Details for: SP4

Gene ID: 6671

Symbol: SP4

Ensembl ID: ENSG00000105866

Description: Sp4 transcription factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168591
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.35
    Marker Score: 5232
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.31
    Marker Score: 5349.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.3
    Marker Score: 49477
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12203
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.26
    Marker Score: 759
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76684
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9138
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.19
    Marker Score: 372
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1813
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 11002
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.16
    Marker Score: 9976
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18152
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.11
    Marker Score: 357
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4576
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.09
    Marker Score: 11256
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.09
    Marker Score: 21617
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.06
    Marker Score: 39073
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15782
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.05
    Marker Score: 2473
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71746
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47970
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.92
    Marker Score: 1058
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.91
    Marker Score: 30814
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 605
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1545
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5002
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.87
    Marker Score: 18582
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4915
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.81
    Marker Score: 1787
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.79
    Marker Score: 1896
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1218
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.75
    Marker Score: 219
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3038
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.71
    Marker Score: 374
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.71
    Marker Score: 322
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.7
    Marker Score: 3259
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.7
    Marker Score: 262
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.7
    Marker Score: 758
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.7
    Marker Score: 302
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7
    Marker Score: 208
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.69
    Marker Score: 742
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.67
    Marker Score: 336
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.66
    Marker Score: 511
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.66
    Marker Score: 818
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.66
    Marker Score: 205
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.64
    Marker Score: 223
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.62
    Marker Score: 313
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 159
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.6
    Marker Score: 1677
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.59
    Marker Score: 589
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.59
    Marker Score: 212
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.58
    Marker Score: 1116
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 345
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.57
    Marker Score: 281
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.56
    Marker Score: 484
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.56
    Marker Score: 313
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.56
    Marker Score: 494
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.56
    Marker Score: 2918
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.55
    Marker Score: 272
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.53
    Marker Score: 400
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.53
    Marker Score: 235
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.53
    Marker Score: 1671
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.52
    Marker Score: 212
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 344
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.52
    Marker Score: 729
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 327
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.5
    Marker Score: 1794
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.5
    Marker Score: 1687
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5
    Marker Score: 207
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5
    Marker Score: 701
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.49
    Marker Score: 1394.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.48
    Marker Score: 177
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.48
    Marker Score: 297
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 434.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.47
    Marker Score: 3016
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 454
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.47
    Marker Score: 356
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.47
    Marker Score: 411
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.47
    Marker Score: 159
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.47
    Marker Score: 244
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.47
    Marker Score: 402
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.46
    Marker Score: 141

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Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: SP4 is a transcription factor that modulates the expression of target genes by interacting with RNA polymerase II and other chromatin-modifying enzymes. 2. **Cell-type specificity**: SP4 expression is observed in various cell types, including neural cells, lymphoid lineage restricted progenitor cells, and kidney capillary endothelial cells, suggesting a role in regulating gene expression in distinct cell types. 3. **Metal ion binding**: SP4 contains metal ion-binding domains, which may contribute to its interactions with chromatin-modifying enzymes and other transcription factors. 4. **DNA-binding specificity**: SP4 exhibits sequence-specific DNA binding, allowing it to target specific genomic regions and regulate gene expression. **Pathways and Functions:** 1. **Chromatin regulation**: SP4 interacts with chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases, to regulate chromatin structure and gene expression. 2. **Transcriptional regulation**: SP4 modulates transcription by interacting with RNA polymerase II and other transcription factors, influencing the initiation and elongation phases of transcription. 3. **Neurodevelopmental processes**: SP4 expression in neural cells suggests a role in regulating neurodevelopmental processes, including neuronal differentiation, migration, and synaptogenesis. 4. **Immunological regulation**: SP4 expression in lymphoid lineage restricted progenitor cells implies a role in regulating immune cell development and function. **Clinical Significance:** Dysregulation of SP4 expression has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, SP4 has been shown to play a role in regulating immune cell development and function, making it a potential target for the treatment of immune-related disorders. Further research is needed to fully elucidate the functional significance of SP4 in human disease and to explore its potential as a therapeutic target. In conclusion, the SP4 transcription factor is a complex regulatory element that plays a crucial role in modulating gene expression in the nervous system and beyond. Its dysregulation has been implicated in various neurological and immune-related disorders, highlighting the need for further research into its functional significance and potential therapeutic applications.

Genular Protein ID: 2437151373

Symbol: SP4_HUMAN

Name: Transcription factor Sp4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1454515

Title: Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

PubMed ID: 1454515

DOI: 10.1093/nar/20.21.5519

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 784
  • Mass: 81985
  • Checksum: 5B0B03EC03657993
  • Sequence:
  • MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL LAATCSKIGT 
    PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN AWQLVASTPP ASKENNVSQP 
    ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ 
    INPTSSSSLQ DLQGQIQLIS AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP 
    LQLQTLPGTQ AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL 
    VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST SASSSERTIE 
    ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG QPILQQIQIQ QPQQQIIQAI 
    PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL 
    SNLQVQNAGL SQQLTITPVS SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN 
    LGAAGVQVQG VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ 
    VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH IEGCGKVYGK 
    TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT HTGEKRFECP ECSKRFMRSD 
    HLSKHVKTHQ NKKGGGTALA IVTSGELDSS VTEVLGSPRI VTVAAISQDS NPATPNVSTN 
    MEEF

Genular Protein ID: 1588854583

Symbol: Q32M51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 471
  • Mass: 50181
  • Checksum: B27928D35AD22DB5
  • Sequence:
  • MPESPSSSTT CTTTASTSLT SSDTLVSSAD TGQYASTSAS SSERTIEESQ TPAATESEAQ 
    SSSQLQPNGM QNAQDQSNSL QQVQIVGQPI LQQIQIQQPQ QQIIQAIPPQ SFQLQSGQTI 
    QTIQQQPLQN VQLQAVNPTQ VLIRAPTLTP SGQISWQTVQ VQNIQSLSNL QVQNAGLSQQ 
    LTITPVSSSG GTTLAQIAPV AVAGAPITLN TAQLASVPNL QTVSVANLGA AGVQVQGVPV 
    TITSVAGQQQ GQDGVKVQQA TIAPVTVAVG GIANATIGAV SPDQLTQVHL QQGQQTSDQE 
    VQPGKRLRRV ACSCPNCREG EGRGSNEPGK KKQHICHIEG CGKVYGKTSH LRAHLRWHTG 
    ERPFICNWMF CGKRFTRSDE LQRHRRTHTG EKRFECPECS KRFMRSDHLS KHVKTHQNKK 
    GGGTALAIVT SGELDSSVTE VLGSPRIVTV AAISQDSNPA TPNVSTNMEE F

Genular Protein ID: 3423414700

Symbol: A0A3B3IRW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 767
  • Mass: 80195
  • Checksum: 6F744643DCE4E401
  • Sequence:
  • MATEGGKTSE PENNNKKPKT SGSQDSQPSP LALLAATCSK IGTPGENQAT GQQQIIIDPS 
    QGLVQLQNQP QQLELVTTQL AGNAWQLVAS TPPASKENNV SQPASSSSSS SSSNNGSASP 
    TKTKSGNSST PGQFQVIQVQ NPSGSVQYQV IPQLQTVEGQ QIQINPTSSS SLQDLQGQIQ 
    LISAGNNQAI LTAANRTASG NILAQNLANQ TVPVQIRPGV SIPLQLQTLP GTQAQVVTTL 
    PINIGGVTLA LPVINNVAAG GGTGQVGQPA ATADSGTSNG NQLVSTPTNT TTSASTMPES 
    PSSSTTCTTT ASTSLTSSDT LVSSADTGQY ASTSASSSER TIEESQTPAA TESEAQSSSQ 
    LQPNGMQNAQ DQSNSLQQVQ IVGQPILQQI QIQQPQQQII QAIPPQSFQL QSGQTIQTIQ 
    QQPLQNVQLQ AVNPTQVLIR APTLTPSGQI SWQTVQVQNI QSLSNLQVQN AGLSQQLTIT 
    PVSSSGGTTL AQIAPVAVAG APITLNTAQL ASVPNLQTVS VANLGAAGVQ VQGVPVTITS 
    VAGQQQGQDG VKVQQATIAP VTVAVGGIAN ATIGAVSPDQ LTQVHLQQGQ QTSDQEVQPG 
    KRLRRVACSC PNCREGEGRG SNEPGKKKQH ICHIEGCGKV YGKTSHLRAH LRWHTGERPF 
    ICNWMFCGKR FTRSDELQRH RRTHTGEKRF ECPECSKRFM RSDHLSKHVK THQNKKGGGT 
    ALAIVTSGEL DSSVTEVLGS PRIVTVAAIS QDSNPATPNV STNMEEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.