Details for: SNAPC3

Gene ID: 6619

Symbol: SNAPC3

Ensembl ID: ENSG00000164975

Description: small nuclear RNA activating complex polypeptide 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.6508
    Cell Significance Index: -35.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.7451
    Cell Significance Index: -36.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.0973
    Cell Significance Index: -38.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.5217
    Cell Significance Index: -31.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.6778
    Cell Significance Index: -36.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.5588
    Cell Significance Index: -32.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3093
    Cell Significance Index: -37.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0209
    Cell Significance Index: -37.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5792
    Cell Significance Index: -37.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8903
    Cell Significance Index: -15.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.1230
    Cell Significance Index: 34.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7811
    Cell Significance Index: 207.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6037
    Cell Significance Index: 321.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5433
    Cell Significance Index: 152.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3926
    Cell Significance Index: 93.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3083
    Cell Significance Index: 1181.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9949
    Cell Significance Index: 55.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9252
    Cell Significance Index: 183.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8542
    Cell Significance Index: 306.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8295
    Cell Significance Index: 90.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8275
    Cell Significance Index: 134.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7136
    Cell Significance Index: 43.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6694
    Cell Significance Index: 40.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6481
    Cell Significance Index: 448.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5568
    Cell Significance Index: 42.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5350
    Cell Significance Index: 12.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4872
    Cell Significance Index: 13.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3950
    Cell Significance Index: 215.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3781
    Cell Significance Index: 10.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3777
    Cell Significance Index: 8.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3769
    Cell Significance Index: 8.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3709
    Cell Significance Index: 5.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3651
    Cell Significance Index: 16.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3529
    Cell Significance Index: 63.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3140
    Cell Significance Index: 11.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3063
    Cell Significance Index: 8.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2767
    Cell Significance Index: 5.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2687
    Cell Significance Index: 34.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2611
    Cell Significance Index: 7.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2388
    Cell Significance Index: 12.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2332
    Cell Significance Index: 28.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2086
    Cell Significance Index: 28.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1845
    Cell Significance Index: 3.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1618
    Cell Significance Index: 30.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1595
    Cell Significance Index: 7.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1113
    Cell Significance Index: 1.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1080
    Cell Significance Index: 1.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0949
    Cell Significance Index: 6.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0802
    Cell Significance Index: 36.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0742
    Cell Significance Index: 139.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0733
    Cell Significance Index: 32.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0631
    Cell Significance Index: 3.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0490
    Cell Significance Index: 2.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0447
    Cell Significance Index: 68.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0423
    Cell Significance Index: 26.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0342
    Cell Significance Index: 63.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0242
    Cell Significance Index: 32.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0313
    Cell Significance Index: -22.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0391
    Cell Significance Index: -29.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0409
    Cell Significance Index: -6.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0464
    Cell Significance Index: -26.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0658
    Cell Significance Index: -7.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0769
    Cell Significance Index: -7.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0816
    Cell Significance Index: -2.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0852
    Cell Significance Index: -2.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1032
    Cell Significance Index: -4.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1049
    Cell Significance Index: -2.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1116
    Cell Significance Index: -32.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1180
    Cell Significance Index: -24.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1199
    Cell Significance Index: -2.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1247
    Cell Significance Index: -18.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1861
    Cell Significance Index: -4.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1865
    Cell Significance Index: -24.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1967
    Cell Significance Index: -12.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2067
    Cell Significance Index: -3.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2388
    Cell Significance Index: -16.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2389
    Cell Significance Index: -27.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2651
    Cell Significance Index: -8.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2843
    Cell Significance Index: -29.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2985
    Cell Significance Index: -7.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3087
    Cell Significance Index: -14.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3127
    Cell Significance Index: -16.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3149
    Cell Significance Index: -23.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3234
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3420
    Cell Significance Index: -39.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4177
    Cell Significance Index: -33.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4486
    Cell Significance Index: -12.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4728
    Cell Significance Index: -28.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5181
    Cell Significance Index: -12.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5793
    Cell Significance Index: -8.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5820
    Cell Significance Index: -8.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5955
    Cell Significance Index: -17.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6075
    Cell Significance Index: -19.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6283
    Cell Significance Index: -14.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6331
    Cell Significance Index: -20.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6441
    Cell Significance Index: -13.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNAPC3 is a polypeptide encoded by the ENSG00000164975 gene. It is a component of the snRNA-activating protein complex, which is involved in the regulation of snRNA transcription. The SNAPC3 subunit is specifically implicated in the activation of snRNA transcription by RNA polymerase II and III. The gene exhibits tissue-specific expression, with highest levels detected in neurons, where it is likely involved in regulating the expression of neuronal-specific genes. **Pathways and Functions** SNAPC3 is involved in several critical cellular pathways, including: 1. **Transcription by RNA polymerase II**: SNAPC3 is required for the activation of snRNA transcription by RNA polymerase II, a key enzyme responsible for transcribing protein-coding and non-coding RNAs in eukaryotic cells. 2. **Transcription by RNA polymerase III**: SNAPC3 also plays a role in the activation of snRNA transcription by RNA polymerase III, which transcribes genes involved in ribosome biogenesis and other cellular processes. 3. **Gene expression (transcription)**: SNAPC3 is involved in regulating the expression of genes involved in various cellular processes, including splicing, transcription, and ribosome biogenesis. 4. **Nuclear body and nucleolus**: SNAPC3 is localized to the nuclear body and nucleolus, where it is likely involved in regulating the expression of genes involved in ribosome biogenesis and other cellular processes. **Clinical Significance** The clinical significance of SNAPC3 is still emerging, but its involvement in neuronal development and function suggests that alterations in its expression may contribute to neurological disorders. For example, changes in SNAPC3 expression have been implicated in autism spectrum disorder, a neurodevelopmental disorder characterized by impairments in social communication and behavior. Additionally, SNAPC3 may play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where disruptions in RNA polymerase II and III-mediated transcription have been observed. In conclusion, SNAPC3 is a critical regulator of snRNA transcription, involved in various cellular pathways, including transcription by RNA polymerase II and III. Its widespread expression in neurons and other tissues underscores its importance in maintaining cellular homeostasis and regulating the expression of critical genes. Further studies are needed to fully elucidate the clinical significance of SNAPC3 and its role in neurological disorders.

Genular Protein ID: 1191183903

Symbol: SNPC3_HUMAN

Name: snRNA-activating protein complex subunit 3

UniProtKB Accession Codes:

Q92966 D3DRI8 Q2VPI6 Q5T285

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 9 Ensembl 4 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9003788

Title: Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc.

PubMed ID: 9003788

DOI: 10.1002/j.1460-2075.1996.tb01104.x

PubMed ID: 8816454

Title: Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.

PubMed ID: 8816454

DOI: 10.1128/mcb.16.10.5419

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11056176

Title: A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.

PubMed ID: 11056176

DOI: 10.1074/jbc.m009301200

PubMed ID: 12621023

Title: The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.

PubMed ID: 12621023

DOI: 10.1074/jbc.m204247200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

Sequence Information:

  • Length: 411
  • Mass: 46753
  • Checksum: 920584BE4CFA366A
  • Sequence:
    • MAEGSRGGPT CSGVGGRQDP VSGSGGCNFP EYELPELNTR AFHVGAFGEL WRGRLRGAGD 
LSLREPPASA LPGSQAADSD REDAAVARDL DCSLEAAAEL RAVCGLDKLK CLEDGEDPEV 
IPENTDLVTL GVRKRFLEHR EETITIDRAC RQETFVYEME SHAIGKKPEN SADMIEEGEL 
ILSVNILYPV IFHKHKEHKP YQTMLVLGSQ KLTQLRDSIR CVSDLQIGGE FSNTPDQAPE 
HISKDLYKSA FFYFEGTFYN DKRYPECRDL SRTIIEWSES HDRGYGKFQT ARMEDFTFND 
LCIKLGFPYL YCHQGDCEHV IVITDIRLVH HDDCLDRTLY PLLIKKHWLW TRKCFVCKMY 
TARWVTNNDS FAPEDPCFFC DVCFRMLHYD SEGNKLGEFL AYPYVDPGTF N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.