Details for: SLC1A4

Gene ID: 6509

Symbol: SLC1A4

Ensembl ID: ENSG00000115902

Description: solute carrier family 1 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.0428
    Cell Significance Index: -16.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.6828
    Cell Significance Index: -16.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.5286
    Cell Significance Index: -14.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.6757
    Cell Significance Index: -17.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.6482
    Cell Significance Index: -14.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1773
    Cell Significance Index: -17.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3609
    Cell Significance Index: -17.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4880
    Cell Significance Index: -17.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0209
    Cell Significance Index: -8.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2911
    Cell Significance Index: 34.6000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.0437
    Cell Significance Index: 14.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0180
    Cell Significance Index: 21.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9924
    Cell Significance Index: 199.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7999
    Cell Significance Index: 1231.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6878
    Cell Significance Index: 111.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6310
    Cell Significance Index: 226.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6216
    Cell Significance Index: 67.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5771
    Cell Significance Index: 114.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4932
    Cell Significance Index: 10.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4841
    Cell Significance Index: 57.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4763
    Cell Significance Index: 13.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3786
    Cell Significance Index: 22.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3564
    Cell Significance Index: 60.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3187
    Cell Significance Index: 37.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3036
    Cell Significance Index: 18.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2925
    Cell Significance Index: 20.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2639
    Cell Significance Index: 486.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2047
    Cell Significance Index: 141.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2031
    Cell Significance Index: 12.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2017
    Cell Significance Index: 8.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1595
    Cell Significance Index: 6.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1553
    Cell Significance Index: 2.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1493
    Cell Significance Index: 3.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1451
    Cell Significance Index: 4.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1437
    Cell Significance Index: 19.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1434
    Cell Significance Index: 63.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1295
    Cell Significance Index: 9.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1253
    Cell Significance Index: 9.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1057
    Cell Significance Index: 7.1100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1056
    Cell Significance Index: 1.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0982
    Cell Significance Index: 5.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0958
    Cell Significance Index: 6.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0891
    Cell Significance Index: 6.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0828
    Cell Significance Index: 2.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0764
    Cell Significance Index: 14.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0559
    Cell Significance Index: 5.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0559
    Cell Significance Index: 1.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0516
    Cell Significance Index: 1.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0347
    Cell Significance Index: 47.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0321
    Cell Significance Index: 0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0254
    Cell Significance Index: 13.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0228
    Cell Significance Index: 0.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0214
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0114
    Cell Significance Index: 21.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0073
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0089
    Cell Significance Index: -5.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0138
    Cell Significance Index: -2.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0203
    Cell Significance Index: -2.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0244
    Cell Significance Index: -0.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0254
    Cell Significance Index: -11.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0272
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0443
    Cell Significance Index: -9.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0498
    Cell Significance Index: -14.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0527
    Cell Significance Index: -6.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0578
    Cell Significance Index: -5.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0697
    Cell Significance Index: -3.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0781
    Cell Significance Index: -9.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0818
    Cell Significance Index: -10.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0843
    Cell Significance Index: -1.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0965
    Cell Significance Index: -1.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1092
    Cell Significance Index: -2.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1134
    Cell Significance Index: -14.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1270
    Cell Significance Index: -14.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1436
    Cell Significance Index: -3.8400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1444
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1637
    Cell Significance Index: -17.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1836
    Cell Significance Index: -8.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1878
    Cell Significance Index: -2.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1942
    Cell Significance Index: -3.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2114
    Cell Significance Index: -16.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2258
    Cell Significance Index: -11.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2321
    Cell Significance Index: -7.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2342
    Cell Significance Index: -7.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2349
    Cell Significance Index: -4.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2393
    Cell Significance Index: -14.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2438
    Cell Significance Index: -4.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2541
    Cell Significance Index: -8.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2578
    Cell Significance Index: -6.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2613
    Cell Significance Index: -13.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2739
    Cell Significance Index: -12.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2935
    Cell Significance Index: -3.6600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2961
    Cell Significance Index: -3.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3073
    Cell Significance Index: -6.6400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3089
    Cell Significance Index: -2.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The SLC1A4 protein exhibits the following key characteristics: 1. **Amino acid transport**: SLC1A4 is involved in the transport of various amino acids, including L-alanine, L-aspartate, L-glutamate, L-glutamine, L-hydroxyproline, L-proline, L-serine, and L-threonine. 2. **Glutamine transport**: SLC1A4 is specifically involved in the transport of glutamine, which is an essential amino acid for various cellular processes, including neurotransmission and energy metabolism. 3. **Symporter activity**: SLC1A4 exhibits symporter activity, which allows it to transport two or more substrates in the same direction across the cell membrane. 4. **Blood-brain barrier transport**: SLC1A4 is involved in the transport of amino acids and small molecules across the blood-brain barrier, which is a critical process for maintaining the homeostasis of the central nervous system. 5. **Cognitive functions**: SLC1A4 is expressed in brain regions involved in cognitive functions, including the cerebral cortex, and is thought to play a role in neurotransmission and synaptic transmission. **Pathways and Functions** The SLC1A4 protein is involved in various cellular pathways, including: 1. **Amino acid metabolism**: SLC1A4 is involved in the regulation of amino acid metabolism, including the uptake and transport of amino acids for protein synthesis and energy production. 2. **Neurotransmission**: SLC1A4 is involved in the transport of glutamine and other amino acids that are essential for neurotransmission, including the release and uptake of neurotransmitters. 3. **Energy metabolism**: SLC1A4 is involved in the regulation of energy metabolism, including the transport of amino acids and small molecules that are essential for energy production. 4. **Cell signaling**: SLC1A4 is involved in cell signaling pathways, including the regulation of synaptic transmission and neurotransmission. **Clinical Significance** SLC1A4 has been implicated in various neurological and psychiatric disorders, including: 1. **Neurodegenerative diseases**: SLC1A4 has been implicated in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Mental health disorders**: SLC1A4 has been implicated in mental health disorders, including schizophrenia, bipolar disorder, and major depressive disorder. 3. **Cerebral vasculature disorders**: SLC1A4 has been implicated in cerebral vasculature disorders, including cerebral vasculitis and cerebral amyloid angiopathy. In summary, SLC1A4 is a gene that encodes for a protein involved in various physiological processes, including amino acid transport, neurotransmission, and energy metabolism. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the role of SLC1A4 in human health and disease.

Genular Protein ID: 198071476

Symbol: SATT_HUMAN

Name: Solute carrier family 1 member 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8101838

Title: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.

PubMed ID: 8101838

DOI: 10.1016/s0021-9258(18)82257-8

PubMed ID: 8340364

Title: Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.

PubMed ID: 8340364

DOI: 10.1016/s0021-9258(18)82263-3

PubMed ID: 7896285

Title: Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.

PubMed ID: 7896285

DOI: 10.1006/geno.1994.1577

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14502423

Title: Transport of proline and hydroxyproline by the neutral amino-acid exchanger ASCT1.

PubMed ID: 14502423

DOI: 10.1007/s00232-003-2041-9

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25930971

Title: A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.

PubMed ID: 25930971

DOI: 10.1111/cge.12605

PubMed ID: 26138499

Title: SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum.

PubMed ID: 26138499

DOI: 10.1111/cge.12637

PubMed ID: 26041762

Title: Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.

PubMed ID: 26041762

DOI: 10.1136/jmedgenet-2015-103104

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 532
  • Mass: 55723
  • Checksum: 57925860042FCEB6
  • Sequence:
  • MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA 
    ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY 
    FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP 
    SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL 
    GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA 
    SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN 
    GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA 
    AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK 
    ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.