Details for: SLC1A5

Gene ID: 6510

Symbol: SLC1A5

Ensembl ID: ENSG00000105281

Description: solute carrier family 1 member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.8328
    Cell Significance Index: -21.0100
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.4326
    Cell Significance Index: -9.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.1099
    Cell Significance Index: -21.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.7354
    Cell Significance Index: -24.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.3177
    Cell Significance Index: -24.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.3306
    Cell Significance Index: -21.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.8577
    Cell Significance Index: -14.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9399
    Cell Significance Index: -21.2700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.0371
    Cell Significance Index: 37.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7425
    Cell Significance Index: -22.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.2420
    Cell Significance Index: 71.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0391
    Cell Significance Index: 109.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.8826
    Cell Significance Index: 738.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0065
    Cell Significance Index: -6.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6554
    Cell Significance Index: 137.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6795
    Cell Significance Index: 206.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6609
    Cell Significance Index: 47.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.5763
    Cell Significance Index: 10.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5572
    Cell Significance Index: 280.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5026
    Cell Significance Index: 1356.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3341
    Cell Significance Index: 23.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2637
    Cell Significance Index: 58.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2613
    Cell Significance Index: 59.2800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2589
    Cell Significance Index: 11.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2385
    Cell Significance Index: 87.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1871
    Cell Significance Index: 129.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1265
    Cell Significance Index: 16.8800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1105
    Cell Significance Index: 6.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9800
    Cell Significance Index: 159.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8743
    Cell Significance Index: 56.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8205
    Cell Significance Index: 37.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7251
    Cell Significance Index: 99.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6220
    Cell Significance Index: 14.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6008
    Cell Significance Index: 41.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4897
    Cell Significance Index: 267.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4554
    Cell Significance Index: 13.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4479
    Cell Significance Index: 44.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4245
    Cell Significance Index: 11.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3878
    Cell Significance Index: 50.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3714
    Cell Significance Index: 10.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3330
    Cell Significance Index: 9.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3290
    Cell Significance Index: 145.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3187
    Cell Significance Index: 8.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2232
    Cell Significance Index: 2.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2070
    Cell Significance Index: 7.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1866
    Cell Significance Index: 37.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1821
    Cell Significance Index: 13.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1637
    Cell Significance Index: 20.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1426
    Cell Significance Index: 1.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1158
    Cell Significance Index: 13.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1091
    Cell Significance Index: 12.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1024
    Cell Significance Index: 17.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0859
    Cell Significance Index: 1.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0832
    Cell Significance Index: 62.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0804
    Cell Significance Index: 2.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0189
    Cell Significance Index: 0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0170
    Cell Significance Index: 12.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0090
    Cell Significance Index: 0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0130
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0142
    Cell Significance Index: -10.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0146
    Cell Significance Index: -26.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0170
    Cell Significance Index: -26.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0194
    Cell Significance Index: -0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -28.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0246
    Cell Significance Index: -13.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0342
    Cell Significance Index: -21.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0377
    Cell Significance Index: -17.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0505
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0729
    Cell Significance Index: -15.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0774
    Cell Significance Index: -22.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0780
    Cell Significance Index: -15.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1228
    Cell Significance Index: -14.3100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1446
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1538
    Cell Significance Index: -3.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1540
    Cell Significance Index: -22.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1542
    Cell Significance Index: -7.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2133
    Cell Significance Index: -5.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2171
    Cell Significance Index: -22.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2495
    Cell Significance Index: -19.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2768
    Cell Significance Index: -2.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2874
    Cell Significance Index: -17.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2936
    Cell Significance Index: -3.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2959
    Cell Significance Index: -12.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2993
    Cell Significance Index: -10.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3205
    Cell Significance Index: -19.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3257
    Cell Significance Index: -24.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3574
    Cell Significance Index: -7.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3617
    Cell Significance Index: -24.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3690
    Cell Significance Index: -19.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3755
    Cell Significance Index: -21.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3873
    Cell Significance Index: -2.3400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4066
    Cell Significance Index: -2.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4203
    Cell Significance Index: -4.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4486
    Cell Significance Index: -6.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4653
    Cell Significance Index: -11.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5108
    Cell Significance Index: -18.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5234
    Cell Significance Index: -27.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Neutral Amino Acid Transporter**: The SLC1A5 protein is a neutral amino acid transporter that facilitates the uptake and secretion of neutral amino acids across the plasma membrane. 2. **Transmembrane Transporter**: The protein is a transmembrane transporter, consisting of three subunits, which allows it to span the plasma membrane and interact with extracellular and intracellular molecules. 3. **Glutamine Secretion**: The SLC1A5 protein plays a crucial role in glutamine secretion, which is essential for maintaining amino acid homeostasis in the body. 4. **Cellular Expression**: The SLC1A5 gene is widely expressed in various cell types, including myoepithelial cells, basal cells, and fibroblasts, suggesting its involvement in multiple cellular processes. **Pathways and Functions** 1. **Amino Acid Transport**: The SLC1A5 protein is involved in the transport of neutral amino acids, including glutamine, aspartate, and serine, across the plasma membrane. 2. **Erythrocyte Differentiation**: The protein's activity is required for erythrocyte differentiation, which is essential for the development and maintenance of red blood cells. 3. **Extracellular Exosome Formation**: The SLC1A5 protein is involved in the formation of extracellular exosomes, which are small vesicles that play a crucial role in intercellular communication. 4. **Signaling Pathways**: The protein's activity is also involved in signaling pathways mediated by Rho GTPases, which regulate various cellular processes, including cell migration, proliferation, and differentiation. 5. **Blood-Brain Barrier**: The SLC1A5 protein is involved in the transport of amino acids across the blood-brain barrier, which is essential for maintaining amino acid homeostasis in the central nervous system. **Clinical Significance** 1. **Amino Acid Metabolism Disorders**: Mutations in the SLC1A5 gene have been associated with amino acid metabolism disorders, such as hyperammonemia and hyperargininemia. 2. **Cancer**: The SLC1A5 protein has been implicated in the development and progression of cancer, particularly in epithelial tissues, where it is involved in the transport of amino acids and the regulation of cell growth and differentiation. 3. **Neurological Disorders**: The protein's activity has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it is involved in the regulation of amino acid homeostasis and signaling pathways. 4. **Infectious Diseases**: The SLC1A5 protein has been implicated in the entry of viruses into host cells, suggesting its potential as a target for antiviral therapies. In conclusion, the SLC1A5 gene encodes for a critical protein involved in the transport of neutral amino acids across the plasma membrane and plays a significant role in various cellular processes, including erythrocyte differentiation, extracellular exosome formation, and signaling pathways mediated by Rho GTPases. The protein's activity has been implicated in various diseases, including amino acid metabolism disorders, cancer, neurological disorders, and infectious diseases, highlighting its potential as a therapeutic target.

Genular Protein ID: 3404882236

Symbol: AAAT_HUMAN

Name: Neutral amino acid transporter B(0)

UniProtKB Accession Codes:

Q15758 A8K9H5 B4DR77 B4DWS4 B7ZB81 D0EYG6 E9PC01 O95720 Q96RL9 Q9BWQ3 Q9UNP2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CPTAC 2 CTD 1 ChEBI 45 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 12 EMDB 10 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 Rhea 15 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8702519

Title: Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.

PubMed ID: 8702519

DOI: 10.1074/jbc.271.31.18657

PubMed ID: 10051606

Title: The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.

PubMed ID: 10051606

DOI: 10.1073/pnas.96.5.2129

PubMed ID: 10196349

Title: A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses.

PubMed ID: 10196349

DOI: 10.1128/jvi.73.5.4470-4474.1999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11350958

Title: Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons.

PubMed ID: 11350958

DOI: 10.1074/jbc.m100737200

PubMed ID: 10708449

Title: An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor.

PubMed ID: 10708449

DOI: 10.1128/jvi.74.7.3321-3329.2000

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 17094966

Title: Functional and molecular analysis of D-serine transport in retinal Mueller cells.

PubMed ID: 17094966

DOI: 10.1016/j.exer.2006.09.015

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23756778

Title: Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris--functional and kinetic asymmetry revealed in proteoliposomes.

PubMed ID: 23756778

DOI: 10.1016/j.bbamem.2013.05.034

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23492904

Title: A novel human endogenous retroviral protein inhibits cell-cell fusion.

PubMed ID: 23492904

DOI: 10.1038/srep01462

PubMed ID: 24953180

Title: Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification.

PubMed ID: 24953180

DOI: 10.1016/j.stem.2014.06.002

PubMed ID: 26492990

Title: Cysteine is not a substrate but a specific modulator of human ASCT2 (SLC1A5) transporter.

PubMed ID: 26492990

DOI: 10.1016/j.febslet.2015.10.011

PubMed ID: 32733894

Title: The Human SLC1A5 Neutral Amino Acid Transporter Catalyzes a pH-Dependent Glutamate/Glutamine Antiport, as Well.

PubMed ID: 32733894

DOI: 10.3389/fcell.2020.00603

PubMed ID: 34741534

Title: The involvement of sodium in the function of the human amino acid transporter ASCT2.

PubMed ID: 34741534

DOI: 10.1002/1873-3468.14224

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28424515

Title: Structure and allosteric inhibition of excitatory amino acid transporter 1.

PubMed ID: 28424515

DOI: 10.1038/nature22064

PubMed ID: 29872227

Title: Cryo-EM structure of the human neutral amino acid transporter ASCT2.

PubMed ID: 29872227

DOI: 10.1038/s41594-018-0076-y

Sequence Information:

  • Length: 541
  • Mass: 56598
  • Checksum: AD61C789CCFFE934
  • Sequence:
    • MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV 
AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD 
PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV 
LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV 
FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA 
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM 
MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT 
ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG 
LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV 
M

Genular Protein ID: 1510911004

Symbol: Q59ES3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59ES3

Database IDs:

ARBA 29 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 40 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 15 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 548
  • Mass: 57390
  • Checksum: A2E5CB6B373D9EAE
  • Sequence:
    • ETPVLPIMVA DPPRDSKGLA AAEPTANGGL ALASIEDQGA AAGGYCGSRD QVRRCLRANL 
LVLLTVVAVV AGVALGLGVS GAGGALALGP ERLSAFVFPG ELLLRLLRMI ILPLVVCSLI 
GGAASLDPGA LGRLGAWALL FFLVTTLLAS ALGVGLALAL QPGAASAAIN ASVGAAGSAE 
NAPSKEVLDS FLDLARNIFP SNLVSAAFRS YSTTYEERNI TGTRVKVPVG QEVEGMNILG 
LVVFAIVFGV ALRKLGPEGE LLIRFFNSFN EATMVLVSWI MWYAPVGIMF LVAGKIVEME 
DVGLLFARLG KYILCCLLGH AIHGLLVLPL IYFLFTRKNP YRFLWGIVTP LATAFGTSSS 
SATLPLMMKC VEENNGVVKH ISRFILPIGA TVNMDGAALF QCVAAVFIAQ LSQQSLDFVK 
IITILVTATA SSVGAAGIPA GGVLTLAIIL EAVNLPVDHI SLILAVDWLV DRSCTVLNVE 
GDALGAGLLQ NYVDRTESRS TEPELIQVKS ELPLDPLPLP TEEGNPLLKH YRGPAGDATV 
ASEKESVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.