Details for: SPOCK1

Gene ID: 6695

Symbol: SPOCK1

Ensembl ID: ENSG00000152377

Description: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 307.9126
    Cell Significance Index: -78.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 209.1285
    Cell Significance Index: -86.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 165.3596
    Cell Significance Index: -78.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.1572
    Cell Significance Index: -77.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.5319
    Cell Significance Index: -38.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.9331
    Cell Significance Index: 1769.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.2958
    Cell Significance Index: 288.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.0087
    Cell Significance Index: 177.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.2197
    Cell Significance Index: 121.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0853
    Cell Significance Index: 618.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8555
    Cell Significance Index: 175.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.5533
    Cell Significance Index: 156.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4676
    Cell Significance Index: 59.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8349
    Cell Significance Index: 1269.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5375
    Cell Significance Index: 43.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4600
    Cell Significance Index: 25.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.3939
    Cell Significance Index: 22.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2916
    Cell Significance Index: 33.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8595
    Cell Significance Index: 163.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8326
    Cell Significance Index: 37.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6238
    Cell Significance Index: 19.9800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5585
    Cell Significance Index: 7.4500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5202
    Cell Significance Index: 7.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5060
    Cell Significance Index: 952.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4680
    Cell Significance Index: 297.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4200
    Cell Significance Index: 646.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4066
    Cell Significance Index: 367.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4062
    Cell Significance Index: 9.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.3317
    Cell Significance Index: 34.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2370
    Cell Significance Index: 2.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1793
    Cell Significance Index: 330.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0779
    Cell Significance Index: 7.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0499
    Cell Significance Index: 67.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0012
    Cell Significance Index: 0.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0147
    Cell Significance Index: -6.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0176
    Cell Significance Index: -3.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0299
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0438
    Cell Significance Index: -32.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0539
    Cell Significance Index: -7.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0541
    Cell Significance Index: -33.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0745
    Cell Significance Index: -42.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1041
    Cell Significance Index: -76.3100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1041
    Cell Significance Index: -0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1173
    Cell Significance Index: -88.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1246
    Cell Significance Index: -68.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1437
    Cell Significance Index: -4.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1516
    Cell Significance Index: -3.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1535
    Cell Significance Index: -69.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1545
    Cell Significance Index: -8.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2019
    Cell Significance Index: -3.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2097
    Cell Significance Index: -41.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2315
    Cell Significance Index: -28.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2416
    Cell Significance Index: -69.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2630
    Cell Significance Index: -36.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2700
    Cell Significance Index: -20.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2878
    Cell Significance Index: -31.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3239
    Cell Significance Index: -68.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3629
    Cell Significance Index: -61.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5209
    Cell Significance Index: -27.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5620
    Cell Significance Index: -57.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6042
    Cell Significance Index: -41.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.6247
    Cell Significance Index: -80.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6650
    Cell Significance Index: -75.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6745
    Cell Significance Index: -9.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6854
    Cell Significance Index: -87.8600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7376
    Cell Significance Index: -9.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7573
    Cell Significance Index: -88.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7706
    Cell Significance Index: -88.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8132
    Cell Significance Index: -48.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8918
    Cell Significance Index: -19.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9063
    Cell Significance Index: -19.5800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9155
    Cell Significance Index: -10.6800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9280
    Cell Significance Index: -18.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9687
    Cell Significance Index: -20.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9768
    Cell Significance Index: -77.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0743
    Cell Significance Index: -34.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.0808
    Cell Significance Index: -80.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0844
    Cell Significance Index: -23.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1211
    Cell Significance Index: -31.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.1454
    Cell Significance Index: -49.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1860
    Cell Significance Index: -61.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.2765
    Cell Significance Index: -90.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3199
    Cell Significance Index: -68.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.3208
    Cell Significance Index: -14.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4040
    Cell Significance Index: -88.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4316
    Cell Significance Index: -35.7100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4500
    Cell Significance Index: -22.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5434
    Cell Significance Index: -54.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5672
    Cell Significance Index: -51.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.5730
    Cell Significance Index: -73.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6736
    Cell Significance Index: -33.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.6808
    Cell Significance Index: -35.0800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.7007
    Cell Significance Index: -24.2100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.7250
    Cell Significance Index: -54.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.7609
    Cell Significance Index: -18.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.7620
    Cell Significance Index: -36.5500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.7742
    Cell Significance Index: -13.6500
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.7834
    Cell Significance Index: -16.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.8920
    Cell Significance Index: -54.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.9163
    Cell Significance Index: -41.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPOCK1 is a proteoglycan composed of a core protein and multiple glycosaminoglycan (GAG) chains. The core protein is rich in cysteine, glutamic acid, and aspartic acid residues, which are essential for its binding properties. SPOCK1 is characterized by the presence of four distinct domains: a cysteine-rich domain, a zinc-binding domain, a collagenous domain, and a kazal-like domain. These domains confer SPOCK1 with a range of functions, including cell adhesion, signaling, and inhibition of proteases. **Pathways and Functions:** SPOCK1 is involved in various signaling pathways, including: 1. **Cell adhesion:** SPOCK1 interacts with integrins and other cell surface receptors to regulate cell adhesion and migration. 2. **Neurogenesis:** SPOCK1 is expressed in neural stem cells and promotes the differentiation of neurons. 3. **Neuron migration and development:** SPOCK1 regulates the migration and development of neurons, including the formation of the node of Ranvier. 4. **Cysteine-type endopeptidase inhibition:** SPOCK1 inhibits the activity of cysteine-type endopeptidases, such as cathepsin B and L. 5. **Regulation of cell growth:** SPOCK1 regulates cell growth and proliferation by modulating the activity of growth factor receptors. **Clinical Significance:** Abnormal expression of SPOCK1 has been implicated in various diseases, including: 1. **Neurological disorders:** SPOCK1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as to neurological disorders, such as epilepsy and multiple sclerosis. 2. **Cancer:** SPOCK1 has been found to be overexpressed in certain types of cancer, including breast, prostate, and lung cancer. 3. **Cardiovascular disease:** SPOCK1 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac fibrosis. 4. **Muscular dystrophy:** SPOCK1 has been found to be expressed in muscle tissue and has been implicated in the development of muscular dystrophy. In conclusion, SPOCK1 is a multifunctional proteoglycan that plays a critical role in various cellular processes, including cell adhesion, differentiation, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SPOCK1 and its role in human health and disease.

Genular Protein ID: 2103839081

Symbol: TICN1_HUMAN

Name: Testican-1

UniProtKB Accession Codes:

Q08629 B3KSW3 Q59EW0 Q8N630 Q9UCL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8389704

Title: Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour.

PubMed ID: 8389704

DOI: 10.1111/j.1432-1033.1993.tb17930.x

PubMed ID: 9272383

Title: Endothelial cell expression of testican mRNA.

PubMed ID: 9272383

DOI: 10.3109/10623329709053399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1463459

Title: Characterization of a human seminal plasma glycosaminoglycan-bearing polypeptide.

PubMed ID: 1463459

DOI: 10.1042/bj2880565

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 439
  • Mass: 49124
  • Checksum: 1971601D90F1D0AD
  • Sequence:
    • MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ YDRDKYWNRF 
RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ DYQTALCVSR KHLLPRQKKG 
NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS DGHSYTSKCK LEFHACSTGK SLATLCDGPC 
PCLPEPEPPK HKAERSACTD KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS 
ILPICKDSLG WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE 
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK 
YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY ERELGPKDKE GKLRVHTRAV 
TEDDEDEDDD KEDEVGYIW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.