Details for: SLC12A2

Gene ID: 6558

Symbol: SLC12A2

Ensembl ID: ENSG00000064651

Description: solute carrier family 12 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 355.9093
    Cell Significance Index: -55.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 211.9314
    Cell Significance Index: -53.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.3892
    Cell Significance Index: -54.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.9980
    Cell Significance Index: -45.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.5174
    Cell Significance Index: -54.7000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 48.7643
    Cell Significance Index: 34.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.8453
    Cell Significance Index: -45.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.9732
    Cell Significance Index: -55.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7458
    Cell Significance Index: -55.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1813
    Cell Significance Index: -55.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2264
    Cell Significance Index: -24.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.2026
    Cell Significance Index: 242.5700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 4.9690
    Cell Significance Index: 49.7300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.7076
    Cell Significance Index: 47.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 4.0600
    Cell Significance Index: 243.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.1447
    Cell Significance Index: 78.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1332
    Cell Significance Index: 90.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.0650
    Cell Significance Index: 159.6500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.3100
    Cell Significance Index: 17.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.1992
    Cell Significance Index: 50.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0797
    Cell Significance Index: 417.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0057
    Cell Significance Index: 1810.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9664
    Cell Significance Index: 92.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3782
    Cell Significance Index: 62.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3406
    Cell Significance Index: 75.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1410
    Cell Significance Index: 112.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1141
    Cell Significance Index: 181.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0755
    Cell Significance Index: 138.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0251
    Cell Significance Index: 12.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9436
    Cell Significance Index: 338.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9044
    Cell Significance Index: 163.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7946
    Cell Significance Index: 50.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7886
    Cell Significance Index: 156.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7657
    Cell Significance Index: 418.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6781
    Cell Significance Index: 73.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6286
    Cell Significance Index: 48.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6231
    Cell Significance Index: 847.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5331
    Cell Significance Index: 36.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5245
    Cell Significance Index: 362.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5244
    Cell Significance Index: 18.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4823
    Cell Significance Index: 213.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4818
    Cell Significance Index: 21.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3979
    Cell Significance Index: 48.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3802
    Cell Significance Index: 172.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3633
    Cell Significance Index: 69.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3620
    Cell Significance Index: 49.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3064
    Cell Significance Index: 5.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3000
    Cell Significance Index: 20.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2886
    Cell Significance Index: 10.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2623
    Cell Significance Index: 483.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2089
    Cell Significance Index: 15.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1778
    Cell Significance Index: 273.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1257
    Cell Significance Index: 21.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1189
    Cell Significance Index: 1.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1145
    Cell Significance Index: 14.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0565
    Cell Significance Index: 106.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0084
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0053
    Cell Significance Index: 3.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0370
    Cell Significance Index: -1.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0511
    Cell Significance Index: -38.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0517
    Cell Significance Index: -37.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0616
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0710
    Cell Significance Index: -40.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0803
    Cell Significance Index: -4.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1202
    Cell Significance Index: -3.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1324
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1535
    Cell Significance Index: -4.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1624
    Cell Significance Index: -46.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1761
    Cell Significance Index: -37.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1871
    Cell Significance Index: -27.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1932
    Cell Significance Index: -22.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2469
    Cell Significance Index: -28.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2720
    Cell Significance Index: -16.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2890
    Cell Significance Index: -33.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3032
    Cell Significance Index: -4.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3113
    Cell Significance Index: -8.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3160
    Cell Significance Index: -22.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3171
    Cell Significance Index: -36.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3212
    Cell Significance Index: -32.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3601
    Cell Significance Index: -23.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4066
    Cell Significance Index: -8.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4711
    Cell Significance Index: -49.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4868
    Cell Significance Index: -10.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5596
    Cell Significance Index: -11.6700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.5934
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6308
    Cell Significance Index: -49.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6380
    Cell Significance Index: -16.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6485
    Cell Significance Index: -39.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6822
    Cell Significance Index: -14.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7075
    Cell Significance Index: -11.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7189
    Cell Significance Index: -24.9800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.7948
    Cell Significance Index: -8.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8051
    Cell Significance Index: -42.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8868
    Cell Significance Index: -29.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9325
    Cell Significance Index: -29.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9424
    Cell Significance Index: -19.5500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.9439
    Cell Significance Index: -10.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9982
    Cell Significance Index: -14.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ion Transport:** SLC12A2 is a chloride:monoatomic cation symporter, which means it facilitates the transport of chloride ions and monoatomic cations (such as sodium, potassium, and ammonium) across cell membranes. 2. **Cell Membrane Localization:** The SLC12A2 protein is primarily localized to the apical plasma membrane, where it regulates the transport of ions and molecules across epithelial cells. 3. **Regulation of Ion Homeostasis:** SLC12A2 helps maintain the balance of various ions, including sodium, potassium, chloride, and ammonium, which is essential for maintaining proper cellular function and overall health. 4. **Cellular Response to Stimuli:** The SLC12A2 protein is involved in cellular responses to various stimuli, including changes in ion concentrations, osmotic pressure, and inflammatory signals. **Pathways and Functions:** 1. **Ammonium Transport:** SLC12A2 is involved in the transport of ammonium ions across cell membranes, which is essential for maintaining proper nitrogen metabolism and preventing ammonia toxicity. 2. **Potassium Ion Homeostasis:** The SLC12A2 protein helps regulate potassium ion concentrations across cell membranes, which is crucial for maintaining proper neuronal function and preventing hyperkalemia. 3. **Chloride Ion Homeostasis:** SLC12A2 is involved in the regulation of chloride ion concentrations across cell membranes, which is essential for maintaining proper fluid balance and preventing chloride-related disorders. 4. **Cell Volume Regulation:** The SLC12A2 protein helps regulate cell volume by controlling the transport of ions and molecules across cell membranes. 5. **Neurological Function:** SLC12A2 is involved in the regulation of neuronal function, including synaptic transmission and neuronal plasticity. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of SLC12A2 has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Cancer:** SLC12A2 is overexpressed in certain types of cancer, including breast cancer and lung cancer, and its dysregulation has been associated with cancer progression and metastasis. 3. **Inflammatory Conditions:** SLC12A2 is involved in the regulation of inflammation, and its dysregulation has been implicated in various inflammatory conditions, including arthritis and inflammatory bowel disease. 4. **Blood-Brain Barrier Dysfunction:** SLC12A2 is involved in the regulation of the blood-brain barrier, and its dysregulation has been associated with blood-brain barrier dysfunction and neurological disorders. In conclusion, the SLC12A2 gene plays a critical role in maintaining the balance of various ions across cell membranes and is involved in various cellular processes, including ion homeostasis, cell volume regulation, and neurological function. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, and inflammatory conditions, highlighting the need for further research into the molecular mechanisms underlying SLC12A2 function and its clinical significance.

Genular Protein ID: 4200810514

Symbol: S12A2_HUMAN

Name: Solute carrier family 12 member 2

UniProtKB Accession Codes:

P55011 Q8N713 Q8WWH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 2 EMDB 11 Ensembl 2 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7629105

Title: Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.

PubMed ID: 7629105

DOI: 10.1074/jbc.270.30.17977

PubMed ID: 11700976

Title: Quantitation of Na(+)-K(+)-2Cl(-) cotransport splice variants in human tissues using kinetic polymerase chain reaction.

PubMed ID: 11700976

DOI: 10.1006/abio.2001.5398

PubMed ID: 12145305

Title: Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody.

PubMed ID: 12145305

DOI: 10.1074/jbc.m206294200

PubMed ID: 16669787

Title: Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

PubMed ID: 16669787

DOI: 10.1042/bj20060220

PubMed ID: 16832045

Title: WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

PubMed ID: 16832045

DOI: 10.1073/pnas.0604607103

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21613606

Title: Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.

PubMed ID: 21613606

DOI: 10.1152/ajpcell.00070.2011

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32081947

Title: Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.

PubMed ID: 32081947

DOI: 10.1038/s41467-020-14790-3

PubMed ID: 33597714

Title: The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2.

PubMed ID: 33597714

DOI: 10.1038/s42003-021-01750-w

PubMed ID: 36239040

Title: Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.

PubMed ID: 36239040

DOI: 10.15252/embj.2021110169

PubMed ID: 35585053

Title: Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide.

PubMed ID: 35585053

DOI: 10.1038/s41467-022-30407-3

PubMed ID: 36306358

Title: Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.

PubMed ID: 36306358

DOI: 10.1126/sciadv.abq0952

PubMed ID: 30740830

Title: Kilquist syndrome: A novel syndromic hearing loss disorder caused by homozygous deletion of SLC12A2.

PubMed ID: 30740830

DOI: 10.1002/humu.23722

PubMed ID: 32658972

Title: SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect.

PubMed ID: 32658972

DOI: 10.1093/brain/awaa176

PubMed ID: 32754646

Title: SLC12A2 mutations cause NKCC1 deficiency with encephalopathy and impaired secretory epithelia.

PubMed ID: 32754646

DOI: 10.1212/nxg.0000000000000478

PubMed ID: 32294086

Title: Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.

PubMed ID: 32294086

DOI: 10.1371/journal.pgen.1008643

Sequence Information:

  • Length: 1212
  • Mass: 131447
  • Checksum: A6BF174ACCDA2EC1
  • Sequence:
    • MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVP SVPEDAAPAS RDGGGVRDEG 
PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADG 
EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS 
EGSSLHSGGG GGSGHHQHYY YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR 
PSLAELHDEL EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW 
GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG GAYYLISRSL 
GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI LMIDEINDIR IIGAITVVIL 
LGISVAGMEW EAKAQIVLLV ILLLAIGDFV IGTFIPLESK KPKGFFGYKS EIFNENFGPD 
FREEETFFSV FAIFFPAATG ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV 
GSCVVRDATG NVNDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT 
PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE PLRGYILTFL 
IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK SPGWRPAFKY YNMWISLLGA 
ILCCIVMFVI NWWAALLTYV IVLGLYIYVT YKKPDVNWGS STQALTYLNA LQHSIRLSGV 
EDHVKNFRPQ CLVMTGAPNS RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA 
KYQRWLIKNK MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV 
DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV VVSVEYSKKS 
DLDTSKPLSE KPITHKVEEE DGKTATQPLL KKESKGPIVP LNVADQKLLE ASTQFQKKQG 
KNTIDVWWLF DDGGLTLLIP YLLTTKKKWK DCKIRVFIGG KINRIDHDRR AMATLLSKFR 
IDFSDIMVLG DINTKPKKEN IIAFEEIIEP YRLHEDDKEQ DIADKMKEDE PWRITDNELE 
LYKTKTYRQI RLNELLKEHS STANIIVMSL PVARKGAVSS ALYMAWLEAL SKDLPPILLV 
RGNHQSVLTF YS

Genular Protein ID: 3747488918

Symbol: B7ZM24_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZM24

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 8 Gene3D 1 IntAct 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 Pfam 6 RefSeq 1 Rhea 2 SAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1196
  • Mass: 129718
  • Checksum: 90FFD6F8278F6B79
  • Sequence:
    • MEPRPTAPSS GAPGLAGVGE TPSAAALAAA RVELPGTAVS SVPEDAAPAS RDGGGVRDEG 
PAAAGDGLGR PLGPTPSQSR FQVDLVSENA GRAAAAAAAA AAAAAAAGAG AGAKQTPADG 
EASGESEPAK GSEEAKGRFR VNFVDPAASS SAEDSLSDAA GVGVDGPNVS FQNGGDTVLS 
EGSSLHSGGG GGSGHHQHYY YDTHTNTYYL RTFGHNTMDA VPRIDHYRHT AAQLGEKLLR 
PSLAELHDEL EKEPFEDGFA NGEESTPTRD AVVTYTAESK GVVKFGWIKG VLVRCMLNIW 
GVMLFIRLSW IVGQAGIGLS VLVIMMATVV TTITGLSTSA IATNGFVRGG GAYYLISRSL 
GPEFGGAIGL IFAFANAVAV AMYVVGFAET VVELLKEHSI LMIDEINDIR IIGAITVVIL 
LGISVAGMEW EAKAQIVLLV ILLLAIGDFV IGTFIPLESK KPKGFFGYKS EIFNENFGPD 
FREEETFFSV FAIFFPAATG ILAGANISGD LADPQSAIPK GTLLAILITT LVYVGIAVSV 
GSCVVRDATG NVYDTIVTEL TNCTSAACKL NFDFSSCESS PCSYGLMNNF QVMSMVSGFT 
PLISAGIFSA TLSSALASLV SAPKIFQALC KDNIYPAFQM FAKGYGKNNE PLRGYILTFL 
IALGFILIAE LNVIAPIISN FFLASYALIN FSVFHASLAK SPGWRPAFKY YNMWISLLGA 
ILCCIVMFVI NWWAALLTYV IVLGLYIYVT YKKPDVNWGS STQALTYLNA LQHSIRLSGV 
EDHVKNFRPQ CLVMTGAPNS RPALLHLVHD FTKNVGLMIC GHVHMGPRRQ AMKEMSIDQA 
KYQRWLIKNK MKAFYAPVHA DDLREGAQYL MQAAGLGRMK PNTLVLGFKK DWLQADMRDV 
DMYINLFHDA FDIQYGVVVI RLKEGLDISH LQGQEELLSS QEKSPGTKDV VVSVEYSKKS 
DLDTSKPLSE KPITHKESKG PIVPLNVADQ KLLEASTQFQ KKQGKNTIDV WWLFDDGGLT 
LLIPYLLTTK KKWKDCKIRV FIGGKINRID HDRRAMATLL SKFRIDFSDI MVLGDINTKP 
KKENIIAFEE IIEPYRLHED DKEQDIADKM KEDEPWRITD NELELYKTKT YRQIRLNELL 
KEHSSTANII VMSLPVARKG AVSSALYMAW LEALSKDLPP ILLVRGNHQS VLTFYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.