Details for: SORL1

Gene ID: 6653

Symbol: SORL1

Ensembl ID: ENSG00000137642

Description: sortilin related receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 315.2138
    Cell Significance Index: -49.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.8273
    Cell Significance Index: -38.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.0874
    Cell Significance Index: -43.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.6676
    Cell Significance Index: -49.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.8317
    Cell Significance Index: -43.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.6608
    Cell Significance Index: -48.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.0417
    Cell Significance Index: -67.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.4365
    Cell Significance Index: -46.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.5138
    Cell Significance Index: -49.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.6455
    Cell Significance Index: -21.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.3954
    Cell Significance Index: 170.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4193
    Cell Significance Index: 236.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.9964
    Cell Significance Index: 201.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5248
    Cell Significance Index: 506.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1611
    Cell Significance Index: 61.6700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.9886
    Cell Significance Index: 17.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8340
    Cell Significance Index: 181.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7808
    Cell Significance Index: 30.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4424
    Cell Significance Index: 156.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4312
    Cell Significance Index: 85.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3470
    Cell Significance Index: 242.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3190
    Cell Significance Index: 1190.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2389
    Cell Significance Index: 676.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2340
    Cell Significance Index: 145.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1855
    Cell Significance Index: 235.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1780
    Cell Significance Index: 422.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1357
    Cell Significance Index: 139.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0444
    Cell Significance Index: 14.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9977
    Cell Significance Index: 51.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8041
    Cell Significance Index: 7.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.7809
    Cell Significance Index: 10.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6794
    Cell Significance Index: 14.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6009
    Cell Significance Index: 16.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5598
    Cell Significance Index: 36.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4789
    Cell Significance Index: 12.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3790
    Cell Significance Index: 17.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3444
    Cell Significance Index: 15.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3188
    Cell Significance Index: 220.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2681
    Cell Significance Index: 5.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1959
    Cell Significance Index: 5.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1211
    Cell Significance Index: 53.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1086
    Cell Significance Index: 20.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1027
    Cell Significance Index: 1.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0514
    Cell Significance Index: 23.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0340
    Cell Significance Index: 24.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0209
    Cell Significance Index: 39.3300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0011
    Cell Significance Index: -0.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0239
    Cell Significance Index: -2.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0242
    Cell Significance Index: -44.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0264
    Cell Significance Index: -40.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0329
    Cell Significance Index: -44.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0330
    Cell Significance Index: -24.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0344
    Cell Significance Index: -0.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0407
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0421
    Cell Significance Index: -26.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0468
    Cell Significance Index: -0.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0528
    Cell Significance Index: -33.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0561
    Cell Significance Index: -31.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0572
    Cell Significance Index: -43.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0912
    Cell Significance Index: -13.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0966
    Cell Significance Index: -20.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1430
    Cell Significance Index: -18.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1495
    Cell Significance Index: -43.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1714
    Cell Significance Index: -29.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1763
    Cell Significance Index: -20.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1901
    Cell Significance Index: -14.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2317
    Cell Significance Index: -14.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2466
    Cell Significance Index: -33.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2640
    Cell Significance Index: -13.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3129
    Cell Significance Index: -14.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3290
    Cell Significance Index: -37.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3681
    Cell Significance Index: -7.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3907
    Cell Significance Index: -17.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3959
    Cell Significance Index: -14.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4152
    Cell Significance Index: -31.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4477
    Cell Significance Index: -4.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4489
    Cell Significance Index: -6.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4513
    Cell Significance Index: -51.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4692
    Cell Significance Index: -48.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5178
    Cell Significance Index: -66.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5437
    Cell Significance Index: -13.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5515
    Cell Significance Index: -14.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5518
    Cell Significance Index: -30.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5640
    Cell Significance Index: -44.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6171
    Cell Significance Index: -19.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6489
    Cell Significance Index: -13.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6555
    Cell Significance Index: -40.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7351
    Cell Significance Index: -46.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7404
    Cell Significance Index: -24.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7634
    Cell Significance Index: -22.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7767
    Cell Significance Index: -9.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7807
    Cell Significance Index: -16.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7906
    Cell Significance Index: -13.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8153
    Cell Significance Index: -42.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8532
    Cell Significance Index: -60.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8575
    Cell Significance Index: -21.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9122
    Cell Significance Index: -23.9900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.9579
    Cell Significance Index: -5.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9663
    Cell Significance Index: -33.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SORL1 is a transmembrane receptor that belongs to the sortilin family of proteins. Its structure consists of two extracellular domains and a single transmembrane domain, followed by a cytoplasmic tail. The gene is highly expressed in various tissues, including the brain, kidney, and immune cells. SORL1 is also known to interact with numerous proteins, including amyloid precursor protein, insulin receptor, and low-density lipoprotein receptors, among others. **Pathways and Functions:** SORL1 is involved in a myriad of cellular processes, including: 1. **Amyloid-beta binding and clearance**: SORL1 interacts with amyloid precursor protein (APP) and facilitates its clearance from the brain, potentially playing a role in preventing amyloid-beta accumulation and neurodegeneration. 2. **Endocytic recycling**: SORL1 regulates the endocytic recycling of insulin receptors, which is essential for glucose homeostasis and insulin signaling. 3. **Cell migration and adhesion**: SORL1 is involved in the regulation of smooth muscle cell migration and adhesion, which is critical for various physiological processes, including wound healing and vascular development. 4. **Neuroprotection**: SORL1 has been shown to protect against neurodegeneration by regulating the clearance of amyloid-beta and other neurotoxic proteins. 5. **Metabolism and protein processing**: SORL1 is involved in the regulation of protein metabolism, including the processing and degradation of various proteins. **Clinical Significance:** SORL1 has been implicated in various diseases, including: 1. **Alzheimer's disease**: SORL1's role in amyloid-beta clearance and neuroprotection makes it a potential therapeutic target for Alzheimer's disease. 2. **Type 2 diabetes**: SORL1's involvement in insulin signaling and glucose homeostasis makes it a potential therapeutic target for type 2 diabetes. 3. **Cardiovascular disease**: SORL1's role in smooth muscle cell migration and adhesion makes it a potential therapeutic target for cardiovascular disease. 4. **Neurodegenerative disorders**: SORL1's neuroprotective functions make it a potential therapeutic target for various neurodegenerative disorders, including Parkinson's disease and Huntington's disease. In conclusion, SORL1 is a complex gene with a wide range of functions and interactions within various cellular processes. Further research is necessary to fully understand the mechanisms underlying SORL1's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1079653286

Symbol: SORL_HUMAN

Name: Sortilin-related receptor

UniProtKB Accession Codes:

Q92673 B2RNX7 Q92856

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 60 Gene3D 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9157966

Title: A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens.

PubMed ID: 9157966

DOI: 10.1161/01.atv.17.5.996

PubMed ID: 8940146

Title: Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.

PubMed ID: 8940146

DOI: 10.1074/jbc.271.49.31379

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11082041

Title: Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator.

PubMed ID: 11082041

DOI: 10.1242/jcs.113.24.4475

PubMed ID: 11294867

Title: Activation and functional characterization of the mosaic receptor SorLA/LR11.

PubMed ID: 11294867

DOI: 10.1074/jbc.m100857200

PubMed ID: 12530537

Title: Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA.

PubMed ID: 12530537

DOI: 10.1515/bc.2002.193

PubMed ID: 11821067

Title: The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.

PubMed ID: 11821067

DOI: 10.1016/s0014-5793(01)03299-9

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 14764453

Title: LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.

PubMed ID: 14764453

DOI: 10.1161/01.res.0000120862.79154.0f

PubMed ID: 15364913

Title: Functional organization of the sortilin Vps10p domain.

PubMed ID: 15364913

DOI: 10.1074/jbc.m408873200

PubMed ID: 16174740

Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

PubMed ID: 16174740

DOI: 10.1073/pnas.0503689102

PubMed ID: 16393139

Title: Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.

PubMed ID: 16393139

DOI: 10.1042/bj20051364

PubMed ID: 16531402

Title: SorLA signaling by regulated intramembrane proteolysis.

PubMed ID: 16531402

DOI: 10.1074/jbc.m601660200

PubMed ID: 16407538

Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

PubMed ID: 16407538

DOI: 10.1523/jneurosci.3882-05.2006

PubMed ID: 17326667

Title: Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.

PubMed ID: 17326667

DOI: 10.1021/bi7000533

PubMed ID: 17855360

Title: SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

PubMed ID: 17855360

DOI: 10.1074/jbc.m705073200

PubMed ID: 17646382

Title: Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

PubMed ID: 17646382

DOI: 10.1128/mcb.00815-07

PubMed ID: 18603531

Title: Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.

PubMed ID: 18603531

DOI: 10.1074/jbc.m802721200

PubMed ID: 18562096

Title: No association of SORL1 SNPs with Alzheimer's disease.

PubMed ID: 18562096

DOI: 10.1016/j.neulet.2008.05.082

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20385770

Title: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

PubMed ID: 20385770

DOI: 10.1128/mcb.01560-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21220680

Title: Meta-analysis of the association between variants in SORL1 and Alzheimer disease.

PubMed ID: 21220680

DOI: 10.1001/archneurol.2010.346

PubMed ID: 21147781

Title: Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.

PubMed ID: 21147781

DOI: 10.1074/jbc.m110.167239

PubMed ID: 21994944

Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.

PubMed ID: 21994944

DOI: 10.1074/jbc.m111.246413

PubMed ID: 21385844

Title: SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.

PubMed ID: 21385844

DOI: 10.1242/jcs.072538

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

PubMed ID: 23486467

Title: The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.

PubMed ID: 23486467

DOI: 10.1074/jbc.m112.442491

PubMed ID: 23565137

Title: SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

PubMed ID: 23565137

DOI: 10.1371/journal.pone.0058618

PubMed ID: 23977241

Title: SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

PubMed ID: 23977241

DOI: 10.1371/journal.pone.0072164

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24523320

Title: Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

PubMed ID: 24523320

DOI: 10.1126/scitranslmed.3007747

PubMed ID: 26584636

Title: Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.

PubMed ID: 26584636

DOI: 10.1038/ncomms9951

PubMed ID: 27322061

Title: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

PubMed ID: 27322061

DOI: 10.1172/jci84708

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 30448281

Title: Soluble LR11 competes with amyloid beta in binding to cerebrospinal fluid-high-density lipoprotein.

PubMed ID: 30448281

DOI: 10.1016/j.cca.2018.11.024

PubMed ID: 31138794

Title: SORLA regulates endosomal trafficking and oncogenic fitness of HER2.

PubMed ID: 31138794

DOI: 10.1038/s41467-019-10275-0

PubMed ID: 30679749

Title: HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.

PubMed ID: 30679749

DOI: 10.1038/s41598-018-37336-6

PubMed ID: 20015111

Title: GGA autoinhibition revisited.

PubMed ID: 20015111

DOI: 10.1111/j.1600-0854.2009.01017.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18407551

Title: SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.

PubMed ID: 18407551

DOI: 10.1002/humu.20725

PubMed ID: 22472873

Title: High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

PubMed ID: 22472873

DOI: 10.1038/mp.2012.15

Sequence Information:

  • Length: 2214
  • Mass: 248426
  • Checksum: 4C215BB33E65C0B2
  • Sequence:
    • MATRSSRRES RLPFLFTLVA LLPPGALCEV WTQRLHGGSA PLPQDRGFLV VQGDPRELRL 
WARGDARGAS RADEKPLRRK RSAALQPEPI KVYGQVSLND SHNQMVVHWA GEKSNVIVAL 
ARDSLALARP KSSDVYVSYD YGKSFKKISD KLNFGLGNRS EAVIAQFYHS PADNKRYIFA 
DAYAQYLWIT FDFCNTLQGF SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT 
WIMIQEHVKS FSWGIDPYDK PNTIYIERHE PSGYSTVFRS TDFFQSRENQ EVILEEVRDF 
QLRDKYMFAT KVVHLLGSEQ QSSVQLWVSF GRKPMRAAQF VTRHPINEYY IADASEDQVF 
VCVSHSNNRT NLYISEAEGL KFSLSLENVL YYSPGGAGSD TLVRYFANEP FADFHRVEGL 
QGVYIATLIN GSMNEENMRS VITFDKGGTW EFLQAPAFTG YGEKINCELS QGCSLHLAQR 
LSQLLNLQLR RMPILSKESA PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY 
TWGDHGGIIT AIAQGMETNE LKYSTNEGET WKTFIFSEKP VFVYGLLTEP GEKSTVFTIF 
GSNKENVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV FKRRTPHATC 
FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV PDPEFSGKSY SPPVPCPVGS 
TYRRTRGYRK ISGDTCSGGD VEARLEGELV PCPLAEENEF ILYAVRKSIY RYDLASGATE 
QLPLTGLRAA VALDFDYEHN CLYWSDLALD VIQRLCLNGS TGQEVIINSG LETVEALAFE 
PLSQLLYWVD AGFKKIEVAN PDGDFRLTIV NSSVLDRPRA LVLVPQEGVM FWTDWGDLKP 
GIYRSNMDGS AAYHLVSEDV KWPNGISVDD QWIYWTDAYL ECIERITFSG QQRSVILDNL 
PHPYAIAVFK NEIYWDDWSQ LSIFRASKYS GSQMEILANQ LTGLMDMKIF YKGKNTGSNA 
CVPRPCSLLC LPKANNSRSC RCPEDVSSSV LPSGDLMCDC PQGYQLKNNT CVKQENTCLR 
NQYRCSNGNC INSIWWCDFD NDCGDMSDER NCPTTICDLD TQFRCQESGT CIPLSYKCDL 
EDDCGDNSDE SHCEMHQCRS DEYNCSSGMC IRSSWVCDGD NDCRDWSDEA NCTAIYHTCE 
ASNFQCRNGH CIPQRWACDG DTDCQDGSDE DPVNCEKKCN GFRCPNGTCI PSSKHCDGLR 
DCSDGSDEQH CEPLCTHFMD FVCKNRQQCL FHSMVCDGII QCRDGSDEDA AFAGCSQDPE 
FHKVCDEFGF QCQNGVCISL IWKCDGMDDC GDYSDEANCE NPTEAPNCSR YFQFRCENGH 
CIPNRWKCDR ENDCGDWSDE KDCGDSHILP FSTPGPSTCL PNYYRCSSGT CVMDTWVCDG 
YRDCADGSDE EACPLLANVT AASTPTQLGR CDRFEFECHQ PKTCIPNWKR CDGHQDCQDG 
RDEANCPTHS TLTCMSREFQ CEDGEACIVL SERCDGFLDC SDESDEKACS DELTVYKVQN 
LQWTADFSGD VTLTWMRPKK MPSASCVYNV YYRVVGESIW KTLETHSNKT NTVLKVLKPD 
TTYQVKVQVQ CLSKAHNTND FVTLRTPEGL PDAPRNLQLS LPREAEGVIV GHWAPPIHTH 
GLIREYIVEY SRSGSKMWAS QRAASNFTEI KNLLVNTLYT VRVAAVTSRG IGNWSDSKSI 
TTIKGKVIPP PDIHIDSYGE NYLSFTLTME SDIKVNGYVV NLFWAFDTHK QERRTLNFRG 
SILSHKVGNL TAHTSYEISA WAKTDLGDSP LAFEHVMTRG VRPPAPSLKA KAINQTAVEC 
TWTGPRNVVY GIFYATSFLD LYRNPKSLTT SLHNKTVIVS KDEQYLFLVR VVVPYQGPSS 
DYVVVKMIPD SRLPPRHLHV VHTGKTSVVI KWESPYDSPD QDLLYAVAVK DLIRKTDRSY 
KVKSRNSTVE YTLNKLEPGG KYHIIVQLGN MSKDSSIKIT TVSLSAPDAL KIITENDHVL 
LFWKSLALKE KHFNESRGYE IHMFDSAMNI TAYLGNTTDN FFKISNLKMG HNYTFTVQAR 
CLFGNQICGE PAILLYDELG SGADASATQA ARSTDVAAVV VPILFLILLS LGVGFAILYT 
KHRRLQSSFT AFANSHYSSR LGSAIFSSGD DLGEDDEDAP MITGFSDDVP MVIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.