Details for: SLC22A2

Gene ID: 6582

Symbol: SLC22A2

Ensembl ID: ENSG00000112499

Description: solute carrier family 22 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.7071
    Cell Significance Index: 13.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7733
    Cell Significance Index: 16.5300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3600
    Cell Significance Index: 3.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3519
    Cell Significance Index: 6.0300
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2444
    Cell Significance Index: 2.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2150
    Cell Significance Index: 5.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1829
    Cell Significance Index: 2.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1497
    Cell Significance Index: 2.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1402
    Cell Significance Index: 3.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1355
    Cell Significance Index: 99.3600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0923
    Cell Significance Index: 1.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0807
    Cell Significance Index: 6.4000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.0784
    Cell Significance Index: 0.8300
  • Cell Name: MHC-II-positive classical monocyte (CL0002470)
    Fold Change: 0.0574
    Cell Significance Index: 0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0423
    Cell Significance Index: 26.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0398
    Cell Significance Index: 0.6700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0323
    Cell Significance Index: 0.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0309
    Cell Significance Index: 0.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0299
    Cell Significance Index: 0.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0224
    Cell Significance Index: 0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0185
    Cell Significance Index: 3.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0084
    Cell Significance Index: 0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0024
    Cell Significance Index: 0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0011
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0009
    Cell Significance Index: 1.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0007
    Cell Significance Index: 0.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0007
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0012
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0013
    Cell Significance Index: -0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0024
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0078
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0092
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0122
    Cell Significance Index: -0.3400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.0131
    Cell Significance Index: -0.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0132
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0168
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0182
    Cell Significance Index: -2.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0193
    Cell Significance Index: -2.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0211
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0259
    Cell Significance Index: -1.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0265
    Cell Significance Index: -2.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0323
    Cell Significance Index: -0.8300
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0348
    Cell Significance Index: -0.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0365
    Cell Significance Index: -1.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0385
    Cell Significance Index: -2.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0393
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0407
    Cell Significance Index: -1.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0409
    Cell Significance Index: -0.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0414
    Cell Significance Index: -1.4500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0452
    Cell Significance Index: -0.9200
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0472
    Cell Significance Index: -0.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0472
    Cell Significance Index: -2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0473
    Cell Significance Index: -1.5500
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0476
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0484
    Cell Significance Index: -1.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0512
    Cell Significance Index: -2.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0535
    Cell Significance Index: -1.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0560
    Cell Significance Index: -2.6100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0571
    Cell Significance Index: -0.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0578
    Cell Significance Index: -1.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0637
    Cell Significance Index: -1.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0663
    Cell Significance Index: -2.3300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0667
    Cell Significance Index: -0.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0679
    Cell Significance Index: -2.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0695
    Cell Significance Index: -1.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0738
    Cell Significance Index: -1.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0764
    Cell Significance Index: -1.6500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0764
    Cell Significance Index: -0.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0778
    Cell Significance Index: -2.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0778
    Cell Significance Index: -1.3100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0785
    Cell Significance Index: -1.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0791
    Cell Significance Index: -2.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0834
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0836
    Cell Significance Index: -0.8300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0839
    Cell Significance Index: -1.0000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0842
    Cell Significance Index: -1.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0860
    Cell Significance Index: -1.7000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0872
    Cell Significance Index: -1.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0880
    Cell Significance Index: -1.7600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0899
    Cell Significance Index: -1.7700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0914
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0915
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0916
    Cell Significance Index: -1.5100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0943
    Cell Significance Index: -1.1400
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0954
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0960
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0961
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0962
    Cell Significance Index: -1.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Multifunctional transporter**: SLC22A2 exhibits a broad substrate specificity, transporting a wide range of molecules, including amino acids, neurotransmitters, and xenobiotics. 2. **Cell membrane localization**: SLC22A2 is primarily localized to the plasma membrane, where it can interact with various substrates and influence cellular processes. 3. **Regulatory mechanisms**: SLC22A2 is subject to various regulatory mechanisms, including phosphorylation, ubiquitination, and interaction with other proteins, which can modulate its activity and localization. 4. **Evolutionary conservation**: SLC22A2 is conserved across species, suggesting its importance in maintaining cellular homeostasis and function. **Pathways and Functions** 1. **Amino acid transport**: SLC22A2 plays a crucial role in the transport of amino acids across the plasma membrane, influencing cellular metabolism and protein synthesis. 2. **Neurotransmitter transport**: SLC22A2 is involved in the transport of neurotransmitters, such as dopamine, serotonin, and acetylcholine, which are essential for neural signaling and behavior. 3. **Xenobiotic transport**: SLC22A2 can transport xenobiotics, including drugs and environmental toxins, influencing their distribution and elimination from the body. 4. **Blood-brain barrier transport**: SLC22A2 is expressed in the blood-brain barrier and plays a role in the transport of substances across this critical barrier. 5. **Gene expression regulation**: SLC22A2 can influence gene expression by regulating the transport of transcription factors and other signaling molecules. **Clinical Significance** 1. **Disease association**: Variants in the SLC22A2 gene have been associated with various diseases, including epilepsy, Parkinson's disease, and certain types of cancer. 2. **Pharmacokinetics**: SLC22A2 can influence the pharmacokinetics of certain drugs, affecting their absorption, distribution, and elimination. 3. **Toxicity**: SLC22A2 can also contribute to the toxicity of certain substances, such as heavy metals and environmental toxins. 4. **Therapeutic applications**: SLC22A2 has been explored as a target for the development of novel therapeutic agents, including drugs and gene therapies, which can modulate its activity and influence cellular processes. In conclusion, the SLC22A2 gene plays a critical role in maintaining cellular homeostasis and function, influencing various physiological and pathological processes. Its multifunctional nature and regulatory mechanisms make it an attractive target for the development of novel therapeutic agents and the study of disease mechanisms.

Genular Protein ID: 3467177422

Symbol: S22A2_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15244 Q5T7Q6 Q6PIQ8 Q8NG62 Q9NQB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 8 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 1 Rhea 22 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9260930

Title: Cloning and characterization of two human polyspecific organic cation transporters.

PubMed ID: 9260930

DOI: 10.1089/dna.1997.16.871

PubMed ID: 12089365

Title: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.

PubMed ID: 12089365

DOI: 10.1097/01.asn.0000019413.78751.46

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10942111

Title: Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.

PubMed ID: 10942111

DOI: 10.1007/s004390000309

PubMed ID: 9687576

Title: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.

PubMed ID: 9687576

DOI: 10.1124/mol.54.2.342

PubMed ID: 11912245

Title: Gene expression levels and immunolocalization of organic ion transporters in the human kidney.

PubMed ID: 11912245

DOI: 10.1681/asn.v134866

PubMed ID: 12395288

Title: The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP.

PubMed ID: 12395288

DOI: 10.1007/s00232-002-1023-7

PubMed ID: 11907186

Title: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

PubMed ID: 11907186

DOI: 10.1124/jpet.301.1.293

PubMed ID: 12538837

Title: Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).

PubMed ID: 12538837

DOI: 10.1124/jpet.102.044404

PubMed ID: 15496291

Title: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).

PubMed ID: 15496291

DOI: 10.1016/j.ejphar.2004.09.032

PubMed ID: 15212162

Title: Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney.

PubMed ID: 15212162

DOI: 10.1023/b:pham.0000029286.45788.ad

PubMed ID: 16314463

Title: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.

PubMed ID: 16314463

DOI: 10.1016/s0002-9440(10)61234-5

PubMed ID: 15817714

Title: Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.

PubMed ID: 15817714

DOI: 10.1165/rcmb.2004-0363oc

PubMed ID: 16263091

Title: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

PubMed ID: 16263091

DOI: 10.1016/j.bcp.2005.09.011

PubMed ID: 16272756

Title: Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

PubMed ID: 16272756

DOI: 10.2133/dmpk.20.379

PubMed ID: 16006492

Title: A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters.

PubMed ID: 16006492

DOI: 10.1124/jpet.105.088104

PubMed ID: 15783073

Title: Metformin transport by renal basolateral organic cation transporter hOCT2.

PubMed ID: 15783073

DOI: 10.1007/s11095-004-1193-3

PubMed ID: 16394027

Title: Characterization of regulatory mechanisms and states of human organic cation transporter 2.

PubMed ID: 16394027

DOI: 10.1152/ajpcell.00622.2005

PubMed ID: 16951202

Title: Organic cation transporters are determinants of oxaliplatin cytotoxicity.

PubMed ID: 16951202

DOI: 10.1158/0008-5472.can-06-0769

PubMed ID: 17072098

Title: Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2.

PubMed ID: 17072098

DOI: 10.2133/dmpk.21.432

PubMed ID: 16914559

Title: Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).

PubMed ID: 16914559

DOI: 10.1124/jpet.106.110346

PubMed ID: 16581093

Title: Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.

PubMed ID: 16581093

DOI: 10.1016/j.neuropharm.2006.01.005

PubMed ID: 17393420

Title: The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.

PubMed ID: 17393420

DOI: 10.1002/mrd.20697

PubMed ID: 21128598

Title: OCT2 and MATE1 provide bidirectional agmatine transport.

PubMed ID: 21128598

DOI: 10.1021/mp100180a

PubMed ID: 24961373

Title: OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

PubMed ID: 24961373

DOI: 10.1073/pnas.1314939111

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 12142729

Title: Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.

PubMed ID: 12142729

DOI: 10.1097/00008571-200207000-00007

PubMed ID: 17111267

Title: Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

PubMed ID: 17111267

DOI: 10.1007/s10038-006-0087-0

PubMed ID: 17460754

Title: Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

PubMed ID: 17460754

DOI: 10.1371/journal.pone.0000385

Sequence Information:

  • Length: 555
  • Mass: 62581
  • Checksum: 06528F9519CE211E
  • Sequence:
    • MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS 
LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG 
PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL 
LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF 
YQVAYTVGLL VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM 
RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV 
LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA 
SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII 
TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE 
KMIYLQVQKL DIPLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.