Details for: SP4

Gene ID: 6671

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SP4

Ensembl ID: ENSG00000105866

Description: Sp4 transcription factor

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • amacrine cell CL0000561
    CSI 7.03
    rCSI 20.37%
    PRS 54.28
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.73
    rCSI 3.39%
    PRS 78.79
  • plasmablast CL0000980
    CSI 4.7
    rCSI 3.7%
    PRS 71.45
  • cerebral cortex endothelial cell CL1001602
    CSI 4.59
    rCSI 7.95%
    PRS 54.83
  • unswitched memory B cell CL0000970
    CSI 3.77
    rCSI 3.17%
    PRS 81.24
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.56
    rCSI 2.71%
    PRS 77.75
  • mucosal invariant T cell CL0000940
    CSI 3.5
    rCSI 2.82%
    PRS 75.17
  • retinal cone cell CL0000573
    CSI 3.36
    rCSI 5.41%
    PRS 54.22
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.09
    rCSI 6.93%
    PRS 46.86
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.91
    rCSI 1.72%
    PRS 81.84
  • lung neuroendocrine cell CL1000223
    CSI 2.91
    rCSI 4.3%
    PRS 69.96
  • double negative thymocyte CL0002489
    CSI 2.68
    rCSI 1.87%
    PRS 75.86
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.66
    rCSI 3.18%
    PRS 45.97
  • melanocyte CL0000148
    CSI 2.62
    rCSI 1.94%
    PRS 57.32
  • renal alpha-intercalated cell CL0005011
    CSI 2.58
    rCSI 3.44%
    PRS 73.6
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.45
    rCSI 2.4%
    PRS 80.32
  • precursor B cell CL0000817
    CSI 2.38
    rCSI 2.09%
    PRS 73.78
  • naive B cell CL0000788
    CSI 2.37
    rCSI 2.04%
    PRS 72.31
  • chondrocyte CL0000138
    CSI 2.36
    rCSI 3.75%
    PRS 57.14
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.35
    rCSI 2.14%
    PRS 78.97
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.35
    rCSI 5.96%
    PRS 54.13
  • group 3 innate lymphoid cell CL0001071
    CSI 2.35
    rCSI 1.77%
    PRS 70.34
  • interneuron CL0000099
    CSI 2.35
    rCSI 4.71%
    PRS 53.74
  • alpha-beta T cell CL0000789
    CSI 2.26
    rCSI 2.64%
    PRS 80.68
  • mature T cell CL0002419
    CSI 2.22
    rCSI 1.72%
    PRS 82.01
  • class switched memory B cell CL0000972
    CSI 2.21
    rCSI 1.65%
    PRS 80.79
  • direct pathway medium spiny neuron CL4023026
    CSI 2.2
    rCSI 52.68%
    PRS 45.2
  • hepatic stellate cell CL0000632
    CSI 2.16
    rCSI 8.07%
    PRS 56.59
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 2.15
    rCSI 10.78%
    PRS 77.21
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.13
    rCSI 51.37%
    PRS 46.01
  • choroid plexus epithelial cell CL0000706
    CSI 2.13
    rCSI 3.49%
    PRS 53.81
  • erythrocyte CL0000232
    CSI 2.1
    rCSI 4.76%
    PRS 68.13
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 2.09
    rCSI 2.49%
    PRS 83.53
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.06
    rCSI 1.39%
    PRS 77.89
  • naive T cell CL0000898
    CSI 2.05
    rCSI 1.43%
    PRS 79.87
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.03
    rCSI 12.66%
    PRS 56.48
  • neural crest cell CL0011012
    CSI 2.02
    rCSI 1.6%
    PRS 51.57
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.02
    rCSI 7.27%
    PRS 44.45
  • pro-B cell CL0000826
    CSI 1.98
    rCSI 1.64%
    PRS 67.13
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.91
    rCSI 1.94%
    PRS 76.98
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.91
    rCSI 3.07%
    PRS 48.1
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 1.9
    rCSI 5.6%
    PRS 67.46
  • retinal bipolar neuron CL0000748
    CSI 1.85
    rCSI 3.47%
    PRS 52.89
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.84
    rCSI 2.12%
    PRS 57.6
  • type B pancreatic cell CL0000169
    CSI 1.81
    rCSI 4.01%
    PRS 62.87
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.73
    rCSI 4.22%
    PRS 44.62
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.72
    rCSI 6.48%
    PRS 46.82
  • cardiac muscle cell CL0000746
    CSI 1.71
    rCSI 2.46%
    PRS 54.29
  • conjunctival epithelial cell CL1000432
    CSI 1.66
    rCSI 2.54%
    PRS 65.44
  • rod bipolar cell CL0000751
    CSI 1.63
    rCSI 2.93%
    PRS 57.94
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.58
    rCSI 4.95%
    PRS 50.25
  • pancreatic A cell CL0000171
    CSI 1.55
    rCSI 1.63%
    PRS 68.23
  • Schwann cell CL0002573
    CSI 1.54
    rCSI 4.38%
    PRS 62.59
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.51
    rCSI 1.87%
    PRS 44.32
  • inhibitory interneuron CL0000498
    CSI 1.5
    rCSI 3.47%
    PRS 53.4
  • granulocyte CL0000094
    CSI 1.49
    rCSI 2.28%
    PRS 73.89
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.45
    rCSI 1.87%
    PRS 47.43
  • keratocyte CL0002363
    CSI 1.4
    rCSI 3.37%
    PRS 71.8
  • retinal pigment epithelial cell CL0002586
    CSI 1.34
    rCSI 2.67%
    PRS 62
  • retinal rod cell CL0000604
    CSI 1.33
    rCSI 2.34%
    PRS 61.28
  • BEST4+ enteroycte CL4030026
    CSI 1.26
    rCSI 1.57%
    PRS 66.35
  • renal principal cell CL0005009
    CSI 1.17
    rCSI 3.03%
    PRS 68.01
  • lung secretory cell CL1000272
    CSI 1.15
    rCSI 2.86%
    PRS 63.27
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.06
    rCSI 2.74%
    PRS 59.77
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.06
    rCSI 0.82%
    PRS 65.45
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.01
    rCSI 3.16%
    PRS 47.82
  • parietal epithelial cell CL1000452
    CSI 0.99
    rCSI 2.63%
    PRS 55.72
  • cardiac neuron CL0010022
    CSI 0.96
    rCSI 3.09%
    PRS 61.82
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.96
    rCSI 3.14%
    PRS 51.59
  • retinal ganglion cell CL0000740
    CSI 0.91
    rCSI 2.02%
    PRS 50.7
  • GABAergic neuron CL0000617
    CSI 0.86
    rCSI 2.9%
    PRS 49.57
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.81
    rCSI 1.36%
    PRS 46.13
  • erythroblast CL0000765
    CSI 0.79
    rCSI 2.09%
    PRS 75.23
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.75
    rCSI 1.33%
    PRS 45.25
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.54
    rCSI 3.21%
    PRS 47.28
  • central nervous system neuron CL2000029
    CSI 0.39
    rCSI 2.89%
    PRS 51.25
  • medium spiny neuron CL1001474
    CSI 0.35
    rCSI 3.04%
    PRS 51.85

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SP4](/details-gene/6671) is a protein-coding gene located on chromosome 7 that encodes Sp4, a member of the Sp family of transcription factors. Functionally, it is a sequence-specific DNA-binding protein that plays a crucial role in the regulation of transcription by RNA polymerase II ([GO:0006357](https://www.ebi.ac.uk/QuickGO/term/GO:0006357)). As a transcription factor, it is primarily localized to the [nucleoplasm](/details-go/GO0005654) and [chromatin](/details-go/GO0005654). The **Overall** expression profile indicates that [SP4](/details-gene/6671) has significant roles in a diverse array of highly specialized cells. It is most prominent as a defining marker in neuronal populations, particularly the [amacrine cell](/details-cell/CL0000561) of the retina, and also shows high significance across multiple lineages of the adaptive immune system, including memory [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) and antibody-producing [plasmablast](/details-cell/CL0000980) cells. Its broad yet specific expression pattern suggests it orchestrates key transcriptional programs essential for both neuronal function and immunological memory. The gene is clinically associated with susceptibility to schizophrenia ([OMIM: 600540](https://omim.org/entry/600540)). ## Cellular Roles and Expression Landscape The expression profile of [SP4](/details-gene/6671) highlights its importance in distinct and highly specialized cellular contexts, primarily within the nervous and immune systems. **Overall**, the gene's most significant expression is observed in the [amacrine cell](/details-cell/CL0000561) (CSI: 7.03), a type of interneuron in the retina, suggesting a critical role in visual processing. Its importance in the nervous system is further supported by high significance in other retinal cells like the [retinal cone cell](/details-cell/CL0000573) and in glial cells such as the [astrocyte of the cerebral cortex](/details-cell/CL0002605). Concurrently, [SP4](/details-gene/6671) demonstrates a widespread and significant role across the adaptive immune system. It is a key marker in various lymphocyte populations, including [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: 4.73), [plasmablast](/details-cell/CL0000980) (CSI: 4.70), [unswitched memory B cell](/details-cell/CL0000970) (CSI: 3.77), and [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) (CSI: 3.56). This pattern suggests that [SP4](/details-gene/6671) is involved in regulating transcriptional programs related to lymphocyte activation, differentiation, and the maintenance of immunological memory. Beyond these two major systems, [SP4](/details-gene/6671) also shows notable significance in other specialized cell types, including [cerebral cortex endothelial cell](/details-cell/CL1001602) and [lung neuroendocrine cell](/details-cell/CL1000223), indicating a broader, context-specific regulatory function in various tissues. ## Pathways and Molecular Function As a member of the Sp family of transcription factors, the primary function of [SP4](/details-gene/6671) is to control gene expression. This is corroborated by its functional annotations, which define it as having [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-go/GO0000981) and being involved in the [Regulation of transcription by rna polymerase ii](/details-go/GO0006357). Its molecular activity relies on its ability to bind specific DNA sequences within the cis-regulatory regions of target genes ([GO:0000978](https://www.ebi.ac.uk/QuickGO/term/GO:0000978)), a function first characterized in early cloning studies [Link](https://doi.org/10.1093/nar/20.21.5519). The protein's structure is consistent with its function, featuring domains for [Metal ion binding](/details-go/GO0046872) (characteristic of zinc-finger proteins) and [Protein binding](/details-go/GO0005515), including [Identical protein binding](/details-go/GO0042802), which suggests it may form homodimers or complexes with other proteins to modulate its transcriptional activity. Its localization within the cell to the [nucleoplasm](/details-go/GO0005654) and [chromatin](/details-go/GO0000785) places it at the site of gene regulation. The presence in the [cytosol](/details-go/GO0005829) may also suggest regulation via nuclear translocation. This fundamental role in controlling gene expression likely underpins its significance in the diverse and highly differentiated cell types where it is prominently expressed, from retinal neurons to memory T cells. ## Research Directions The expression profile of [SP4](/details-gene/6671) across neuronal and immune cell types, coupled with its known function as a transcription factor, points toward several avenues for future research. Based on the available data, the following hypotheses can be proposed: 1. **[SP4](/details-gene/6671) is a master regulator of transcriptional networks essential for the functional specification and maintenance of retinal interneurons.** Given its exceptionally high significance in [amacrine cell](/details-cell/CL0000561) and notable presence in [retinal cone cell](/details-cell/CL0000573), its dysregulation could contribute to defects in visual signal processing and potentially underlie certain retinopathies. 2. **[SP4](/details-gene/6671) plays a critical role in the establishment and long-term persistence of immunological memory.** Its high significance in both B and T lymphocyte memory populations ([CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897), [unswitched memory B cell](/details-cell/CL0000970)) suggests it may control the expression of genes required for the survival and recall function of these long-lived cells. A key experiment to test the second hypothesis would be to investigate its role in T cell memory formation in vivo. One could generate a conditional knockout mouse model where [SP4](/details-gene/6671) is specifically deleted in T cells (e.g., using a *Cd4-Cre* driver). These mice, alongside wild-type controls, could be subjected to an acute viral infection model (e.g., LCMV). The subsequent formation, maintenance, and recall capacity of antigen-specific memory CD8+ and CD4+ T cells could be quantified using flow cytometry and functional assays. A significant reduction in the memory T cell pool or a compromised secondary response in knockout mice would confirm the essential role of [SP4](/details-gene/6671) in this process. From a therapeutic perspective, [SP4](/details-gene/6671) presents a challenging target. As a nuclear transcription factor, it is not easily amenable to direct inhibition by small molecules or antibodies. Furthermore, its broad expression in essential cell types within both the central nervous system and the immune system raises a high risk of off-target effects. Therefore, direct therapeutic modulation of [SP4](/details-gene/6671) itself is likely not a viable strategy. Instead, future research could focus on identifying the specific downstream genes it regulates in disease-relevant cell types, as these downstream effectors may represent more tractable targets for therapeutic intervention.

Genular Protein ID: 2437151373

Symbol: SP4_HUMAN

Name: Transcription factor Sp4

UniProtKB Accession Codes:

Q02446 O60402 Q32M52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1454515

Title: Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

PubMed ID: 1454515

DOI: 10.1093/nar/20.21.5519

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 784
  • Mass: 81985
  • Checksum: 5B0B03EC03657993
  • Sequence:
    • MSDQKKEEEE EAAAAAAMAT EGGKTSEPEN NNKKPKTSGS QDSQPSPLAL LAATCSKIGT 
PGENQATGQQ QIIIDPSQGL VQLQNQPQQL ELVTTQLAGN AWQLVASTPP ASKENNVSQP 
ASSSSSSSSS NNGSASPTKT KSGNSSTPGQ FQVIQVQNPS GSVQYQVIPQ LQTVEGQQIQ 
INPTSSSSLQ DLQGQIQLIS AGNNQAILTA ANRTASGNIL AQNLANQTVP VQIRPGVSIP 
LQLQTLPGTQ AQVVTTLPIN IGGVTLALPV INNVAAGGGT GQVGQPAATA DSGTSNGNQL 
VSTPTNTTTS ASTMPESPSS STTCTTTAST SLTSSDTLVS SADTGQYAST SASSSERTIE 
ESQTPAATES EAQSSSQLQP NGMQNAQDQS NSLQQVQIVG QPILQQIQIQ QPQQQIIQAI 
PPQSFQLQSG QTIQTIQQQP LQNVQLQAVN PTQVLIRAPT LTPSGQISWQ TVQVQNIQSL 
SNLQVQNAGL SQQLTITPVS SSGGTTLAQI APVAVAGAPI TLNTAQLASV PNLQTVSVAN 
LGAAGVQVQG VPVTITSVAG QQQGQDGVKV QQATIAPVTV AVGGIANATI GAVSPDQLTQ 
VHLQQGQQTS DQEVQPGKRL RRVACSCPNC REGEGRGSNE PGKKKQHICH IEGCGKVYGK 
TSHLRAHLRW HTGERPFICN WMFCGKRFTR SDELQRHRRT HTGEKRFECP ECSKRFMRSD 
HLSKHVKTHQ NKKGGGTALA IVTSGELDSS VTEVLGSPRI VTVAAISQDS NPATPNVSTN 
MEEF

Genular Protein ID: 1588854583

Symbol: Q32M51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32M51

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 471
  • Mass: 50181
  • Checksum: B27928D35AD22DB5
  • Sequence:
    • MPESPSSSTT CTTTASTSLT SSDTLVSSAD TGQYASTSAS SSERTIEESQ TPAATESEAQ 
SSSQLQPNGM QNAQDQSNSL QQVQIVGQPI LQQIQIQQPQ QQIIQAIPPQ SFQLQSGQTI 
QTIQQQPLQN VQLQAVNPTQ VLIRAPTLTP SGQISWQTVQ VQNIQSLSNL QVQNAGLSQQ 
LTITPVSSSG GTTLAQIAPV AVAGAPITLN TAQLASVPNL QTVSVANLGA AGVQVQGVPV 
TITSVAGQQQ GQDGVKVQQA TIAPVTVAVG GIANATIGAV SPDQLTQVHL QQGQQTSDQE 
VQPGKRLRRV ACSCPNCREG EGRGSNEPGK KKQHICHIEG CGKVYGKTSH LRAHLRWHTG 
ERPFICNWMF CGKRFTRSDE LQRHRRTHTG EKRFECPECS KRFMRSDHLS KHVKTHQNKK 
GGGTALAIVT SGELDSSVTE VLGSPRIVTV AAISQDSNPA TPNVSTNMEE F

Genular Protein ID: 3423414700

Symbol: A0A3B3IRW4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3IRW4

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 767
  • Mass: 80195
  • Checksum: 6F744643DCE4E401
  • Sequence:
    • MATEGGKTSE PENNNKKPKT SGSQDSQPSP LALLAATCSK IGTPGENQAT GQQQIIIDPS 
QGLVQLQNQP QQLELVTTQL AGNAWQLVAS TPPASKENNV SQPASSSSSS SSSNNGSASP 
TKTKSGNSST PGQFQVIQVQ NPSGSVQYQV IPQLQTVEGQ QIQINPTSSS SLQDLQGQIQ 
LISAGNNQAI LTAANRTASG NILAQNLANQ TVPVQIRPGV SIPLQLQTLP GTQAQVVTTL 
PINIGGVTLA LPVINNVAAG GGTGQVGQPA ATADSGTSNG NQLVSTPTNT TTSASTMPES 
PSSSTTCTTT ASTSLTSSDT LVSSADTGQY ASTSASSSER TIEESQTPAA TESEAQSSSQ 
LQPNGMQNAQ DQSNSLQQVQ IVGQPILQQI QIQQPQQQII QAIPPQSFQL QSGQTIQTIQ 
QQPLQNVQLQ AVNPTQVLIR APTLTPSGQI SWQTVQVQNI QSLSNLQVQN AGLSQQLTIT 
PVSSSGGTTL AQIAPVAVAG APITLNTAQL ASVPNLQTVS VANLGAAGVQ VQGVPVTITS 
VAGQQQGQDG VKVQQATIAP VTVAVGGIAN ATIGAVSPDQ LTQVHLQQGQ QTSDQEVQPG 
KRLRRVACSC PNCREGEGRG SNEPGKKKQH ICHIEGCGKV YGKTSHLRAH LRWHTGERPF 
ICNWMFCGKR FTRSDELQRH RRTHTGEKRF ECPECSKRFM RSDHLSKHVK THQNKKGGGT 
ALAIVTSGEL DSSVTEVLGS PRIVTVAAIS QDSNPATPNV STNMEEF