Details for: SLC22A3

Gene ID: 6581

Symbol: SLC22A3

Ensembl ID: ENSG00000146477

Description: solute carrier family 22 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8113
    Cell Significance Index: -10.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.9856
    Cell Significance Index: 106.8000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.6492
    Cell Significance Index: 58.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8773
    Cell Significance Index: 372.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4592
    Cell Significance Index: 24.5800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.2241
    Cell Significance Index: 12.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1874
    Cell Significance Index: 19.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9039
    Cell Significance Index: 172.0100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7521
    Cell Significance Index: 18.3500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6599
    Cell Significance Index: 7.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6560
    Cell Significance Index: 15.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6018
    Cell Significance Index: 59.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4838
    Cell Significance Index: 13.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4613
    Cell Significance Index: 13.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4576
    Cell Significance Index: 413.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3245
    Cell Significance Index: 35.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3108
    Cell Significance Index: 56.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3060
    Cell Significance Index: 49.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2486
    Cell Significance Index: 11.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2054
    Cell Significance Index: 28.2100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1604
    Cell Significance Index: 2.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1275
    Cell Significance Index: 88.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1199
    Cell Significance Index: 8.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1158
    Cell Significance Index: 14.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0821
    Cell Significance Index: 1.7600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0561
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0299
    Cell Significance Index: 22.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0162
    Cell Significance Index: 1.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0091
    Cell Significance Index: 5.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0039
    Cell Significance Index: -1.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0058
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -4.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0074
    Cell Significance Index: -3.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0114
    Cell Significance Index: -17.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0182
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0189
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0201
    Cell Significance Index: -12.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0234
    Cell Significance Index: -12.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0254
    Cell Significance Index: -0.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0270
    Cell Significance Index: -5.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0329
    Cell Significance Index: -9.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0333
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0342
    Cell Significance Index: -0.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0500
    Cell Significance Index: -2.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0586
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0595
    Cell Significance Index: -12.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0717
    Cell Significance Index: -10.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0820
    Cell Significance Index: -14.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0918
    Cell Significance Index: -2.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0958
    Cell Significance Index: -12.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0973
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1034
    Cell Significance Index: -6.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1038
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1073
    Cell Significance Index: -1.1200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1082
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1114
    Cell Significance Index: -12.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1121
    Cell Significance Index: -11.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1169
    Cell Significance Index: -12.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1202
    Cell Significance Index: -3.8500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1223
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1444
    Cell Significance Index: -4.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1465
    Cell Significance Index: -10.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1501
    Cell Significance Index: -11.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1524
    Cell Significance Index: -9.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1563
    Cell Significance Index: -12.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1677
    Cell Significance Index: -12.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1743
    Cell Significance Index: -11.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1765
    Cell Significance Index: -9.1700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1982
    Cell Significance Index: -2.5700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1993
    Cell Significance Index: -0.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2006
    Cell Significance Index: -10.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2113
    Cell Significance Index: -4.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2189
    Cell Significance Index: -10.2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2291
    Cell Significance Index: -2.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2293
    Cell Significance Index: -5.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2377
    Cell Significance Index: -10.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2427
    Cell Significance Index: -13.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2681
    Cell Significance Index: -7.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2785
    Cell Significance Index: -14.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2803
    Cell Significance Index: -12.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3163
    Cell Significance Index: -11.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3359
    Cell Significance Index: -12.7200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3397
    Cell Significance Index: -2.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3459
    Cell Significance Index: -4.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3500
    Cell Significance Index: -12.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3575
    Cell Significance Index: -5.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3589
    Cell Significance Index: -11.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3599
    Cell Significance Index: -12.5100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3631
    Cell Significance Index: -5.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3651
    Cell Significance Index: -5.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3757
    Cell Significance Index: -12.3000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3813
    Cell Significance Index: -1.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SLC22A3 is a membrane-bound protein with a large extracellular domain and a smaller intracellular domain. The protein has a distinct topology, with the extracellular domain containing multiple transmembrane helices and the intracellular domain containing a characteristic "hairpin" structure. The protein is highly expressed in various tissues, including the brain, liver, and kidneys, and is also found in immune cells, such as granulocytes and monocytes. SLC22A3 is a substrate for multiple transporters and has been shown to interact with various ligands, including neurotransmitters, hormones, and xenobiotics. **Pathways and Functions** SLC22A3 is involved in various cellular processes, including: 1. **Neurotransmitter transport**: SLC22A3 is responsible for the transport of neurotransmitters, such as dopamine, serotonin, and norepinephrine, across the blood-brain barrier. 2. **Hormone transport**: SLC22A3 is involved in the transport of hormones, such as epinephrine and histamine, across cellular membranes. 3. **Xenobiotic transport**: SLC22A3 is responsible for the transport of xenobiotics, including drugs and toxins, across cellular membranes. 4. **Metabolic regulation**: SLC22A3 is involved in the regulation of appetite and metabolism through the transport of small molecules, such as monocarboxylic acids. 5. **Immune cell function**: SLC22A3 is expressed in immune cells, such as granulocytes and monocytes, and is involved in the transport of immune-related molecules. **Clinical Significance** SLC22A3 has been implicated in various diseases, including: 1. **AIDS**: SLC22A3 has been identified as a key player in the transport of antiretroviral drugs, such as abacavir, across the blood-brain barrier. 2. **Neurological disorders**: SLC22A3 has been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and depression, through its role in neurotransmitter transport. 3. **Cancer**: SLC22A3 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, and is thought to play a role in the transport of chemotherapy agents. 4. **Metabolic disorders**: SLC22A3 has been implicated in the regulation of appetite and metabolism, and has been shown to be associated with metabolic disorders, such as obesity and type 2 diabetes. In conclusion, SLC22A3 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes, including neurotransmitter transport, hormone transport, and xenobiotic transport. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of SLC22A3.

Genular Protein ID: 2562113354

Symbol: S22A3_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75751 Q5SYN6 Q9UP02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 43 DrugCentral 1 EMBL 6 EMDB 3 Ensembl 1 GO 40 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 11 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10196521

Title: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.

PubMed ID: 10196521

DOI: 10.1038/1557

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9933568

Title: Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.

PubMed ID: 9933568

DOI: 10.1006/geno.1998.5639

PubMed ID: 10966924

Title: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.

PubMed ID: 10966924

DOI: 10.1152/ajprenal.2000.279.3.f449

PubMed ID: 12538837

Title: Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).

PubMed ID: 12538837

DOI: 10.1124/jpet.102.044404

PubMed ID: 15817714

Title: Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.

PubMed ID: 15817714

DOI: 10.1165/rcmb.2004-0363oc

PubMed ID: 16263091

Title: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

PubMed ID: 16263091

DOI: 10.1016/j.bcp.2005.09.011

PubMed ID: 16914559

Title: Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).

PubMed ID: 16914559

DOI: 10.1124/jpet.106.110346

PubMed ID: 16581093

Title: Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.

PubMed ID: 16581093

DOI: 10.1016/j.neuropharm.2006.01.005

PubMed ID: 17460754

Title: Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

PubMed ID: 17460754

DOI: 10.1371/journal.pone.0000385

PubMed ID: 20858707

Title: Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.

PubMed ID: 20858707

DOI: 10.1124/jpet.110.170142

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

Sequence Information:

  • Length: 556
  • Mass: 61280
  • Checksum: C3CA2D77DD21C658
  • Sequence:
    • MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA 
ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR 
SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG 
RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR 
IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK 
GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT 
SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA 
CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG 
GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS 
CKCGRNKKTP VSRSHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.