Details for: FBXW4

Gene ID: 6468

Symbol: FBXW4

Ensembl ID: ENSG00000107829

Description: F-box and WD repeat domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 248.2236
    Cell Significance Index: -38.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.1571
    Cell Significance Index: -38.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.4214
    Cell Significance Index: -36.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.3084
    Cell Significance Index: -36.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.8341
    Cell Significance Index: -39.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8417
    Cell Significance Index: -37.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9249
    Cell Significance Index: -23.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1808
    Cell Significance Index: -31.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0037
    Cell Significance Index: -39.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5242
    Cell Significance Index: 34.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8570
    Cell Significance Index: 372.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4325
    Cell Significance Index: 284.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2376
    Cell Significance Index: 54.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2321
    Cell Significance Index: 143.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2317
    Cell Significance Index: 46.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2144
    Cell Significance Index: 93.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1977
    Cell Significance Index: 67.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1402
    Cell Significance Index: 408.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9321
    Cell Significance Index: 48.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9243
    Cell Significance Index: 55.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8988
    Cell Significance Index: 40.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8164
    Cell Significance Index: 564.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8047
    Cell Significance Index: 54.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8024
    Cell Significance Index: 15.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7947
    Cell Significance Index: 143.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7890
    Cell Significance Index: 20.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7284
    Cell Significance Index: 89.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6347
    Cell Significance Index: 13.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5625
    Cell Significance Index: 15.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5394
    Cell Significance Index: 25.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5344
    Cell Significance Index: 36.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4851
    Cell Significance Index: 47.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4663
    Cell Significance Index: 28.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3618
    Cell Significance Index: 326.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3110
    Cell Significance Index: 141.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2971
    Cell Significance Index: 559.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2550
    Cell Significance Index: 3.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2432
    Cell Significance Index: 107.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2317
    Cell Significance Index: 3.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2067
    Cell Significance Index: 5.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1997
    Cell Significance Index: 109.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1841
    Cell Significance Index: 116.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1795
    Cell Significance Index: 24.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1463
    Cell Significance Index: 225.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1297
    Cell Significance Index: 239.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1097
    Cell Significance Index: 149.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0840
    Cell Significance Index: 14.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0681
    Cell Significance Index: 12.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0061
    Cell Significance Index: 0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0052
    Cell Significance Index: 0.2600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0300
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0495
    Cell Significance Index: -27.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0536
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0700
    Cell Significance Index: -43.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0715
    Cell Significance Index: -9.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0773
    Cell Significance Index: -9.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0927
    Cell Significance Index: -2.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0981
    Cell Significance Index: -2.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1042
    Cell Significance Index: -0.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1076
    Cell Significance Index: -11.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1139
    Cell Significance Index: -32.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1185
    Cell Significance Index: -17.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1319
    Cell Significance Index: -3.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1412
    Cell Significance Index: -10.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1496
    Cell Significance Index: -7.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1521
    Cell Significance Index: -15.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1647
    Cell Significance Index: -10.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1696
    Cell Significance Index: -2.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1720
    Cell Significance Index: -20.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1787
    Cell Significance Index: -5.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1829
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1857
    Cell Significance Index: -39.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1872
    Cell Significance Index: -12.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2013
    Cell Significance Index: -23.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2774
    Cell Significance Index: -6.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3344
    Cell Significance Index: -10.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3510
    Cell Significance Index: -18.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4024
    Cell Significance Index: -31.8700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4475
    Cell Significance Index: -5.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4839
    Cell Significance Index: -29.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4873
    Cell Significance Index: -10.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5056
    Cell Significance Index: -10.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5561
    Cell Significance Index: -17.7100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5892
    Cell Significance Index: -5.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6161
    Cell Significance Index: -20.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6556
    Cell Significance Index: -8.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6696
    Cell Significance Index: -13.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6733
    Cell Significance Index: -19.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6754
    Cell Significance Index: -10.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6766
    Cell Significance Index: -23.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7180
    Cell Significance Index: -18.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7442
    Cell Significance Index: -14.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7482
    Cell Significance Index: -16.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7576
    Cell Significance Index: -26.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FBXW4 is a member of the F-box protein family, characterized by the presence of an F-box domain and WD repeat domains. These domains enable FBXW4 to interact with the SCF complex and other proteins, facilitating its role in protein degradation and ubiquitination. FBXW4 is also known to interact with various cellular pathways, including the adaptive immune system, antigen processing, and protein metabolism. **Pathways and Functions:** FBXW4 is involved in several key pathways, including: 1. **Adaptive Immune System:** FBXW4 plays a crucial role in the regulation of immune responses by modulating the degradation of key immune-related proteins. 2. **Antigen Processing and Presentation:** FBXW4 is involved in the ubiquitination and degradation of antigens, which are then presented to T-cells by MHC class I molecules. 3. **Protein Binding and Folding:** FBXW4 interacts with chaperonins and other proteins to facilitate protein folding and binding. 4. **Wnt Signaling Pathway:** FBXW4 has been implicated in the regulation of Wnt signaling, which is involved in various cellular processes, including development and immune responses. **Functions:** FBXW4 functions as an E3 ubiquitin ligase, interacting with the SCF complex to ubiquitinate and degrade target proteins. This process is essential for the regulation of various cellular processes, including: 1. **Immune Response:** FBXW4 regulates the degradation of immune-related proteins, modulating the adaptive immune response. 2. **Antigen Presentation:** FBXW4 is involved in the ubiquitination and degradation of antigens, which are then presented to T-cells. 3. **Cellular Homeostasis:** FBXW4 regulates the degradation of proteins involved in cellular homeostasis, maintaining protein balance and preventing protein aggregation. **Clinical Significance:** FBXW4 has been implicated in various diseases, including: 1. **Cancer:** FBXW4 is often downregulated in cancer cells, leading to increased protein stability and tumorigenesis. 2. **Autoimmune Diseases:** FBXW4 dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurodegenerative Diseases:** FBXW4 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's. **Tissue-Specific Expression:** FBXW4 is expressed in various tissues, including: 1. **Immune Cells:** FBXW4 is expressed in immune cells, including T-cells, B-cells, and dendritic cells. 2. **Neural Tissue:** FBXW4 is expressed in neural tissue, including neurons and glial cells. 3. **Epithelial Tissue:** FBXW4 is expressed in epithelial tissue, including lung, skin, and intestinal epithelial cells. In conclusion, FBXW4 is a crucial component of the immune system, playing a pivotal role in the regulation of protein degradation and antigen presentation. Its dysregulation has been implicated in various diseases, highlighting the importance of FBXW4 in maintaining immune homeostasis and overall cellular health.

Genular Protein ID: 4111694117

Symbol: FBXW4_HUMAN

Name: F-box/WD repeat-containing protein 4

UniProtKB Accession Codes:

P57775 Q5SVS1 Q96IM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10405324

Title: A novel human gene encoding an F-box/WD40 containing protein maps in the SHFM3 critical region on 10q24.

PubMed ID: 10405324

DOI: 10.1006/bbrc.1999.0963

PubMed ID: 10945468

Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.

PubMed ID: 10945468

DOI: 10.1006/geno.2000.6211

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12913067

Title: A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.

PubMed ID: 12913067

DOI: 10.1093/hmg/ddg212

Sequence Information:

  • Length: 412
  • Mass: 46337
  • Checksum: 36C175FDE30D283B
  • Sequence:
    • MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR 
FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ 
MPWMQLEDDS LYISQANFIL AYQFRPDGAS LNRRPLGVFA GHDEDVCHFV LANSHIVSAG 
GDGKIGIHKI HSTFTVKYSA HEQEVNCVDC KGGIIVSGSR DRTAKVWPLA SGRLGQCLHT 
IQTEDRVWSI AISPLLSSFV TGTACCGHFS PLRIWDLNSG QLMTHLGSDF PPGAGVLDVM 
YESPFTLLSC GYDTYVRYWD LRTSVRKCVM EWEEPHDSTL YCLQTDGNHL LATGSSYYGV 
VRLWDRRQRA CLHAFPLTST PLSSPVYCLR LTTKHLYAAL SYNLHVLDFQ NP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.