: 17965184

Title: Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.

PubMed ID: 17965184

DOI: 10.1110/ps.073161707

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 431
  • Mass: 48942
  • Checksum: F3697C63AB1F499D
  • Sequence:
    • MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 
SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 
EVFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 
GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 
FGLCKENIEH NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 
NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK SHVFFSLINW 
DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK SPDSVLVTAS VKEAAEAFLG 
FSYAPPTDSF L

Genular Protein ID: 885274416

Symbol: B7Z325_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z325

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 387
  • Mass: 43783
  • Checksum: 34775AE1248702D7
  • Sequence:
    • MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 
SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 
EVFYAVKVLQ KKAILKKKEL FYHLQRERCF LEPRARFYAA EIASALGYLH SLNIVYRDLK 
PENILLDSQG HIVLTDFGLC KENIEHNSTT STFCGTPEYL APEVLHKQPY DRTVDWWCLG 
AVLYEMLYGL PPFYSRNTAE MYDNILNKPL QLKPNITNSA RHLLEGLLQK DRTKRLGAKD 
DFMEIKSHVF FSLINWDDLI NKKITPPFNP NVSGPNDLRH FDPEFTEEPV PNSIGKSPDS 
VLVTASAKEA AEAFLGFSYA PPTDSFL

Genular Protein ID: 381791136

Symbol: E9PR89_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PR89

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 387
  • Mass: 43811
  • Checksum: 34775AE13C3052D7
  • Sequence:
    • MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 
SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 
EVFYAVKVLQ KKAILKKKEL FYHLQRERCF LEPRARFYAA EIASALGYLH SLNIVYRDLK 
PENILLDSQG HIVLTDFGLC KENIEHNSTT STFCGTPEYL APEVLHKQPY DRTVDWWCLG 
AVLYEMLYGL PPFYSRNTAE MYDNILNKPL QLKPNITNSA RHLLEGLLQK DRTKRLGAKD 
DFMEIKSHVF FSLINWDDLI NKKITPPFNP NVSGPNDLRH FDPEFTEEPV PNSIGKSPDS 
VLVTASVKEA AEAFLGFSYA PPTDSFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.