Details for: SP4

Gene ID: 6671

Symbol: SP4

Ensembl ID: ENSG00000105866

Description: Sp4 transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.6729
    Cell Significance Index: -20.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.6751
    Cell Significance Index: -20.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.7500
    Cell Significance Index: -18.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.1570
    Cell Significance Index: -18.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.2431
    Cell Significance Index: -21.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8952
    Cell Significance Index: -21.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0395
    Cell Significance Index: -18.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4865
    Cell Significance Index: -21.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3091
    Cell Significance Index: 73.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1575
    Cell Significance Index: 232.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0013
    Cell Significance Index: 21.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8724
    Cell Significance Index: 86.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8180
    Cell Significance Index: 293.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8164
    Cell Significance Index: 36.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7833
    Cell Significance Index: 29.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6843
    Cell Significance Index: 617.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6607
    Cell Significance Index: 14.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6378
    Cell Significance Index: 40.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4543
    Cell Significance Index: 52.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4484
    Cell Significance Index: 48.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4449
    Cell Significance Index: 307.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4392
    Cell Significance Index: 87.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4392
    Cell Significance Index: 11.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4283
    Cell Significance Index: 69.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4209
    Cell Significance Index: 25.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3993
    Cell Significance Index: 71.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3867
    Cell Significance Index: 4.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3720
    Cell Significance Index: 22.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3144
    Cell Significance Index: 24.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2935
    Cell Significance Index: 7.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2882
    Cell Significance Index: 19.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2243
    Cell Significance Index: 3.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1836
    Cell Significance Index: 12.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1732
    Cell Significance Index: 21.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1056
    Cell Significance Index: 1.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0988
    Cell Significance Index: 18.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0878
    Cell Significance Index: 3.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0754
    Cell Significance Index: 33.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0748
    Cell Significance Index: 1.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0714
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0694
    Cell Significance Index: 2.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0487
    Cell Significance Index: 30.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0477
    Cell Significance Index: 26.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0318
    Cell Significance Index: 14.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0228
    Cell Significance Index: 3.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0225
    Cell Significance Index: 42.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0139
    Cell Significance Index: 21.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0040
    Cell Significance Index: 7.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0272
    Cell Significance Index: -20.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0382
    Cell Significance Index: -23.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0392
    Cell Significance Index: -5.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0422
    Cell Significance Index: -2.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0453
    Cell Significance Index: -1.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0517
    Cell Significance Index: -3.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0586
    Cell Significance Index: -6.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0588
    Cell Significance Index: -16.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0605
    Cell Significance Index: -10.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0608
    Cell Significance Index: -3.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0630
    Cell Significance Index: -1.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0891
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1022
    Cell Significance Index: -11.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1090
    Cell Significance Index: -22.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1342
    Cell Significance Index: -17.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1426
    Cell Significance Index: -6.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1492
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1638
    Cell Significance Index: -8.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1734
    Cell Significance Index: -18.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1804
    Cell Significance Index: -12.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1826
    Cell Significance Index: -5.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1843
    Cell Significance Index: -8.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2009
    Cell Significance Index: -12.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2049
    Cell Significance Index: -4.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2144
    Cell Significance Index: -15.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2388
    Cell Significance Index: -5.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2412
    Cell Significance Index: -19.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2566
    Cell Significance Index: -5.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2577
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2679
    Cell Significance Index: -8.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3036
    Cell Significance Index: -10.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3067
    Cell Significance Index: -6.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3150
    Cell Significance Index: -4.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3176
    Cell Significance Index: -7.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3209
    Cell Significance Index: -10.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3243
    Cell Significance Index: -6.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3363
    Cell Significance Index: -11.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3449
    Cell Significance Index: -6.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3550
    Cell Significance Index: -5.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3558
    Cell Significance Index: -9.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3736
    Cell Significance Index: -5.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3868
    Cell Significance Index: -4.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4058
    Cell Significance Index: -10.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4439
    Cell Significance Index: -15.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4474
    Cell Significance Index: -11.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4627
    Cell Significance Index: -9.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation**: SP4 is a transcription factor that modulates the expression of target genes by interacting with RNA polymerase II and other chromatin-modifying enzymes. 2. **Cell-type specificity**: SP4 expression is observed in various cell types, including neural cells, lymphoid lineage restricted progenitor cells, and kidney capillary endothelial cells, suggesting a role in regulating gene expression in distinct cell types. 3. **Metal ion binding**: SP4 contains metal ion-binding domains, which may contribute to its interactions with chromatin-modifying enzymes and other transcription factors. 4. **DNA-binding specificity**: SP4 exhibits sequence-specific DNA binding, allowing it to target specific genomic regions and regulate gene expression. **Pathways and Functions:** 1. **Chromatin regulation**: SP4 interacts with chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases, to regulate chromatin structure and gene expression. 2. **Transcriptional regulation**: SP4 modulates transcription by interacting with RNA polymerase II and other transcription factors, influencing the initiation and elongation phases of transcription. 3. **Neurodevelopmental processes**: SP4 expression in neural cells suggests a role in regulating neurodevelopmental processes, including neuronal differentiation, migration, and synaptogenesis. 4. **Immunological regulation**: SP4 expression in lymphoid lineage restricted progenitor cells implies a role in regulating immune cell development and function. **Clinical Significance:** Dysregulation of SP4 expression has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, SP4 has been shown to play a role in regulating immune cell development and function, making it a potential target for the treatment of immune-related disorders. Further research is needed to fully elucidate the functional significance of SP4 in human disease and to explore its potential as a therapeutic target. In conclusion, the SP4 transcription factor is a complex regulatory element that plays a crucial role in modulating gene expression in the nervous system and beyond. Its dysregulation has been implicated in various neurological and immune-related disorders, highlighting the need for further research into its functional significance and potential therapeutic applications.

Genular Protein ID: 2437151373

Symbol: SP4_HUMAN

Name: Transcription factor Sp4

UniProtKB Accession Codes:

Q02446 O60402 Q32M52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1454515

Title: Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

PubMed ID: 1454515

DOI: 10.1093/nar/20.21.5519

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 784
  • Mass: 81985
  • Checksum: 5B0B03EC03657993
  • Sequence:
    • MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL LAATCSKIGT 
PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN AWQLVASTPP ASKENNVSQP 
ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ 
INPTSSSSLQ DLQGQIQLIS AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP 
LQLQTLPGTQ AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL 
VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST SASSSERTIE 
ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG QPILQQIQIQ QPQQQIIQAI 
PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL 
SNLQVQNAGL SQQLTITPVS SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN 
LGAAGVQVQG VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ 
VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH IEGCGKVYGK 
TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT HTGEKRFECP ECSKRFMRSD 
HLSKHVKTHQ NKKGGGTALA IVTSGELDSS VTEVLGSPRI VTVAAISQDS NPATPNVSTN 
MEEF

Genular Protein ID: 1588854583

Symbol: Q32M51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32M51

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 471
  • Mass: 50181
  • Checksum: B27928D35AD22DB5
  • Sequence:
    • MPESPSSSTT CTTTASTSLT SSDTLVSSAD TGQYASTSAS SSERTIEESQ TPAATESEAQ 
SSSQLQPNGM QNAQDQSNSL QQVQIVGQPI LQQIQIQQPQ QQIIQAIPPQ SFQLQSGQTI 
QTIQQQPLQN VQLQAVNPTQ VLIRAPTLTP SGQISWQTVQ VQNIQSLSNL QVQNAGLSQQ 
LTITPVSSSG GTTLAQIAPV AVAGAPITLN TAQLASVPNL QTVSVANLGA AGVQVQGVPV 
TITSVAGQQQ GQDGVKVQQA TIAPVTVAVG GIANATIGAV SPDQLTQVHL QQGQQTSDQE 
VQPGKRLRRV ACSCPNCREG EGRGSNEPGK KKQHICHIEG CGKVYGKTSH LRAHLRWHTG 
ERPFICNWMF CGKRFTRSDE LQRHRRTHTG EKRFECPECS KRFMRSDHLS KHVKTHQNKK 
GGGTALAIVT SGELDSSVTE VLGSPRIVTV AAISQDSNPA TPNVSTNMEE F

Genular Protein ID: 3423414700

Symbol: A0A3B3IRW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3IRW4

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 767
  • Mass: 80195
  • Checksum: 6F744643DCE4E401
  • Sequence:
    • MATEGGKTSE PENNNKKPKT SGSQDSQPSP LALLAATCSK IGTPGENQAT GQQQIIIDPS 
QGLVQLQNQP QQLELVTTQL AGNAWQLVAS TPPASKENNV SQPASSSSSS SSSNNGSASP 
TKTKSGNSST PGQFQVIQVQ NPSGSVQYQV IPQLQTVEGQ QIQINPTSSS SLQDLQGQIQ 
LISAGNNQAI LTAANRTASG NILAQNLANQ TVPVQIRPGV SIPLQLQTLP GTQAQVVTTL 
PINIGGVTLA LPVINNVAAG GGTGQVGQPA ATADSGTSNG NQLVSTPTNT TTSASTMPES 
PSSSTTCTTT ASTSLTSSDT LVSSADTGQY ASTSASSSER TIEESQTPAA TESEAQSSSQ 
LQPNGMQNAQ DQSNSLQQVQ IVGQPILQQI QIQQPQQQII QAIPPQSFQL QSGQTIQTIQ 
QQPLQNVQLQ AVNPTQVLIR APTLTPSGQI SWQTVQVQNI QSLSNLQVQN AGLSQQLTIT 
PVSSSGGTTL AQIAPVAVAG APITLNTAQL ASVPNLQTVS VANLGAAGVQ VQGVPVTITS 
VAGQQQGQDG VKVQQATIAP VTVAVGGIAN ATIGAVSPDQ LTQVHLQQGQ QTSDQEVQPG 
KRLRRVACSC PNCREGEGRG SNEPGKKKQH ICHIEGCGKV YGKTSHLRAH LRWHTGERPF 
ICNWMFCGKR FTRSDELQRH RRTHTGEKRF ECPECSKRFM RSDHLSKHVK THQNKKGGGT 
ALAIVTSGEL DSSVTEVLGS PRIVTVAAIS QDSNPATPNV STNMEEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.