Details for: SNTB1

Gene ID: 6641

Symbol: SNTB1

Ensembl ID: ENSG00000172164

Description: syntrophin beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.8640
    Cell Significance Index: -16.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.4105
    Cell Significance Index: -15.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.6321
    Cell Significance Index: -19.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.7285
    Cell Significance Index: -16.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.0321
    Cell Significance Index: -18.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.9470
    Cell Significance Index: -16.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.3720
    Cell Significance Index: -17.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6808
    Cell Significance Index: -16.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5438
    Cell Significance Index: -17.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.7616
    Cell Significance Index: 944.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.5963
    Cell Significance Index: 123.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5843
    Cell Significance Index: -18.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.5812
    Cell Significance Index: 77.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.6241
    Cell Significance Index: 56.0900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.6205
    Cell Significance Index: 22.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4795
    Cell Significance Index: 281.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4615
    Cell Significance Index: 28.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2744
    Cell Significance Index: 18.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.1713
    Cell Significance Index: 59.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0666
    Cell Significance Index: 105.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8672
    Cell Significance Index: 22.2900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.7848
    Cell Significance Index: 3.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7456
    Cell Significance Index: 673.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5591
    Cell Significance Index: 90.9300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4939
    Cell Significance Index: 2.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4907
    Cell Significance Index: 29.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4700
    Cell Significance Index: 6.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2604
    Cell Significance Index: 18.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2218
    Cell Significance Index: 10.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2052
    Cell Significance Index: 112.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1657
    Cell Significance Index: 3.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1567
    Cell Significance Index: 213.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1419
    Cell Significance Index: 90.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1294
    Cell Significance Index: 22.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1179
    Cell Significance Index: 81.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1038
    Cell Significance Index: 2.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0861
    Cell Significance Index: 17.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0776
    Cell Significance Index: 1.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0718
    Cell Significance Index: 1.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0604
    Cell Significance Index: 1.7400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0480
    Cell Significance Index: 0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0287
    Cell Significance Index: 53.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0200
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0159
    Cell Significance Index: 29.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0127
    Cell Significance Index: 9.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0049
    Cell Significance Index: 7.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0153
    Cell Significance Index: -2.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0177
    Cell Significance Index: -6.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0346
    Cell Significance Index: -3.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0394
    Cell Significance Index: -0.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0395
    Cell Significance Index: -17.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0404
    Cell Significance Index: -0.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0489
    Cell Significance Index: -6.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0510
    Cell Significance Index: -14.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0663
    Cell Significance Index: -8.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0700
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0747
    Cell Significance Index: -3.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0886
    Cell Significance Index: -10.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0902
    Cell Significance Index: -5.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0911
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0955
    Cell Significance Index: -20.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0990
    Cell Significance Index: -11.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0993
    Cell Significance Index: -12.2100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1088
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1189
    Cell Significance Index: -2.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1203
    Cell Significance Index: -9.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1212
    Cell Significance Index: -1.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1250
    Cell Significance Index: -16.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1260
    Cell Significance Index: -5.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1267
    Cell Significance Index: -3.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1313
    Cell Significance Index: -2.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1319
    Cell Significance Index: -1.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1324
    Cell Significance Index: -1.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1340
    Cell Significance Index: -8.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1352
    Cell Significance Index: -8.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1398
    Cell Significance Index: -16.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1461
    Cell Significance Index: -3.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1541
    Cell Significance Index: -4.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1923
    Cell Significance Index: -14.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1933
    Cell Significance Index: -11.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1999
    Cell Significance Index: -3.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2089
    Cell Significance Index: -10.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2131
    Cell Significance Index: -16.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2259
    Cell Significance Index: -15.1900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.2331
    Cell Significance Index: -2.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2359
    Cell Significance Index: -6.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2423
    Cell Significance Index: -12.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2589
    Cell Significance Index: -18.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2923
    Cell Significance Index: -7.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2998
    Cell Significance Index: -18.9000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3076
    Cell Significance Index: -4.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3158
    Cell Significance Index: -2.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNTB1 is a cytoplasmic protein that belongs to the syntrophin family, which is composed of three isoforms: alpha, beta, and gamma. SNTB1 is characterized by its ability to interact with dystrophin, a cytoplasmic protein that is crucial for muscle function. The interaction between SNTB1 and dystrophin is mediated by the PDZ domain of SNTB1, which binds to the C-terminal domain of dystrophin. This interaction is essential for maintaining the stability and function of the DGC. **Pathways and Functions:** SNTB1 is involved in several signaling pathways that regulate muscle function and integrity. These pathways include: 1. **Actin binding:** SNTB1 interacts with actin filaments, which are essential for muscle contraction and relaxation. 2. **Calmodulin binding:** SNTB1 binds to calmodulin, a calcium-binding protein that regulates muscle contraction and relaxation. 3. **Cytoskeleton organization:** SNTB1 is involved in the organization and regulation of the cytoskeleton, which is essential for maintaining muscle cell shape and function. 4. **Muscle contraction:** SNTB1 plays a critical role in regulating muscle contraction by interacting with dystrophin and other components of the DGC. **Clinical Significance:** Mutations in the SNTB1 gene have been associated with various neuromuscular disorders, including: 1. **Duchenne muscular dystrophy (DMD):** A severe X-linked recessive disorder characterized by progressive muscle degeneration and weakness. 2. **Becker muscular dystrophy (BMD):** A milder X-linked recessive disorder characterized by progressive muscle degeneration and weakness. 3. **Muscle wasting:** SNTB1 mutations have been associated with muscle wasting and wasting syndromes, such as limb-girdle muscular dystrophy. In addition to its role in neuromuscular disorders, SNTB1 is also expressed in other tissues, including the liver, kidneys, and adrenal glands. Mutations in the SNTB1 gene have been associated with various non-muscle disorders, including liver disease and cancer. **Conclusion:** In conclusion, SNTB1 is a critical component of the DGC, and its dysregulation has been associated with various neuromuscular disorders. Further research is needed to fully understand the mechanisms by which SNTB1 regulates muscle function and integrity, as well as its role in non-muscle diseases.

Genular Protein ID: 545583267

Symbol: SNTB1_HUMAN

Name: Beta-1-syntrophin

UniProtKB Accession Codes:

Q13884 A8K9E0 O14912 Q4KMG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8183929

Title: Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.

PubMed ID: 8183929

DOI: 10.1073/pnas.91.10.4446

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9482110

Title: The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins.

PubMed ID: 9482110

DOI: 10.1038/sj.onc.1201567

PubMed ID: 7844150

Title: Syntrophin binds to an alternatively spliced exon of dystrophin.

PubMed ID: 7844150

DOI: 10.1083/jcb.128.3.363

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 538
  • Mass: 58061
  • Checksum: BF8E7B416D5CF289
  • Sequence:
    • MAVAAAAAAA GPAGAGGGRA QRSGLLEVLV RDRWHKVLVN LSEDALVLSS EEGAAAYNGI 
GTATNGSFCR GAGAGHPGAG GAQPPDSPAG VRTAFTDLPE QVPESISNQK RGVKVLKQEL 
GGLGISIKGG KENKMPILIS KIFKGLAADQ TQALYVGDAI LSVNGADLRD ATHDEAVQAL 
KRAGKEVLLE VKYMREATPY VKKGSPVSEI GWETPPPESP RLGGSTSDPP SSQSFSFHRD 
RKSIPLKMCY VTRSMALADP ENRQLEIHSP DAKHTVILRS KDSATAQAWF SAIHSNVNDL 
LTRVIAEVRE QLGKTGIAGS REIRHLGWLA EKVPGESKKQ WKPALVVLTE KDLLIYDSMP 
RRKEAWFSPV HTYPLLATRL VHSGPGKGSP QAGVDLSFAT RTGTRQGIET HLFRAETSRD 
LSHWTRSIVQ GCHNSAELIA EISTACTYKN QECRLTIHYE NGFSITTEPQ EGAFPKTIIQ 
SPYEKLKMSS DDGIRMLYLD FGGKDGEIQL DLHSCPKPIV FIIHSFLSAK ITRLGLVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.