Details for: SPOCK1

Gene ID: 6695

Symbol: SPOCK1

Ensembl ID: ENSG00000152377

Description: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.78
    Marker Score: 6720
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.9
    Marker Score: 20943
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.32
    Marker Score: 7937
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.16
    Marker Score: 14611
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.91
    Marker Score: 8313
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.85
    Marker Score: 1278
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.83
    Marker Score: 42379
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.64
    Marker Score: 3191.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10772
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48967
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.44
    Marker Score: 805
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.4
    Marker Score: 758
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.33
    Marker Score: 9020
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.26
    Marker Score: 17354
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47207
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20679
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.08
    Marker Score: 76635
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126385
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.05
    Marker Score: 77758
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.04
    Marker Score: 595
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.03
    Marker Score: 8512
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2
    Marker Score: 1316
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.95
    Marker Score: 8430
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.88
    Marker Score: 2325
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.87
    Marker Score: 4691
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.81
    Marker Score: 3036
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17031
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.78
    Marker Score: 2475
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.7
    Marker Score: 392
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.69
    Marker Score: 983
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.68
    Marker Score: 6213
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.67
    Marker Score: 413
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.63
    Marker Score: 3311
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.62
    Marker Score: 1407
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.61
    Marker Score: 5392
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.59
    Marker Score: 1001
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.58
    Marker Score: 745.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.57
    Marker Score: 5576.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.55
    Marker Score: 2083
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.54
    Marker Score: 1703
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.54
    Marker Score: 52041
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.54
    Marker Score: 1012
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2370
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6046
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.48
    Marker Score: 548
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167754
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 854
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.44
    Marker Score: 373
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.44
    Marker Score: 3387
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.33
    Marker Score: 941
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.32
    Marker Score: 771
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20640
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.3
    Marker Score: 627
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.23
    Marker Score: 3361
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 741
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.23
    Marker Score: 2233
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11846
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.13
    Marker Score: 719
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.08
    Marker Score: 2071
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.08
    Marker Score: 6461
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.06
    Marker Score: 9104
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 710
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.01
    Marker Score: 4210
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1
    Marker Score: 654
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 447.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.96
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5299
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.92
    Marker Score: 984
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.91
    Marker Score: 983
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.9
    Marker Score: 502
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.9
    Marker Score: 511
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.89
    Marker Score: 221
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.88
    Marker Score: 1359
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.88
    Marker Score: 221
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 416
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.86
    Marker Score: 482
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.85
    Marker Score: 957
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.83
    Marker Score: 956
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.83
    Marker Score: 1031
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.82
    Marker Score: 256
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.81
    Marker Score: 292
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.81
    Marker Score: 336
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.8
    Marker Score: 389
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.78
    Marker Score: 663
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704

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Other Information

**Key Characteristics:** SPOCK1 is a proteoglycan composed of a core protein and multiple glycosaminoglycan (GAG) chains. The core protein is rich in cysteine, glutamic acid, and aspartic acid residues, which are essential for its binding properties. SPOCK1 is characterized by the presence of four distinct domains: a cysteine-rich domain, a zinc-binding domain, a collagenous domain, and a kazal-like domain. These domains confer SPOCK1 with a range of functions, including cell adhesion, signaling, and inhibition of proteases. **Pathways and Functions:** SPOCK1 is involved in various signaling pathways, including: 1. **Cell adhesion:** SPOCK1 interacts with integrins and other cell surface receptors to regulate cell adhesion and migration. 2. **Neurogenesis:** SPOCK1 is expressed in neural stem cells and promotes the differentiation of neurons. 3. **Neuron migration and development:** SPOCK1 regulates the migration and development of neurons, including the formation of the node of Ranvier. 4. **Cysteine-type endopeptidase inhibition:** SPOCK1 inhibits the activity of cysteine-type endopeptidases, such as cathepsin B and L. 5. **Regulation of cell growth:** SPOCK1 regulates cell growth and proliferation by modulating the activity of growth factor receptors. **Clinical Significance:** Abnormal expression of SPOCK1 has been implicated in various diseases, including: 1. **Neurological disorders:** SPOCK1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as to neurological disorders, such as epilepsy and multiple sclerosis. 2. **Cancer:** SPOCK1 has been found to be overexpressed in certain types of cancer, including breast, prostate, and lung cancer. 3. **Cardiovascular disease:** SPOCK1 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac fibrosis. 4. **Muscular dystrophy:** SPOCK1 has been found to be expressed in muscle tissue and has been implicated in the development of muscular dystrophy. In conclusion, SPOCK1 is a multifunctional proteoglycan that plays a critical role in various cellular processes, including cell adhesion, differentiation, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SPOCK1 and its role in human health and disease.

Genular Protein ID: 2103839081

Symbol: TICN1_HUMAN

Name: Testican-1

UniProtKB Accession Codes:

Q08629 B3KSW3 Q59EW0 Q8N630 Q9UCL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8389704

Title: Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour.

PubMed ID: 8389704

DOI: 10.1111/j.1432-1033.1993.tb17930.x

PubMed ID: 9272383

Title: Endothelial cell expression of testican mRNA.

PubMed ID: 9272383

DOI: 10.3109/10623329709053399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1463459

Title: Characterization of a human seminal plasma glycosaminoglycan-bearing polypeptide.

PubMed ID: 1463459

DOI: 10.1042/bj2880565

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 439
  • Mass: 49124
  • Checksum: 1971601D90F1D0AD
  • Sequence:
    • MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ YDRDKYWNRF 
RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ DYQTALCVSR KHLLPRQKKG 
NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS DGHSYTSKCK LEFHACSTGK SLATLCDGPC 
PCLPEPEPPK HKAERSACTD KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS 
ILPICKDSLG WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE 
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK 
YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY ERELGPKDKE GKLRVHTRAV 
TEDDEDEDDD KEDEVGYIW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.