Details for: SLC1A4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 107.0428
Cell Significance Index: -16.6500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 65.6828
Cell Significance Index: -16.6600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 36.5286
Cell Significance Index: -14.8400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 26.6757
Cell Significance Index: -17.9000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.6482
Cell Significance Index: -14.9400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.1773
Cell Significance Index: -17.4800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.3609
Cell Significance Index: -17.0400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.4880
Cell Significance Index: -17.7100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.0209
Cell Significance Index: -8.8000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.2911
Cell Significance Index: 34.6000 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 1.0437
Cell Significance Index: 14.6000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.0180
Cell Significance Index: 21.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9924
Cell Significance Index: 199.0700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.7999
Cell Significance Index: 1231.4500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6878
Cell Significance Index: 111.8700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6310
Cell Significance Index: 226.3300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6216
Cell Significance Index: 67.6200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5771
Cell Significance Index: 114.5300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4932
Cell Significance Index: 10.8000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4841
Cell Significance Index: 57.1000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4763
Cell Significance Index: 13.3100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3786
Cell Significance Index: 22.7300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3564
Cell Significance Index: 60.8500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3187
Cell Significance Index: 37.1400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3036
Cell Significance Index: 18.6600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2925
Cell Significance Index: 20.2300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2639
Cell Significance Index: 486.6900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2047
Cell Significance Index: 141.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2031
Cell Significance Index: 12.8000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2017
Cell Significance Index: 8.9200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1595
Cell Significance Index: 6.0400 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1553
Cell Significance Index: 2.1800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1493
Cell Significance Index: 3.5800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1451
Cell Significance Index: 4.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1437
Cell Significance Index: 19.7300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1434
Cell Significance Index: 63.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1295
Cell Significance Index: 9.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1253
Cell Significance Index: 9.6200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1057
Cell Significance Index: 7.1100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1056
Cell Significance Index: 1.3100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0982
Cell Significance Index: 5.5100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0958
Cell Significance Index: 6.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0891
Cell Significance Index: 6.6400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.0828
Cell Significance Index: 2.6200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0764
Cell Significance Index: 14.5400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0559
Cell Significance Index: 5.5300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0559
Cell Significance Index: 1.6100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0516
Cell Significance Index: 1.2900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0347
Cell Significance Index: 47.1700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0321
Cell Significance Index: 0.5500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0254
Cell Significance Index: 13.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0228
Cell Significance Index: 0.8000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.0214
Cell Significance Index: 0.3700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0114
Cell Significance Index: 21.5100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0073
Cell Significance Index: 0.3300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0057
Cell Significance Index: -3.2000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0065
Cell Significance Index: -4.0300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0088
Cell Significance Index: -0.1200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0089
Cell Significance Index: -5.6400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0090
Cell Significance Index: -6.8200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0138
Cell Significance Index: -2.4800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0203
Cell Significance Index: -2.9500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0225
Cell Significance Index: -16.4800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0244
Cell Significance Index: -0.6900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0254
Cell Significance Index: -11.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0272
Cell Significance Index: -0.5900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0443
Cell Significance Index: -9.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0498
Cell Significance Index: -14.3200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0527
Cell Significance Index: -6.0200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0578
Cell Significance Index: -5.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0697
Cell Significance Index: -3.6600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0781
Cell Significance Index: -9.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0818
Cell Significance Index: -10.4900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0843
Cell Significance Index: -1.7900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0965
Cell Significance Index: -1.1500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1092
Cell Significance Index: -2.7900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1134
Cell Significance Index: -14.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1270
Cell Significance Index: -14.5500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1436
Cell Significance Index: -3.8400 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1444
Cell Significance Index: -2.3800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1637
Cell Significance Index: -17.0500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1836
Cell Significance Index: -8.6300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1878
Cell Significance Index: -2.6900 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1942
Cell Significance Index: -3.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2114
Cell Significance Index: -16.7400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2258
Cell Significance Index: -11.7300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2321
Cell Significance Index: -7.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2342
Cell Significance Index: -7.4600 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2349
Cell Significance Index: -4.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2393
Cell Significance Index: -14.6700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2438
Cell Significance Index: -4.8200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2541
Cell Significance Index: -8.1400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2578
Cell Significance Index: -6.2900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2613
Cell Significance Index: -13.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2739
Cell Significance Index: -12.7700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2935
Cell Significance Index: -3.6600 - Cell Name: mature astrocyte (CL0002627)
Fold Change: -0.2961
Cell Significance Index: -3.2900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3073
Cell Significance Index: -6.6400 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.3089
Cell Significance Index: -2.5500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 198071476
Symbol: SATT_HUMAN
Name: Solute carrier family 1 member 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8101838
Title: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.
PubMed ID: 8101838
PubMed ID: 8340364
Title: Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.
PubMed ID: 8340364
PubMed ID: 7896285
Title: Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.
PubMed ID: 7896285
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14502423
Title: Transport of proline and hydroxyproline by the neutral amino-acid exchanger ASCT1.
PubMed ID: 14502423
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25930971
Title: A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.
PubMed ID: 25930971
DOI: 10.1111/cge.12605
PubMed ID: 26138499
Title: SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum.
PubMed ID: 26138499
DOI: 10.1111/cge.12637
PubMed ID: 26041762
Title: Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.
PubMed ID: 26041762
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 532
- Mass: 55723
- Checksum: 57925860042FCEB6
- Sequence:
MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.