Details for: SLC12A4

Gene ID: 6560

Symbol: SLC12A4

Ensembl ID: ENSG00000124067

Description: solute carrier family 12 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.4618
    Cell Significance Index: -10.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.0238
    Cell Significance Index: -11.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.6550
    Cell Significance Index: -9.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4651
    Cell Significance Index: -11.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9929
    Cell Significance Index: -11.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9608
    Cell Significance Index: -6.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7987
    Cell Significance Index: 21.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7771
    Cell Significance Index: 35.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6090
    Cell Significance Index: 115.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5880
    Cell Significance Index: 15.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5234
    Cell Significance Index: 51.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5197
    Cell Significance Index: 60.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4251
    Cell Significance Index: 84.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3487
    Cell Significance Index: 314.8200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2906
    Cell Significance Index: 4.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2756
    Cell Significance Index: 21.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2676
    Cell Significance Index: 7.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2614
    Cell Significance Index: 42.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2418
    Cell Significance Index: 6.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2364
    Cell Significance Index: 11.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2006
    Cell Significance Index: 21.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1989
    Cell Significance Index: 10.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1701
    Cell Significance Index: 3.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1547
    Cell Significance Index: 27.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1515
    Cell Significance Index: 20.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1444
    Cell Significance Index: 18.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1278
    Cell Significance Index: 15.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1249
    Cell Significance Index: 68.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1007
    Cell Significance Index: 44.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0776
    Cell Significance Index: 4.6600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0723
    Cell Significance Index: 1.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0666
    Cell Significance Index: 1.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0591
    Cell Significance Index: 4.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0402
    Cell Significance Index: 2.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0297
    Cell Significance Index: 0.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0120
    Cell Significance Index: 18.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0103
    Cell Significance Index: 18.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0097
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0078
    Cell Significance Index: 14.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0024
    Cell Significance Index: 3.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0005
    Cell Significance Index: -0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0067
    Cell Significance Index: -0.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0117
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0194
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0195
    Cell Significance Index: -3.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0218
    Cell Significance Index: -12.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0222
    Cell Significance Index: -2.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0240
    Cell Significance Index: -1.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0264
    Cell Significance Index: -9.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0265
    Cell Significance Index: -3.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0277
    Cell Significance Index: -0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0354
    Cell Significance Index: -7.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0358
    Cell Significance Index: -10.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0374
    Cell Significance Index: -2.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0385
    Cell Significance Index: -4.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0411
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0627
    Cell Significance Index: -13.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0755
    Cell Significance Index: -1.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0855
    Cell Significance Index: -5.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0863
    Cell Significance Index: -1.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0935
    Cell Significance Index: -1.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0967
    Cell Significance Index: -10.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1000
    Cell Significance Index: -2.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1134
    Cell Significance Index: -2.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1198
    Cell Significance Index: -6.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1210
    Cell Significance Index: -2.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1275
    Cell Significance Index: -10.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1315
    Cell Significance Index: -7.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1468
    Cell Significance Index: -9.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1600
    Cell Significance Index: -4.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1642
    Cell Significance Index: -5.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1726
    Cell Significance Index: -1.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1758
    Cell Significance Index: -11.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1762
    Cell Significance Index: -11.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1770
    Cell Significance Index: -6.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1863
    Cell Significance Index: -4.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1992
    Cell Significance Index: -2.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2293
    Cell Significance Index: -1.8700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2348
    Cell Significance Index: -2.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2413
    Cell Significance Index: -12.6700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2447
    Cell Significance Index: -3.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2460
    Cell Significance Index: -10.8800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2497
    Cell Significance Index: -4.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2865
    Cell Significance Index: -10.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2938
    Cell Significance Index: -8.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2991
    Cell Significance Index: -8.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2992
    Cell Significance Index: -4.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3047
    Cell Significance Index: -11.1900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3065
    Cell Significance Index: -3.2000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3119
    Cell Significance Index: -4.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3189
    Cell Significance Index: -11.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3337
    Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Electroneutral cotransport**: NKCC1 is an electroneutral cotransporter, meaning it transports two ions (K+ and Cl-) simultaneously without generating a net electrical charge across the cell membrane. 2. **Potassium-chloride symporter activity**: NKCC1 exhibits potassium-chloride symporter activity, facilitating the exchange of K+ and Cl- ions across the cell membrane. 3. **Atp-dependent transport**: NKCC1 is an ATP-dependent transporter, relying on the energy generated by ATP hydrolysis to drive the transport of K+ and Cl- ions. 4. **Regulation of cellular volume**: NKCC1 plays a crucial role in maintaining cellular volume homeostasis by regulating the transport of K+ and Cl- ions across the cell membrane. **Pathways and Functions:** 1. **Ammonium import**: NKCC1 is involved in the import of ammonium (NH4+) ions across the plasma membrane, which is essential for maintaining nitrogen homeostasis in the body. 2. **Cell volume regulation**: NKCC1 helps regulate cellular volume by controlling the transport of K+ and Cl- ions across the cell membrane. 3. **Neurotransmission**: NKCC1 is expressed in GABAergic interneurons and plays a role in regulating neurotransmitter release and synaptic transmission. 4. **Cardiac function**: NKCC1 is expressed in cardiac muscle cells and helps regulate cardiac function by controlling the transport of K+ and Cl- ions across the cell membrane. 5. **Cancer development**: Abnormal expression of NKCC1 has been linked to cancer development, particularly in colon cancer, where it is overexpressed in tumor cells. **Clinical Significance:** 1. **Neurological disorders**: Mutations in the SLC12A4 gene have been associated with neurological disorders, such as epilepsy and autism spectrum disorder. 2. **Cancer**: Abnormal expression of NKCC1 has been linked to cancer development and progression, particularly in colon cancer. 3. **Cardiac dysfunction**: Altered expression of NKCC1 has been implicated in cardiac dysfunction and arrhythmias. 4. **Nutritional disorders**: NKCC1 plays a crucial role in regulating nutrient absorption and transport, making it essential for maintaining proper nutrition and preventing disorders such as malabsorption. 5. **Therapeutic targets**: NKCC1 is a potential therapeutic target for the treatment of various diseases, including cancer, neurological disorders, and cardiac dysfunction. In conclusion, the SLC12A4 gene and its encoded protein, NKCC1, play a critical role in maintaining cellular homeostasis and regulating various physiological processes. Further research is needed to fully elucidate the functions and clinical significance of NKCC1, but its importance in human health and disease is clear.

Genular Protein ID: 2953846600

Symbol: S12A4_HUMAN

Name: Electroneutral potassium-chloride cotransporter 1

UniProtKB Accession Codes:

Q9UP95 B4DF69 B4DR04 B4DZ82 B7ZAV0 F5H066 F5H0S9 F5H3C0 O60632 O75893 Q13953 Q96LD5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 12 EMDB 8 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663127

Title: Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.

PubMed ID: 8663127

DOI: 10.1074/jbc.271.27.16237

PubMed ID: 9516379

Title: Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.

PubMed ID: 9516379

DOI: 10.1006/bcmd.1998.0168

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551954

Title: A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

PubMed ID: 11551954

DOI: 10.1074/jbc.m107155200

PubMed ID: 10913127

Title: Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.

PubMed ID: 10913127

DOI: 10.1074/jbc.m003112200

PubMed ID: 10564083

Title: Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.

PubMed ID: 10564083

DOI: 10.1152/ajpcell.1999.277.5.c899

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21613606

Title: Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.

PubMed ID: 21613606

DOI: 10.1152/ajpcell.00070.2011

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31649201

Title: Cryo-EM structures of the human cation-chloride cotransporter KCC1.

PubMed ID: 31649201

DOI: 10.1126/science.aay3129

PubMed ID: 34031912

Title: Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

PubMed ID: 34031912

DOI: 10.15252/embj.2020107294

PubMed ID: 35759661

Title: Structure of the human cation-chloride cotransport KCC1 in an outward-open state.

PubMed ID: 35759661

DOI: 10.1073/pnas.2109083119

Sequence Information:

  • Length: 1085
  • Mass: 120650
  • Checksum: 42B590EC3D94EA4D
  • Sequence:
    • MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL SPLEASRGID 
YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGTRR RAAEAPSMGT 
LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV LQALLIVLIC CCCTLLTAIS MSAIATNGVV 
PAGGSYFMIS RSLGPEFGGA VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA 
HDTSNATLNN MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT DSCDPYFMLN 
NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD APSLKESLPL YVVADIATSF 
TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS IPVGTILAII TTSLVYFSSV VLFGACIEGV 
VLRDKYGDGV SRNLVVGTLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP 
FLRVFGHGKV NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK YIEYQGAEKE 
WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKYPR LLTFASQLKA 
GKGLTIVGSV IQGSFLESYG EAQAAEQTIK NMMEIEKVKG FCQVVVASKV REGLAHLIQS 
CGLGGMRHNS VVLGWPYGWR QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER 
YLEGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 
HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTEREREA QLVKDRHSAL 
RLESLYSDEE DESAVGADKI QMTWTRDKYM TETWDPSHAP DNFRELVHIK PDQSNVRRMH 
TAVKLNEVIV TRSHDARLVL LNMPGPPRNS EGDENYMEFL EVLTEGLERV LLVRGGGREV 
ITIYS

Genular Protein ID: 3267358954

Symbol: B4DF30_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DF30

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 1 SAM 1

Sequence Information:

  • Length: 1079
  • Mass: 119980
  • Checksum: 210594864D797654
  • Sequence:
    • MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAELDDSDGH GNHRESSPFL SPLEASRGID 
YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGTRR RAAEAPSMGT 
LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV LQALLIVLIC CCCTLLTAIS MSAIATNGVV 
PAGGSYFMIS RSLGPEFGGA VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGA 
HDTSNATLNN MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYAGGIKSIF 
DPPVFPVCML GNRTLSRDQF DICAKTAVVD NETVATQLWS FFCHSPNLTT DSCDPYFMLN 
NVTEIPGIPG AAAGVLQENL WSAYLEKGDI VEKHGLPSAD APSLKECLPL YVVADIATSF 
TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS IPVGTILAII TTSLVYFSSV VLFGACIEGV 
VLRDKYGDGV SRNLVVGTLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP 
FLRVFGHGKV NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
LLRTPNWRPR FEYYHWALSF LGMSLCLALM FVSSWYYALV AMLIAGMIYK YIEYQGAEKE 
WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKYPR LLTFASQLKA 
GKGLTIVGSV IQGSFLESYG EAQAAEQTIK NMMEIEKVKG FCQVVVASKV REGLAHLIQS 
CGLGGMRHNS VVLGWPYGWR QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER 
YLEGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQMDDNSIQ MKKDLAVFLY 
HLRLEAEHNS DISAYTYERT LMMEQRSQML RQMRLTKTER EREAQLVKDR HSALRLESLY 
SDEEDESAVG ADKIQMTWTR DKYMTETWDP SHAPDNFREL VHIKPDQSNV RRMHTAVKLN 
EVIVTRSHDA RLVLLNMPGP PRNSEGDENY MEFLEVLTEG LERVLLVRGG GREVITIYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.